Strain Name:
C57BL/6J-MtgxR6626Btlr/Mmmh
Stock Number:
044748-MU
Citation ID:
RRID:MMRRC_044748-MU
Other Names:
R6626 (G1)
Major Collection:

Strain Information

Notch2
Name: notch 2
Synonyms: Motch B, N2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18129
HGNC: HGNC:7882
Homologene: 7865
Olig2
Name: oligodendrocyte transcription factor 2
Synonyms: Bhlhb1, bHLHe19, Olg-2, RK17
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50913
HGNC: HGNC:9398
Homologene: 4241
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: p53BP1, 53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Klhdc4
Name: kelch domain containing 4
Synonyms: G430025P05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234825
Homologene: 69234
Flnb
Name: filamin, beta
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 286940
HGNC: HGNC:3755
Homologene: 37480
Zfp516
Name: zinc finger protein 516
Synonyms: Zfp26l, C330029B10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329003
VEGA: 18
Homologene: 37122
Phkb
Name: phosphorylase kinase beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102093
HGNC: HGNC:8927
Homologene: 247
Nav2
Name: neuron navigator 2
Synonyms: 5330421F07Rik, Unc53H2, HELAD1, RAINB2, Rainb1, POMFIL2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Tank
Name: TRAF family member-associated Nf-kappa B activator
Synonyms: I-TRAF, E430026L09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21353
Homologene: 3081
Ncbp3
Name: nuclear cap binding subunit 3
Synonyms: 1200014J11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66874
Homologene: 10231
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 30054
VEGA: 14
Homologene: 23727
Vps50
Name: VPS50 EARP/GARPII complex subunit
Synonyms: 1700034M03Rik, 8430415E05Rik, Ccdc132
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73288
Homologene: 11498
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12294
Homologene: 74929
Boc
Name: BOC cell adhesion associated, oncogene regulated
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 117606
Homologene: 32819
Bcl9
Name: B cell CLL/lymphoma 9
Synonyms: 2610202E01Rik, 8030475K17Rik, A330041G23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77578
HGNC: HGNC:1008
Homologene: 3191
Slc16a4
Name: solute carrier family 16 (monocarboxylic acid transporters), member 4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229699
Homologene: 74529
Ank1
Name: ankyrin 1, erythroid
Synonyms: pale, Ank-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11733
HGNC: HGNC:492
Homologene: 55427
Zscan10
Name: zinc finger and SCAN domain containing 10
Synonyms: Zscan10, Zfp206
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 332221
Homologene: 13122
Muc6
Name: mucin 6, gastric
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 353328
HGNC: HGNC:7517
Homologene: 18768
Tnr
Name: tenascin R
Synonyms: J1-tenascin, janusin, restrictin, TN-R
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21960
Homologene: 124416
Gpld1
Name: glycosylphosphatidylinositol specific phospholipase D1
Synonyms: 6330541J12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14756
HGNC: HGNC:4459
Homologene: 1152
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Cacna1s
Name: calcium channel, voltage-dependent, L type, alpha 1S subunit
Synonyms: mdg, DHPR alpha1s, sj, muscle dysgenesis, Cav1.1, Cchl1a3, fmd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12292
HGNC: HGNC:1397
Homologene: 37257
C8a
Name: complement component 8, alpha polypeptide
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230558
HGNC: HGNC:1352
Homologene: 472
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Krt26
Name: keratin 26
Synonyms: 4732407F15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320864
Homologene: 37118
Or8k53
Name: olfactory receptor family 8 subfamily K member 53
Synonyms: Olfr1055, GA_x6K02T2Q125-47819205-47818258, MOR186-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259023
Homologene: 131140
Dnm1
Name: dynamin 1
Synonyms: dynamin 1, Ftfl
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13429
HGNC: HGNC:2972
Homologene: 123905
4930556J24Rik
Name: RIKEN cDNA 4930556J24 gene
Type: Gene
Species: Mouse
Chromosome: 11
Or8g17
Name: olfactory receptor family 8 subfamily G member 17
Synonyms: Olfr146, GA_x6K02T2PVTD-32715386-32714466, M15, MOR171-10
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258742
VEGA: 9
Txndc16
Name: thioredoxin domain containing 16
Synonyms: 5730420B22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70561
Homologene: 18197
Nt5c1b
Name: 5'-nucleotidase, cytosolic IB
Synonyms: CN-IB, 4921514H13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70881
Homologene: 12370
Gm9493
Name: predicted gene 9493
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 102638448
VEGA: 19
Homologene: 137145
Or6b1
Name: olfactory receptor family 6 subfamily B member 1
Synonyms: MOR103-1, GA_x6K02T2P3E9-4722003-4721068, Olfr449
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 259067
HGNC: HGNC:8354
Homologene: 17485
Sfxn2
Name: sideroflexin 2
Synonyms: F630107H02Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 94279
VEGA: 19
Homologene: 14227
Ugp2
Name: UDP-glucose pyrophosphorylase 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216558
Homologene: 121676
Hacd1
Name: 3-hydroxyacyl-CoA dehydratase 1
Synonyms: Ptpla
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 30963
HGNC: HGNC:9639
Homologene: 69153
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 136,094,965 bp
  • A to T, chromosome 1 at 159,850,252 bp
  • T to A, chromosome 2 at 14,026,944 bp
  • A to G, chromosome 2 at 32,340,880 bp
  • T to A, chromosome 2 at 61,650,296 bp
  • C to T, chromosome 2 at 86,347,020 bp
  • T to C, chromosome 2 at 121,207,803 bp
  • C to T, chromosome 3 at 97,215,396 bp
  • T to G, chromosome 3 at 98,101,605 bp
  • G to A, chromosome 3 at 107,301,196 bp
  • T to C, chromosome 4 at 104,845,967 bp
  • G to A, chromosome 6 at 3,551,101 bp
  • A to G, chromosome 6 at 42,838,648 bp
  • A to G, chromosome 7 at 49,594,352 bp
  • CG to CGACGGCGGGG, chromosome 7 at 97,579,908 bp
  • G to A, chromosome 7 at 141,639,559 bp
  • T to A, chromosome 8 at 22,975,191 bp
  • T to A, chromosome 8 at 85,922,151 bp
  • A to G, chromosome 8 at 121,820,162 bp
  • A to G, chromosome 9 at 39,019,106 bp
  • A to G, chromosome 10 at 82,292,833 bp
  • T to C, chromosome 11 at 3,938,056 bp
  • A to G, chromosome 11 at 21,331,028 bp
  • T to A, chromosome 11 at 73,073,384 bp
  • C to T, chromosome 11 at 99,329,702 bp
  • A to T, chromosome 12 at 10,374,837 bp
  • T to C, chromosome 13 at 24,979,970 bp
  • T to A, chromosome 13 at 81,518,126 bp
  • C to T, chromosome 14 at 7,929,012 bp
  • T to C, chromosome 14 at 29,064,186 bp
  • T to C, chromosome 14 at 45,161,335 bp
  • A to G, chromosome 14 at 56,427,924 bp
  • A to T, chromosome 16 at 44,520,440 bp
  • T to C, chromosome 16 at 91,227,156 bp
  • C to T, chromosome 17 at 23,605,857 bp
  • T to A, chromosome 18 at 82,988,107 bp
  • A to T, chromosome 19 at 23,619,845 bp
  • A to T, chromosome 19 at 46,582,528 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6626 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044748-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.