Strain Name:
C57BL/6J-MtgxR6611Btlr/Mmmh
Stock Number:
044734-MU
Citation ID:
RRID:MMRRC_044734-MU
Other Names:
R6611 (G1)
Major Collection:

Strain Information

Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
Synonyms: trkB, Tkrb, C030027L06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18212
VEGA: 13
HGNC: HGNC:8032
Homologene: 4504
Irx3
Name: Iroquois related homeobox 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16373
Homologene: 7385
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Mob2
Name: MOB kinase activator 2
Synonyms: 2700078K21Rik, 1110017M21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101513
Homologene: 12477
Flnb
Name: filamin, beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: Mll, Mll1, trithorax Drosophila, ALL-1, Cxxc7, HTRX1, All1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, XAP8, Hbxap, C030033M12Rik, p325
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: nesprin-1, enaptin165, SYNE-1, C130039F11Rik, A330049M09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Traf3
Name: TNF receptor-associated factor 3
Synonyms: CRAF1, CAP-1, CD40bp, LAP1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22031
Homologene: 7981
Smc5
Name: structural maintenance of chromosomes 5
Synonyms: Smc5l1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226026
VEGA: 19
Homologene: 41009
Snap91
Name: synaptosomal-associated protein 91
Synonyms: 91kDa, F1-20, AP180
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20616
Homologene: 8429
Ubxn11
Name: UBX domain protein 11
Synonyms: Ubxd5, Soci, 4930506L07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67586
Homologene: 12159
Chd2
Name: chromodomain helicase DNA binding protein 2
Synonyms: 5630401D06Rik, 2810040A01Rik, 2810013C04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244059
HGNC: HGNC:1917
Homologene: 37462
Brca2
Name: breast cancer 2, early onset
Synonyms: RAB163, Fancd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12190
HGNC: HGNC:1101
Homologene: 41
Hmbs
Name: hydroxymethylbilane synthase
Synonyms: Uros1, PBGD, porphobilinogen deaminase, Ups
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15288
VEGA: 9
HGNC: HGNC:4982
Homologene: 158
Efcab6
Name: EF-hand calcium binding domain 6
Synonyms: 4931407K02Rik, 4932408N08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 77627
Homologene: 11259
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Pik3r4
Name: phosphoinositide-3-kinase regulatory subunit 4
Synonyms: Vps15, p150
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75669
HGNC: HGNC:8982
Homologene: 24678
Drc3
Name: dynein regulatory complex subunit 3
Synonyms: Lrrc48, m6Bei, 4930449E07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74665
Homologene: 12581
Cdc16
Name: CDC16 cell division cycle 16
Synonyms: 2810431D22Rik, 2700071J12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69957
HGNC: HGNC:1720
Homologene: 2899
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Or5j1
Name: olfactory receptor family 5 subfamily J member 1
Synonyms: Olfr1106, GA_x6K02T2Q125-48541463-48540525, MOR172-8_p, MOR172-6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258747
Homologene: 27251
Phykpl
Name: 5-phosphohydroxy-L-lysine phospholyase
Synonyms: 2900006B13Rik, Agxt2l2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72947
Homologene: 75268
Cfhr4
Name: complement factor H-related 4
Synonyms: Gm4788
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214403
HGNC: HGNC:4883
Ccng2
Name: cyclin G2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12452
HGNC: HGNC:1593
Homologene: 3208
Slc9a9
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 9
Synonyms: 5730527A11Rik, Nhe9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 331004
Homologene: 69753
Pnpla1
Name: patatin-like phospholipase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433091
Homologene: 25324
Or8b44
Name: olfactory receptor family 8 subfamily B member 44
Synonyms: Olfr907, GA_x6K02T2PVTD-32204729-32205661, MOR165-5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258801
VEGA: 9
Homologene: 27268
Ssh3
Name: slingshot protein phosphatase 3
Synonyms: SSH-3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 245857
VEGA: 19
Homologene: 32372
Fstl4
Name: follistatin-like 4
Synonyms: B230374F23Rik, SPIG1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320027
Homologene: 18543
Or4d5
Name: olfactory receptor family 4 subfamily D member 5
Synonyms: GA_x6K02T2PVTD-33799484-33798540, Olfr984, MOR239-6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258601
VEGA: 9
Homologene: 17314
Pramel7
Name: PRAME like 7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 347712
Homologene: 87261
Gm10428
Name: predicted gene 10428
Type: Gene
Species: Mouse
Chromosome: 11
Cep112
Name: centrosomal protein 112
Synonyms: 8430407H02Rik, 1700029K01Rik, 1700001M19Rik, Ccdc46, Macoco
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76380
Homologene: 44915
1810009J06Rik
Name: RIKEN cDNA 1810009J06 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73626
Homologene: 117995
Oxct2a
Name: 3-oxoacid CoA transferase 2A
Synonyms: Scot-t1, Oxct2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64059
Homologene: 137359
Bex6
Name: brain expressed family member 6
Synonyms: B020003O03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 328660
Fer1l5
Name: fer-1 like family member 5
Synonyms: 4930533C12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100534273
Homologene: 85232
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,406,654 bp
  • A to G, chromosome 1 at 139,732,390 bp
  • A to T, chromosome 2 at 87,049,233 bp
  • A to G, chromosome 2 at 87,490,049 bp
  • T to C, chromosome 4 at 123,322,847 bp
  • C to A, chromosome 4 at 134,123,599 bp
  • C to G, chromosome 5 at 93,273,343 bp
  • T to C, chromosome 5 at 150,536,193 bp
  • A to T, chromosome 6 at 40,966,779 bp
  • A to G, chromosome 7 at 73,493,565 bp
  • G to GACGGCGGCT, chromosome 7 at 97,579,909 bp
  • G to C, chromosome 7 at 141,640,433 bp
  • G to T, chromosome 7 at 142,009,556 bp
  • C to A, chromosome 8 at 13,781,512 bp
  • T to C, chromosome 8 at 91,800,003 bp
  • A to T, chromosome 9 at 38,499,238 bp
  • T to C, chromosome 9 at 40,101,020 bp
  • C to A, chromosome 9 at 44,341,691 bp
  • T to A, chromosome 9 at 44,849,272 bp
  • C to T, chromosome 9 at 86,790,127 bp
  • G to T, chromosome 9 at 94,939,478 bp
  • T to G, chromosome 9 at 105,644,277 bp
  • A to T, chromosome 10 at 5,045,273 bp
  • G to T, chromosome 11 at 51,598,354 bp
  • A to T, chromosome 11 at 53,186,725 bp
  • A to G, chromosome 11 at 59,064,230 bp
  • G to T, chromosome 11 at 60,364,947 bp
  • A to T, chromosome 11 at 62,753,289 bp
  • T to C, chromosome 11 at 108,506,551 bp
  • T to G, chromosome 12 at 111,237,640 bp
  • T to C, chromosome 13 at 59,054,414 bp
  • A to G, chromosome 14 at 7,915,318 bp
  • T to G, chromosome 15 at 6,750,659 bp
  • T to A, chromosome 15 at 83,892,835 bp
  • A to G, chromosome 16 at 32,186,665 bp
  • A to G, chromosome 17 at 28,881,047 bp
  • T to C, chromosome 19 at 4,264,422 bp
  • A to G, chromosome 19 at 23,228,919 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6611 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044734-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.