Strain Name:
C57BL/6J-MtgxR6468Btlr/Mmmh
Stock Number:
044601-MU
Citation ID:
RRID:MMRRC_044601-MU
Other Names:
R6468 (G1)
Major Collection:

Strain Information

Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269473
Homologene: 8882
Cacna1g
Name: calcium channel, voltage-dependent, T type, alpha 1G subunit
Synonyms: a1G, Cav3.1d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12291
HGNC: HGNC:1394
Homologene: 22544
Snta1
Name: syntrophin, acidic 1
Synonyms: Snt1, alpha1-syntrophin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20648
Homologene: 2331
B3galnt1
Name: UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1
Synonyms: Mbrn 1, Brainiac 1, Globoside blood group, B3galt3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26879
HGNC: HGNC:918
Homologene: 32457
Cryzl1
Name: crystallin zeta like 1
Synonyms: 2210407J23Rik, 2410006O11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66609
HGNC: HGNC:2420
Homologene: 3749
Hspa4
Name: heat shock protein 4
Synonyms: Hsp70RY, Hsp110, APG-2, 70kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15525
HGNC: HGNC:5237
Homologene: 1624
Prep
Name: prolyl endopeptidase
Synonyms: Pop, prolyl oligopeptidase, D10Wsu136e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19072
VEGA: 10
HGNC: HGNC:9358
Homologene: 2042
Ano6
Name: anoctamin 6
Synonyms: 2900059G15Rik, F730003B03Rik, Tmem16f
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105722
VEGA: 15
Homologene: 27888
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: 1110005P14Rik, D1Ertd101e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Depdc5
Name: DEP domain containing 5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 277854
Homologene: 34718
Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms: GCN2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27103
Homologene: 40891
Hunk
Name: hormonally upregulated Neu-associated kinase
Synonyms: Bstk1, Mak-v
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 26559
VEGA: 16
Homologene: 8742
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: 4932438A13Rik, FSA, Tweek
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Fanci
Name: Fanconi anemia, complementation group I
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 208836
Homologene: 49530
Rad50
Name: RAD50 double strand break repair protein
Synonyms: Rad50l, Mrell
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19360
HGNC: HGNC:9816
Homologene: 38092
Myo1d
Name: myosin ID
Synonyms: D11Ertd9e, 9930104H07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 338367
HGNC: HGNC:7598
Homologene: 45576
Dock7
Name: dedicator of cytokinesis 7
Synonyms: m, LOC242555, 3110056M06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67299
Homologene: 23566
Adgrl4
Name: adhesion G protein-coupled receptor L4
Synonyms: Etl, EGF-TM7 receptor, Eltd1, 1110033N21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170757
Homologene: 11170
Cpxm2
Name: carboxypeptidase X, M14 family member 2
Synonyms: 4632435C11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 55987
Homologene: 69259
Btbd10
Name: BTB domain containing 10
Synonyms: Gmrp1, 1110056N09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68815
Homologene: 13009
Chd6
Name: chromodomain helicase DNA binding protein 6
Synonyms: 5430439G14Rik, 6330406J24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71389
Homologene: 32772
Gak
Name: cyclin G associated kinase
Synonyms: D130045N16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231580
HGNC: HGNC:4113
Homologene: 3846
Eea1
Name: early endosome antigen 1
Synonyms: B230358H09Rik, ZFYVE2, A430109M19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216238
VEGA: 10
HGNC: HGNC:3185
Homologene: 37822
Stk38
Name: serine/threonine kinase 38
Synonyms: 5830476G13Rik, 9530097A09Rik, Ndr1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106504
Homologene: 56033
Uggt1
Name: UDP-glucose glycoprotein glucosyltransferase 1
Synonyms: A930007H10Rik, 0910001L17Rik, Ugcgl1, C820010P03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320011
Homologene: 10586
Mecom
Name: MDS1 and EVI1 complex locus
Synonyms: Jbo, Mds1, Evi-1, Evi1, ZNFPR1B1, Prdm3, MDS1-EVI1, D630039M04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14013
HGNC: HGNC:3498
Homologene: 21086
Scn4a
Name: sodium channel, voltage-gated, type IV, alpha
Synonyms: Nav1.4, mH2, SkM1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 110880
Homologene: 283
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Enpep
Name: glutamyl aminopeptidase
Synonyms: APA, Bp-1/6C3, 6030431M22Rik, aminopeptidase-A, Ly-51, Ly51
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13809
HGNC: HGNC:3355
Homologene: 68216
Tapbp
Name: TAP binding protein
Synonyms: tapasin, D17Wsu91e, TPN
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21356
Homologene: 2401
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Pik3r4
Name: phosphoinositide-3-kinase regulatory subunit 4
Synonyms: Vps15, p150
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75669
HGNC: HGNC:8982
Homologene: 24678
Gucy2d
Name: guanylate cyclase 2d
Synonyms: guanylyl cyclase D
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14918
Homologene: 71540
Neu2
Name: neuraminidase 2
Synonyms: cystolic sialidase, brain sialidase, MTS, MSS, MBS
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23956
HGNC: HGNC:7759
Homologene: 3927
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229574
Homologene: 134146
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Fam83b
Name: family with sequence similarity 83, member B
Synonyms: C530008M07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208994
Homologene: 19478
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Fmi1, Adgrc3, flamingo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Ptk6
Name: PTK6 protein tyrosine kinase 6
Synonyms: Sik, Tksk
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20459
HGNC: HGNC:9617
Homologene: 68494
Vmn2r74
Name: vomeronasal 2, receptor 74
Synonyms: EG546980
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 546980
Homologene: 115466
Ms4a15
Name: membrane-spanning 4-domains, subfamily A, member 15
Synonyms: E530011F12Rik, Gm1286, LOC383468
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 545279
Homologene: 27391
Mctp1
Name: multiple C2 domains, transmembrane 1
Synonyms: 2810465F10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78771
Homologene: 75211
Zfp114
Name: zinc finger protein 114
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232966
Dcbld2
Name: discoidin, CUB and LCCL domain containing 2
Synonyms: 1700055P21Rik, CLCP1, Esdn
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 73379
Homologene: 12499
Fam83f
Name: family with sequence similarity 83, member F
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213956
VEGA: 15
Homologene: 16313
Mgst1
Name: microsomal glutathione S-transferase 1
Synonyms: 1500002K10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56615
HGNC: HGNC:7061
Homologene: 10544
Or8k25
Name: olfactory receptor family 8 subfamily K member 25
Synonyms: GA_x6K02T2Q125-47883395-47882454, MOR188-9, MOR188-7, MOR188-1, Olfr1515, Olfr1061, MOR188-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259022
Homologene: 79468
Lce1j
Name: late cornified envelope 1J
Synonyms: Sprrl8
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 545547
Vmn1r4
Name: vomeronasal 1 receptor 4
Synonyms: C230065D10Rik, V1rc21
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171194
Homologene: 131060
Vash2
Name: vasohibin 2
Synonyms: B130052G07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226841
Homologene: 57005
Or4n4b
Name: olfactory receptor family 4 subfamily N member 4B
Synonyms: MOR241-2, GA_x6K02T2PMLR-5992342-5991416, Olfr733
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258657
Homologene: 128266
Adamtsl5
Name: ADAMTS-like 5
Synonyms: 2010109H09Rik, Thsd6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66548
Homologene: 19803
Ppl
Name: periplakin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Nipa1
Name: non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human)
Synonyms: A830014A18Rik, 1110027G09Rik, Spg6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233280
Homologene: 42327
Lrat
Name: lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
Synonyms: 1300010A18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 79235
HGNC: HGNC:6685
Homologene: 3483
Gcnt7
Name: glucosaminyl (N-acetyl) transferase family member 7
Synonyms: A330041C17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 654821
Homologene: 107308
Or6c35
Name: olfactory receptor family 6 subfamily C member 35
Synonyms: MOR114-6, Olfr781, GA_x6K02T2PULF-11013616-11014551
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258723
Homologene: 37000
Hacd1
Name: 3-hydroxyacyl-CoA dehydratase 1
Synonyms: Ptpla
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 30963
HGNC: HGNC:9639
Homologene: 69153
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 36,173,450 bp
  • A to G, chromosome 1 at 87,596,878 bp
  • T to A, chromosome 1 at 93,417,667 bp
  • G to A, chromosome 1 at 190,978,287 bp
  • T to C, chromosome 2 at 14,035,944 bp
  • T to A, chromosome 2 at 86,414,037 bp
  • C to A, chromosome 2 at 118,436,241 bp
  • T to A, chromosome 2 at 154,377,149 bp
  • A to G, chromosome 2 at 161,013,067 bp
  • A to G, chromosome 2 at 172,454,073 bp
  • A to T, chromosome 2 at 181,199,102 bp
  • T to A, chromosome 3 at 30,140,386 bp
  • T to C, chromosome 3 at 37,008,443 bp
  • A to G, chromosome 3 at 69,575,533 bp
  • A to T, chromosome 3 at 82,903,492 bp
  • A to T, chromosome 3 at 92,789,422 bp
  • A to T, chromosome 3 at 93,214,421 bp
  • G to A, chromosome 3 at 104,467,193 bp
  • A to G, chromosome 3 at 129,331,860 bp
  • A to G, chromosome 3 at 151,492,375 bp
  • G to A, chromosome 4 at 98,967,227 bp
  • A to G, chromosome 5 at 32,912,231 bp
  • G to T, chromosome 5 at 108,623,336 bp
  • G to A, chromosome 6 at 56,956,867 bp
  • A to G, chromosome 6 at 138,141,587 bp
  • T to C, chromosome 7 at 24,177,781 bp
  • A to T, chromosome 7 at 56,019,504 bp
  • A to G, chromosome 7 at 79,417,939 bp
  • T to C, chromosome 7 at 85,961,391 bp
  • A to G, chromosome 7 at 98,449,961 bp
  • A to T, chromosome 7 at 113,347,059 bp
  • T to C, chromosome 7 at 132,070,860 bp
  • T to A, chromosome 9 at 76,502,131 bp
  • A to G, chromosome 9 at 105,685,190 bp
  • A to G, chromosome 9 at 108,835,790 bp
  • T to A, chromosome 10 at 45,115,107 bp
  • A to G, chromosome 10 at 80,341,913 bp
  • G to T, chromosome 10 at 82,295,316 bp
  • T to G, chromosome 10 at 96,028,412 bp
  • T to C, chromosome 10 at 129,333,711 bp
  • A to T, chromosome 11 at 53,265,056 bp
  • A to G, chromosome 11 at 53,692,144 bp
  • T to C, chromosome 11 at 80,557,474 bp
  • A to T, chromosome 11 at 94,439,722 bp
  • A to C, chromosome 11 at 103,460,840 bp
  • C to T, chromosome 11 at 106,345,676 bp
  • T to A, chromosome 11 at 119,452,687 bp
  • T to A, chromosome 13 at 76,731,811 bp
  • A to T, chromosome 14 at 50,298,467 bp
  • A to G, chromosome 15 at 80,692,111 bp
  • A to G, chromosome 15 at 95,967,714 bp
  • T to C, chromosome 16 at 5,092,441 bp
  • A to T, chromosome 16 at 58,433,373 bp
  • A to G, chromosome 16 at 90,493,432 bp
  • A to C, chromosome 16 at 91,692,525 bp
  • A to G, chromosome 17 at 28,984,112 bp
  • T to C, chromosome 17 at 33,926,098 bp
  • T to G, chromosome 19 at 10,993,170 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6468 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044601-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.