Strain Name:
C57BL/6J-MtgxR6497Btlr/Mmmh
Stock Number:
044629-MU
Citation ID:
RRID:MMRRC_044629-MU
Other Names:
R6497 (G1)
Major Collection:

Strain Information

Gad2
Name: glutamic acid decarboxylase 2
Synonyms: GAD65, Gad-2, 6330404F12Rik, GAD(65)
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14417
HGNC: HGNC:4093
Homologene: 20223
Bicral
Name: BRD4 interacting chromatin remodeling complex associated protein like
Synonyms: BC032203, Gltscr1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210982
VEGA: 17
Homologene: 19366
Snapc3
Name: small nuclear RNA activating complex, polypeptide 3
Synonyms: 1810020H02Rik, E030018J20Rik, 5031401C21Rik, 4930558A07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77634
Homologene: 31130
Srrt
Name: serrate RNA effector molecule homolog (Arabidopsis)
Synonyms: Ars2, Asr2, 2810019G02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83701
Homologene: 9298
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Gm14393
Name: predicted gene 14393
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 664987
Aldh16a1
Name: aldehyde dehydrogenase 16 family, member A1
Synonyms: 2410004H02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69748
Homologene: 34938
Coch
Name: cochlin
Synonyms: D12H14S564E, Coch-5B2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 12810
VEGA: 12
HGNC: HGNC:2180
Homologene: 20868
Limk2
Name: LIM domain kinase 2
Synonyms: A930024P04Rik, whe, LIM kinase 2, Limk2b, Limk2a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16886
HGNC: HGNC:6614
Homologene: 55911
Cntrl
Name: centriolin
Synonyms: Cep110, b2b1468Clo, IB3/5, Ma2a8, 6720467O09Rik, Cep1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Dsg3
Name: desmoglein 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13512
VEGA: 18
HGNC: HGNC:3050
Homologene: 55513
Primpol
Name: primase and polymerase (DNA-directed)
Synonyms: Ccdc111
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 408022
Homologene: 14065
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Cyp2c66
Name: cytochrome P450, family 2, subfamily c, polypeptide 66
Synonyms: 2010301M18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69888
Homologene: 133566
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Cdh7
Name: cadherin 7, type 2
Synonyms: CDH7L1, 9330156F07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241201
HGNC: HGNC:1766
Homologene: 68391
Gprc6a
Name: G protein-coupled receptor, family C, group 6, member A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210198
VEGA: 10
Homologene: 17529
Egflam
Name: EGF-like, fibronectin type III and laminin G domains
Synonyms: nectican, pikachurin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268780
Homologene: 65044
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 1300010F03Rik, 4932416F07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Caskin1
Name: CASK interacting protein 1
Synonyms: 3300002N10Rik, C630036E02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268932
VEGA: 17
Homologene: 25873
Skint6
Name: selection and upkeep of intraepithelial T cells 6
Synonyms: OTTMUSG00000008519
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230622
Homologene: 135888
Ror2
Name: receptor tyrosine kinase-like orphan receptor 2
Synonyms: Ntrkr2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26564
Homologene: 55831
Col22a1
Name: collagen, type XXII, alpha 1
Synonyms: C80743, 2310067L16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69700
Homologene: 43567
Sspo
Name: SCO-spondin
Synonyms: Scospondin, C79529
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Atp13a4
Name: ATPase type 13A4
Synonyms: 9330174J19Rik, 4631413J11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224079
Homologene: 75330
Or52d1
Name: olfactory receptor family 52 subfamily D member 1
Synonyms: MOR33-2, Olfr646, GA_x6K02T2PBJ9-6841330-6842268
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259058
Homologene: 17481
Abcc2
Name: ATP-binding cassette, sub-family member 2
Synonyms: multidrug resistance protein 2, Mrp2, Cmoat
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Or8d1b
Name: olfactory receptor family 8 subfamily D member 1B
Synonyms: MOR171-22, Olfr933, GA_x6K02T2PVTD-32671531-32672457
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258433
VEGA: 9
HGNC: HGNC:8481
Homologene: 79676
Fut10
Name: fucosyltransferase 10
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 171167
Homologene: 32790
Or51f5
Name: olfactory receptor family 51 subfamily F member 5
Synonyms: GA_x6K02T2PBJ9-5491151-5492095, MOR14-2, Olfr561
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259096
Homologene: 133029
Clca3a1
Name: chloride channel accessory 3A1
Synonyms: Clca1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12722
HGNC: HGNC:2017
Homologene: 77224
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Srrm4
Name: serine/arginine repetitive matrix 4
Synonyms: bv, nSR100, 1500001A10Rik, flopsy, B230202K19Rik, fp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68955
Homologene: 49869
Cntnap5a
Name: contactin associated protein-like 5A
Synonyms: Caspr5-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 636808
Homologene: 43974
Prr14
Name: proline rich 14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233895
Homologene: 11424
Stk36
Name: serine/threonine kinase 36
Synonyms: 1700112N14Rik, Fused
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269209
Homologene: 49432
Acsm3
Name: acyl-CoA synthetase medium-chain family member 3
Synonyms: Sah, Sa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20216
Homologene: 74559
Rbm12b1
Name: RNA binding motif protein 12 B1
Synonyms: Rbm12b, 3000004N20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72397
Homologene: 28658
Zfp827
Name: zinc finger protein 827
Synonyms: D630040G17Rik, 2810449M09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 622675
Homologene: 45622
Sh2d4b
Name: SH2 domain containing 4B
Synonyms: A430109M18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328381
Homologene: 19164
Cd209c
Name: CD209c antigen
Synonyms: SIGNR2, mSIGNR2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170776
HGNC: HGNC:1641
Homologene: 87186
Tmem184a
Name: transmembrane protein 184a
Synonyms: Sdmg1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231832
Homologene: 64815
Armc7
Name: armadillo repeat containing 7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276905
Homologene: 11603
Pcdhgb7
Name: protocadherin gamma subfamily B, 7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93704
HGNC: HGNC:8714
Homologene: 75102
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 74,603,232 bp
  • G to A, chromosome 1 at 110,065,798 bp
  • T to C, chromosome 1 at 116,577,897 bp
  • C to T, chromosome 2 at 22,668,257 bp
  • A to G, chromosome 2 at 35,135,572 bp
  • A to T, chromosome 2 at 52,258,289 bp
  • T to C, chromosome 2 at 175,061,634 bp
  • A to T, chromosome 3 at 144,759,259 bp
  • T to C, chromosome 4 at 12,146,431 bp
  • G to T, chromosome 4 at 83,453,126 bp
  • A to G, chromosome 4 at 113,236,398 bp
  • A to C, chromosome 5 at 14,793,855 bp
  • A to T, chromosome 5 at 116,467,491 bp
  • G to T, chromosome 5 at 137,297,506 bp
  • A to G, chromosome 5 at 139,813,000 bp
  • A to T, chromosome 6 at 48,495,208 bp
  • T to A, chromosome 7 at 45,144,937 bp
  • G to GACGGCGGCT, chromosome 7 at 97,579,909 bp
  • T to A, chromosome 7 at 102,775,450 bp
  • T to C, chromosome 7 at 104,107,215 bp
  • G to A, chromosome 7 at 119,780,749 bp
  • C to T, chromosome 7 at 127,474,578 bp
  • T to C, chromosome 8 at 3,944,122 bp
  • T to A, chromosome 8 at 31,236,250 bp
  • A to T, chromosome 8 at 46,586,341 bp
  • T to A, chromosome 8 at 79,180,128 bp
  • G to A, chromosome 9 at 38,976,194 bp
  • T to C, chromosome 10 at 51,615,701 bp
  • A to G, chromosome 11 at 3,360,492 bp
  • T to C, chromosome 11 at 115,476,251 bp
  • G to A, chromosome 12 at 51,602,721 bp
  • A to T, chromosome 13 at 53,131,919 bp
  • A to G, chromosome 14 at 40,874,182 bp
  • A to G, chromosome 14 at 79,096,401 bp
  • A to T, chromosome 15 at 7,251,303 bp
  • T to C, chromosome 15 at 71,890,576 bp
  • T to C, chromosome 16 at 29,479,901 bp
  • A to G, chromosome 17 at 3,506,827 bp
  • T to C, chromosome 17 at 24,504,548 bp
  • A to T, chromosome 17 at 46,825,573 bp
  • A to G, chromosome 18 at 20,537,248 bp
  • T to A, chromosome 18 at 37,753,853 bp
  • T to A, chromosome 19 at 39,163,377 bp
  • T to A, chromosome 19 at 43,805,105 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6497 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044629-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.