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Strain Name:
C57BL/6J-MtgxR6513Btlr/Mmmh
Stock Number:
044640-MU
Citation ID:
RRID:MMRRC_044640-MU
Other Names:
R6513 (G1)
Major Collection:

Strain Information

Tle4
Name: transducin-like enhancer of split 4
Synonyms: Grg4, ESTM13, ESTM14, Bce1, 5730411M05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21888
VEGA: 19
Homologene: 38259
Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269473
Homologene: 8882
Ptf1a
Name: pancreas specific transcription factor, 1a
Synonyms: PTF1-p48, bHLHa29
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19213
Homologene: 10304
Gli2
Name: GLI-Kruppel family member GLI2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14633
HGNC: HGNC:4318
Homologene: 12725
Mtap
Name: methylthioadenosine phosphorylase
Synonyms: 1300019I21Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66902
HGNC: HGNC:7413
Homologene: 1838
Tfr2
Name: transferrin receptor 2
Synonyms: Tfr2, Trfr2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50765
Homologene: 2428
Kdm2b
Name: lysine (K)-specific demethylase 2B
Synonyms: Cxxc2, Jhdm1b, Fbxl10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 30841
Homologene: 13069
Pds5a
Name: PDS5 cohesin associated factor A
Synonyms: E230024D05Rik, 9030416H16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71521
Homologene: 22877
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 2410104C19Rik, 9530048I21Rik, 3010027A04Rik, Yod
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 77087
Homologene: 69134
Racgap1
Name: Rac GTPase-activating protein 1
Synonyms: MgcRacGAP, GTPase, Band25, gtl11
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 26934
HGNC: HGNC:9804
Homologene: 8077
Kifbp
Name: kinesin family binding protein
Synonyms: 2510003E04Rik, Kif1bp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72320
Homologene: 9223
Zfp516
Name: zinc finger protein 516
Synonyms: C330029B10Rik, Zfp26l
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329003
VEGA: 18
Homologene: 37122
Ankfy1
Name: ankyrin repeat and FYVE domain containing 1
Synonyms: Ankhzn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11736
Homologene: 9491
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20658
Homologene: 10551
Trak1
Name: trafficking protein, kinesin binding 1
Synonyms: 2310001H13Rik, hyrt
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67095
Homologene: 25103
Meaf6
Name: MYST/Esa1-associated factor 6
Synonyms: 2810036M01Rik, 2310005N01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70088
Homologene: 11240
Kif26a
Name: kinesin family member 26A
Synonyms: N-11 kinesin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668303
Homologene: 18970
Arhgap17
Name: Rho GTPase activating protein 17
Synonyms: WBP15, Nadrin, Rich1, 5730403H17Rik, Nadrin2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70497
Homologene: 9984
Sppl3
Name: signal peptide peptidase 3
Synonyms: 4833416I09Rik, Usmg3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74585
Homologene: 15563
Caap1
Name: caspase activity and apoptosis inhibitor 1
Synonyms: 5830433M19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67770
Homologene: 32607
Cep72
Name: centrosomal protein 72
Synonyms: 2610029E11Rik, 4933440J22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74470
VEGA: 13
Homologene: 10027
Pnpla7
Name: patatin-like phospholipase domain containing 7
Synonyms: E430013P11Rik, NRE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241274
Homologene: 62431
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Synonyms: Cox-2, cyclooxygenase 2, Pghs2, COX2, prostaglandin G/H synthase, PHS-2, cyclooxygenase-2, PGHS-2, Tis10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19225
HGNC: HGNC:9605
Homologene: 31000
Zbtb1
Name: zinc finger and BTB domain containing 1
Synonyms: C430003J21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268564
Homologene: 8974
Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
Synonyms: TEC, NOR-1, Nor1, MINOR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18124
HGNC: HGNC:7982
Homologene: 5074
Cabp1
Name: calcium binding protein 1
Synonyms: caldendrin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 29867
HGNC: HGNC:1384
Homologene: 99790
Cfap74
Name: cilia and flagella associated protein 74
Synonyms: 2010015L04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 544678
Homologene: 129584
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Kidins220
Name: kinase D-interacting substrate 220
Synonyms: 3110039L19Rik, C330002I19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 77480
VEGA: 12
Homologene: 14254
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Tprg1l
Name: transformation related protein 63 regulated 1 like
Synonyms: 1200015A19Rik, mover, Tprgl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67808
Homologene: 12192
Or10ak14
Name: olfactory receptor family 10 subfamily AK member 14
Synonyms: MOR259-4P, GA_x6K02T2QD9B-18795136-18796077, MOR259-4P, MOR259-9, Olfr1524-ps1, Olfr1338
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258259
Homologene: 115537
Krt72
Name: keratin 72
Synonyms: K6irs2, Krt72-ps
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105866
Homologene: 25876
Zc3h7a
Name: zinc finger CCCH type containing 7 A
Synonyms: A430104C18Rik, Zc3h7
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106205
Homologene: 8563
Zfp623
Name: zinc finger protein 623
Synonyms: 2610029D06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78834
VEGA: 15
Homologene: 15994
Pam
Name: peptidylglycine alpha-amidating monooxygenase
Synonyms: PHM
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18484
HGNC: HGNC:8596
Homologene: 37369
Shcbp1
Name: Shc SH2-domain binding protein 1
Synonyms: mPAL
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20419
Homologene: 32123
Epcip
Name: exosomal polycystin 1 interacting protein
Synonyms: 4932438H23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74387
HGNC: HGNC:1305
Homologene: 49594
Aox4
Name: aldehyde oxidase 4
Synonyms: AOH2, 2310003G12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71872
Homologene: 70273
Phldb2
Name: pleckstrin homology like domain, family B, member 2
Synonyms: LL5beta, LL5b, C820004H04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208177
Homologene: 17100
Dsg1c
Name: desmoglein 1 gamma
Synonyms: Dsg6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 211924
HGNC: HGNC:3048
Gbp4
Name: guanylate binding protein 4
Synonyms: Mag-2, Mpa-2, Mpa2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17472
Homologene: 128731
Tbc1d31
Name: TBC1 domain family, member 31
Synonyms: LOC210544, D330013L20Rik, Wdr67
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 210544
Homologene: 17089
Dsc2
Name: desmocollin 2
Synonyms: Dsc2b, Dsc2a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Vmn2r118
Name: vomeronasal 2, receptor 118
Synonyms: EG668547, Vmn2r119, EG383258
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 383258
Homologene: 129687
Calhm4
Name: calcium homeostasis modulator family member 4
Synonyms: LOC270711, 4732454E20Rik, Fam26d
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 270711
VEGA: 10
Homologene: 19551
Zkscan7
Name: zinc finger with KRAB and SCAN domains 7
Synonyms: Zfp167
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382118
VEGA: 9
Homologene: 83284
Vmn2r49
Name: vomeronasal 2, receptor 49
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 625605
Homologene: 113703
Pcare
Name: photoreceptor cilium actin regulator
Synonyms: BC027072
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225004
VEGA: 17
Homologene: 19792
Wee2
Name: WEE1 homolog 2 (S. pombe)
Synonyms: LOC381759, Wee1b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381759
Homologene: 52392
Lactb
Name: lactamase, beta
Synonyms: Mrpl56
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80907
VEGA: 9
Homologene: 12755
Wdr38
Name: WD repeat domain 38
Synonyms: 1700123D08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76646
Homologene: 79011
Or4f14
Name: olfactory receptor family 4 subfamily F member 14
Synonyms: GA_x6K02T2Q125-72954873-72953935, MOR245-15, Olfr1306
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258023
Homologene: 128383
Klk1b27
Name: kallikrein 1-related peptidase b27
Synonyms: mGK-27, Klk27, Klk21l
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16619
Homologene: 68141
Telo2
Name: telomere maintenance 2
Synonyms: 1200003M09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71718
Homologene: 41107
Gpr146
Name: G protein-coupled receptor 146
Synonyms: PGR8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80290
Homologene: 36472
Fkrp
Name: fukutin related protein
Synonyms: LGMD1I, MDC1C, A830029B19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243853
Homologene: 11513
Vmn2r113
Name: vomeronasal 2, receptor 113
Synonyms: EG434701
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 434701
Phospho1
Name: phosphatase, orphan 1
Synonyms: D11Moh36
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237928
Homologene: 13330
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,213,053 bp
  • A to G, chromosome 1 at 97,838,027 bp
  • G to A, chromosome 1 at 118,855,554 bp
  • A to T, chromosome 1 at 150,100,128 bp
  • A to G, chromosome 1 at 182,014,355 bp
  • T to A, chromosome 2 at 19,447,037 bp
  • G to A, chromosome 2 at 22,407,332 bp
  • G to A, chromosome 2 at 25,016,538 bp
  • T to A, chromosome 2 at 38,999,958 bp
  • C to G, chromosome 2 at 111,912,883 bp
  • T to A, chromosome 2 at 125,383,671 bp
  • T to C, chromosome 3 at 93,396,112 bp
  • A to T, chromosome 3 at 104,465,729 bp
  • C to T, chromosome 4 at 48,083,255 bp
  • G to A, chromosome 4 at 48,397,534 bp
  • A to G, chromosome 4 at 89,148,261 bp
  • A to T, chromosome 4 at 94,501,403 bp
  • A to T, chromosome 4 at 118,754,027 bp
  • A to C, chromosome 4 at 125,089,904 bp
  • A to G, chromosome 4 at 154,159,405 bp
  • A to G, chromosome 4 at 155,441,286 bp
  • T to A, chromosome 5 at 65,615,601 bp
  • C to A, chromosome 5 at 93,637,532 bp
  • C to T, chromosome 5 at 105,123,120 bp
  • T to C, chromosome 5 at 115,095,936 bp
  • T to A, chromosome 5 at 115,169,134 bp
  • C to A, chromosome 5 at 121,356,196 bp
  • A to G, chromosome 5 at 122,880,239 bp
  • A to G, chromosome 5 at 137,574,531 bp
  • A to G, chromosome 5 at 139,392,818 bp
  • A to G, chromosome 6 at 40,452,619 bp
  • A to G, chromosome 7 at 9,976,597 bp
  • C to A, chromosome 7 at 16,811,112 bp
  • A to G, chromosome 7 at 44,055,745 bp
  • T to C, chromosome 7 at 123,292,156 bp
  • T to C, chromosome 8 at 4,744,507 bp
  • A to G, chromosome 8 at 122,890,180 bp
  • C to T, chromosome 9 at 66,970,890 bp
  • C to T, chromosome 9 at 121,443,756 bp
  • G to A, chromosome 9 at 122,896,105 bp
  • T to C, chromosome 10 at 11,186,893 bp
  • T to A, chromosome 10 at 34,041,634 bp
  • T to C, chromosome 10 at 62,575,034 bp
  • G to A, chromosome 11 at 72,730,482 bp
  • C to T, chromosome 11 at 95,830,687 bp
  • T to A, chromosome 12 at 25,038,435 bp
  • T to C, chromosome 12 at 76,385,830 bp
  • T to A, chromosome 12 at 112,175,492 bp
  • A to T, chromosome 13 at 74,058,463 bp
  • A to T, chromosome 15 at 57,955,382 bp
  • G to A, chromosome 15 at 75,947,468 bp
  • T to C, chromosome 15 at 99,624,275 bp
  • T to G, chromosome 15 at 101,776,752 bp
  • T to C, chromosome 16 at 11,158,765 bp
  • T to A, chromosome 16 at 45,747,877 bp
  • T to C, chromosome 16 at 91,055,766 bp
  • T to C, chromosome 16 at 91,659,947 bp
  • T to C, chromosome 17 at 22,958,741 bp
  • T to C, chromosome 17 at 25,101,412 bp
  • T to A, chromosome 17 at 55,608,093 bp
  • T to A, chromosome 17 at 71,744,706 bp
  • T to C, chromosome 18 at 20,046,238 bp
  • T to G, chromosome 18 at 20,274,630 bp
  • T to A, chromosome 18 at 82,955,710 bp
  • T to C, chromosome 19 at 14,451,692 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6513 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044640-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.