Strain Name:
C57BL/6J-MtgxR6621Btlr/Mmmh
Stock Number:
044744-MU
Citation ID:
RRID:MMRRC_044744-MU
Other Names:
R6621 (G1)
Major Collection:

Strain Information

Kif3a
Name: kinesin family member 3A
Synonyms: kinesin-II subunit, Kifl, Kns3, Kif3, N-4 kinesin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16568
HGNC: HGNC:6319
Homologene: 38266
Chat
Name: choline acetyltransferase
Synonyms: B230380D24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12647
VEGA: 14
HGNC: HGNC:1912
Homologene: 40693
Lemd2
Name: LEM domain containing 2
Synonyms: Lem2, NET25
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224640
VEGA: 17
Homologene: 17136
Akap13
Name: A kinase anchor protein 13
Synonyms: PROTO-LB, 1700026G02Rik, 5830460E08Rik, 5730522G15Rik, Ht31, PROTO-LBC, AKAP-Lbc
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Hat1
Name: histone aminotransferase 1
Synonyms: KAT1, 2410071B14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107435
HGNC: HGNC:4821
Homologene: 2701
Slc10a7
Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 7
Synonyms: 2410193C02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76775
Homologene: 81628
Abcb8
Name: ATP-binding cassette, sub-family B member 8
Synonyms: 4833412N02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74610
HGNC: HGNC:49
Homologene: 5203
Mllt3
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
Synonyms: 2210011H10Rik, 2610012I03Rik, D4Ertd321e, Af9, 3830408D16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70122
HGNC: HGNC:7136
Homologene: 37933
Cpt1a
Name: carnitine palmitoyltransferase 1a, liver
Synonyms: Cpt1, L-CPT I, CPTI
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12894
VEGA: 19
HGNC: HGNC:2328
Homologene: 1413
Mcm9
Name: minichromosome maintenance 9 homologous recombination repair factor
Synonyms: Mcmdc1, 9030408O17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71567
VEGA: 10
Homologene: 13546
Rnf214
Name: ring finger protein 214
Synonyms: D130054N24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235315
Homologene: 109357
Cpsf1
Name: cleavage and polyadenylation specific factor 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 94230
VEGA: 15
HGNC: HGNC:2324
Homologene: 40865
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Nudt8
Name: nudix hydrolase 8
Synonyms: 2310039H17Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 8
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66387
VEGA: 19
HGNC: HGNC:8055
Homologene: 41633
Or51ah3
Name: olfactory receptor family 51 subfamily AH member 3
Synonyms: MOR19-2, Olfr615, GA_x6K02T2PBJ9-6284902-6285843
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259084
Homologene: 17494
Pde8a
Name: phosphodiesterase 8A
Synonyms: Pde8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18584
HGNC: HGNC:8793
Homologene: 1957
Greb1
Name: gene regulated by estrogen in breast cancer protein
Synonyms: 5730583K22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268527
Homologene: 8780
Manea
Name: mannosidase, endo-alpha
Synonyms: 4932703L02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242362
Homologene: 11636
Nrxn1
Name: neurexin I
Synonyms: 1700062G21Rik, A230068P09Rik, neurexin I alpha, 9330127H16Rik, neurexin I alpha, neurexin I alpha, neurexin I beta, alpha-latrotoxin receptor (calcium-dependent), neurexin I beta, neurexin I beta
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
6430548M08Rik
Name: RIKEN cDNA 6430548M08 gene
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234797
Homologene: 8825
Ankrd34a
Name: ankyrin repeat domain 34A
Synonyms: Ankrd34
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 545554
Homologene: 82882
Osm
Name: oncostatin M
Synonyms: OncoM
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18413
HGNC: HGNC:8506
Homologene: 10741
Fam234a
Name: family with sequence similarity 234, member A
Synonyms: Itfg3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106581
Homologene: 12932
Ccdc186
Name: coiled-coil domain containing 186
Synonyms: Otg1, A630007B06Rik, 1810028B20Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 213993
Homologene: 9963
Or13a27
Name: olfactory receptor family 13 subfamily A member 27
Synonyms: Olfr60, IH6, MOR253-6, GA_x6K02T2PBJ9-42496183-42495251
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18361
Homologene: 34961
Or5w14
Name: olfactory receptor family 5 subfamily W member 14
Synonyms: GA_x6K02T2Q125-49215724-49214792, Olfr1137, MOR40-9P, MOR177-20
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258101
Homologene: 79380
Or8c9
Name: olfactory receptor family 8 subfamily C member 9
Synonyms: MTPCR18, MOR170-4, GA_x6K02T2PVTD-32017922-32018863, Olfr25
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18323
VEGA: 9
Dpp4
Name: dipeptidylpeptidase 4
Synonyms: Dpp-4, Cd26, THAM
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13482
HGNC: HGNC:3009
Homologene: 3279
Dpysl5
Name: dihydropyrimidinase-like 5
Synonyms: CRAM, CRMP-5, Crmp5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 65254
Homologene: 41347
Zfp174
Name: zinc finger protein 174
Synonyms: LOC385674
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385674
Homologene: 55755
Phtf2
Name: putative homeodomain transcription factor 2
Synonyms: 1110054G21Rik, 9530062N20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68770
Homologene: 10713
Or5ac15
Name: olfactory receptor family 5 subfamily AC member 15
Synonyms: GA_x54KRFPKG5P-55348161-55347241, Olfr194, MOR182-13, MOR182-7P
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 433031
Homologene: 122781
Or2y15
Name: olfactory receptor family 2 subfamily Y member 15
Synonyms: GA_x6K02T2QP88-5975166-5974231, Olfr1387, MOR256-22
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258465
Homologene: 74034
Slc5a6
Name: solute carrier family 5 (sodium-dependent vitamin transporter), member 6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330064
Homologene: 23277
Sun3
Name: Sad1 and UNC84 domain containing 3
Synonyms: Sunc1, D630047F21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 194974
Homologene: 51273
Gm28363
Name: predicted gene 28363
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 117,727,357 bp
  • T to A, chromosome 2 at 62,352,140 bp
  • T to A, chromosome 2 at 71,421,715 bp
  • T to G, chromosome 2 at 82,989,814 bp
  • A to G, chromosome 2 at 87,711,555 bp
  • A to G, chromosome 3 at 96,598,215 bp
  • T to C, chromosome 4 at 26,340,363 bp
  • T to G, chromosome 4 at 87,840,797 bp
  • T to C, chromosome 5 at 20,812,956 bp
  • T to C, chromosome 5 at 24,394,510 bp
  • T to C, chromosome 5 at 30,784,469 bp
  • A to G, chromosome 5 at 31,040,778 bp
  • G to T, chromosome 7 at 75,569,981 bp
  • A to G, chromosome 7 at 81,293,130 bp
  • A to G, chromosome 7 at 103,560,878 bp
  • A to G, chromosome 7 at 140,345,455 bp
  • T to C, chromosome 8 at 78,515,634 bp
  • C to T, chromosome 8 at 120,145,423 bp
  • A to T, chromosome 9 at 38,330,462 bp
  • T to C, chromosome 9 at 45,896,170 bp
  • T to C, chromosome 10 at 53,563,313 bp
  • T to A, chromosome 11 at 4,239,541 bp
  • T to A, chromosome 11 at 9,016,242 bp
  • A to G, chromosome 11 at 49,459,771 bp
  • A to G, chromosome 11 at 53,579,130 bp
  • A to G, chromosome 12 at 16,692,717 bp
  • C to T, chromosome 14 at 32,419,013 bp
  • T to C, chromosome 15 at 76,603,519 bp
  • A to G, chromosome 16 at 3,847,955 bp
  • A to T, chromosome 16 at 59,119,924 bp
  • A to G, chromosome 17 at 26,213,881 bp
  • T to C, chromosome 17 at 27,195,392 bp
  • T to C, chromosome 17 at 90,162,182 bp
  • T to A, chromosome 19 at 3,378,472 bp
  • T to A, chromosome 19 at 4,001,320 bp
  • T to C, chromosome 19 at 56,813,487 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6621 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044744-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.