Strain Name:
C57BL/6J-MtgxR6473Btlr/Mmmh
Stock Number:
044606-MU
Citation ID:
RRID:MMRRC_044606-MU
Other Names:
R6473 (G1)
Major Collection:

Strain Information

Gba1
Name: glucosylceramidase beta 1
Synonyms: betaGC, GC, GCase, GBA1, Gba, glucocerebrosidase
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14466
HGNC: HGNC:4177
Homologene: 68040
Eps8
Name: epidermal growth factor receptor pathway substrate 8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13860
HGNC: HGNC:3420
Homologene: 3272
Ash2l
Name: ASH2 like histone lysine methyltransferase complex subunit
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23808
HGNC: HGNC:744
Homologene: 3436
B3galnt1
Name: UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1
Synonyms: Mbrn 1, B3galt3, Globoside blood group, Brainiac 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26879
HGNC: HGNC:918
Homologene: 32457
Usp48
Name: ubiquitin specific peptidase 48
Synonyms: 2810449C13Rik, D330022K21Rik, Usp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 170707
Homologene: 12988
Chmp2b
Name: charged multivesicular body protein 2B
Synonyms: 1190006E07Rik, chromatin modifying protein 2B
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 68942
VEGA: 16
Homologene: 8534
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Dact1
Name: dishevelled-binding antagonist of beta-catenin 1
Synonyms: Frd1, Frodo, THYEX3, Frodo1, Dapper1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 59036
Homologene: 9613
Ptgfrn
Name: prostaglandin F2 receptor negative regulator
Synonyms: CD9P-1, 4833445A08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19221
HGNC: HGNC:9601
Homologene: 7908
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: 6030441H18Rik, Mtmr15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Enpp5
Name: ectonucleotide pyrophosphatase/phosphodiesterase 5
Synonyms: D17Abb1e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 83965
Homologene: 23313
Eif2s1
Name: eukaryotic translation initiation factor 2, subunit 1 alpha
Synonyms: 0910001O23Rik, eIF2alpha, 2410026C18Rik, Eif2a
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13665
HGNC: HGNC:3265
Homologene: 3020
Ddx3y
Name: DEAD box helicase 3, Y-linked
Synonyms: D1Pas1-rs1, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked, Dby, 8030469F12Rik
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 26900
HGNC: HGNC:2699
Homologene: 55839
Zfp157
Name: zinc finger protein 157
Synonyms: A630094N24Rik, 2610020C11Rik, Roma
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72154
Homologene: 57009
Kalrn
Name: kalirin, RhoGEF kinase
Synonyms: LOC224126, E530005C20Rik, 2210407G14Rik, Hapip
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 545156
HGNC: HGNC:4814
Homologene: 57160
St3gal1
Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Synonyms: ST3GalI, Siat4, Siat4a, CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20442
VEGA: 15
Homologene: 7540
Tnik
Name: TRAF2 and NCK interacting kinase
Synonyms: 4831440I19Rik, C530008O15Rik, 1500031A17Rik, C630040K21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 665113
Homologene: 77943
Madd
Name: MAP-kinase activating death domain
Synonyms: Rab3 GEP, 9630059K23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228355
HGNC: HGNC:6766
Homologene: 14249
Vipr1
Name: vasoactive intestinal peptide receptor 1
Synonyms: VIP-R1, VIP receptor subtype 1, VPAC1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22354
Homologene: 3399
Fbxw7
Name: F-box and WD-40 domain protein 7
Synonyms: AGO, 1110001A17Rik, Fbxo30, SEL-10, Fbxw6, Cdc4, Fbw7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 50754
Homologene: 117451
Dnm3
Name: dynamin 3
Synonyms: 9630020E24Rik, B230343F03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 103967
Homologene: 22906
Thbs2
Name: thrombospondin 2
Synonyms: Thrombospondin-2, Thbs-2, TSP2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
Idh3b
Name: isocitrate dehydrogenase 3 (NAD+) beta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170718
HGNC: HGNC:5385
Homologene: 5035
Adamts1
Name: ADAM metallopeptidase with thrombospondin type 1 motif 1
Synonyms: METH-1, ADAM-TS1, METH1, ADAMTS-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11504
HGNC: HGNC:217
Homologene: 21381
Cyp46a1
Name: cytochrome P450, family 46, subfamily a, polypeptide 1
Synonyms: Cyp46, cholestrol 24-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13116
VEGA: 12
HGNC: HGNC:2641
Homologene: 134501
Cyp2d26
Name: cytochrome P450, family 2, subfamily d, polypeptide 26
Synonyms: 1300006E06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 76279
VEGA: 15
Homologene: 130660
Ampd1
Name: adenosine monophosphate deaminase 1
Synonyms: Ampd-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229665
HGNC: HGNC:468
Homologene: 20
Akt1
Name: thymoma viral proto-oncogene 1
Synonyms: PKB, Akt, PKB/Akt, PKBalpha
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11651
HGNC: HGNC:391
Homologene: 3785
Or5h23
Name: olfactory receptor family 5 subfamily H member 23
Synonyms: GA_x54KRFPKG5P-55314632-55313703, MOR183-5P, Olfr191
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258035
Homologene: 128162
Mrps31
Name: mitochondrial ribosomal protein S31
Synonyms: 1500002D03Rik, Imogen44
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 57312
Homologene: 4255
Usp16
Name: ubiquitin specific peptidase 16
Synonyms: 1200004E02Rik, UBP-M, 2810483I07Rik, 6330514E22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74112
Homologene: 38183
P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Synonyms: P2Y12, 4921504D23Rik, 2900079B22Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70839
Homologene: 11260
Terb1
Name: telomere repeat binding bouquet formation protein 1
Synonyms: 4930532D21Rik, Ccdc79
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320022
Homologene: 18330
Slpi
Name: secretory leukocyte peptidase inhibitor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20568
Homologene: 2305
Or14j4
Name: olfactory receptor family 14 subfamily J member 4
Synonyms: MOR218-11P, GA_x6K02T2PSCP-2070203-2069271, Olfr115
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 257908
Homologene: 115497
Vmn1r21
Name: vomeronasal 1 receptor 21
Synonyms: V1rc28
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171201
Homologene: 74363
Adat3
Name: adenosine deaminase, tRNA-specific 3
Synonyms: A430024H01Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100113398
VEGA: 10
Homologene: 50671
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 162,477,705 bp
  • T to C, chromosome 2 at 91,167,059 bp
  • AG to AGCACCACAACTG, chromosome 2 at 130,279,673 bp
  • T to C, chromosome 2 at 164,354,926 bp
  • A to G, chromosome 3 at 28,263,643 bp
  • T to A, chromosome 3 at 59,217,511 bp
  • T to C, chromosome 3 at 69,575,340 bp
  • T to C, chromosome 3 at 84,952,380 bp
  • C to T, chromosome 3 at 89,204,081 bp
  • T to C, chromosome 3 at 101,045,639 bp
  • C to T, chromosome 3 at 103,095,646 bp
  • T to C, chromosome 4 at 137,609,108 bp
  • T to C, chromosome 5 at 138,455,926 bp
  • A to T, chromosome 6 at 57,843,598 bp
  • A to T, chromosome 6 at 137,479,098 bp
  • T to A, chromosome 7 at 64,372,486 bp
  • CG to CGACGGCGGGG, chromosome 7 at 97,579,908 bp
  • A to G, chromosome 8 at 22,414,865 bp
  • T to A, chromosome 8 at 25,834,980 bp
  • T to A, chromosome 8 at 104,473,037 bp
  • T to C, chromosome 9 at 121,668,555 bp
  • A to G, chromosome 10 at 80,606,967 bp
  • A to G, chromosome 12 at 71,317,698 bp
  • T to C, chromosome 12 at 78,881,225 bp
  • G to T, chromosome 12 at 108,355,475 bp
  • T to C, chromosome 12 at 112,662,260 bp
  • A to G, chromosome 15 at 67,111,346 bp
  • T to C, chromosome 15 at 82,791,767 bp
  • A to G, chromosome 16 at 34,205,302 bp
  • A to T, chromosome 16 at 59,086,043 bp
  • C to T, chromosome 16 at 65,546,872 bp
  • T to C, chromosome 16 at 85,799,643 bp
  • G to A, chromosome 16 at 87,483,135 bp
  • A to G, chromosome 17 at 14,685,796 bp
  • T to A, chromosome 17 at 37,609,996 bp
  • G to A, chromosome 17 at 44,085,264 bp
  • T to C, chromosome Y at 1,265,971 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6473 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044606-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.