Strain Name:
C57BL/6J-MtgxR6633Btlr/Mmmh
Stock Number:
044755-MU
Citation ID:
RRID:MMRRC_044755-MU
Other Names:
R6633 (G1)
Major Collection:

Strain Information

Aatf
Name: apoptosis antagonizing transcription factor
Synonyms: 5830465M17Rik, Che-1, Trb, 4933415H02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56321
Homologene: 40811
Jarid2
Name: jumonji and AT-rich interaction domain containing 2
Synonyms: jumonji, Jmj
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16468
HGNC: HGNC:6196
Homologene: 31279
Cdk8
Name: cyclin dependent kinase 8
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 264064
HGNC: HGNC:1779
Homologene: 55565
Acot7
Name: acyl-CoA thioesterase 7
Synonyms: Bach, 2410041A17Rik, AU014716
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70025
Homologene: 15780
Dock6
Name: dedicator of cytokinesis 6
Synonyms: 2410095B20Rik, 4931431C02Rik, C330023D02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
Polr2a
Name: polymerase (RNA) II (DNA directed) polypeptide A
Synonyms: Rpo2-1, 220kDa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20020
HGNC: HGNC:9187
Homologene: 721
Tpx2
Name: TPX2, microtubule-associated
Synonyms: DIL2, p100, REPP86, 2610005B21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72119
HGNC: HGNC:1249
Homologene: 8107
Tango6
Name: transport and golgi organization 6
Synonyms: Tango6, Tmco7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 272538
Homologene: 52121
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, tbl, 2810449H11Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Ccdc80
Name: coiled-coil domain containing 80
Synonyms: 2610001E17Rik, DRO1, Urb, Ssg1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67896
Homologene: 12206
Rag1
Name: recombination activating 1
Synonyms: Rag-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19373
HGNC: HGNC:9831
Homologene: 387
Csf2rb2
Name: colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
Synonyms: Bil3, Il3rb2, Il3r, BetaIl3, AIC2A
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12984
VEGA: 15
HGNC: HGNC:2436
Homologene: 339
Wnt2b
Name: wingless-type MMTV integration site family, member 2B
Synonyms: Wnt13
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22414
Homologene: 22526
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Gbx2
Name: gastrulation brain homeobox 2
Synonyms: Gbx-2, Stra7, MMoxA
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14472
HGNC: HGNC:4186
Homologene: 1138
Irx4
Name: Iroquois homeobox 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 50916
HGNC: HGNC:6129
Homologene: 9485
Lrp10
Name: low-density lipoprotein receptor-related protein 10
Synonyms: Lrp9
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 65107
VEGA: 14
Homologene: 8535
Arf1
Name: ADP-ribosylation factor 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11840
HGNC: HGNC:652
Homologene: 133930
Tex30
Name: testis expressed 30
Synonyms: 3110030D08Rik, 1700029F09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75623
Homologene: 16344
Esco1
Name: establishment of sister chromatid cohesion N-acetyltransferase 1
Synonyms: A930014I12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 77805
Homologene: 62166
Dgcr8
Name: DGCR8, microprocessor complex subunit
Synonyms: Gy1, N41, DiGeorge syndrome critical region gene 8, Vo59c07, D16H22S1742E, D16Wis2, D16H22S788E
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 94223
HGNC: HGNC:2847
Homologene: 11223
Tpcn1
Name: two pore channel 1
Synonyms: 5730403B01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 252972
Homologene: 9905
Agtr1a
Name: angiotensin II receptor, type 1a
Synonyms: Agt1ar, Agtr-1a, AT1a, 1810074K20Rik, Angtr-1a, AT1, Agtr1a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11607
HGNC: HGNC:336
Homologene: 3556
Anapc4
Name: anaphase promoting complex subunit 4
Synonyms: APC4, 2610306D21Rik, D5Ertd249e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52206
Homologene: 40873
Dnah5
Name: dynein, axonemal, heavy chain 5
Synonyms: b2b3491Clo, Mdnah5, b2b1537Clo, b2b1134Clo, Dnahc5, b2b1154Clo, b2b1565Clo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110082
HGNC: HGNC:2950
Homologene: 1048
Rusc2
Name: RUN and SH3 domain containing 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100213
Homologene: 18967
Fcer1a
Name: Fc receptor, IgE, high affinity I, alpha polypeptide
Synonyms: Fce1a, Fcr-5, FcERI
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14125
HGNC: HGNC:3609
Homologene: 1516
Ephb2
Name: Eph receptor B2
Synonyms: Prkm5, Erk, eteck, Tyro5, Nuk, Cek5, Qek5, Sek3, Hek5, Drt
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13844
HGNC: HGNC:3393
Homologene: 37925
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Ppp6r2
Name: protein phosphatase 6, regulatory subunit 2
Synonyms: Pp6r2, B230107H12Rik, Saps2, 1110033O10Rik, 8430411H09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71474
VEGA: 15
Homologene: 36455
Btnl1
Name: butyrophilin-like 1
Synonyms: LOC240074, Btnl3, LOC240074, NG10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100038862
Homologene: 103816
Naip1
Name: NLR family, apoptosis inhibitory protein 1
Synonyms: Birc1a, D13Lsd1, Naip
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17940
VEGA: 13
HGNC: HGNC:7634
Homologene: 113589
Kprp
Name: keratinocyte expressed, proline-rich
Synonyms: 1110001M24Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433619
Homologene: 54921
Plcl2
Name: phospholipase C-like 2
Synonyms: Plce2, PRIP-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224860
VEGA: 17
HGNC: HGNC:9064
Homologene: 9052
Cdh2
Name: cadherin 2
Synonyms: Ncad, N-cadherin, N-CAD
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12558
HGNC: HGNC:1759
Homologene: 20424
Hic1
Name: hypermethylated in cancer 1
Synonyms: HIC-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15248
HGNC: HGNC:4909
Homologene: 4740
H2-Q2
Name: histocompatibility 2, Q region locus 2
Synonyms: Gm11132, H-2Q2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15013
Homologene: 128352
Ccdc96
Name: coiled-coil domain containing 96
Synonyms: 4921513E08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66717
Homologene: 32639
Adam24
Name: ADAM metallopeptidase domain 24
Synonyms: Dtgn5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13526
HGNC: HGNC:203
Homologene: 137232
Arhgef40
Name: Rho guanine nucleotide exchange factor 40
Synonyms: E130112L23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268739
Homologene: 19560
Adamdec1
Name: ADAM-like, decysin 1
Synonyms: 2210414L24Rik, Dcsn
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 58860
VEGA: 14
Homologene: 8711
Tmbim7
Name: transmembrane BAX inhibitor motif containing 7
Synonyms: 4930511M11Rik, 4930403J02Rik, Lfg5, Tmbim1b, 4930500J03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75010
Homologene: 81927
Or4c12
Name: olfactory receptor family 4 subfamily C member 12
Synonyms: MOR232-9, Olfr1259, GA_x6K02T2Q125-51376062-51375133
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258338
Homologene: 128115
Rxylt1
Name: ribitol xylosyltransferase 1
Synonyms: 6330415D21Rik, Tmem5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216395
Homologene: 8600
Klk1b27
Name: kallikrein 1-related peptidase b27
Synonyms: Klk27, Klk21l, mGK-27
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16619
Homologene: 68141
Adgrg7
Name: adhesion G protein-coupled receptor G7
Synonyms: Gpr128, 9130020O16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239853
Homologene: 13115
Plekhb1
Name: pleckstrin homology domain containing, family B (evectins) member 1
Synonyms: Phret1, evt-1, PHR1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 27276
Homologene: 8449
Vmn1r3
Name: vomeronasal 1 receptor 3
Synonyms: Gm11778
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100312471
Homologene: 128342
Mrgpra6
Name: MAS-related GPR, member A6
Synonyms: MrgA6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381886
Gm44511
Name: predicted gene 44511
Type: Gene
Species: Mouse
Chromosome: 6
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to C, chromosome 1 at 44,087,924 bp
  • TCCCCC to TCCCCCC, chromosome 1 at 89,928,720 bp
  • C to G, chromosome 1 at 173,226,726 bp
  • T to C, chromosome 2 at 89,943,366 bp
  • T to A, chromosome 2 at 101,642,710 bp
  • T to G, chromosome 2 at 152,867,354 bp
  • G to A, chromosome 2 at 180,191,662 bp
  • T to C, chromosome 3 at 92,825,293 bp
  • T to C, chromosome 3 at 104,951,056 bp
  • G to A, chromosome 4 at 3,184,971 bp
  • T to C, chromosome 4 at 43,414,852 bp
  • C to G, chromosome 4 at 136,683,996 bp
  • C to T, chromosome 4 at 152,178,259 bp
  • A to G, chromosome 5 at 3,657,659 bp
  • G to A, chromosome 5 at 36,485,189 bp
  • C to T, chromosome 5 at 52,865,946 bp
  • A to G, chromosome 5 at 120,544,464 bp
  • C to A, chromosome 5 at 146,298,846 bp
  • T to A, chromosome 6 at 128,826,242 bp
  • A to T, chromosome 7 at 44,055,810 bp
  • A to G, chromosome 7 at 47,188,745 bp
  • A to G, chromosome 7 at 100,645,639 bp
  • T to G, chromosome 8 at 40,680,487 bp
  • T to C, chromosome 8 at 106,718,005 bp
  • A to G, chromosome 9 at 21,820,331 bp
  • A to G, chromosome 9 at 21,821,503 bp
  • G to T, chromosome 9 at 66,439,252 bp
  • G to A, chromosome 10 at 122,097,053 bp
  • T to C, chromosome 11 at 59,212,544 bp
  • A to G, chromosome 11 at 69,735,513 bp
  • G to T, chromosome 11 at 75,169,498 bp
  • C to A, chromosome 11 at 84,511,482 bp
  • A to G, chromosome 13 at 30,381,467 bp
  • C to A, chromosome 13 at 44,884,877 bp
  • G to T, chromosome 13 at 73,268,426 bp
  • A to T, chromosome 13 at 81,568,643 bp
  • A to G, chromosome 13 at 100,423,076 bp
  • C to T, chromosome 13 at 100,423,085 bp
  • C to T, chromosome 14 at 51,997,431 bp
  • T to C, chromosome 14 at 54,469,074 bp
  • T to C, chromosome 14 at 68,573,152 bp
  • A to T, chromosome 15 at 28,293,787 bp
  • T to C, chromosome 15 at 78,288,952 bp
  • G to A, chromosome 15 at 89,253,255 bp
  • A to T, chromosome 16 at 18,284,182 bp
  • T to C, chromosome 16 at 45,094,908 bp
  • T to C, chromosome 16 at 56,730,286 bp
  • A to G, chromosome 17 at 34,385,331 bp
  • A to G, chromosome 17 at 35,342,387 bp
  • A to G, chromosome 17 at 50,640,140 bp
  • T to A, chromosome 18 at 10,595,738 bp
  • A to T, chromosome 18 at 16,640,548 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6633 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044755-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.