Strain Name:
C57BL/6J-MtgxR6551Btlr/Mmmh
Stock Number:
044676-MU
Citation ID:
RRID:MMRRC_044676-MU
Other Names:
R6551 (G1)
Major Collection:

Strain Information

Rapgef2
Name: Rap guanine nucleotide exchange factor (GEF) 2
Synonyms: 5830453M24Rik, Pdzgef1, RA-GEF-1, CNRasGEF, nRapGEP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76089
Homologene: 35477
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Fbxo31
Name: F-box protein 31
Synonyms: 2310046N15Rik, Fbx14, Fbxo14, 1110003O08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76454
Homologene: 11684
Brwd1
Name: bromodomain and WD repeat domain containing 1
Synonyms: 5330419I02Rik, D530019K20Rik, G1-403-16, Wdr9, repro5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 93871
Homologene: 23130
Unk
Name: unkempt family zinc finger
Synonyms: B230379M23Rik, Zc3h5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217331
Homologene: 18194
Nol9
Name: nucleolar protein 9
Synonyms: 6030462G04Rik, 4632412I24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74035
Homologene: 32589
Cttnbp2nl
Name: CTTNBP2 N-terminal like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80281
Homologene: 36371
Tmem161b
Name: transmembrane protein 161B
Synonyms: 2810446P07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72745
Homologene: 14519
Clmp
Name: CXADR-like membrane protein
Synonyms: 9030425E11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71566
Homologene: 11705
Srsf7
Name: serine and arginine-rich splicing factor 7
Synonyms: NX-96, 9G8, 9430065L19Rik, Sfrs7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225027
VEGA: 17
Homologene: 134446
Zdhhc18
Name: zinc finger, DHHC domain containing 18
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 503610
Homologene: 110918
Jak1
Name: Janus kinase 1
Synonyms: C130039L05Rik, BAP004
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16451
HGNC: HGNC:6190
Homologene: 1678
Zfp335
Name: zinc finger protein 335
Synonyms: 1810045J01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329559
Homologene: 11129
Rnf103
Name: ring finger protein 103
Synonyms: kf-1, Zfp103
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22644
Homologene: 4146
Muc16
Name: mucin 16
Synonyms: LOC385009, 1110008I14Rik, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Lyar
Name: Ly1 antibody reactive clone
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17089
Homologene: 41200
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Usp8
Name: ubiquitin specific peptidase 8
Synonyms: Ubpy
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 84092
Homologene: 3782
Zbtb48
Name: zinc finger and BTB domain containing 48
Synonyms: 0610011D15Rik, Hkr3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100090
HGNC: HGNC:4930
Homologene: 3905
Dsg3
Name: desmoglein 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13512
VEGA: 18
HGNC: HGNC:3050
Homologene: 55513
Tamm41
Name: TAM41 mitochondrial translocator assembly and maintenance homolog
Synonyms: 1500001M20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68971
Homologene: 13754
Pnldc1
Name: poly(A)-specific ribonuclease (PARN)-like domain containing 1
Synonyms: LOC240023
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240023
VEGA: 17
Homologene: 15054
Rab11fip1
Name: RAB11 family interacting protein 1 (class I)
Synonyms: 2010200K21Rik, 4833414G05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75767
Homologene: 11853
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: NMDAR2B, NR2B, Nmdar2b, GluRepsilon2, GluN2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Or10d1
Name: olfactory receptor family 10 subfamily D member 1
Synonyms: GA_x6K02T2PVTD-33270211-33269276, MOR224-3, Olfr959
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258501
VEGA: 9
Homologene: 71989
Or2y10
Name: olfactory receptor family 2 subfamily Y member 10
Synonyms: GA_x6K02T2QP88-5871967-5871032, MOR256-66_i, Olfr1380
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 404336
Homologene: 72463
Or1e17
Name: olfactory receptor family 1 subfamily E member 17
Synonyms: MTPCR50, MOR135-27, GA_x6K02T2P1NL-4097159-4098136, Olfr23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18321
Homologene: 115483
Ssrp1
Name: structure specific recognition protein 1
Synonyms: T160, Hmgi-rs3, Hmg1-rs1, Hmgox
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20833
Homologene: 110735
Klra10
Name: killer cell lectin-like receptor subfamily A, member 10
Synonyms: Ly49J, Ly49i2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16628
Homologene: 110821
Alkbh7
Name: alkB homolog 7
Synonyms: 2510008E23Rik, 2310045B01Rik, Abh7, Spata11
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66400
Homologene: 11964
Chp1
Name: calcineurin-like EF hand protein 1
Synonyms: Sid470p, 1500003O03Rik, vac
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56398
Homologene: 5235
Rph3al
Name: rabphilin 3A-like (without C2 domains)
Synonyms: 6530413F01Rik, LOC385671, Noc2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380714
Homologene: 5078
Tmem39b
Name: transmembrane protein 39b
Synonyms: 6330509E05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230770
Homologene: 23069
Or2w3b
Name: olfactory receptor family 2 subfamily W member 3B
Synonyms: GA_x6K02T2NKPP-680866-681849, MOR256-47, Olfr317
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257931
Homologene: 128382
Tmem88b
Name: transmembrane protein 88B
Synonyms: A230069A22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320587
Homologene: 85849
Or12e8
Name: olfactory receptor family 12 subfamily E member 8
Synonyms: GA_x6K02T2Q125-48849180-48850100, MOR264-2, Olfr1120
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259031
Homologene: 72054
Cryge
Name: crystallin, gamma E
Synonyms: Cryg-6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12968
HGNC: HGNC:2411
Homologene: 128417
Or1o1
Name: olfactory receptor family 1 subfamily O member 1
Synonyms: MOR156-3, GA_x6K02T2PSCP-1867165-1868094, Olfr107
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258504
Homologene: 115498
Acss2
Name: acyl-CoA synthetase short-chain family member 2
Synonyms: acetyl-CoA synthetase 1, ACAS, AceCS1, Acas1, Acs1, Acas2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 60525
Homologene: 6469
Ager
Name: advanced glycosylation end product-specific receptor
Synonyms: RAGE
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11596
HGNC: HGNC:320
Homologene: 883
Lhx1
Name: LIM homeobox protein 1
Synonyms: Lim1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16869
HGNC: HGNC:6593
Homologene: 4068
A130010J15Rik
Name: RIKEN cDNA A130010J15 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 319266
Homologene: 17592
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 65,048,637 bp
  • A to T, chromosome 1 at 193,174,523 bp
  • A to G, chromosome 2 at 85,041,106 bp
  • T to C, chromosome 2 at 87,846,661 bp
  • T to A, chromosome 2 at 119,571,813 bp
  • T to A, chromosome 2 at 126,733,182 bp
  • T to C, chromosome 2 at 155,551,208 bp
  • G to A, chromosome 2 at 164,909,365 bp
  • A to T, chromosome 3 at 79,215,035 bp
  • A to T, chromosome 3 at 105,005,117 bp
  • C to A, chromosome 4 at 101,193,843 bp
  • A to G, chromosome 4 at 129,692,103 bp
  • T to C, chromosome 4 at 133,613,649 bp
  • T to G, chromosome 4 at 152,022,221 bp
  • G to A, chromosome 4 at 152,051,868 bp
  • T to C, chromosome 4 at 152,128,766 bp
  • G to T, chromosome 4 at 155,785,692 bp
  • C to A, chromosome 5 at 38,233,272 bp
  • G to A, chromosome 6 at 71,510,365 bp
  • T to C, chromosome 6 at 115,012,181 bp
  • A to T, chromosome 6 at 130,275,755 bp
  • A to G, chromosome 6 at 135,733,344 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • A to T, chromosome 7 at 116,417,496 bp
  • G to A, chromosome 8 at 27,156,484 bp
  • A to C, chromosome 8 at 121,564,704 bp
  • A to C, chromosome 9 at 18,562,562 bp
  • C to A, chromosome 9 at 39,572,560 bp
  • T to C, chromosome 9 at 40,771,277 bp
  • G to T, chromosome 11 at 49,563,989 bp
  • A to T, chromosome 11 at 58,732,757 bp
  • T to C, chromosome 11 at 73,940,303 bp
  • G to A, chromosome 11 at 75,906,546 bp
  • A to C, chromosome 11 at 84,521,913 bp
  • T to C, chromosome 11 at 116,050,724 bp
  • C to A, chromosome 13 at 84,222,418 bp
  • T to C, chromosome 16 at 95,993,962 bp
  • A to G, chromosome 17 at 12,905,569 bp
  • A to G, chromosome 17 at 34,599,468 bp
  • G to A, chromosome 17 at 37,405,905 bp
  • T to A, chromosome 17 at 56,998,945 bp
  • A to C, chromosome 17 at 80,204,219 bp
  • C to A, chromosome 18 at 20,539,911 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6551 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044676-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.