Strain Name:
C57BL/6J-MtgxR6566Btlr/Mmmh
Stock Number:
044690-MU
Citation ID:
RRID:MMRRC_044690-MU
Other Names:
R6566 (G1)
Major Collection:

Strain Information

Rgs16
Name: regulator of G-protein signaling 16
Synonyms: Rgsr
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19734
HGNC: HGNC:9997
Homologene: 2196
Khdc4
Name: KH domain containing 4, pre-mRNA splicing factor
Synonyms: 2810403A07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74200
Homologene: 41761
Plcd3
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72469
HGNC: HGNC:9061
Homologene: 14858
Bcat1
Name: branched chain aminotransferase 1, cytosolic
Synonyms: BCATc, Bcat-1, Eca39
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12035
HGNC: HGNC:976
Homologene: 20320
Serpina9
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
Synonyms: 2310014L03Rik, Centerin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71907
Homologene: 23633
Wdr7
Name: WD repeat domain 7
Synonyms: TRAG, TGF-beta resistance associated gene
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 104082
VEGA: 18
Homologene: 11408
Uvssa
Name: UV stimulated scaffold protein A
Synonyms: D330017J19Rik, 4933407H18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71101
Homologene: 13807
Ice2
Name: interactor of little elongation complex ELL subunit 2
Synonyms: B230343B06Rik, Narg2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93697
Homologene: 11618
Aldh16a1
Name: aldehyde dehydrogenase 16 family, member A1
Synonyms: 2410004H02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69748
Homologene: 34938
Runx2
Name: runt related transcription factor 2
Synonyms: Pebpa2a, AML3, polyomavirus enhancer binding factor 2 (PEBP2), Osf2, PEBP2aA, PEBP2 alpha A, SL3-3 enhancer factor 1, Cbfa1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12393
Homologene: 68389
Mtnap1
Name: mitochondrial nucleoid associated protein 1
Synonyms: D11Wsu47e, Gm57859
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276852
Homologene: 9928
Lsr
Name: lipolysis stimulated lipoprotein receptor
Synonyms: Lisch7, ILDR3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54135
Homologene: 9306
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54403
Homologene: 55776
Zbtb5
Name: zinc finger and BTB domain containing 5
Synonyms: 9430083K24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230119
Homologene: 8913
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Adcy3
Name: adenylate cyclase 3
Synonyms: ACIII, AC3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104111
HGNC: HGNC:234
Homologene: 2978
Rb1cc1
Name: RB1-inducible coiled-coil 1
Synonyms: Cc1, 2900055E04Rik, Fip200, 5930404L04Rik, LaXp180
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12421
Homologene: 7659
Rad9b
Name: RAD9 checkpoint clamp component B
Synonyms: A630082N15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231724
Homologene: 17006
Mrps30
Name: mitochondrial ribosomal protein S30
Synonyms: 2610020A16Rik, Pdcd9
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 59054
HGNC: HGNC:8769
Homologene: 9607
Tmc5
Name: transmembrane channel-like gene family 5
Synonyms: 4932443L08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74424
Homologene: 11713
Pign
Name: phosphatidylinositol glycan anchor biosynthesis, class N
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27392
HGNC: HGNC:8967
Homologene: 6330
Dsg1b
Name: desmoglein 1 beta
Synonyms: Dsg5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225256
HGNC: HGNC:3048
Homologene: 1463
Serpina1f
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1F
Synonyms: 0610012A11Rik, epserin, Serpina2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68348
HGNC: HGNC:8985
Homologene: 87037
Speg
Name: SPEG complex locus
Synonyms: SPEGbeta, BPEG, SPEGalpha, Apeg1, SPEG, D1Bwg1450e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Zfp944
Name: zinc finger protein 944
Synonyms: 6330416L07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 319615
VEGA: 17
Homologene: 133237
Syne3
Name: spectrin repeat containing, nuclear envelope family member 3
Synonyms: nesprin-3alpha, 4831426I19Rik, nesprin-3beta, nesprin-3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 212073
VEGA: 12
Homologene: 17625
Tuba4a
Name: tubulin, alpha 4A
Synonyms: Tuba4, M[a]4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22145
Homologene: 68496
Abcd2
Name: ATP-binding cassette, sub-family D member 2
Synonyms: ABC39, ALDR, ALDL1, adrenoleukodystrophy related
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 26874
VEGA: 15
HGNC: HGNC:66
Homologene: 55873
Hecw1
Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms: E130207I19Rik, NEDL1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94253
VEGA: 13
Homologene: 9004
Adad2
Name: adenosine deaminase domain containing 2
Synonyms: 4930403J07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75773
Homologene: 16392
Exoc8
Name: exocyst complex component 8
Synonyms: SEC84, Exo84p, EXO84
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102058
Homologene: 44545
Tymp
Name: thymidine phosphorylase
Synonyms: Pdgfec, PDECGF, 2900072D10Rik, PD-ECGF, Ecgf1, gliostatin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72962
VEGA: 15
HGNC: HGNC:3148
Homologene: 1474
Or6c217
Name: olfactory receptor family 6 subfamily C member 217
Synonyms: Olfr815, GA_x6K02T2PULF-11581263-11580331, MOR113-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258665
Dcstamp
Name: dendrocyte expressed seven transmembrane protein
Synonyms: Tm7sf4, 4833414I07Rik, DC-STAMP
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75766
VEGA: 15
Homologene: 12769
Myl10
Name: myosin, light chain 10, regulatory
Synonyms: Mylc2pl, PLRLC-A, 1700027I08Rik, PLRLC, PLRLC-B, PLRLC-C
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59310
Homologene: 69341
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 6,249,092 bp
  • G to A, chromosome 1 at 75,217,286 bp
  • A to T, chromosome 1 at 75,388,463 bp
  • A to G, chromosome 1 at 105,638,181 bp
  • C to T, chromosome 1 at 153,743,800 bp
  • T to C, chromosome 3 at 38,957,126 bp
  • C to T, chromosome 3 at 88,711,654 bp
  • G to A, chromosome 4 at 44,994,508 bp
  • A to G, chromosome 5 at 33,392,176 bp
  • T to C, chromosome 5 at 89,149,333 bp
  • A to G, chromosome 5 at 122,352,567 bp
  • G to C, chromosome 5 at 136,697,971 bp
  • A to G, chromosome 6 at 145,015,484 bp
  • T to A, chromosome 7 at 30,972,083 bp
  • A to C, chromosome 7 at 45,143,227 bp
  • T to C, chromosome 7 at 118,647,844 bp
  • C to T, chromosome 8 at 119,614,232 bp
  • A to C, chromosome 8 at 124,896,044 bp
  • G to A, chromosome 9 at 69,416,229 bp
  • T to A, chromosome 10 at 129,902,078 bp
  • A to G, chromosome 11 at 103,073,800 bp
  • C to T, chromosome 11 at 113,687,998 bp
  • T to A, chromosome 12 at 4,194,324 bp
  • T to A, chromosome 12 at 103,693,535 bp
  • T to C, chromosome 12 at 103,997,037 bp
  • A to G, chromosome 12 at 104,946,707 bp
  • T to C, chromosome 13 at 14,297,283 bp
  • C to A, chromosome 13 at 118,387,126 bp
  • T to C, chromosome 15 at 39,754,336 bp
  • T to A, chromosome 15 at 89,373,600 bp
  • A to G, chromosome 15 at 91,191,118 bp
  • T to G, chromosome 17 at 22,339,745 bp
  • A to G, chromosome 17 at 44,814,488 bp
  • T to C, chromosome 18 at 20,397,442 bp
  • T to G, chromosome 18 at 63,755,055 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6566 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044690-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.