Strain Name:
C57BL/6J-MtgxR6454Btlr/Mmmh
Stock Number:
044590-MU
Citation ID:
RRID:MMRRC_044590-MU
Other Names:
R6454 (G1)
Major Collection:

Strain Information

Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Chrnb3
Name: cholinergic receptor, nicotinic, beta polypeptide 3
Synonyms: Acrb3, 5730417K16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108043
HGNC: HGNC:1963
Homologene: 36035
Omd
Name: osteomodulin
Synonyms: SLRR2C, osteoadherin, OSAD
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27047
VEGA: 13
HGNC: HGNC:8134
Homologene: 3677
Xpnpep1
Name: X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Synonyms: D230045I08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 170750
Homologene: 6424
Ppp1r9a
Name: protein phosphatase 1, regulatory subunit 9A
Synonyms: 4930518N04Rik, A230094E16Rik, neurabin-I, 2810430P21Rik, Neurabin I, NRB
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243725
Homologene: 14247
Odf2l
Name: outer dense fiber of sperm tails 2-like
Synonyms: 4733401D09Rik, 9630045K08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 52184
Homologene: 12011
Tpst1
Name: protein-tyrosine sulfotransferase 1
Synonyms: Tango13a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22021
Homologene: 2667
Plekhm1
Name: pleckstrin homology domain containing, family M (with RUN domain) member 1
Synonyms: D330036J23Rik, AP162, B2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 353047
Homologene: 8871
Sbno1
Name: strawberry notch 1
Synonyms: sno, 9330180L10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243272
Homologene: 10055
Ube2g2
Name: ubiquitin-conjugating enzyme E2G 2
Synonyms: D10Xrf369, Ubc7p, UBC7, 1110003O05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22213
Homologene: 6599
Faf1
Name: Fas-associated factor 1
Synonyms: Fam, Dffrx
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14084
HGNC: HGNC:3578
Homologene: 5120
Arid2
Name: AT-rich interaction domain 2
Synonyms: 4432409D24Rik, zipzap/p200, 1700124K17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77044
Homologene: 14601
Wdr33
Name: WD repeat domain 33
Synonyms: 2810021O11Rik, 8430413N20Rik, 2310011G05Rik, 1110001N06Rik, WDC146
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74320
VEGA: 18
Homologene: 56807
Tshr
Name: thyroid stimulating hormone receptor
Synonyms: hyt, pet, hypothroid
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22095
Homologene: 315
Casz1
Name: castor zinc finger 1
Synonyms: 2410019P08Rik, D4Ertd432e, castor, Cst
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69743
Homologene: 9824
Gm14496
Name: predicted gene 14496
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 672125
Homologene: 129606
Creld2
Name: cysteine-rich with EGF-like domains 2
Synonyms: 5730592L21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76737
VEGA: 15
Homologene: 11526
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83965
Homologene: 23313
Itih5
Name: inter-alpha-trypsin inhibitor, heavy chain 5
Synonyms: 5430408M01Rik, 4631408O11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209378
Homologene: 57115
Tln1
Name: talin 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21894
Homologene: 21267
Eipr1
Name: EARP complex and GARP complex interacting protein 1
Synonyms: D12Ertd604e, Tssc1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380752
VEGA: 12
Homologene: 2481
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Swiss-cheese, MSws, Nte
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50767
Homologene: 21333
Tsc22d2
Name: TSC22 domain family, member 2
Synonyms: 1810043J12Rik, 5530402M19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72033
Homologene: 8860
Nup153
Name: nucleoporin 153
Synonyms: B130015D15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218210
HGNC: HGNC:8062
Homologene: 68442
Dpp9
Name: dipeptidylpeptidase 9
Synonyms: DPRP2, 6430584G11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224897
VEGA: 17
Homologene: 16385
Fam13b
Name: family with sequence similarity 13, member B
Synonyms: 2610024E20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225358
VEGA: 18
HGNC: HGNC:1335
Homologene: 9585
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Atp12a
Name: ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Synonyms: HKalpha2, cHKA, Atp1al1, ATPase H+K+-transporting, alpha 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192113
VEGA: 14
Homologene: 68197
Nphs2
Name: nephrosis 2, podocin
Synonyms: podocin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 170484
Homologene: 22826
Myo7a
Name: myosin VIIA
Synonyms: Myo7, USH1B, nmf371, polka, Hdb
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Klhl1
Name: kelch-like 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93688
HGNC: HGNC:6352
Homologene: 56903
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: extraocular myosin, EO Myosin, MyHC-eo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b598Clo, b2b1727Clo, b2b1203Clo, b2b1279Clo, b2b1289Clo, Dnahc11, avc4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, A230079K17Rik, Gm980, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Nlrp9c
Name: NLR family, pyrin domain containing 9C
Synonyms: Nalp9c, Nalp-zeta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330490
Homologene: 116072
Slc44a5
Name: solute carrier family 44, member 5
Synonyms: LOC242259
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242259
Homologene: 72094
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Ttc38
Name: tetratricopeptide repeat domain 38
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239570
Homologene: 41208
Usp35
Name: ubiquitin specific peptidase 35
Synonyms: LOC244144, LOC381901
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244144
Homologene: 35459
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384813
Homologene: 78104
Lgi4
Name: leucine-rich repeat LGI family, member 4
Synonyms: clp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243914
Homologene: 16408
Ugt2b37
Name: UDP glucuronosyltransferase 2 family, polypeptide B37
Synonyms: 0610033E06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 112417
Homologene: 137225
Tm6sf1
Name: transmembrane 6 superfamily member 1
Synonyms: C630016D09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 107769
Homologene: 11305
Grm8
Name: glutamate receptor, metabotropic 8
Synonyms: mGluR8, Gprc1h
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14823
HGNC: HGNC:4600
Homologene: 654
Pcdhb19
Name: protocadherin beta 19
Synonyms: Pcdhb11, PcdhbS
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93890
Homologene: 128411
Or5b12
Name: olfactory receptor family 5 subfamily B member 12
Synonyms: GA_x6K02T2RE5P-3249780-3248836, MOR202-5, Olfr1448
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258696
Homologene: 64904
Smco1
Name: single-pass membrane protein with coiled-coil domains 1
Synonyms: 2310010M20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69576
Homologene: 18842
Or10d1b
Name: olfactory receptor family 10 subfamily D member 1B
Synonyms: M31, GA_x6K02T2PVTD-33400306-33399371, MOR224-8, Olfr149
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235256
VEGA: 9
Homologene: 28452
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Nup50l
Name: nucleoporin 50 like
Synonyms: 1700123L14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78482
HGNC: HGNC:8065
Rigi
Name: RNA sensor RIG-I
Synonyms: 6430573D20Rik, RIG-I, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, Ddx58
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230073
Homologene: 32215
Atp8a2
Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Synonyms: Ib, wl, agil
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50769
Homologene: 4443
Tent5b
Name: terminal nucleotidyltransferase 5B
Synonyms: 4732473B16Rik, Fam46b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100342
Homologene: 24928
Papolb
Name: poly (A) polymerase beta (testis specific)
Synonyms: Papt, TPAP, Plap-ps, Papola-ps
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56522
Homologene: 121622
Or9g19
Name: olfactory receptor family 9 subfamily G member 19
Synonyms: GA_x6K02T2Q125-47248551-47249468, MOR213-2, Olfr1013
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258757
Homologene: 74096
Spg7
Name: SPG7, paraplegin matrix AAA peptidase subunit
Synonyms: paraplegin, Cmar, spastic paraplegia 7 homolog (human)
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234847
Homologene: 31133
Tmem35b
Name: transmembrane protein 35B
Synonyms: Zmym6nb
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100039968
Homologene: 106612
Speer4f2
Name: spermatogenesis associated glutamate (E)-rich protein 4f2
Synonyms: Gm3535, Gm3495
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041749
Or4a81
Name: olfactory receptor family 4 subfamily A member 81
Synonyms: GA_x6K02T2Q125-51230155-51229211, MOR231-13, Olfr1254
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258468
Homologene: 103784
Spem2
Name: SPEM family member 2
Synonyms: 4933402P03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 108803
Homologene: 52178
Gm15922
Name: predicted gene 15922
Type: Gene
Species: Mouse
Chromosome: 7
Rnf5
Name: ring finger protein 5
Synonyms: 2410131O05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54197
Homologene: 56004
Ovol3
Name: ovo like zinc finger 3
Synonyms: LOC381867, movo3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381867
Homologene: 35553
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 156,318,767 bp
  • T to C, chromosome 1 at 181,783,705 bp
  • T to C, chromosome 2 at 10,240,668 bp
  • A to G, chromosome 2 at 85,770,373 bp
  • T to C, chromosome 2 at 89,789,178 bp
  • A to T, chromosome 2 at 181,996,222 bp
  • T to A, chromosome 3 at 58,415,840 bp
  • T to C, chromosome 3 at 98,137,406 bp
  • C to A, chromosome 3 at 145,153,420 bp
  • C to T, chromosome 3 at 154,243,159 bp
  • T to A, chromosome 4 at 40,220,456 bp
  • T to C, chromosome 4 at 43,533,866 bp
  • G to T, chromosome 4 at 109,842,334 bp
  • T to C, chromosome 4 at 127,129,018 bp
  • A to G, chromosome 4 at 133,480,409 bp
  • A to T, chromosome 4 at 148,951,495 bp
  • A to T, chromosome 5 at 17,374,433 bp
  • T to G, chromosome 5 at 87,240,977 bp
  • A to T, chromosome 5 at 124,400,847 bp
  • A to G, chromosome 5 at 130,102,051 bp
  • T to C, chromosome 5 at 142,529,598 bp
  • T to A, chromosome 6 at 4,905,827 bp
  • T to G, chromosome 6 at 27,363,776 bp
  • T to G, chromosome 6 at 96,165,628 bp
  • C to G, chromosome 7 at 3,737,320 bp
  • G to A, chromosome 7 at 26,385,774 bp
  • A to G, chromosome 7 at 30,235,375 bp
  • A to T, chromosome 7 at 31,060,132 bp
  • A to G, chromosome 7 at 46,305,817 bp
  • A to G, chromosome 7 at 81,876,053 bp
  • A to T, chromosome 7 at 97,311,560 bp
  • A to T, chromosome 7 at 97,311,644 bp
  • C to T, chromosome 7 at 98,073,167 bp
  • G to T, chromosome 8 at 3,537,986 bp
  • A to T, chromosome 8 at 15,921,150 bp
  • T to C, chromosome 8 at 27,393,375 bp
  • G to T, chromosome 8 at 43,626,808 bp
  • A to G, chromosome 8 at 123,079,423 bp
  • A to G, chromosome 9 at 39,701,834 bp
  • T to G, chromosome 10 at 77,634,746 bp
  • T to A, chromosome 11 at 67,350,365 bp
  • A to G, chromosome 11 at 69,817,428 bp
  • G to A, chromosome 11 at 103,377,382 bp
  • T to G, chromosome 12 at 28,864,762 bp
  • C to A, chromosome 12 at 91,538,549 bp
  • T to A, chromosome 12 at 117,916,855 bp
  • T to C, chromosome 13 at 46,709,660 bp
  • A to T, chromosome 13 at 49,589,869 bp
  • A to G, chromosome 14 at 56,370,833 bp
  • A to T, chromosome 14 at 60,008,499 bp
  • A to T, chromosome 14 at 96,280,091 bp
  • T to A, chromosome 15 at 85,838,822 bp
  • T to A, chromosome 15 at 88,823,071 bp
  • C to T, chromosome 15 at 96,372,413 bp
  • A to G, chromosome 16 at 32,273,223 bp
  • A to T, chromosome 17 at 3,438,663 bp
  • A to C, chromosome 17 at 34,602,309 bp
  • G to A, chromosome 17 at 44,085,264 bp
  • A to T, chromosome 17 at 56,206,808 bp
  • T to C, chromosome 18 at 31,829,975 bp
  • A to G, chromosome 18 at 34,457,662 bp
  • G to T, chromosome 18 at 37,499,269 bp
  • T to A, chromosome 19 at 12,920,031 bp
  • G to A, chromosome 19 at 52,997,879 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6454 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044590-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.