Strain Name:
C57BL/6J-MtgxR6504Btlr/Mmmh
Stock Number:
044636-MU
Citation ID:
RRID:MMRRC_044636-MU
Other Names:
R6504 (G1)
Major Collection:

Strain Information

Sulf2
Name: sulfatase 2
Synonyms: 2010004N24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72043
Homologene: 10313
Elavl4
Name: ELAV like RNA binding protein 4
Synonyms: Hud
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15572
HGNC: HGNC:3315
Homologene: 40729
Dysf
Name: dysferlin
Synonyms: 2310004N10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 26903
HGNC: HGNC:3097
Homologene: 20748
Ep400
Name: E1A binding protein p400
Synonyms: 1700020J09Rik, p400, mDomino
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75560
Homologene: 38779
Orc1
Name: origin recognition complex, subunit 1
Synonyms: Orc1l, MmORC1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18392
HGNC: HGNC:8487
Homologene: 31221
Med13l
Name: mediator complex subunit 13-like
Synonyms: 9030618F05Rik, Trap240L, Thrap2, 6330591G05Rik, 2210413I17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76199
Homologene: 25256
Kif1b
Name: kinesin family member 1B
Synonyms: Kif1b beta, A530096N05Rik, N-3 kinesin, D4Mil1e, KIF1Bp204, KIF1Bp130, Kif1b alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Prrc2c
Name: proline-rich coiled-coil 2C
Synonyms: Bat2l2, 9630039I18Rik, 1810043M20Rik, Bat2d
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226562
Homologene: 41015
Hdac4
Name: histone deacetylase 4
Synonyms: 4932408F19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208727
Homologene: 55946
Dph5
Name: diphthamide biosynthesis 5
Synonyms: 2410012M04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69740
Homologene: 6471
Sh3d19
Name: SH3 domain protein D19
Synonyms: Kryn
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 27059
Homologene: 19064
Ap4m1
Name: adaptor-related protein complex AP-4, mu 1
Synonyms: 4930443L05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11781
HGNC: HGNC:574
Homologene: 3467
Adam12
Name: ADAM metallopeptidase domain 12
Synonyms: ADAM12, Mltna
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11489
HGNC: HGNC:190
Homologene: 74862
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: A930031B09Rik, D330024H06Rik, Ankrd15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107351
Homologene: 17706
Dmkn
Name: dermokine
Synonyms: 1110014F24Rik, Dmkn, sk30, cI-36, dermokine, sk89
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73712
Homologene: 136295
Smap2
Name: small ArfGAP 2
Synonyms: Smap1l, 1810031K02Rik, Smap2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69780
Homologene: 41489
Shq1
Name: SHQ1 homolog (S. cerevisiae)
Synonyms: 2810403P18Rik, Grim-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72171
Homologene: 31683
Slitrk1
Name: SLIT and NTRK-like family, member 1
Synonyms: 3200001I04Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76965
VEGA: 14
Homologene: 14174
Tlr3
Name: toll-like receptor 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 142980
Homologene: 20696
Wif1
Name: Wnt inhibitory factor 1
Synonyms: WIF-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 24117
Homologene: 31430
Stxbp1
Name: syntaxin binding protein 1
Synonyms: nsec1, Sxtbp1, Munc-18a, Unc18h, Munc18-1, N-sec1, Rb-sec1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20910
Homologene: 2382
Dnah10
Name: dynein, axonemal, heavy chain 10
Synonyms: Dnahc10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56087
HGNC: HGNC:2941
Homologene: 25816
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: crash, Adgrc1, Crsh, Scy
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Fat2
Name: FAT atypical cadherin 2
Synonyms: EMI2, mKIAA0811, LOC245827, Fath2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Dhx36
Name: DEAH-box helicase 36
Synonyms: RHAU, Ddx36, 2810407E23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72162
Homologene: 6356
Ush2a
Name: usherin
Synonyms: MUSH2A, LOC269160, Ush2a, A930037M10Rik, A930011D15Rik, LOC381317, Ushrn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
1700006A11Rik
Name: RIKEN cDNA 1700006A11 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71824
Vmn1r214
Name: vomeronasal 1 receptor 214
Synonyms: V1rh5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171248
Homologene: 110880
Ofcc1
Name: orofacial cleft 1 candidate 1
Synonyms: Opo, ojoplano
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218165
VEGA: 13
Homologene: 125376
Ranbp3l
Name: RAN binding protein 3-like
Synonyms: C130037N17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223332
VEGA: 15
Homologene: 35407
Ampd1
Name: adenosine monophosphate deaminase 1
Synonyms: Ampd-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229665
HGNC: HGNC:468
Homologene: 20
Scaf11
Name: SR-related CTD-associated factor 11
Synonyms: CASP11, SIP1, Srsf2ip, 2610510E10Rik, 1110061H03Rik, Sfrs2ip, SRRP129
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72193
VEGA: 15
Homologene: 37957
Grik2
Name: glutamate receptor, ionotropic, kainate 2 (beta 2)
Synonyms: Glurbeta2, Glur-6, C130030K03Rik, Glur6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14806
HGNC: HGNC:4580
Homologene: 40717
Thoc5
Name: THO complex 5
Synonyms: 1700060C24Rik, Fmip, PK1.3, A430085L24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107829
Homologene: 37836
Pom121l2
Name: POM121 transmembrane nucleoporin like 2
Synonyms: LOC195236
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 195236
Homologene: 123536
Or10d3
Name: olfactory receptor family 10 subfamily D member 3
Synonyms: MOR224-9, Olfr958, GA_x6K02T2PVTD-33247839-33246901
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258327
VEGA: 9
HGNC: HGNC:8168
Homologene: 27128
Gm7233
Name: predicted gene 7233
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 638262
Or5b110-ps1
Name: olfactory receptor family 5 subfamily B member 110, pseudogene 1
Synonyms: Olfr1464-ps1, MOR202-27P, GA_x6K02T2RE5P-3614075-3613153, Gm8561
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667300
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 91,968,455 bp
  • A to G, chromosome 1 at 162,697,795 bp
  • A to G, chromosome 1 at 188,911,247 bp
  • T to C, chromosome 2 at 32,801,883 bp
  • A to G, chromosome 2 at 166,083,921 bp
  • G to T, chromosome 3 at 62,488,639 bp
  • A to G, chromosome 3 at 86,085,336 bp
  • A to G, chromosome 3 at 103,099,595 bp
  • A to G, chromosome 3 at 115,926,803 bp
  • T to C, chromosome 3 at 124,419,920 bp
  • A to G, chromosome 4 at 108,590,717 bp
  • A to T, chromosome 4 at 110,255,382 bp
  • GACTCTAC to GAC, chromosome 4 at 120,973,085 bp
  • T to C, chromosome 4 at 149,192,596 bp
  • T to C, chromosome 5 at 110,708,837 bp
  • T to A, chromosome 5 at 118,754,321 bp
  • T to C, chromosome 5 at 124,762,782 bp
  • T to A, chromosome 5 at 138,178,096 bp
  • T to C, chromosome 6 at 84,008,925 bp
  • T to A, chromosome 6 at 100,648,247 bp
  • A to T, chromosome 7 at 30,776,429 bp
  • A to T, chromosome 7 at 133,929,984 bp
  • T to C, chromosome 8 at 45,397,449 bp
  • C to T, chromosome 9 at 39,550,278 bp
  • A to G, chromosome 10 at 49,356,102 bp
  • C to G, chromosome 10 at 121,035,091 bp
  • T to A, chromosome 11 at 4,924,815 bp
  • A to G, chromosome 11 at 55,262,397 bp
  • A to G, chromosome 13 at 21,983,461 bp
  • A to T, chromosome 13 at 23,035,440 bp
  • A to T, chromosome 13 at 40,097,055 bp
  • T to A, chromosome 14 at 43,179,937 bp
  • A to T, chromosome 14 at 108,911,697 bp
  • T to C, chromosome 15 at 8,968,462 bp
  • T to C, chromosome 15 at 85,978,920 bp
  • T to C, chromosome 15 at 96,419,460 bp
  • A to C, chromosome 19 at 13,282,484 bp
  • T to C, chromosome 19 at 25,428,154 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6504 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044636-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.