Strain Name:
C57BL/6J-MtgxR6643Btlr/Mmmh
Stock Number:
044764-MU
Citation ID:
RRID:MMRRC_044764-MU
Other Names:
R6643 (G1)
Major Collection:

Strain Information

Ntsr1
Name: neurotensin receptor 1
Synonyms: NTR-1, NT-1R, NTR1, Ntsr1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18216
HGNC: HGNC:8039
Homologene: 68261
Slc27a4
Name: solute carrier family 27 (fatty acid transporter), member 4
Synonyms: fatty acid transport protein 4, FATP4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26569
Homologene: 68437
Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 9330107J05Rik, 4930431J08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
Brd4
Name: bromodomain containing 4
Synonyms: HUNK1, WI-11513, MCAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57261
Homologene: 136213
Suco
Name: SUN domain containing ossification factor
Synonyms: osteopotentia, Opt, AI848100
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226551
HGNC: HGNC:1240
Homologene: 32212
Ddx42
Name: DEAD box helicase 42
Synonyms: B430002H05Rik, 1810047H21Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 42, SF3b125
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72047
Homologene: 49137
Wdr1
Name: WD repeat domain 1
Synonyms: D5Wsu185e, Aip1, rede
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22388
Homologene: 6628
E130308A19Rik
Name: RIKEN cDNA E130308A19 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230259
Homologene: 136157
Cntrob
Name: centrobin, centrosomal BRCA2 interacting protein
Synonyms: Nip2, Lip8, 9830165K03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216846
Homologene: 14205
Stxbp3
Name: syntaxin binding protein 3
Synonyms: Munc-18c, Stxbp3, Stxbp3a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20912
Homologene: 5260
Ywhaz
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Synonyms: 1110013I11Rik, 14-3-3 zeta
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22631
Homologene: 56528
Kifc1
Name: kinesin family member C1
Synonyms: Tctex-7A, Gm4137, Tctex7a, kinesin family c-terminal 5A, Knsl2a, Tctex-7, Kifc5a, KNSL2, HSET, Tctex7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100502766
HGNC: HGNC:6389
Homologene: 83229
Eif2b3
Name: eukaryotic translation initiation factor 2B, subunit 3
Synonyms: 1190002P15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 108067
HGNC: HGNC:3259
Homologene: 7005
Vmn1r28
Name: vomeronasal 1 receptor 28
Synonyms: V1rc25
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171198
Homologene: 138094
Reg3b
Name: regenerating islet-derived 3 beta
Synonyms: RegIII (beta), PAP1, REG-III, Pap
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18489
Homologene: 130506
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: mdig, 6430526J12Rik, Megf7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Or6z5
Name: olfactory receptor family 6 subfamily Z member 5
Synonyms: MOR103-6, GA_x6K02T2QGBW-3203957-3204898, Olfr1346
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258918
Homologene: 74134
Myo1c
Name: myosin IC
Synonyms: myosin-Ibeta, mm1beta, C80397, myr2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17913
HGNC: HGNC:7597
Homologene: 32046
Col22a1
Name: collagen, type XXII, alpha 1
Synonyms: 2310067L16Rik, C80743
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69700
Homologene: 43567
Slc4a10
Name: solute carrier family 4, sodium bicarbonate cotransporter-like, member 10
Synonyms: NCBE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94229
Homologene: 23340
Cts6
Name: cathepsin 6
Synonyms: 1600022N02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 58518
Homologene: 75165
Col6a4
Name: collagen, type VI, alpha 4
Synonyms: Dvwa, Vwa6, 1110001D15Rik, EG235580
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68553
Homologene: 130754
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Gm1043
Name: predicted gene 1043
Synonyms: LOC381634
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381634
Homologene: 52625
Or2ag15
Name: olfactory receptor family 2 subfamily AG member 15
Synonyms: GA_x6K02T2PBJ9-9119301-9118348, MOR283-5, Olfr697
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258592
Pcolce
Name: procollagen C-endopeptidase enhancer protein
Synonyms: Astt2, Astt-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18542
HGNC: HGNC:8738
Homologene: 1946
Or2ag16
Name: olfactory receptor family 2 subfamily AG member 16
Synonyms: Olfr698, GA_x6K02T2PBJ9-9130754-9129519, MOR283-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258595
Homologene: 133598
Slc5a7
Name: solute carrier family 5 (choline transporter), member 7
Synonyms: CHT1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 63993
VEGA: 17
Homologene: 32516
Or6n2
Name: olfactory receptor family 6 subfamily N member 2
Synonyms: MOR105-5P, GA_x6K02T2P20D-21108443-21107490, Olfr430
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258713
Homologene: 17362
Xylb
Name: xylulokinase homolog (H. influenzae)
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102448
VEGA: 9
Homologene: 3746
Ttl
Name: tubulin tyrosine ligase
Synonyms: 2410003M22Rik, 2700049H19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69737
Homologene: 32678
Rps6ka4
Name: ribosomal protein S6 kinase, polypeptide 4
Synonyms: MSK2, 90kDa, 1110069D02Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56613
VEGA: 19
Homologene: 69288
Aadacl3
Name: arylacetamide deacetylase like 3
Synonyms: LOC230883
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230883
Homologene: 28426
Lancl1
Name: LanC (bacterial lantibiotic synthetase component C)-like 1
Synonyms: LanC-like protein 1, p40, Gpr69a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14768
HGNC: HGNC:6508
Homologene: 4417
Cpn1
Name: carboxypeptidase N, polypeptide 1
Synonyms: CPN, 0610011F20Rik, 50 kDa
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 93721
HGNC: HGNC:2312
Homologene: 1002
Mroh9
Name: maestro heat-like repeat family member 9
Synonyms: Armc11, 4921528O07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78258
Homologene: 123521
Tnni2
Name: troponin I, skeletal, fast 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21953
Homologene: 37752
Atp5mc1
Name: ATP synthase membrane subunit c locus 1
Synonyms: Atp5g1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11951
HGNC: HGNC:841
Homologene: 38017
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 63,304,508 bp
  • T to C, chromosome 1 at 67,004,383 bp
  • A to T, chromosome 1 at 161,859,432 bp
  • T to A, chromosome 1 at 163,075,561 bp
  • T to C, chromosome 1 at 174,070,045 bp
  • A to G, chromosome 2 at 29,812,848 bp
  • C to T, chromosome 2 at 62,228,710 bp
  • T to C, chromosome 2 at 91,501,995 bp
  • T to C, chromosome 2 at 129,081,342 bp
  • T to C, chromosome 2 at 180,500,926 bp
  • A to G, chromosome 3 at 108,793,834 bp
  • A to G, chromosome 4 at 59,720,561 bp
  • T to C, chromosome 4 at 117,070,757 bp
  • A to G, chromosome 4 at 128,372,597 bp
  • A to G, chromosome 4 at 144,457,074 bp
  • T to C, chromosome 5 at 37,173,551 bp
  • A to T, chromosome 5 at 38,540,178 bp
  • T to A, chromosome 5 at 137,608,903 bp
  • A to G, chromosome 6 at 58,265,960 bp
  • C to A, chromosome 6 at 78,372,922 bp
  • G to A, chromosome 7 at 6,474,721 bp
  • T to A, chromosome 7 at 106,741,704 bp
  • A to G, chromosome 7 at 106,752,569 bp
  • G to T, chromosome 7 at 142,444,279 bp
  • T to C, chromosome 9 at 106,000,631 bp
  • A to G, chromosome 9 at 119,367,493 bp
  • A to G, chromosome 11 at 69,311,422 bp
  • C to T, chromosome 11 at 75,671,635 bp
  • A to C, chromosome 11 at 96,074,028 bp
  • G to T, chromosome 11 at 106,228,820 bp
  • T to A, chromosome 13 at 61,201,793 bp
  • T to C, chromosome 15 at 36,790,922 bp
  • T to C, chromosome 15 at 71,822,037 bp
  • A to G, chromosome 17 at 32,198,496 bp
  • C to T, chromosome 17 at 33,885,855 bp
  • G to T, chromosome 17 at 54,276,616 bp
  • A to G, chromosome 19 at 6,832,363 bp
  • C to T, chromosome 19 at 43,960,033 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6643 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044764-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.