Strain Name:
C57BL/6J-MtgxR6634Btlr/Mmmh
Stock Number:
044756-MU
Citation ID:
RRID:MMRRC_044756-MU
Other Names:
R6634 (G1)
Major Collection:

Strain Information

Alox12b
Name: arachidonate 12-lipoxygenase, 12R type
Synonyms: e-LOX2, Aloxe2, 12R-LOX
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11686
HGNC: HGNC:430
Homologene: 884
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: 2810449H11Rik, D130015N03Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Lpin2
Name: lipin 2
Synonyms: 2610511G02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64898
Homologene: 8769
Pias1
Name: protein inhibitor of activated STAT 1
Synonyms: Ddxbp1, GBP, 2900068C24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56469
VEGA: 9
HGNC: HGNC:2752
Homologene: 22953
Sfxn1
Name: sideroflexin 1
Synonyms: 2810002O05Rik, A930015P12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14057
VEGA: 13
Homologene: 41494
Usp53
Name: ubiquitin specific peptidase 53
Synonyms: mbo, Phxr3, Sp6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99526
Homologene: 34521
Satb2
Name: special AT-rich sequence binding protein 2
Synonyms: BAP002
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 212712
Homologene: 32249
Crebbp
Name: CREB binding protein
Synonyms: KAT3A, CBP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12914
HGNC: HGNC:2348
Homologene: 68393
Iqcd
Name: IQ motif containing D
Synonyms: 4933433C09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75732
Homologene: 49921
Ebf3
Name: early B cell factor 3
Synonyms: 3110018A08Rik, Olf-1/EBF-like 2, O/E-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13593
Homologene: 56472
Morc2a
Name: microrchidia 2A
Synonyms: 8430403M08Rik, Zcwcc1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74522
Homologene: 8966
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Or10aa3
Name: olfactory receptor family 10 subfamily AA member 3
Synonyms: GA_x6K02T2P20D-21124681-21123743, Olfr432, MOR123-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258711
Homologene: 81532
Galnt16
Name: polypeptide N-acetylgalactosaminyltransferase 16
Synonyms: Galntl1, 5730405L21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 108760
VEGA: 12
Homologene: 18907
Gm5800
Name: predicted gene 5800
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545047
Homologene: 128452
Myh1
Name: myosin, heavy polypeptide 1, skeletal muscle, adult
Synonyms: IId, IId/x, Myhs-f2, A530084A17Rik, MyHC-IId/x, Myhs-f, Myhsf2, MYHC-IIX, myosin heavy chain 2X
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17879
HGNC: HGNC:7567
Homologene: 133718
Chl1
Name: cell adhesion molecule L1-like
Synonyms: A530023M13Rik, close homolog of L1, LICAM2, CALL
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12661
HGNC: HGNC:1939
Homologene: 21314
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Pcnx1
Name: pecanex 1
Synonyms: Pcnx, 3526401J03Rik, 2900024E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Pitpnm3
Name: PITPNM family member 3
Synonyms: Ackr6, A330068P14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327958
Homologene: 66271
4921539E11Rik
Name: RIKEN cDNA 4921539E11 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 70941
Homologene: 52843
Cyp2t4
Name: cytochrome P450, family 2, subfamily t, polypeptide 4
Synonyms: LOC384724
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384724
Homologene: 76639
Dkkl1
Name: dickkopf-like 1
Synonyms: Soggy, mSgy, SGY1, SGY-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50722
Homologene: 56674
Cpa5
Name: carboxypeptidase A5
Synonyms: 4930430M09Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74649
Homologene: 62246
Nedd9
Name: neural precursor cell expressed, developmentally down-regulated gene 9
Synonyms: Cas-L, CasL, HEF1, E230025G09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18003
VEGA: 13
HGNC: HGNC:7733
Homologene: 4669
Slc35g3
Name: solute carrier family 35, member G3
Synonyms: Amac1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56293
Homologene: 89413
Gstp1
Name: glutathione S-transferase, pi 1
Synonyms: GstpiB, Gst p-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14870
HGNC: HGNC:4638
Homologene: 660
Ltb4r2
Name: leukotriene B4 receptor 2
Synonyms: 5830462O07Rik, BLT2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57260
VEGA: 14
Homologene: 10519
Tmem200c
Name: transmembrane protein 200C
Synonyms: Gm6338
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 622645
VEGA: 17
Homologene: 78765
Igkv8-24
Name: immunoglobulin kappa chain variable 8-24
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 677858
HGNC: HGNC:5834
Fer1l5
Name: fer-1 like family member 5
Synonyms: 4930533C12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100534273
Homologene: 85232
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,411,385 bp
  • G to T, chromosome 1 at 56,845,721 bp
  • A to G, chromosome 1 at 174,050,969 bp
  • T to A, chromosome 3 at 122,964,286 bp
  • C to T, chromosome 4 at 103,236,930 bp
  • C to A, chromosome 5 at 120,600,491 bp
  • T to A, chromosome 6 at 30,626,364 bp
  • C to T, chromosome 6 at 70,217,381 bp
  • T to A, chromosome 6 at 103,690,259 bp
  • C to A, chromosome 7 at 27,155,788 bp
  • C to A, chromosome 7 at 45,210,458 bp
  • A to G, chromosome 7 at 137,201,160 bp
  • A to T, chromosome 9 at 62,919,424 bp
  • T to C, chromosome 9 at 66,437,744 bp
  • A to C, chromosome 10 at 107,862,304 bp
  • T to C, chromosome 11 at 3,672,376 bp
  • A to T, chromosome 11 at 67,209,064 bp
  • C to A, chromosome 11 at 69,168,821 bp
  • A to T, chromosome 11 at 69,760,283 bp
  • T to C, chromosome 11 at 72,051,929 bp
  • T to C, chromosome 11 at 104,893,783 bp
  • T to A, chromosome 12 at 80,519,170 bp
  • T to A, chromosome 12 at 81,917,882 bp
  • T to A, chromosome 13 at 41,312,108 bp
  • T to A, chromosome 13 at 54,093,029 bp
  • A to G, chromosome 14 at 51,716,138 bp
  • T to A, chromosome 14 at 55,762,505 bp
  • C to T, chromosome 16 at 4,119,806 bp
  • C to A, chromosome 17 at 68,842,106 bp
  • T to A, chromosome 17 at 71,246,418 bp
  • T to A, chromosome 19 at 4,035,510 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6634 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044756-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.