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Strain Name:
C57BL/6J-MtgxR6478Btlr/Mmmh
Stock Number:
044610-MU
Citation ID:
RRID:MMRRC_044610-MU
Other Names:
R6478 (G1)
Major Collection:

Strain Information

Wnt5b
Name: wingless-type MMTV integration site family, member 5B
Synonyms: Wnt-5b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22419
Homologene: 22530
Rcan2
Name: regulator of calcineurin 2
Synonyms: MCIP2, ZAKI-4, Csp2, Dscr1l1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53901
VEGA: 17
HGNC: HGNC:3041
Homologene: 130985
Adgre1
Name: adhesion G protein-coupled receptor E1
Synonyms: F4/80, DD7A5-7, TM7LN3, EGF-TM7, Ly71, Emr1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13733
VEGA: 17
HGNC: HGNC:3336
Homologene: 1493
Ints6
Name: integrator complex subunit 6
Synonyms: Notch2l, 2900075H24Rik, DICE1, Ddx26
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18130
VEGA: 14
Homologene: 8121
Bcar3
Name: breast cancer anti-estrogen resistance 3
Synonyms: AND-34
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 29815
HGNC: HGNC:973
Homologene: 31181
Clasp1
Name: CLIP associating protein 1
Synonyms: 5730583A19Rik, 1700030C23Rik, mCLASP1, CLASP1alpha, CLASP1, B130045P17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76707
Homologene: 41024
Zmym6
Name: zinc finger, MYM-type 6
Synonyms: D4Wsu24e, 9330177P20Rik, Zfp258
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100177
Homologene: 5186
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 24,185,405 bp
  • A to G, chromosome 1 at 36,402,531 bp
  • A to T, chromosome 1 at 118,512,180 bp
  • T to A, chromosome 1 at 150,664,784 bp
  • A to G, chromosome 1 at 188,972,364 bp
  • T to A, chromosome 2 at 27,952,436 bp
  • A to G, chromosome 2 at 70,348,960 bp
  • T to G, chromosome 2 at 76,841,771 bp
  • A to G, chromosome 2 at 82,990,086 bp
  • T to G, chromosome 2 at 89,609,446 bp
  • T to C, chromosome 2 at 112,660,068 bp
  • C to A, chromosome 2 at 131,051,346 bp
  • T to C, chromosome 2 at 135,335,451 bp
  • G to T, chromosome 2 at 169,884,664 bp
  • A to T, chromosome 3 at 54,782,443 bp
  • C to A, chromosome 3 at 87,389,639 bp
  • T to A, chromosome 3 at 96,436,006 bp
  • C to T, chromosome 3 at 106,533,445 bp
  • T to A, chromosome 3 at 116,621,397 bp
  • G to T, chromosome 3 at 122,426,576 bp
  • A to T, chromosome 4 at 58,810,785 bp
  • A to T, chromosome 4 at 63,132,706 bp
  • A to C, chromosome 4 at 116,999,586 bp
  • G to T, chromosome 4 at 127,123,383 bp
  • T to A, chromosome 4 at 140,542,757 bp
  • G to T, chromosome 4 at 140,917,637 bp
  • A to G, chromosome 5 at 122,707,700 bp
  • A to G, chromosome 5 at 125,110,005 bp
  • T to G, chromosome 6 at 118,511,638 bp
  • T to C, chromosome 6 at 119,433,790 bp
  • C to T, chromosome 6 at 128,433,231 bp
  • T to C, chromosome 6 at 130,272,544 bp
  • A to T, chromosome 6 at 141,993,642 bp
  • C to T, chromosome 6 at 142,679,308 bp
  • A to T, chromosome 7 at 5,544,865 bp
  • C to G, chromosome 7 at 28,155,373 bp
  • A to G, chromosome 7 at 45,798,589 bp
  • A to G, chromosome 7 at 66,262,733 bp
  • A to G, chromosome 7 at 83,622,316 bp
  • T to A, chromosome 7 at 83,793,276 bp
  • A to G, chromosome 7 at 112,955,707 bp
  • A to G, chromosome 8 at 43,185,128 bp
  • T to C, chromosome 8 at 95,095,456 bp
  • A to T, chromosome 8 at 95,321,266 bp
  • T to C, chromosome 8 at 106,904,446 bp
  • A to T, chromosome 9 at 24,450,696 bp
  • A to T, chromosome 9 at 53,490,254 bp
  • T to G, chromosome 10 at 128,379,331 bp
  • G to A, chromosome 11 at 8,863,911 bp
  • T to C, chromosome 11 at 11,462,318 bp
  • T to C, chromosome 11 at 69,516,010 bp
  • T to C, chromosome 11 at 70,056,894 bp
  • T to C, chromosome 11 at 76,452,332 bp
  • G to T, chromosome 11 at 87,514,373 bp
  • C to T, chromosome 11 at 97,258,273 bp
  • T to A, chromosome 11 at 120,010,991 bp
  • G to T, chromosome 12 at 8,499,585 bp
  • T to A, chromosome 12 at 111,445,663 bp
  • A to G, chromosome 12 at 112,977,312 bp
  • G to A, chromosome 13 at 75,847,299 bp
  • C to A, chromosome 13 at 90,937,347 bp
  • A to T, chromosome 13 at 98,268,442 bp
  • A to C, chromosome 13 at 100,162,041 bp
  • A to G, chromosome 14 at 49,773,332 bp
  • A to T, chromosome 14 at 62,700,786 bp
  • A to G, chromosome 15 at 27,856,107 bp
  • A to T, chromosome 15 at 85,925,518 bp
  • A to T, chromosome 17 at 14,001,464 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • A to G, chromosome 17 at 30,959,155 bp
  • G to T, chromosome 17 at 34,970,306 bp
  • A to G, chromosome 17 at 35,524,703 bp
  • A to G, chromosome 17 at 35,835,842 bp
  • T to A, chromosome 17 at 42,580,749 bp
  • A to G, chromosome 17 at 43,836,334 bp
  • A to T, chromosome 17 at 56,009,575 bp
  • A to G, chromosome 17 at 57,401,955 bp
  • A to T, chromosome 19 at 4,040,499 bp
  • G to A, chromosome 19 at 37,903,831 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6478 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044610-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.