Strain Name:
C57BL/6J-MtgxR6625Btlr/Mmmh
Stock Number:
044747-MU
Citation ID:
RRID:MMRRC_044747-MU
Other Names:
R6625 (G1)
Major Collection:

Strain Information

Sim1
Name: single-minded family bHLH transcription factor 1
Synonyms: bHLHe14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20464
VEGA: 10
Homologene: 3715
Dtnbp1
Name: dystrobrevin binding protein 1
Synonyms: Bloc1s8, 5430437B18Rik, dysbindin, sdy
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94245
VEGA: 13
Homologene: 12037
Dnmt3b
Name: DNA methyltransferase 3B
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13436
HGNC: HGNC:2979
Homologene: 56000
Akap9
Name: A kinase anchor protein 9
Synonyms: G1-448-15, repro12, AKAP450, mei2-5, 5730481H23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Snupn
Name: snurportin 1
Synonyms: Rnut1, 0610031A09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66069
Homologene: 4166
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
G2e3
Name: G2/M-phase specific E3 ubiquitin ligase
Synonyms: D930034K21Rik, 6030408C04Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217558
Homologene: 32362
Pcolce2
Name: procollagen C-endopeptidase enhancer 2
Synonyms: 2400001O18Rik, Pcpe2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76477
HGNC: HGNC:8739
Homologene: 8357
Plagl1
Name: pleiomorphic adenoma gene-like 1
Synonyms: Zac1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22634
HGNC: HGNC:9046
Homologene: 31401
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: Piezo2, Fam38b, 9030411M15Rik, Fam38b2, 9430028L06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 667742
Homologene: 49695
Nelfe
Name: negative elongation factor complex member E, Rdbp
Synonyms: Rdbp, NELF-E
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27632
Homologene: 134736
Usp40
Name: ubiquitin specific peptidase 40
Synonyms: B230215L03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227334
Homologene: 32400
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Zbtb38
Name: zinc finger and BTB domain containing 38
Synonyms: A930014K01Rik, Zenon homolog, CIBZ
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245007
Homologene: 19529
Mre11a
Name: MRE11A homolog A, double strand break repair nuclease
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17535
HGNC: HGNC:7230
Homologene: 4083
Vmn2r59
Name: vomeronasal 2, receptor 59
Synonyms: EG628444
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628444
Homologene: 129683
Thap12
Name: THAP domain containing 12
Synonyms: Dap4, Prkrir, 2900052B10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72981
HGNC: HGNC:9440
Homologene: 37952
Sh3pxd2b
Name: SH3 and PX domains 2B
Synonyms: Fad49, Tks4, G431001E03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268396
Homologene: 27952
Kiss1r
Name: KISS1 receptor
Synonyms: Gpr54
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 114229
VEGA: 10
HGNC: HGNC:4510
Homologene: 11411
Usp13
Name: ubiquitin specific peptidase 13 (isopeptidase T-3)
Synonyms: 2700071E21Rik, IsoT-3, ISOT3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72607
Homologene: 68372
St6galnac1
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Synonyms: ST6GalNAc I, Siat7a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20445
Homologene: 7937
Cacna2d1
Name: calcium channel, voltage-dependent, alpha2/delta subunit 1
Synonyms: Cchl2a, Ca(v)alpha2delta1, Cacna2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12293
HGNC: HGNC:1399
Homologene: 579
Apcdd1
Name: adenomatosis polyposis coli down-regulated 1
Synonyms: EIG180, Drapc1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 494504
VEGA: 18
Homologene: 77420
Saxo4
Name: stabilizer of axonemal microtubules 4
Synonyms: IIIG9S, IIIG9L, Ppp1r32, IIIG9, 4930579J09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67752
VEGA: 19
Homologene: 15863
Or2v2
Name: olfactory receptor family 2 subfamily V member 2
Synonyms: MOR276-2, Olfr1396, GA_x6K02T2QP88-6321048-6321995
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258334
Homologene: 28537
Or5a3
Name: olfactory receptor family 5 subfamily A member 3
Synonyms: GA_x6K02T2RE5P-2753221-2754177, MOR215-2, Olfr1441
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258678
Homologene: 17343
Prss48
Name: serine protease 48
Synonyms: Gm1019, Esspl
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 368202
Homologene: 133731
Zfp493
Name: zinc finger protein 493
Synonyms: 2900054J07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72958
Zfp873
Name: zinc finger protein 873
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 408062
Homologene: 134319
Fam162b
Name: family with sequence similarity 162, member B
Synonyms: 9430073N08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77296
VEGA: 10
Homologene: 82459
Scyl1
Name: SCY1-like 1 (S. cerevisiae)
Synonyms: 2810011O19Rik, Ntkl, mdf, mfd, p105
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78891
VEGA: 19
Homologene: 6947
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 53,565,757 bp
  • T to C, chromosome 1 at 87,967,213 bp
  • T to C, chromosome 2 at 153,665,313 bp
  • T to A, chromosome 3 at 32,894,876 bp
  • G to T, chromosome 3 at 85,998,066 bp
  • T to A, chromosome 4 at 144,363,799 bp
  • C to G, chromosome 5 at 3,968,745 bp
  • A to T, chromosome 5 at 16,362,393 bp
  • C to T, chromosome 5 at 95,521,483 bp
  • A to T, chromosome 7 at 42,043,753 bp
  • G to A, chromosome 7 at 98,716,070 bp
  • T to C, chromosome 9 at 14,805,391 bp
  • A to T, chromosome 9 at 18,660,278 bp
  • G to A, chromosome 9 at 56,982,770 bp
  • T to A, chromosome 9 at 95,678,439 bp
  • T to C, chromosome 9 at 96,687,313 bp
  • T to C, chromosome 10 at 13,128,062 bp
  • A to G, chromosome 10 at 50,983,986 bp
  • C to T, chromosome 10 at 51,590,295 bp
  • G to A, chromosome 10 at 79,919,534 bp
  • C to A, chromosome 10 at 82,060,304 bp
  • T to A, chromosome 11 at 32,422,594 bp
  • T to A, chromosome 11 at 49,113,069 bp
  • T to C, chromosome 11 at 116,765,891 bp
  • T to G, chromosome 12 at 51,353,789 bp
  • T to C, chromosome 13 at 44,992,031 bp
  • C to T, chromosome 13 at 67,786,395 bp
  • T to G, chromosome 15 at 47,607,075 bp
  • C to T, chromosome 17 at 34,854,358 bp
  • C to A, chromosome 18 at 62,951,858 bp
  • A to T, chromosome 18 at 63,021,262 bp
  • C to A, chromosome 19 at 5,760,826 bp
  • G to A, chromosome 19 at 10,481,736 bp
  • T to G, chromosome 19 at 12,422,841 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6625 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044747-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.