Strain Name:
C57BL/6J-MtgxR6592Btlr/Mmmh
Stock Number:
044716-MU
Citation ID:
RRID:MMRRC_044716-MU
Other Names:
R6592 (G1)
Major Collection:

Strain Information

Slc12a8
Name: solute carrier family 12 (potassium/chloride transporters), member 8
Synonyms: E330020C02Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 171286
Homologene: 11628
Btbd17
Name: BTB domain containing 17
Synonyms: Tango10a, 1500005I02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72014
Homologene: 46324
Epha7
Name: Eph receptor A7
Synonyms: MDK1, Hek11, Mdk1, Cek11, Ebk, Ehk3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13841
HGNC: HGNC:3390
Homologene: 20935
Ppp1r1a
Name: protein phosphatase 1, regulatory inhibitor subunit 1A
Synonyms: I-1, protein phosphatase inhibitor-1, 0610038N18Rik, inhibitor-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 58200
VEGA: 15
HGNC: HGNC:9286
Homologene: 4905
Usp1
Name: ubiquitin specific peptidase 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230484
Homologene: 2528
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: D1Ertd101e, 1110005P14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Exoc6
Name: exocyst complex component 6
Synonyms: hbd, Sec15, Sec15l1, 4833405E05Rik, msec15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107371
VEGA: 19
Homologene: 41305
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108989
Homologene: 37753
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F37S1, D7H15F32S1, rjs, jdf2, D15F32S1h
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Mcph1
Name: microcephaly, primary autosomal recessive 1
Synonyms: BRIT1, 5430437K10Rik, D030046N04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244329
HGNC: HGNC:6954
Homologene: 32586
Tlk1
Name: tousled-like kinase 1
Synonyms: 4930545J15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228012
Homologene: 130657
Nat10
Name: N-acetyltransferase 10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98956
Homologene: 6785
Pgm3
Name: phosphoglucomutase 3
Synonyms: 2810473H05Rik, Pgm-3, GlcNAc-P mutase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109785
HGNC: HGNC:8907
Homologene: 9205
Serinc5
Name: serine incorporator 5
Synonyms: AIGP3, A130038L21Rik, TPO1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218442
VEGA: 13
Homologene: 65246
Htt
Name: huntingtin
Synonyms: HD, IT15, C430023I11Rik, htt, Hdh, huntingtin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Zcchc14
Name: zinc finger, CCHC domain containing 14
Synonyms: Bdg29
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 142682
Homologene: 9037
Acss3
Name: acyl-CoA synthetase short-chain family member 3
Synonyms: 8430416H19Rik, LOC380660
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380660
Homologene: 11587
Slc51a
Name: solute carrier family 51, alpha subunit
Synonyms: OSTalpha, Osta, D630035O19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106407
Homologene: 44941
Man2a2
Name: mannosidase 2, alpha 2
Synonyms: MX, 4931438M07Rik, alpha mannosidase IIx, 1700052O22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 140481
HGNC: HGNC:6825
Homologene: 55954
Lgmn
Name: legumain
Synonyms: preprolegumain, Prsc1, AEP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19141
HGNC: HGNC:9472
Homologene: 38075
Efcab5
Name: EF-hand calcium binding domain 5
Synonyms: 4930563A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319634
Homologene: 63366
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329679
Homologene: 46417
Tchhl1
Name: trichohyalin-like 1
Synonyms: S100a17, Thhl1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 71325
Homologene: 84625
Or4a67
Name: olfactory receptor family 4 subfamily A member 67
Synonyms: MOR225-12, Olfr1200, GA_x6K02T2Q125-50243231-50242221
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257887
Homologene: 123770
Proca1
Name: protein interacting with cyclin A1
Synonyms: 4933404M19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216974
Homologene: 51856
Clca1
Name: chloride channel accessory 1
Synonyms: gob5, gob-5, Clca3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 23844
HGNC: HGNC:2015
Homologene: 984
Lhfpl7
Name: LHFPL tetraspan subfamily member 7
Synonyms: Tmem211, LOC333048
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 333048
Homologene: 52993
Gm17430
Name: predicted gene, 17430
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 118568368
VEGA: 18
Gpr149
Name: G protein-coupled receptor 149
Synonyms: R35, 9630018L10Rik, Ieda, PGR10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229357
Homologene: 16359
Cyp4v3
Name: cytochrome P450, family 4, subfamily v, polypeptide 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102294
Homologene: 133054
Or5v1
Name: olfactory receptor family 5 subfamily V member 1
Synonyms: GA_x6K02T2PSCP-1956307-1957260, MOR249-2, Olfr110
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258325
Homologene: 73968
Lysmd1
Name: LysM, putative peptidoglycan-binding, domain containing 1
Synonyms: 2610022K04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 217779
Homologene: 41742
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 93,412,361 bp
  • T to C, chromosome 1 at 150,411,905 bp
  • G to A, chromosome 2 at 70,714,153 bp
  • G to A, chromosome 2 at 88,768,127 bp
  • T to C, chromosome 2 at 103,754,150 bp
  • T to C, chromosome 3 at 62,530,540 bp
  • T to C, chromosome 3 at 79,481,708 bp
  • T to A, chromosome 3 at 93,470,809 bp
  • A to G, chromosome 3 at 95,137,886 bp
  • G to C, chromosome 3 at 145,013,883 bp
  • T to C, chromosome 4 at 28,813,482 bp
  • A to G, chromosome 4 at 98,926,519 bp
  • C to T, chromosome 5 at 34,877,044 bp
  • A to G, chromosome 5 at 113,234,463 bp
  • A to G, chromosome 7 at 56,207,690 bp
  • T to C, chromosome 7 at 80,353,199 bp
  • A to G, chromosome 8 at 18,668,967 bp
  • A to T, chromosome 8 at 45,306,981 bp
  • T to C, chromosome 8 at 121,604,639 bp
  • A to G, chromosome 9 at 86,559,443 bp
  • A to G, chromosome 10 at 107,023,718 bp
  • G to T, chromosome 11 at 77,113,610 bp
  • G to T, chromosome 11 at 78,204,953 bp
  • T to C, chromosome 11 at 114,791,476 bp
  • C to T, chromosome 12 at 102,404,270 bp
  • T to C, chromosome 13 at 92,708,126 bp
  • A to C, chromosome 15 at 103,531,372 bp
  • T to C, chromosome 16 at 32,475,803 bp
  • T to C, chromosome 16 at 33,617,256 bp
  • T to A, chromosome 17 at 37,499,097 bp
  • C to T, chromosome 18 at 9,726,514 bp
  • A to G, chromosome 19 at 37,571,912 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6592 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044716-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.