Strain Name:
C57BL/6J-MtgxR6649Btlr/Mmmh
Stock Number:
044770-MU
Citation ID:
RRID:MMRRC_044770-MU
Other Names:
R6649 (G1)
Major Collection:

Strain Information

Jak2
Name: Janus kinase 2
Synonyms: C81284
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16452
VEGA: 19
HGNC: HGNC:6192
Homologene: 21033
Dlg4
Name: discs large MAGUK scaffold protein 4
Synonyms: SAP90, PSD-95, SAP90A, PSD95, Dlgh4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13385
HGNC: HGNC:2903
Homologene: 1047
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Erp44
Name: endoplasmic reticulum protein 44
Synonyms: 1110001E24Rik, Txndc4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76299
Homologene: 12638
Cep290
Name: centrosomal protein 290
Synonyms: Nphp6, b2b1454Clo, b2b1752Clo, Kiaa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Papola
Name: poly (A) polymerase alpha
Synonyms: Plap, PapIII
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18789
Homologene: 23389
Mon2
Name: MON2 homolog, regulator of endosome to Golgi trafficking
Synonyms: SF21, 2610528O22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 67074
VEGA: 10
Homologene: 44309
Eef2
Name: eukaryotic translation elongation factor 2
Synonyms: Ef-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13629
VEGA: 10
HGNC: HGNC:3214
Homologene: 134867
Cip2a
Name: cell proliferation regulating inhibitor of protein phosphatase 2A
Synonyms: Cip2a, C330027C09Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224171
Homologene: 10842
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Phyhipl
Name: phytanoyl-CoA hydroxylase interacting protein-like
Synonyms: 4921522K17Rik, PHY2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70911
Homologene: 13028
Bcdin3d
Name: BCDIN3 domain containing
Synonyms: 4930556P03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75284
VEGA: 15
Homologene: 12594
Spry1
Name: sprouty RTK signaling antagonist 1
Synonyms: sprouty1, sprouty 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 24063
Homologene: 4266
Bmp1
Name: bone morphogenetic protein 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12153
VEGA: 14
HGNC: HGNC:1067
Homologene: 55955
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: A930005E13Rik, LOC381562, D930005K06Rik, 1810009A16Rik, Zubr1, p600
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Gm14496
Name: predicted gene 14496
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 672125
Homologene: 129606
Hsd17b14
Name: hydroxysteroid (17-beta) dehydrogenase 14
Synonyms: retSDR3, 0610039E24Rik, Dhrs10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66065
Homologene: 133800
Raf1
Name: v-raf-leukemia viral oncogene 1
Synonyms: Raf-1, 6430402F14Rik, v-Raf, sarcoma 3611 oncogene, c-Raf, Craf1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 110157
HGNC: HGNC:9829
Homologene: 48145
Zfp60
Name: zinc finger protein 60
Synonyms: Mfg-3, Mfg3, 6330516O17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22718
Homologene: 137228
Ppp3cb
Name: protein phosphatase 3, catalytic subunit, beta isoform
Synonyms: PP2BA beta, Calnb, CnAbeta, 1110063J16Rik, Cnab
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19056
HGNC: HGNC:9315
Homologene: 56429
Mfsd14b
Name: major facilitator superfamily domain containing 14B
Synonyms: 5730414C17Rik, Hiatl1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66631
Homologene: 64464
Heatr6
Name: HEAT repeat containing 6
Synonyms: 2700008B19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217026
Homologene: 11116
Milr1
Name: mast cell immunoglobulin like receptor 1
Synonyms: LOC380732, Allergin-1, Gm885
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380732
Homologene: 86017
Cmya5
Name: cardiomyopathy associated 5
Synonyms: Myospryn, 2310076E16Rik, 2310076E21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76469
VEGA: 13
Homologene: 137367
Kmt5b
Name: lysine methyltransferase 5B
Synonyms: Suv4-20h1, C630029K18Rik, Suv420h1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225888
Homologene: 32351
Fat3
Name: FAT atypical cadherin 3
Synonyms: LOC234973, LOC382129, 9430076A06Rik, D430038H04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270120
VEGA: 9
Homologene: 82252
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Nlrp9c
Name: NLR family, pyrin domain containing 9C
Synonyms: Nalp9c, Nalp-zeta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330490
Homologene: 116072
Adamts7
Name: ADAM metallopeptidase with thrombospondin type 1 motif 7
Synonyms: ADAM-TS7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 108153
HGNC: HGNC:223
Homologene: 22803
Bbox1
Name: gamma-butyrobetaine hydroxylase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170442
HGNC: HGNC:964
Homologene: 2967
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 1110004O12Rik, 9130019P20Rik, 4933432B13Rik, A530027J04Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 108857
Homologene: 87006
Atosa
Name: atos homolog A
Synonyms: 6330415I01Rik, C130047D21Rik, BC031353, Fam214a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235493
VEGA: 9
Homologene: 35065
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: 4930449A08Rik, 4930538D17Rik, Tmem180
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75146
Homologene: 12592
Gpat2
Name: glycerol-3-phosphate acyltransferase 2, mitochondrial
Synonyms: Gpat2, A530057A03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215456
Homologene: 19037
Slco6c1
Name: solute carrier organic anion transporter family, member 6c1
Synonyms: 4933404A18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74441
Homologene: 65259
Sh3pxd2b
Name: SH3 and PX domains 2B
Synonyms: G431001E03Rik, Fad49, Tks4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268396
Homologene: 27952
Nwd2
Name: NACHT and WD repeat domain containing 2
Synonyms: B830017A01Rik, 3110047P20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319807
Homologene: 14974
Or52b2
Name: olfactory receptor family 52 subfamily B member 2
Synonyms: GA_x6K02T2PBJ9-7966695-7965727, MOR31-6, Olfr691
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259063
Homologene: 17483
Asb15
Name: ankyrin repeat and SOCS box-containing 15
Synonyms: 4930400E23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78910
Homologene: 43797
Abcc2
Name: ATP-binding cassette, sub-family member 2
Synonyms: multidrug resistance protein 2, Mrp2, Cmoat
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Or8g20
Name: olfactory receptor family 8 subfamily G member 20
Synonyms: IB3, MOR171-5, GA_x6K02T2PVTD-33181773-33180838, Olfr44
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18343
VEGA: 9
HGNC: HGNC:8484
Homologene: 133633
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 628185
Homologene: 86604
Cdh18
Name: cadherin 18
Synonyms: B230220E17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320865
HGNC: HGNC:1757
Homologene: 55858
Zfp938
Name: zinc finger protein 938
Synonyms: B230315N10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237411
Homologene: 135924
Mau2
Name: MAU2 sister chromatid cohesion factor
Synonyms: A930019L04Rik, 9130404D08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74549
Homologene: 12574
Or2z2
Name: olfactory receptor family 2 subfamily Z member 2
Synonyms: MTPCR07, MOR281-1, GA_x6K02T2NKPP-957001-957948, Olfr30
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18329
Homologene: 131139
Cutal
Name: cutA divalent cation tolerance homolog-like
Synonyms: D730039F16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77996
Homologene: 66286
Speer4f2
Name: spermatogenesis associated glutamate (E)-rich protein 4f2
Synonyms: Gm3535, Gm3495
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041749
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Prss53
Name: serine protease 53
Synonyms: BC039632
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330657
Homologene: 80097
Abra
Name: actin-binding Rho activating protein
Synonyms: C130068O12Rik, STARS
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223513
VEGA: 15
Homologene: 34713
Asb16
Name: ankyrin repeat and SOCS box-containing 16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217217
Homologene: 76813
Tagap
Name: T cell activation Rho GTPase activating protein
Synonyms: tcs-1, Tcd-1, tcs1, TRD, Tcd1, Tcd1a
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72536
Homologene: 44943
Cops9
Name: COP9 signalosome subunit 9
Synonyms: 1110002M09Rik, Myeov2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66915
Homologene: 82250
Gm6902
Name: predicted gene 6902
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628664
Homologene: 128656
Gm17027
Name: predicted gene 17027
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102637812
Homologene: 128452
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 30,805,023 bp
  • C to A, chromosome 1 at 46,649,340 bp
  • A to G, chromosome 1 at 46,649,351 bp
  • C to T, chromosome 1 at 92,640,414 bp
  • C to T, chromosome 1 at 97,125,711 bp
  • C to T, chromosome 2 at 34,885,921 bp
  • T to C, chromosome 2 at 82,967,817 bp
  • G to T, chromosome 2 at 110,305,569 bp
  • T to G, chromosome 2 at 127,432,435 bp
  • A to T, chromosome 2 at 181,997,476 bp
  • T to C, chromosome 3 at 37,642,722 bp
  • T to C, chromosome 4 at 48,205,130 bp
  • C to A, chromosome 4 at 139,473,624 bp
  • A to G, chromosome 5 at 17,375,769 bp
  • A to G, chromosome 5 at 63,725,184 bp
  • A to G, chromosome 6 at 24,562,633 bp
  • A to T, chromosome 6 at 115,631,341 bp
  • T to G, chromosome 7 at 23,273,734 bp
  • T to A, chromosome 7 at 26,371,322 bp
  • T to C, chromosome 7 at 27,748,726 bp
  • T to C, chromosome 7 at 45,556,076 bp
  • T to C, chromosome 7 at 105,337,707 bp
  • T to G, chromosome 7 at 127,886,575 bp
  • G to T, chromosome 8 at 70,031,516 bp
  • T to C, chromosome 9 at 16,376,742 bp
  • A to G, chromosome 9 at 39,484,752 bp
  • T to G, chromosome 9 at 75,010,150 bp
  • T to C, chromosome 9 at 90,191,937 bp
  • A to G, chromosome 10 at 70,569,013 bp
  • CCC to CCCC, chromosome 10 at 81,178,768 bp
  • A to T, chromosome 10 at 82,225,398 bp
  • A to C, chromosome 10 at 100,518,531 bp
  • T to G, chromosome 10 at 123,038,480 bp
  • T to C, chromosome 11 at 32,415,978 bp
  • A to T, chromosome 11 at 58,455,568 bp
  • G to T, chromosome 11 at 70,023,953 bp
  • A to T, chromosome 11 at 83,759,365 bp
  • A to T, chromosome 11 at 102,269,037 bp
  • C to T, chromosome 11 at 106,757,711 bp
  • A to T, chromosome 12 at 105,812,307 bp
  • A to G, chromosome 13 at 11,595,643 bp
  • A to T, chromosome 13 at 65,066,785 bp
  • G to C, chromosome 13 at 93,098,025 bp
  • A to G, chromosome 14 at 20,531,026 bp
  • T to C, chromosome 14 at 42,159,279 bp
  • A to T, chromosome 14 at 70,490,618 bp
  • A to T, chromosome 15 at 23,436,534 bp
  • G to A, chromosome 15 at 41,869,233 bp
  • T to C, chromosome 15 at 99,470,815 bp
  • A to T, chromosome 16 at 49,017,466 bp
  • T to C, chromosome 17 at 7,933,714 bp
  • T to A, chromosome 17 at 22,601,179 bp
  • A to T, chromosome 18 at 36,600,783 bp
  • G to A, chromosome 19 at 3,807,295 bp
  • T to A, chromosome 19 at 29,288,710 bp
  • T to A, chromosome 19 at 43,812,502 bp
  • G to A, chromosome 19 at 45,049,915 bp
  • T to C, chromosome 19 at 46,367,866 bp
  • A to G, chromosome 19 at 46,372,265 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6649 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044770-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.