Strain Name:
C57BL/6J-MtgxR6501Btlr/Mmmh
Stock Number:
044633-MU
Citation ID:
RRID:MMRRC_044633-MU
Other Names:
R6501 (G1)
Major Collection:

Strain Information

Chrna7
Name: cholinergic receptor, nicotinic, alpha polypeptide 7
Synonyms: alpha7, alpha7 nicotinic receptor, Acra7, alpha7-nAChR
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11441
Homologene: 593
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Prpf6
Name: pre-mRNA splicing factor 6
Synonyms: 2610031L17Rik, 1190003A07Rik, ANT-1, U5-102K
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68879
Homologene: 5368
Birc6
Name: baculoviral IAP repeat-containing 6
Synonyms: D630005A10Rik, apollon, A430032G04Rik, A430040A19Rik, Bruce
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12211
Homologene: 7248
Larp4b
Name: La ribonucleoprotein 4B
Synonyms: Larp5, D13Wsu64e, A130023E24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217980
Homologene: 18195
Bptf
Name: bromodomain PHD finger transcription factor
Synonyms: 9430093H17Rik, Falz
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207165
HGNC: HGNC:3581
Homologene: 114397
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, 2810431N21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109135
Homologene: 10377
Mmp17
Name: matrix metallopeptidase 17
Synonyms: membrane type-4 matrix metalloproteinase, MT4-MMP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23948
HGNC: HGNC:7163
Homologene: 22669
Htr2b
Name: 5-hydroxytryptamine (serotonin) receptor 2B
Synonyms: 5-HT2B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15559
HGNC: HGNC:5294
Homologene: 55492
Pbx1
Name: pre B cell leukemia homeobox 1
Synonyms: Pbx-1, 2310056B04Rik, D230003C07Rik, Pbx1b, Pbx1a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18514
HGNC: HGNC:8632
Homologene: 20574
Vav2
Name: vav 2 oncogene
Synonyms: 2810040F13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22325
Homologene: 2530
Spint2
Name: serine protease inhibitor, Kunitz type 2
Synonyms: HAI-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20733
Homologene: 7955
Skic2
Name: SKI2 subunit of superkiller complex
Synonyms: 4930534J06Rik, Skiv2l, Ski2w
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 108077
Homologene: 123971
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: Dpde3, 9630011N22Rik, dunce
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Abhd8
Name: abhydrolase domain containing 8
Synonyms: 0910001L24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64296
Homologene: 11188
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: D12Ertd777e, Cpfl8, dice, 6820443O06Rik, nesprin-2, syne-2, Nesp2g, diminished cone electroretinogram
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Or8b1c
Name: olfactory receptor family 8 subfamily B member 1C
Synonyms: Olfr905, MOR167-1, GA_x6K02T2PVTD-32165709-32166641
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258800
VEGA: 9
Homologene: 110524
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627636
Homologene: 115024
Sec14l1
Name: SEC14-like lipid binding 1
Synonyms: 2810012L19Rik, 1200017E04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74136
Homologene: 37719
Rabl6
Name: RAB, member RAS oncogene family-like 6
Synonyms: Rbel1b, B230208H17Rik, Rbel1a, Rbel1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227624
Homologene: 11674
Nynrin
Name: NYN domain and retroviral integrase containing
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 277154
VEGA: 14
Homologene: 19483
Vmn1r179
Name: vomeronasal 1 receptor 179
Synonyms: V1rd17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404286
Homologene: 134022
Wnk2
Name: WNK lysine deficient protein kinase 2
Synonyms: ESTM15, 1810073P09Rik, X83337
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75607
Homologene: 19155
Rp1
Name: retinitis pigmentosa 1 (human)
Synonyms: Dcdc3, mG145, oxygen-regulated protein 1, Orp1, Rp1h
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19888
Homologene: 4564
Ada
Name: adenosine deaminase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11486
HGNC: HGNC:186
Homologene: 37249
Cts6
Name: cathepsin 6
Synonyms: 1600022N02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 58518
Homologene: 75165
Sspo
Name: SCO-spondin
Synonyms: Scospondin, C79529
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243369
Homologene: 45453
Slc19a1
Name: solute carrier family 19 (folate transporter), member 1
Synonyms: reduced folate carrier, RFC1, RFC-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20509
Homologene: 57139
Cts8
Name: cathepsin 8
Synonyms: Epcs68, CTS2, Epcs70
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56094
VEGA: 13
Homologene: 129897
Or7e168
Name: olfactory receptor family 7 subfamily E member 168
Synonyms: MOR146-3, GA_x6K02T2PVTD-13548326-13549255, MOR146-10_p, Olfr859
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258519
Homologene: 134093
Cyp26a1
Name: cytochrome P450, family 26, subfamily a, polypeptide 1
Synonyms: P450RA, retinoic acid hydrolase, P450RAI, RAH, Cyp26
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13082
VEGA: 19
HGNC: HGNC:2603
Homologene: 37349
Vmn1r210
Name: vomeronasal 1 receptor 210
Synonyms: V1rh10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171269
Homologene: 110880
Pdlim3
Name: PDZ and LIM domain 3
Synonyms: ALP
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 53318
Homologene: 75063
Cdadc1
Name: cytidine and dCMP deaminase domain containing 1
Synonyms: NYD-SP15, 2310010M10Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71891
VEGA: 14
Homologene: 12794
Slc9a9
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9
Synonyms: Nhe9, 5730527A11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 331004
Homologene: 69753
Disc1
Name: disrupted in schizophrenia 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244667
HGNC: HGNC:2888
Homologene: 10257
Ttll13
Name: tubulin tyrosine ligase-like family, member 13
Synonyms: 1700111A04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269954
Homologene: 136186
Or4k44
Name: olfactory receptor family 4 subfamily K member 44
Synonyms: GA_x6K02T2Q125-72589785-72588847, MOR248-7, Olfr1294
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258887
Homologene: 74216
Trdn
Name: triadin
Synonyms: triadin-2, triadin 2, triadin-3, triadin 3, triadin 1, 2310045H21Rik, triadin-1, EG432451
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76757
VEGA: 10
Homologene: 38137
Nfxl1
Name: nuclear transcription factor, X-box binding-like 1
Synonyms: D430033A06Rik, LOC381696, TCF9, 1700012H24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100978
Homologene: 26752
Mdfic
Name: MyoD family inhibitor domain containing
Synonyms: clone 1.5, Kdt1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16543
Homologene: 18404
Ear6
Name: eosinophil-associated, ribonuclease A family, member 6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93719
Homologene: 40596
Krtap4-9
Name: keratin associated protein 4-9
Synonyms: OTTMUSG00000002198
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 665998
Zfp758
Name: zinc finger protein 758
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224598
Homologene: 138293
Grifin
Name: galectin-related inter-fiber protein
Synonyms: E130101O17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77998
HGNC: HGNC:4577
Homologene: 14293
Slc2a6
Name: solute carrier family 2 (facilitated glucose transporter), member 6
Synonyms: Glut6, F630103L12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227659
Homologene: 69236
Wdr49
Name: WD repeat domain 49
Synonyms: EG213248
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213248
Homologene: 18714
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 4,311,280 bp
  • T to G, chromosome 1 at 86,110,641 bp
  • G to T, chromosome 1 at 168,209,534 bp
  • A to G, chromosome 2 at 25,602,447 bp
  • A to T, chromosome 2 at 27,023,131 bp
  • A to G, chromosome 2 at 27,296,219 bp
  • T to C, chromosome 2 at 76,785,646 bp
  • T to C, chromosome 2 at 76,898,258 bp
  • C to T, chromosome 2 at 111,537,779 bp
  • A to G, chromosome 2 at 163,728,188 bp
  • T to A, chromosome 2 at 181,621,920 bp
  • T to A, chromosome 3 at 75,339,458 bp
  • A to T, chromosome 4 at 123,469,632 bp
  • A to T, chromosome 5 at 72,528,509 bp
  • A to G, chromosome 5 at 129,606,405 bp
  • A to G, chromosome 5 at 140,563,281 bp
  • T to C, chromosome 6 at 15,770,517 bp
  • T to A, chromosome 6 at 48,495,212 bp
  • T to A, chromosome 6 at 140,525,929 bp
  • A to G, chromosome 7 at 23,928,917 bp
  • A to G, chromosome 7 at 29,263,706 bp
  • G to A, chromosome 7 at 63,106,115 bp
  • A to G, chromosome 7 at 80,250,176 bp
  • T to C, chromosome 8 at 45,908,602 bp
  • A to T, chromosome 8 at 71,461,521 bp
  • A to T, chromosome 8 at 125,218,105 bp
  • A to T, chromosome 9 at 19,808,975 bp
  • A to T, chromosome 9 at 38,473,289 bp
  • C to A, chromosome 9 at 94,936,371 bp
  • A to C, chromosome 10 at 33,466,454 bp
  • G to A, chromosome 10 at 77,049,606 bp
  • T to A, chromosome 11 at 99,785,429 bp
  • T to C, chromosome 11 at 107,077,683 bp
  • A to G, chromosome 11 at 117,156,850 bp
  • A to G, chromosome 12 at 76,027,847 bp
  • A to C, chromosome 13 at 9,168,793 bp
  • T to C, chromosome 13 at 22,827,535 bp
  • T to G, chromosome 13 at 49,146,683 bp
  • T to C, chromosome 13 at 61,196,335 bp
  • T to A, chromosome 13 at 61,250,942 bp
  • A to T, chromosome 13 at 109,116,942 bp
  • T to A, chromosome 14 at 51,854,224 bp
  • A to T, chromosome 14 at 55,863,532 bp
  • C to T, chromosome 14 at 59,586,449 bp
  • A to T, chromosome 17 at 19,811,904 bp
  • A to G, chromosome 17 at 22,371,997 bp
  • A to G, chromosome 17 at 34,844,436 bp
  • G to A, chromosome 17 at 74,579,281 bp
  • G to T, chromosome 19 at 37,699,070 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6501 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044633-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.