Strain Name:
C57BL/6J-MtgxR6612Btlr/Mmmh
Stock Number:
044735-MU
Citation ID:
RRID:MMRRC_044735-MU
Other Names:
R6612 (G1)
Major Collection:

Strain Information

Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Olig2
Name: oligodendrocyte transcription factor 2
Synonyms: RK17, Olg-2, Bhlhb1, bHLHe19
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50913
HGNC: HGNC:9398
Homologene: 4241
Plk3
Name: polo like kinase 3
Synonyms: Cnk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12795
HGNC: HGNC:2154
Homologene: 20865
Got1
Name: glutamic-oxaloacetic transaminase 1, soluble
Synonyms: cAspAT, cytosolic aspartate aminotransferase, Got-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14718
HGNC: HGNC:4432
Homologene: 1571
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur-4, Glur4, spkw1, Gluralpha4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Ttc5
Name: tetratricopeptide repeat domain 5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219022
VEGA: 14
Homologene: 14397
Hspbap1
Name: Hspb associated protein 1
Synonyms: 3830421G21Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66667
VEGA: 16
Homologene: 11617
Kdm5a
Name: lysine demethylase 5A
Synonyms: RBP2, Rbbp2, Jarid1a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214899
HGNC: HGNC:9886
Homologene: 3419
Relch
Name: RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing
Synonyms: 2310035C23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227446
Homologene: 10834
Zfp462
Name: zinc finger protein 462
Synonyms: Gt4-2, 9430078C22Rik, Zfpip
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242466
Homologene: 41430
Tet2
Name: tet methylcytosine dioxygenase 2
Synonyms: E130014J05Rik, Ayu17-449
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214133
Homologene: 49498
Nfrkb
Name: nuclear factor related to kappa B binding protein
Synonyms: A530090G11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235134
HGNC: HGNC:7802
Homologene: 4492
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Hipk2
Name: homeodomain interacting protein kinase 2
Synonyms: Stank, 1110014O20Rik, B230339E18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15258
Homologene: 68766
Tbc1d19
Name: TBC1 domain family, member 19
Synonyms: 2810453K03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67249
Homologene: 10130
Stimate
Name: STIM activating enhancer
Synonyms: 1810038N08Rik, 2310014H19Rik, Tmem110
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69179
Homologene: 7082
Zbtb10
Name: zinc finger and BTB domain containing 10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229055
Homologene: 11395
Ssh1
Name: slingshot protein phosphatase 1
Synonyms: mSSH-1L, LOC384311
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231637
Homologene: 41299
Pdgfra
Name: platelet derived growth factor receptor, alpha polypeptide
Synonyms: CD140a, Pdgfr-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18595
HGNC: HGNC:8803
Homologene: 31361
Iqcb1
Name: IQ calmodulin-binding motif containing 1
Synonyms: 6820449I09Rik, NPHP5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320299
Homologene: 8766
Slc25a47
Name: solute carrier family 25, member 47
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104910
VEGA: 12
Homologene: 64441
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Mccc1
Name: methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)
Synonyms: MCCalpha, MCCA, 1810045E08Rik, 2310058B18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72039
HGNC: HGNC:6936
Homologene: 10603
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Slo3, Kcnma3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16532
Homologene: 7392
Snx13
Name: sorting nexin 13
Synonyms: RGS-PX1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217463
VEGA: 12
Homologene: 41011
Ush2a
Name: usherin
Synonyms: MUSH2A, A930011D15Rik, LOC381317, LOC269160, A930037M10Rik, Ushrn, Ush2a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Arsi
Name: arylsulfatase i
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 545260
Homologene: 44428
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Cd244a
Name: CD244 molecule A
Synonyms: 2B4, C9.1, Nmrk, F730046O15Rik, Cd244
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18106
Homologene: 9493
Ciz1
Name: CDKN1A interacting zinc finger protein 1
Synonyms: 0610038H21Rik, 2900056O04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68379
Homologene: 8112
Synm
Name: synemin, intermediate filament protein
Synonyms: 4930412K21Rik, Synemin, Dmn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233335
Homologene: 9081
Slx4
Name: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Synonyms: D16Bwg1016e, Btbd12
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 52864
Homologene: 23770
Jakmip2
Name: janus kinase and microtubule interacting protein 2
Synonyms: 6430702L21Rik, D930046L20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 76217
VEGA: 18
Homologene: 8866
Grin2b
Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2)
Synonyms: NMDAR2B, NR2B, Nmdar2b, GluRepsilon2, GluN2B
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14812
HGNC: HGNC:4586
Homologene: 646
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: C430014K11Rik, Mll4, Mll2, bapa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Cacnb2
Name: calcium channel, voltage-dependent, beta 2 subunit
Synonyms: Cchb2, Cavbeta2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12296
HGNC: HGNC:1402
Homologene: 75191
Nrxn3
Name: neurexin III
Synonyms: neurexin III beta, neurexin III alpha, neurexin III beta, neurexin III alpha, 9330112C09Rik, D12Bwg0831e, 4933401A11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18191
HGNC: HGNC:8010
Homologene: 83225
Ppp1r36
Name: protein phosphatase 1, regulatory subunit 36
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 210762
VEGA: 12
Homologene: 52094
Kcnc2
Name: potassium voltage gated channel, Shaw-related subfamily, member 2
Synonyms: Kv3.2, KShIIIA
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268345
VEGA: 10
HGNC: HGNC:6234
Homologene: 71199
Rab25
Name: RAB25, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53868
Homologene: 22995
Marchf10
Name: membrane associated ring-CH-type finger 10
Synonyms: 4933417C16Rik, Rnf190, OTTMUSG00000002847, March10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 632687
Homologene: 34988
Or11h7
Name: olfactory receptor family 11 subfamily H member 7
Synonyms: GA_x6K02T2PMLR-6372116-6373060, MOR106-12, Olfr746
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258295
Homologene: 134081
Tyk2
Name: tyrosine kinase 2
Synonyms: JTK1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54721
VEGA: 9
Homologene: 20712
Hkdc1
Name: hexokinase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216019
Homologene: 128937
Cyp2a4
Name: cytochrome P450, family 2, subfamily a, polypeptide 4
Synonyms: Cyp15a1, D7Ucla4, testosterone 15alpha-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13086
Homologene: 85917
Cxcr6
Name: C-X-C motif chemokine receptor 6
Synonyms: STRL33, BONZO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80901
VEGA: 9
Homologene: 38197
Mchr1
Name: melanin-concentrating hormone receptor 1
Synonyms: Gpr24-9, melanin-concentrating hormone receptor 1, MCH-1R, Mch1r, Gpr24
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207911
VEGA: 15
HGNC: HGNC:4479
Homologene: 21097
Akr1c14
Name: aldo-keto reductase family 1, member C14
Synonyms: 9030611N15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105387
Homologene: 138093
Spa17
Name: sperm autoantigenic protein 17
Synonyms: band 34, Sp17
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20686
VEGA: 9
Homologene: 7951
Itga7
Name: integrin alpha 7
Synonyms: [a]7, alpha7
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16404
VEGA: 10
HGNC: HGNC:6143
Homologene: 37592
Arhgef37
Name: Rho guanine nucleotide exchange factor 37
Synonyms: 4933429F08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 328967
VEGA: 18
Homologene: 28467
Mrgpra3
Name: MAS-related GPR, member A3
Synonyms: G protein-coupled receptor, MrgA3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233222
Homologene: 131159
Mab21l3
Name: mab-21-like 3
Synonyms: BC037703
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242125
Homologene: 17564
Tpm3-rs7
Name: tropomyosin 3, related sequence 7
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 621054
VEGA: 14
Cep20
Name: centrosomal protein 20
Synonyms: 0610037P05Rik, Fopnl
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66086
Homologene: 11919
Esrra
Name: estrogen related receptor, alpha
Synonyms: Estrra, Err1, ERRalpha, Nr3b1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 26379
HGNC: HGNC:3471
Homologene: 20941
Teddm2
Name: transmembrane epididymal family member 2
Synonyms: e9-2, 5830403L16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240817
Homologene: 65346
4930523C07Rik
Name: RIKEN cDNA 4930523C07 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67647
Homologene: 124386
Pcdha4
Name: protocadherin alpha 4
Synonyms: Cnr1, Crnr1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12936
HGNC: HGNC:8670
Homologene: 130626
Gm17079
Name: predicted gene 17079
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102640847
Homologene: 128452
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 105,692,007 bp
  • C to G, chromosome 1 at 150,595,118 bp
  • T to A, chromosome 1 at 153,850,445 bp
  • A to C, chromosome 1 at 160,075,234 bp
  • A to G, chromosome 1 at 171,574,104 bp
  • T to C, chromosome 1 at 188,911,397 bp
  • A to T, chromosome 2 at 14,975,149 bp
  • T to A, chromosome 2 at 32,377,311 bp
  • C to A, chromosome 3 at 9,252,065 bp
  • T to C, chromosome 3 at 35,993,930 bp
  • G to A, chromosome 3 at 88,543,403 bp
  • A to G, chromosome 3 at 101,818,645 bp
  • T to A, chromosome 3 at 133,487,335 bp
  • A to T, chromosome 4 at 55,012,324 bp
  • G to A, chromosome 4 at 117,132,737 bp
  • A to G, chromosome 5 at 53,809,845 bp
  • T to C, chromosome 5 at 75,167,842 bp
  • C to T, chromosome 5 at 113,958,730 bp
  • T to A, chromosome 6 at 23,052,082 bp
  • T to C, chromosome 6 at 38,818,873 bp
  • T to C, chromosome 6 at 120,430,228 bp
  • A to G, chromosome 6 at 135,740,998 bp
  • T to A, chromosome 7 at 26,308,647 bp
  • T to A, chromosome 7 at 47,590,035 bp
  • G to C, chromosome 7 at 67,733,516 bp
  • A to G, chromosome 8 at 25,918,316 bp
  • C to T, chromosome 9 at 4,472,206 bp
  • G to T, chromosome 9 at 21,108,016 bp
  • T to A, chromosome 9 at 31,397,006 bp
  • A to G, chromosome 9 at 37,605,794 bp
  • T to A, chromosome 9 at 59,827,196 bp
  • T to A, chromosome 9 at 123,810,720 bp
  • T to C, chromosome 10 at 62,395,441 bp
  • T to A, chromosome 10 at 74,185,378 bp
  • G to C, chromosome 10 at 112,271,856 bp
  • A to G, chromosome 10 at 128,948,993 bp
  • A to T, chromosome 11 at 105,397,078 bp
  • A to T, chromosome 11 at 115,984,071 bp
  • C to T, chromosome 12 at 35,106,759 bp
  • T to C, chromosome 12 at 76,437,604 bp
  • A to T, chromosome 12 at 89,813,332 bp
  • T to C, chromosome 12 at 108,855,978 bp
  • A to T, chromosome 13 at 4,065,331 bp
  • T to A, chromosome 14 at 30,871,564 bp
  • A to T, chromosome 14 at 50,653,633 bp
  • T to A, chromosome 14 at 50,785,469 bp
  • C to A, chromosome 14 at 51,694,375 bp
  • T to A, chromosome 14 at 51,694,376 bp
  • G to T, chromosome 14 at 113,314,836 bp
  • G to A, chromosome 15 at 81,237,870 bp
  • A to G, chromosome 15 at 98,845,858 bp
  • G to A, chromosome 16 at 3,985,276 bp
  • TTGTG to TTG, chromosome 16 at 14,300,145 bp
  • T to G, chromosome 16 at 35,801,591 bp
  • G to A, chromosome 16 at 36,871,661 bp
  • T to A, chromosome 16 at 91,226,881 bp
  • T to C, chromosome 18 at 36,954,978 bp
  • T to C, chromosome 18 at 43,557,367 bp
  • A to G, chromosome 18 at 60,912,456 bp
  • T to C, chromosome 18 at 61,494,881 bp
  • T to C, chromosome 19 at 6,911,852 bp
  • A to G, chromosome 19 at 43,504,803 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6612 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044735-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.