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Strain Name:
C57BL/6J-MtgxR6560Btlr/Mmmh
Stock Number:
044684-MU
Citation ID:
RRID:MMRRC_044684-MU
Other Names:
R6560 (G1)
Major Collection:

Strain Information

Mfn1
Name: mitofusin 1
Synonyms: 6330416C07Rik, 2310002F04Rik, D3Ertd265e, HR2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67414
Homologene: 11481
Klf9
Name: Kruppel-like transcription factor 9
Synonyms: BTEB-1, Bteb1, Klf9, 2310051E17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16601
VEGA: 19
HGNC: HGNC:1123
Homologene: 931
Zfp619
Name: zinc finger protein 619
Synonyms: 3000002G13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70227
Homologene: 133818
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Exosc4
Name: exosome component 4
Synonyms: 1500001N04Rik, 1110039I09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109075
Homologene: 6017
Zfp90
Name: zinc finger protein 90
Synonyms: Nk10 expressed protein, NK10, 6430515L01Rik, Zfp64, KRAB17, Zfp83
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22751
Homologene: 86800
Gosr2
Name: golgi SNAP receptor complex member 2
Synonyms: membrin, GS27, SNARE, 2310032N09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56494
HGNC: HGNC:4431
Homologene: 37907
Acin1
Name: apoptotic chromatin condensation inducer 1
Synonyms: 2610510L13Rik, 2610036I19Rik, Acinus
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56215
Homologene: 22853
Neo1
Name: neogenin
Synonyms: D930014N22Rik, 2610028H22Rik, Igdcc2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18007
VEGA: 9
HGNC: HGNC:7754
Homologene: 1870
Card6
Name: caspase recruitment domain family, member 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239319
Homologene: 13067
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Insig1
Name: insulin induced gene 1
Synonyms: Insig-1, 1810013C12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231070
HGNC: HGNC:6083
Homologene: 4047
Adamtsl1
Name: ADAMTS-like 1
Synonyms: punctin-1, 6720426B09Rik, 5930437A14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77739
Homologene: 64642
Bicra
Name: BRD4 interacting chromatin remodeling complex associated protein
Synonyms: Gltscr1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243842
HGNC: HGNC:4332
Homologene: 9250
Ythdc1
Name: YTH domain containing 1
Synonyms: A730098D12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231386
Homologene: 15796
Pcgf3
Name: polycomb group ring finger 3
Synonyms: D630042K08Rik, RNF3A, DONG1, 2310035N15Rik, Rnf3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69587
Homologene: 4605
Bbs5
Name: Bardet-Biedl syndrome 5
Synonyms: 1700049I01Rik, 2700023J09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72569
HGNC: HGNC:970
Homologene: 12471
Dnai3
Name: dynein axonemal intermediate chain 3
Synonyms: 4931433A13Rik, IC140, Ida7, Wdr63
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242253
Homologene: 44922
Crip3
Name: cysteine-rich protein 3
Synonyms: TLP-A, TLP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 114570
Homologene: 28039
Dscam
Name: DS cell adhesion molecule
Synonyms: 4932410A21Rik, Down syndrome cell adhesion molecule
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
Gm10801
Name: predicted gene 10801
Type: Gene
Species: Mouse
Chromosome: 2
Plppr5
Name: phospholipid phosphatase related 5
Synonyms: Lppr5, 4833424O15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 75769
Homologene: 25279
Cyp2c50
Name: cytochrome P450, family 2, subfamily c, polypeptide 50
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107141
Homologene: 137231
Or7e168
Name: olfactory receptor family 7 subfamily E member 168
Synonyms: GA_x6K02T2PVTD-13548326-13549255, MOR146-3, MOR146-10_p, Olfr859
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258519
Homologene: 134093
Dio2
Name: deiodinase, iodothyronine, type II
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13371
VEGA: 12
HGNC: HGNC:2884
Homologene: 621
Tex14
Name: testis expressed gene 14 intercellular bridge forming factor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83560
Homologene: 12838
Has2
Name: hyaluronan synthase 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15117
HGNC: HGNC:4819
Homologene: 3892
Arsk
Name: arylsulfatase K
Synonyms: 4833414G15Rik, 2810429K17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 77041
Homologene: 12670
Glb1l3
Name: galactosidase, beta 1 like 3
Synonyms: 4921509F24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70893
Homologene: 72240
Negr1
Name: neuronal growth regulator 1
Synonyms: 5330422G01Rik, Ntra, neurotractin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320840
Homologene: 41447
Abca7
Name: ATP-binding cassette, sub-family A member 7
Synonyms: Abc51
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27403
HGNC: HGNC:37
Homologene: 22783
Prx
Name: periaxin
Synonyms: L-Periaxin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19153
Homologene: 76542
Akr1b1
Name: aldo-keto reductase family 1 member B
Synonyms: Ahr-1, Aldor1, Aldr1, Ahr1, ALR2, AR, Akr1b3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11677
HGNC: HGNC:381
Homologene: 133743
Or52ab4
Name: olfactory receptor family 52 subfamily AB member 4
Synonyms: GA_x6K02T2PBJ9-6047402-6048349, MOR23-1, Olfr599
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258726
Homologene: 27244
Cept1
Name: choline/ethanolaminephosphotransferase 1
Synonyms: 9930118K05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99712
Homologene: 81624
Myl2
Name: myosin, light polypeptide 2, regulatory, cardiac, slow
Synonyms: MLC-2v, MLC-2, Mlc2v, Mylpc, Gm32672
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17906
HGNC: HGNC:7583
Homologene: 55462
Gm3072
Name: predicted gene 3072
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102639794
Homologene: 128452
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 2 at 69,656,956 bp
  • C to CGTG, chromosome 2 at 98,663,807 bp
  • T to C, chromosome 3 at 32,569,516 bp
  • T to C, chromosome 3 at 106,505,278 bp
  • A to G, chromosome 3 at 117,671,990 bp
  • T to C, chromosome 3 at 146,095,406 bp
  • A to G, chromosome 3 at 157,312,857 bp
  • G to A, chromosome 4 at 86,336,893 bp
  • T to A, chromosome 5 at 28,071,533 bp
  • T to C, chromosome 5 at 86,816,608 bp
  • T to A, chromosome 5 at 108,191,924 bp
  • C to A, chromosome 5 at 108,473,902 bp
  • G to A, chromosome 5 at 122,102,771 bp
  • C to T, chromosome 6 at 32,215,678 bp
  • C to T, chromosome 6 at 34,310,004 bp
  • T to C, chromosome 7 at 15,989,194 bp
  • A to T, chromosome 7 at 27,515,321 bp
  • G to A, chromosome 7 at 39,537,530 bp
  • T to C, chromosome 7 at 103,338,738 bp
  • A to G, chromosome 8 at 106,415,747 bp
  • G to A, chromosome 9 at 19,809,116 bp
  • C to T, chromosome 9 at 26,828,424 bp
  • A to G, chromosome 9 at 58,880,601 bp
  • T to A, chromosome 10 at 80,007,396 bp
  • T to G, chromosome 11 at 87,497,862 bp
  • T to C, chromosome 11 at 103,686,682 bp
  • G to C, chromosome 12 at 90,729,833 bp
  • A to T, chromosome 13 at 76,074,986 bp
  • T to A, chromosome 14 at 41,623,553 bp
  • T to C, chromosome 14 at 54,678,833 bp
  • G to A, chromosome 15 at 5,098,885 bp
  • T to A, chromosome 15 at 56,668,264 bp
  • A to G, chromosome 15 at 76,327,613 bp
  • T to C, chromosome 16 at 96,825,735 bp
  • A to G, chromosome 17 at 46,431,036 bp
  • A to G, chromosome 19 at 23,141,950 bp
  • A to G, chromosome 19 at 40,096,855 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6560 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044684-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.