Strain Name:
C57BL/6J-MtgxR6638Btlr/Mmmh
Stock Number:
044759-MU
Citation ID:
RRID:MMRRC_044759-MU
Other Names:
R6638 (G1)
Major Collection:

Strain Information

Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: RPTPkappa, PTPk
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Hmgcr
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Synonyms: 3-hydroxy-3-methylglutaryl-CoA reductase, Red, HMG-CoAR
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15357
HGNC: HGNC:5006
Homologene: 30994
Vapb
Name: vesicle-associated membrane protein, associated protein B and C
Synonyms: VAMP-associated protein 33b, VAP33b, D2Abb2e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56491
Homologene: 36163
Plxna1
Name: plexin A1
Synonyms: 2600013D04Rik, Plxn1, NOV, PlexA1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18844
HGNC: HGNC:9099
Homologene: 56426
Xrcc5
Name: X-ray repair complementing defective repair in Chinese hamster cells 5
Synonyms: Ku86, Ku80
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22596
VEGA: 1
Homologene: 40681
Eif4enif1
Name: eukaryotic translation initiation factor 4E nuclear import factor 1
Synonyms: D11Ertd166e, 2610509L04Rik, Clast4, A930019J01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74203
Homologene: 10522
Fndc3a
Name: fibronectin type III domain containing 3A
Synonyms: 1700094E19Rik, Fndc3, sys, D14Ertd453e, F730017H24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319448
Homologene: 8952
Poldip3
Name: polymerase (DNA-directed), delta interacting protein 3
Synonyms: PDIP46, 1110008P04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73826
Homologene: 13007
Mtmr2
Name: myotubularin related protein 2
Synonyms: 6030445P13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77116
HGNC: HGNC:7450
Homologene: 22951
Zfyve27
Name: zinc finger, FYVE domain containing 27
Synonyms: 9530077C24Rik, 2210011N02Rik, protrudin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319740
Homologene: 16939
Dlk1
Name: delta like non-canonical Notch ligand 1
Synonyms: pG2, pref-1, FA1, Peg9, DlkI, ZOG, SCP1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13386
HGNC: HGNC:2907
Homologene: 2846
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: Dnahc6, A730004I20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: B230334C09Rik, densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4A, Naip-rs4, Birc1f
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Dppa2
Name: developmental pluripotency associated 2
Synonyms: 2410088E07Rik, ECAT15-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 73703
VEGA: 16
Homologene: 79572
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Kif21a
Name: kinesin family member 21A
Synonyms: N-5 kinesin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16564
VEGA: 15
Homologene: 56761
Wdsub1
Name: WD repeat, SAM and U-box domain containing 1
Synonyms: 1700048E19Rik, 2610014F08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72137
Homologene: 17609
Eva1b
Name: eva-1 homolog B
Synonyms: 2610027C15Rik, Fam176b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230752
Homologene: 18151
Vmn1r35
Name: vomeronasal 1 receptor 35
Synonyms: V1rc12
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171185
Homologene: 110800
Ovch2
Name: ovochymase 2
Synonyms: 9230106D23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244199
Homologene: 18255
Or9r3
Name: olfactory receptor family 9 subfamily R member 3
Synonyms: Olfr823, MOR210-4, GA_x6K02T2PULF-11783479-11782532
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258668
Homologene: 45026
Cep112
Name: centrosomal protein 112
Synonyms: 1700029K01Rik, 8430407H02Rik, Macoco, Ccdc46, 1700001M19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76380
Homologene: 44915
Tagap
Name: T cell activation Rho GTPase activating protein
Synonyms: TRD, Tcd-1, tcs1, Tcd1a, tcs-1, Tcd1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72536
Homologene: 44943
Prss44
Name: serine protease 44
Synonyms: 1700036D21Rik, TESSP4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73336
Homologene: 135977
Rpl36al
Name: ribosomal protein L36A-like
Synonyms: 2410038A03Rik, RPL36A
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66483
Homologene: 133572
Polr3h
Name: polymerase (RNA) III (DNA directed) polypeptide H
Synonyms: RPC8, 5031409G22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78929
VEGA: 15
Homologene: 6337
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 72,383,362 bp
  • A to T, chromosome 2 at 59,870,441 bp
  • A to G, chromosome 2 at 173,771,569 bp
  • A to G, chromosome 3 at 158,135,303 bp
  • T to C, chromosome 4 at 126,149,472 bp
  • A to T, chromosome 5 at 96,758,094 bp
  • G to A, chromosome 6 at 66,678,864 bp
  • A to T, chromosome 6 at 73,035,280 bp
  • A to T, chromosome 6 at 89,324,400 bp
  • A to T, chromosome 7 at 107,789,094 bp
  • C to A, chromosome 9 at 13,796,133 bp
  • G to A, chromosome 9 at 110,817,203 bp
  • C to T, chromosome 10 at 28,595,811 bp
  • T to C, chromosome 10 at 130,111,870 bp
  • T to C, chromosome 11 at 3,242,463 bp
  • T to C, chromosome 11 at 108,855,870 bp
  • A to G, chromosome 12 at 69,182,934 bp
  • A to G, chromosome 12 at 109,460,278 bp
  • T to A, chromosome 13 at 77,303,402 bp
  • T to C, chromosome 13 at 96,658,982 bp
  • C to A, chromosome 13 at 100,300,401 bp
  • A to G, chromosome 14 at 57,699,365 bp
  • G to A, chromosome 14 at 72,559,248 bp
  • A to G, chromosome 15 at 81,918,304 bp
  • A to T, chromosome 15 at 83,133,200 bp
  • A to G, chromosome 15 at 90,966,407 bp
  • A to T, chromosome 16 at 48,314,160 bp
  • T to C, chromosome 17 at 7,927,074 bp
  • T to A, chromosome 19 at 42,181,497 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6638 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044759-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.