Strain Name:
C57BL/6J-MtgxR6606Btlr/Mmmh
Stock Number:
044729-MU
Citation ID:
RRID:MMRRC_044729-MU
Other Names:
R6606 (G1)
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: PTPzeta, DSD-1-PG, phosphacan, RPTPz, Ptprz, Ptpz, Rptpbeta, PTPbeta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Atn1
Name: atrophin 1
Synonyms: atrophin-1, Atr1, Drpla
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13498
HGNC: HGNC:3033
Homologene: 1461
Zbtb43
Name: zinc finger and BTB domain containing 43
Synonyms: Zfp297b, 1700010E06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71834
Homologene: 8514
Ptpn3
Name: protein tyrosine phosphatase, non-receptor type 3
Synonyms: 9530011I20Rik, PTPCL, PTP-H1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545622
HGNC: HGNC:9655
Homologene: 74451
Fbxl17
Name: F-box and leucine-rich repeat protein 17
Synonyms: C130023C01Rik, 6330576B01Rik, Fbxo13, Fbx13
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50758
Homologene: 79859
Prpf40a
Name: pre-mRNA processing factor 40A
Synonyms: FBP11, Fnbp3, 2810012K09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56194
Homologene: 6377
Chd4
Name: chromodomain helicase DNA binding protein 4
Synonyms: 9530019N15Rik, D6Ertd380e, Mi-2beta
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107932
HGNC: HGNC:1919
Homologene: 68175
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207932
Homologene: 45941
Rnd2
Name: Rho family GTPase 2
Synonyms: Rohn, Arhn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11858
Homologene: 21123
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Rspo3
Name: R-spondin 3
Synonyms: Thsd2, Cristin1, 2810459H04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72780
VEGA: 10
Homologene: 12484
Gprc5b
Name: G protein-coupled receptor, family C, group 5, member B
Synonyms: hypothetical protein, clone 2-63
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64297
Homologene: 9435
Scn4a
Name: sodium channel, voltage-gated, type IV, alpha
Synonyms: Nav1.4, SkM1, mH2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 110880
Homologene: 283
Ccnt2
Name: cyclin T2
Synonyms: CycT2, 2900041I18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72949
HGNC: HGNC:1600
Homologene: 14043
Klhl1
Name: kelch-like 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 93688
HGNC: HGNC:6352
Homologene: 56903
Adal
Name: adenosine deaminase-like
Synonyms: 4930578F03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75894
Homologene: 13827
Dnah3
Name: dynein, axonemal, heavy chain 3
Synonyms: Dnahc3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381917
HGNC: HGNC:2949
Homologene: 19674
Echdc1
Name: enoyl Coenzyme A hydratase domain containing 1
Synonyms: 1700028A24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52665
Homologene: 23106
Slc15a3
Name: solute carrier family 15, member 3
Synonyms: Ci1, cI-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 65221
Homologene: 69222
Uba5
Name: ubiquitin-like modifier activating enzyme 5
Synonyms: Ube1dc1, 5730525G14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66663
Homologene: 11738
Parp10
Name: poly (ADP-ribose) polymerase family, member 10
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 671535
Homologene: 53133
Ephx4
Name: epoxide hydrolase 4
Synonyms: Abhd7, LOC384214
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 384214
Homologene: 62402
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329421
Homologene: 51393
Erich6
Name: glutamate rich 6
Synonyms: Fam194a, 4932431H17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 545527
Homologene: 65043
Or10n1
Name: olfactory receptor family 10 subfamily N member 1
Synonyms: Olfr148, MOR224-4, GA_x6K02T2PVTD-33310486-33311418, M30
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258498
VEGA: 9
Homologene: 128136
Scai
Name: suppressor of cancer cell invasion
Synonyms: A930041I02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320271
Homologene: 15523
Ces4a
Name: carboxylesterase 4A
Synonyms: Ces8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234677
Homologene: 71949
Crlf1
Name: cytokine receptor-like factor 1
Synonyms: cytokine receptor like molecule 3, CLF-1, CRLM3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12931
HGNC: HGNC:2364
Homologene: 3489
Ankk1
Name: ankyrin repeat and kinase domain containing 1
Synonyms: 9930020N01Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244859
VEGA: 9
Homologene: 18258
Zyg11b
Name: zyg-ll family member B, cell cycle regulator
Synonyms: LOC242610, 2810482G21Rik, 1110046I03Rik, D4Mgi23
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 414872
Homologene: 14600
Fbln7
Name: fibulin 7
Synonyms: 1600015H20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70370
Homologene: 11489
Stfa3
Name: stefin A3
Synonyms: Stf3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20863
VEGA: 16
HGNC: HGNC:2481
Homologene: 115602
Rasa4
Name: RAS p21 protein activator 4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54153
Homologene: 5080
P4ha3
Name: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
Synonyms: D930031A02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320452
Homologene: 27943
Rit1
Name: Ras-like without CAAX 1
Synonyms: Rit
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19769
Homologene: 56003
Gm20449
Name: predicted gene 20449
Type: Gene
Species: Mouse
Chromosome: 7
Cyyr1
Name: cysteine and tyrosine-rich protein 1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224405
Homologene: 14191
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 127,803,241 bp
  • G to T, chromosome 2 at 33,455,054 bp
  • A to T, chromosome 2 at 39,075,135 bp
  • A to G, chromosome 2 at 53,151,751 bp
  • A to G, chromosome 2 at 70,232,485 bp
  • A to G, chromosome 2 at 121,150,288 bp
  • A to G, chromosome 2 at 128,877,376 bp
  • A to G, chromosome 3 at 58,616,500 bp
  • A to G, chromosome 3 at 88,717,638 bp
  • A to T, chromosome 4 at 57,265,104 bp
  • G to A, chromosome 4 at 108,236,089 bp
  • G to T, chromosome 5 at 107,413,065 bp
  • A to G, chromosome 5 at 136,103,947 bp
  • A to C, chromosome 6 at 23,002,501 bp
  • G to A, chromosome 6 at 124,744,956 bp
  • C to A, chromosome 6 at 125,109,426 bp
  • T to C, chromosome 7 at 41,458,829 bp
  • G to T, chromosome 7 at 100,305,644 bp
  • G to A, chromosome 7 at 118,984,073 bp
  • A to T, chromosome 7 at 120,060,956 bp
  • A to G, chromosome 8 at 70,501,174 bp
  • A to G, chromosome 8 at 105,149,378 bp
  • G to A, chromosome 9 at 39,614,082 bp
  • T to C, chromosome 9 at 49,416,346 bp
  • T to C, chromosome 9 at 104,055,221 bp
  • A to G, chromosome 10 at 29,313,715 bp
  • C to T, chromosome 10 at 29,454,281 bp
  • C to T, chromosome 11 at 101,468,999 bp
  • T to C, chromosome 11 at 106,328,073 bp
  • T to C, chromosome 14 at 96,123,222 bp
  • C to A, chromosome 15 at 76,240,108 bp
  • T to C, chromosome 16 at 36,455,285 bp
  • A to G, chromosome 16 at 85,457,550 bp
  • T to C, chromosome 16 at 90,810,268 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • A to G, chromosome 17 at 63,487,788 bp
  • T to A, chromosome 19 at 10,848,682 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6606 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044729-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.