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Strain Name:
C57BL/6J-MtgxR6541Btlr/Mmmh
Stock Number:
044667-MU
Citation ID:
RRID:MMRRC_044667-MU
Other Names:
R6541 (G1)
Major Collection:

Strain Information

Kdm3a
Name: lysine (K)-specific demethylase 3A
Synonyms: 1700105C21Rik, Tsga, C230043E16Rik, Jmjd1, Jmjd1a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 104263
Homologene: 10196
Esf1
Name: ESF1 nucleolar pre-rRNA processing protein homolog
Synonyms: 2610101J03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66580
Homologene: 5717
Cluh
Name: clustered mitochondria homolog
Synonyms: 1300001I01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74148
Homologene: 9063
Rnd2
Name: Rho family GTPase 2
Synonyms: Arhn, Rohn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11858
Homologene: 21123
Ass1
Name: argininosuccinate synthetase 1
Synonyms: ASS, Ass-1, fold
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11898
HGNC: HGNC:758
Homologene: 6899
Ndufa11
Name: NADH:ubiquinone oxidoreductase subunit A11
Synonyms: 11, 14.7kDa, B14.7, 2010012C24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69875
VEGA: 17
Homologene: 17926
Bicra
Name: BRD4 interacting chromatin remodeling complex associated protein
Synonyms: Gltscr1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243842
HGNC: HGNC:4332
Homologene: 9250
Kif18b
Name: kinesin family member 18B
Synonyms: N-8 kinesin, 3000004C01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70218
Homologene: 15214
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: A230074B11Rik, 4921511C04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70853
Homologene: 27053
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: b2b012Clo, Jbts17, Hug, 2410089E03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Slc16a10
Name: solute carrier family 16 (monocarboxylic acid transporters), member 10
Synonyms: PRO0813, TAT1, 2610103N14Rik, Mct10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72472
VEGA: 10
Homologene: 75089
Il36b
Name: interleukin 36B
Synonyms: 2310043N20Rik, Il1f8, If36b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69677
Homologene: 18278
Iba57
Name: IBA57 homolog, iron-sulfur cluster assembly
Synonyms: 4930543L23Rik, A230051G13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216792
Homologene: 13844
Itgal
Name: integrin alpha L
Synonyms: LFA-1, Cd11a, Ly-21, Ly-15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16408
HGNC: HGNC:6148
Homologene: 1666
Or6b6
Name: olfactory receptor family 6 subfamily B member 6
Synonyms: GA_x6K02T2PBJ9-9352783-9351839, MOR103-4, Olfr711
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259037
Homologene: 128111
Or2bd2
Name: olfactory receptor family 2 subfamily BD member 2
Synonyms: GA_x6K02T2QGBW-3169916-3170881, MOR124-1, 4930415J05Rik, Olfr1344
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 257882
Vmn2r108
Name: vomeronasal 2, receptor 108
Synonyms: EG627805
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627805
Homologene: 129678
BC028528
Name: cDNA sequence BC028528
Synonyms: L259
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229600
Homologene: 49773
Sval3
Name: seminal vesicle antigen-like 3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387564
Homologene: 133811
Hhatl
Name: hedgehog acyltransferase-like
Synonyms: 1110011D13Rik, Gup1, Mitsugumin 56, Mg56
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74770
VEGA: 9
Homologene: 19287
Or7h8
Name: olfactory receptor family 7 subfamily H member 8
Synonyms: GA_x6K02T2PVTD-13952555-13953490, MOR141-2, Olfr871
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258905
Homologene: 138319
Ergic2
Name: ERGIC and golgi 2
Synonyms: 4930572C01Rik, 1200009B18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67456
Homologene: 6574
Spaca7b
Name: sperm acrosome associated 7B
Synonyms: GC14, 1700016D06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76413
Ugt1a9
Name: UDP glucuronosyltransferase 1 family, polypeptide A9
Synonyms: mUGTBr/P, A12
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 394434
Homologene: 133281
Crygf
Name: crystallin, gamma F
Synonyms: Len-2, DGcry-2, Cryg-2, 3110001K11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12969
HGNC: HGNC:2411
Homologene: 128417
Or5w19
Name: olfactory receptor family 5 subfamily W member 19
Synonyms: GA_x6K02T2Q125-49372426-49373358, MOR177-12, Olfr1152
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258103
Homologene: 79357
Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Synonyms: PC3, prohormone convertase 1/3, Nec-1, Nec1, PC1, SPC3, Phpp-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18548
HGNC: HGNC:8743
Homologene: 379
Sh2d4b
Name: SH2 domain containing 4B
Synonyms: A430109M18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328381
Homologene: 19164
Pacsin3
Name: protein kinase C and casein kinase substrate in neurons 3
Synonyms: 4921507A02Rik, 6330413E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 80708
HGNC: HGNC:8572
Homologene: 41117
Taar7d
Name: trace amine-associated receptor 7D
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 435206
Homologene: 115653
Mroh9
Name: maestro heat-like repeat family member 9
Synonyms: Armc11, 4921528O07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78258
Homologene: 123521
Rdh5
Name: retinol dehydrogenase 5
Synonyms: cRDH
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19682
HGNC: HGNC:9940
Homologene: 2179
Prr18
Name: proline rich 18
Synonyms: 9630019K15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320111
VEGA: 17
Homologene: 52195
Gm28360
Name: predicted gene 28360
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 37,051,761 bp
  • T to C, chromosome 1 at 65,928,065 bp
  • T to A, chromosome 1 at 88,071,596 bp
  • T to C, chromosome 1 at 117,830,317 bp
  • A to G, chromosome 1 at 163,058,038 bp
  • T to A, chromosome 2 at 24,159,815 bp
  • T to C, chromosome 2 at 31,510,233 bp
  • T to A, chromosome 2 at 76,746,695 bp
  • T to C, chromosome 2 at 87,868,294 bp
  • A to G, chromosome 2 at 91,262,784 bp
  • A to G, chromosome 2 at 140,167,879 bp
  • T to A, chromosome 3 at 95,888,218 bp
  • A to T, chromosome 6 at 41,972,446 bp
  • T to C, chromosome 6 at 71,594,533 bp
  • T to A, chromosome 6 at 148,183,150 bp
  • A to T, chromosome 7 at 6,440,493 bp
  • A to G, chromosome 7 at 12,671,012 bp
  • T to C, chromosome 7 at 15,979,129 bp
  • A to T, chromosome 7 at 106,972,203 bp
  • T to A, chromosome 7 at 127,311,562 bp
  • T to A, chromosome 8 at 11,662,613 bp
  • T to A, chromosome 9 at 20,212,399 bp
  • C to T, chromosome 9 at 121,785,144 bp
  • T to C, chromosome 10 at 24,028,231 bp
  • T to C, chromosome 10 at 40,037,272 bp
  • A to G, chromosome 10 at 128,918,108 bp
  • T to G, chromosome 11 at 52,022,744 bp
  • A to T, chromosome 11 at 59,158,863 bp
  • A to G, chromosome 11 at 74,657,214 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • T to C, chromosome 11 at 102,914,266 bp
  • T to A, chromosome 13 at 75,125,984 bp
  • T to C, chromosome 14 at 40,820,791 bp
  • T to C, chromosome 15 at 8,219,295 bp
  • G to T, chromosome 17 at 8,341,336 bp
  • T to A, chromosome 17 at 20,481,218 bp
  • T to A, chromosome 17 at 56,717,867 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6541 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044667-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.