Strain Name:
C57BL/6J-MtgxR6498Btlr/Mmmh
Stock Number:
044630-MU
Citation ID:
RRID:MMRRC_044630-MU
Other Names:
R6498 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Map2k5
Name: mitogen-activated protein kinase kinase 5
Synonyms: MEK5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23938
VEGA: 9
HGNC: HGNC:6845
Homologene: 115933
D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330286
Homologene: 19782
Wsb1
Name: WD repeat and SOCS box-containing 1
Synonyms: 1110056B13Rik, 2700038M07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78889
Homologene: 9218
Tmprss12
Name: transmembrane (C-terminal) protease, serine 12
Synonyms: 4930478A21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75002
VEGA: 15
Homologene: 16598
Atp9b
Name: ATPase, class II, type 9B
Synonyms: IIb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 50771
VEGA: 18
Homologene: 21915
Gls
Name: glutaminase
Synonyms: B230365M23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14660
HGNC: HGNC:4331
Homologene: 22726
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: perlecan, Plc, Pcn, per
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Exosc10
Name: exosome component 10
Synonyms: Pmscl2, p2, p3, p4, RRP6, PM-Scl, PM/Scl-100
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 50912
HGNC: HGNC:9138
Homologene: 31105
Zfp268
Name: zinc finger protein 268
Synonyms: Gm13212
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433801
Homologene: 133076
Agtpbp1
Name: ATP/GTP binding protein 1
Synonyms: 5730402G09Rik, 4930445M19Rik, 2900054O13Rik, 2310001G17Rik, 1700020N17Rik, Nna1, atms, Ccp1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67269
Homologene: 9067
Macroh2a2
Name: macroH2A.2 histone
Synonyms: H2afy2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 404634
Homologene: 10246
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Eogt
Name: EGF domain specific O-linked N-acetylglucosamine transferase
Synonyms: A130022J15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101351
Homologene: 65276
Fbxo44
Name: F-box protein 44
Synonyms: Fbx6a, FBX30, FBG3, Fbxo6a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230903
Homologene: 13232
Actn2
Name: actinin alpha 2
Synonyms: 1110008F24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11472
HGNC: HGNC:164
Homologene: 31016
Duox1
Name: dual oxidase 1
Synonyms: LNOX1, 9930101G15Rik, THOX1, NOXEF1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99439
HGNC: HGNC:3062
Homologene: 68136
Pls1
Name: plastin 1 (I-isoform)
Synonyms: I-fimbrin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102502
HGNC: HGNC:9090
Homologene: 68270
Synpo2
Name: synaptopodin 2
Synonyms: myopodin, 9530006G20Rik, Myo, 2310068J10Rik, 1110069I04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 118449
Homologene: 15400
Abca5
Name: ATP-binding cassette, sub-family A member 5
Synonyms: B930033A02Rik, ABC13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Per3
Name: period circadian clock 3
Synonyms: 2810049O06Rik, mPer3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18628
HGNC: HGNC:8847
Homologene: 7886
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: EG381742, Zfp469
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231861
Homologene: 45603
Vmn1r39
Name: vomeronasal 1 receptor 39
Synonyms: Gm5993
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 546903
Homologene: 110800
Or13g1
Name: olfactory receptor family 13 subfamily G member 1
Synonyms: GA_x6K02T2NHDJ-9801340-9802266, MOR251-4P, Olfr309
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258196
Homologene: 47595
Pcdh1
Name: protocadherin 1
Synonyms: 2010005A06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75599
HGNC: HGNC:8655
Homologene: 12613
Il33
Name: interleukin 33
Synonyms: 9230117N10Rik, Il-33, Il1f11, NF-HEV
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 77125
Homologene: 14126
Ugt1a10
Name: UDP glycosyltransferase 1 family, polypeptide A10
Synonyms: A13
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 394430
Homologene: 133281
Cep112
Name: centrosomal protein 112
Synonyms: 1700029K01Rik, Ccdc46, 1700001M19Rik, Macoco, 8430407H02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76380
Homologene: 44915
Tekt2
Name: tektin 2
Synonyms: tektin-t
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 24084
Homologene: 8043
Vmn1r44
Name: vomeronasal 1 receptor 44
Synonyms: V1rb4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113854
Homologene: 113975
Arrb2
Name: arrestin, beta 2
Synonyms: beta-arrestin2, Arr3, beta arr2, beta-arrestin-2, arrestin 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216869
HGNC: HGNC:712
Homologene: 3183
Fen1
Name: flap structure specific endonuclease 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14156
HGNC: HGNC:3650
Homologene: 3034
Sys1
Name: SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
Synonyms: 2610042O14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66460
Homologene: 43135
Pcdha5
Name: protocadherin alpha 5
Synonyms: Crnr6, Cnr6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12941
HGNC: HGNC:8671
Homologene: 49565
Or5p61
Name: olfactory receptor family 5 subfamily P member 61
Synonyms: MOR204-30P, MOR204-40_p, Olfr485, GA_x6K02T2PBJ9-10489044-10488091
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258041
Homologene: 110483
Or2t29
Name: olfactory receptor family 2 subfamily T member 29
Synonyms: Olfr329-ps, MOR275-6P, Olfr329, GA_x6K02T2NKPP-882068-883006
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259148
Homologene: 133015
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 52,220,039 bp
  • C to A, chromosome 1 at 88,216,140 bp
  • A to T, chromosome 2 at 122,319,607 bp
  • G to A, chromosome 2 at 164,464,518 bp
  • A to T, chromosome 3 at 123,080,232 bp
  • A to G, chromosome 4 at 126,324,305 bp
  • T to C, chromosome 4 at 137,507,801 bp
  • T to A, chromosome 4 at 145,622,889 bp
  • C to T, chromosome 4 at 148,154,425 bp
  • T to C, chromosome 4 at 148,573,338 bp
  • T to C, chromosome 4 at 151,029,205 bp
  • T to C, chromosome 5 at 14,669,491 bp
  • A to T, chromosome 5 at 142,732,168 bp
  • G to A, chromosome 6 at 38,147,197 bp
  • A to T, chromosome 6 at 66,804,857 bp
  • A to G, chromosome 6 at 89,893,580 bp
  • A to T, chromosome 6 at 97,135,213 bp
  • T to C, chromosome 7 at 86,307,018 bp
  • C to T, chromosome 7 at 108,159,432 bp
  • C to A, chromosome 9 at 63,286,401 bp
  • T to A, chromosome 9 at 88,582,342 bp
  • A to G, chromosome 9 at 95,754,745 bp
  • C to T, chromosome 10 at 12,442,093 bp
  • C to A, chromosome 10 at 61,757,835 bp
  • T to A, chromosome 11 at 58,542,582 bp
  • G to T, chromosome 11 at 70,439,549 bp
  • A to T, chromosome 11 at 79,248,489 bp
  • T to A, chromosome 11 at 108,440,531 bp
  • T to G, chromosome 11 at 110,292,102 bp
  • C to T, chromosome 13 at 12,276,473 bp
  • A to G, chromosome 13 at 59,477,040 bp
  • T to A, chromosome 15 at 100,285,252 bp
  • A to G, chromosome 18 at 36,962,715 bp
  • G to A, chromosome 18 at 38,197,437 bp
  • C to T, chromosome 18 at 80,777,015 bp
  • G to T, chromosome 19 at 10,200,115 bp
  • G to A, chromosome 19 at 29,949,737 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6498 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044630-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.