Strain Name:
C57BL/6J-MtgxR6615Btlr/Mmmh
Stock Number:
044738-MU
Citation ID:
RRID:MMRRC_044738-MU
Other Names:
R6615 (G1)
Major Collection:

Strain Information

Ptch1
Name: patched 1
Synonyms: Ptc, wig, Patched 1, A230106A15Rik, Ptc1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
Bcar3
Name: breast cancer anti-estrogen resistance 3
Synonyms: AND-34
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 29815
HGNC: HGNC:973
Homologene: 31181
Pcf11
Name: PCF11 cleavage and polyadenylation factor subunit
Synonyms: 5730417B17Rik, 2500001H09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74737
Homologene: 32282
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15184
Homologene: 3995
Slc25a13
Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
Synonyms: Ctrn, citrin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50799
Homologene: 22800
Rexo1
Name: REX1, RNA exonuclease 1
Synonyms: 1700021P10Rik, 2610511M11Rik, Rex1, Tceb3bp1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66932
Homologene: 41391
Wac
Name: WW domain containing adaptor with coiled-coil
Synonyms: 1110067P07Rik, Wwp4, A230035H12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225131
Homologene: 41148
Slc12a2
Name: solute carrier family 12, member 2
Synonyms: sodium/potassium/chloride cotransporters, sy-ns, Nkcc1, mBSC2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20496
VEGA: 18
Homologene: 20283
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, A330049M09Rik, enaptin165, nesprin-1, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Ptprm
Name: protein tyrosine phosphatase receptor type M
Synonyms: RPTPmu
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19274
VEGA: 17
HGNC: HGNC:9675
Homologene: 37694
Clhc1
Name: clathrin heavy chain linker domain containing 1
Synonyms: 1700034F02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73324
Homologene: 17569
Serpina3c
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3C
Synonyms: Klkbp, Kalbp, alpha-1 antiproteinase, 1A1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16625
HGNC: HGNC:16
Homologene: 111129
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, Gm21044, LOC385009
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Fbxo7
Name: F-box protein 7
Synonyms: A230052G17Rik, 2410015K21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69754
Homologene: 8136
Tars3
Name: threonyl-tRNA synthetase 3
Synonyms: A530046H20Rik, Tarsl2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272396
Homologene: 65036
Sugp2
Name: SURP and G patch domain containing 2
Synonyms: Srsf14, Sfrs14
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234373
Homologene: 8923
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, Adgrc1, crash
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Dhx36
Name: DEAH-box helicase 36
Synonyms: 2810407E23Rik, RHAU, Ddx36
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72162
Homologene: 6356
Avl9
Name: AVL9 cell migration associated
Synonyms: D730049P16Rik, 5830411G16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78937
Homologene: 62425
Unc13c
Name: unc-13 homolog C
Synonyms: D9Ertd414e, 1500037O19Rik, Munc13-3, Unc13h3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208898
Homologene: 45443
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Zbtb38
Name: zinc finger and BTB domain containing 38
Synonyms: Zenon homolog, CIBZ, A930014K01Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245007
Homologene: 19529
Or4k37
Name: olfactory receptor family 4 subfamily K member 37
Synonyms: MOR248-18, GA_x6K02T2Q125-72379864-72380781, MOR248-14P, Olfr1281
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257979
Homologene: 73992
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Lrrk1
Name: leucine-rich repeat kinase 1
Synonyms: D130026O16Rik, C230002E15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233328
Homologene: 23464
Fbxo41
Name: F-box protein 41
Synonyms: D6Ertd538e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330369
Homologene: 19837
Bean1
Name: brain expressed, associated with Nedd4, 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 65115
Homologene: 110172
Krt87
Name: keratin 87
Synonyms: Krt83, Krt2-25
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 406219
VEGA: 15
Homologene: 133804
F11
Name: coagulation factor XI
Synonyms: FXI, plasma thromboplastin antecedent, Cf11, 1600027G01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 109821
HGNC: HGNC:3529
Homologene: 86654
Dsc2
Name: desmocollin 2
Synonyms: Dsc2a, Dsc2b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13506
HGNC: HGNC:3036
Homologene: 8397
Or14c45
Name: olfactory receptor family 14 subfamily C member 45
Synonyms: MOR220-3, Olfr297, GA_x6K02T2NHDJ-9587747-9586815
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258611
Homologene: 115526
Rdh7
Name: retinol dehydrogenase 7
Synonyms: CRAD2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54150
Homologene: 137324
Tmem8b
Name: transmembrane protein 8B
Synonyms: 4930500O05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242409
Homologene: 72894
Xkr5
Name: X-linked Kx blood group related 5
Synonyms: 5430438H03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319581
Homologene: 52219
Gmnc
Name: geminin coiled-coil domain containing
Synonyms: Gm606, LOC239789, LOC385639
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239789
VEGA: 16
Homologene: 79940
Usp44
Name: ubiquitin specific peptidase 44
Synonyms: E430004F17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327799
VEGA: 10
Homologene: 12961
Or7g35
Name: olfactory receptor family 7 subfamily G member 35
Synonyms: Olfr855, MOR148-1, GA_x6K02T2PVTD-13330461-13331399
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258517
HGNC: HGNC:8466
Homologene: 74176
Nt5el
Name: 5' nucleotidase, ecto-like
Synonyms: 4933425L06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66763
Homologene: 12028
Or2h2c
Name: olfactory receptor family 2 subfamily H member 2C
Synonyms: MOR256-29, Olfr92, GA_x6K02T2PSCP-1552066-1551128
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258448
HGNC: HGNC:8253
Homologene: 115562
Srsf2
Name: serine and arginine-rich splicing factor 2
Synonyms: Sfrs2, SC35, MRF-1, Sfrs10, D11Wsu175e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20382
Homologene: 37721
Marchf8
Name: membrane associated ring-CH-type finger 8
Synonyms: 1300017E09Rik, Mir, March8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71779
Homologene: 12412
Lpxn
Name: leupaxin
Synonyms: A530083L21Rik, 4933402K05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107321
VEGA: 19
Homologene: 3536
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Slc5a6
Name: solute carrier family 5 (sodium-dependent vitamin transporter), member 6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330064
Homologene: 23277
Ccdc113
Name: coiled-coil domain containing 113
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244608
Homologene: 40927
Nipa1
Name: non imprinted in Prader-Willi/Angelman syndrome 1 homolog (human)
Synonyms: A830014A18Rik, Spg6, 1110027G09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233280
Homologene: 42327
Pxmp2
Name: peroxisomal membrane protein 2
Synonyms: PMP22, 22kDa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19301
HGNC: HGNC:9716
Homologene: 32062
Calm3
Name: calmodulin 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12315
HGNC: HGNC:1449
Homologene: 116117
Or51f23c-ps1
Name: olfactory receptor family 51 subfamily F member 23C, pseudogene 1
Synonyms: MOR14-5, Olfr562-ps1, GA_x6K02T2PBJ9-5498153-5499103
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259090
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 46,515,439 bp
  • C to A, chromosome 1 at 46,649,340 bp
  • A to G, chromosome 1 at 46,649,351 bp
  • A to G, chromosome 2 at 111,329,112 bp
  • T to A, chromosome 3 at 62,488,917 bp
  • T to A, chromosome 3 at 122,426,633 bp
  • G to T, chromosome 4 at 43,682,249 bp
  • C to T, chromosome 5 at 31,036,830 bp
  • C to A, chromosome 5 at 110,277,707 bp
  • C to T, chromosome 6 at 6,073,454 bp
  • T to C, chromosome 6 at 56,753,885 bp
  • T to C, chromosome 6 at 85,478,523 bp
  • A to G, chromosome 6 at 116,405,663 bp
  • A to G, chromosome 7 at 16,917,583 bp
  • T to A, chromosome 7 at 55,979,823 bp
  • T to C, chromosome 7 at 65,678,142 bp
  • A to T, chromosome 7 at 66,281,648 bp
  • A to G, chromosome 7 at 86,526,912 bp
  • T to A, chromosome 7 at 92,657,882 bp
  • T to C, chromosome 7 at 102,781,787 bp
  • T to C, chromosome 8 at 18,933,553 bp
  • T to C, chromosome 8 at 45,248,774 bp
  • A to G, chromosome 8 at 70,242,770 bp
  • A to C, chromosome 8 at 95,545,992 bp
  • CT to C, chromosome 8 at 104,182,032 bp
  • T to G, chromosome 9 at 18,647,188 bp
  • A to G, chromosome 9 at 19,584,989 bp
  • A to G, chromosome 9 at 73,930,608 bp
  • A to T, chromosome 9 at 96,686,654 bp
  • T to C, chromosome 10 at 5,301,340 bp
  • C to T, chromosome 10 at 80,544,014 bp
  • A to T, chromosome 10 at 86,044,534 bp
  • T to C, chromosome 10 at 93,846,489 bp
  • T to G, chromosome 10 at 127,884,622 bp
  • T to A, chromosome 11 at 29,578,149 bp
  • C to A, chromosome 11 at 102,197,056 bp
  • T to C, chromosome 11 at 116,853,079 bp
  • C to T, chromosome 12 at 84,813,317 bp
  • A to T, chromosome 12 at 104,151,721 bp
  • T to G, chromosome 13 at 63,539,830 bp
  • T to A, chromosome 13 at 105,112,485 bp
  • A to G, chromosome 14 at 61,208,934 bp
  • C to T, chromosome 15 at 85,902,114 bp
  • A to G, chromosome 15 at 101,436,562 bp
  • T to G, chromosome 16 at 26,960,528 bp
  • G to A, chromosome 17 at 37,111,602 bp
  • C to T, chromosome 17 at 67,353,956 bp
  • C to A, chromosome 18 at 7,868,884 bp
  • T to A, chromosome 18 at 20,032,519 bp
  • T to G, chromosome 18 at 57,898,128 bp
  • G to A, chromosome 19 at 12,824,799 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6615 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044738-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.