Strain Name:
C57BL/6J-MtgxR6653Btlr/Mmmh
Stock Number:
044774-MU
Citation ID:
RRID:MMRRC_044774-MU
Other Names:
R6653 (G1)
Major Collection:

Strain Information

Ubn2
Name: ubinuclein 2
Synonyms: D130059P03Rik, 2900060J04Rik, 6030408G03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320538
Homologene: 45564
Jak2
Name: Janus kinase 2
Synonyms: C81284
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16452
VEGA: 19
HGNC: HGNC:6192
Homologene: 21033
Gpr26
Name: G protein-coupled receptor 26
Synonyms: 9630036A11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233919
HGNC: HGNC:4481
Homologene: 17764
Dlg4
Name: discs large MAGUK scaffold protein 4
Synonyms: Dlgh4, SAP90A, PSD95, PSD-95, SAP90
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13385
HGNC: HGNC:2903
Homologene: 1047
Phf3
Name: PHD finger protein 3
Synonyms: AU020177, 2310061N19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Usp25
Name: ubiquitin specific peptidase 25
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 30940
VEGA: 16
Homologene: 8374
Erp44
Name: endoplasmic reticulum protein 44
Synonyms: Txndc4, 1110001E24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76299
Homologene: 12638
Csde1
Name: cold shock domain containing E1, RNA binding
Synonyms: D3Jfr1, unr
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229663
Homologene: 5179
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Wdr11, 2810004D21Rik, 4632404O06Rik, Ndrp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83946
Homologene: 41209
Rps6ka5
Name: ribosomal protein S6 kinase, polypeptide 5
Synonyms: MSK1, 6330404E13Rik, 3110005L17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73086
VEGA: 12
Homologene: 48302
Bcdin3d
Name: BCDIN3 domain containing
Synonyms: 4930556P03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75284
VEGA: 15
Homologene: 12594
Spry1
Name: sprouty RTK signaling antagonist 1
Synonyms: sprouty 1, sprouty1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 24063
Homologene: 4266
Bmp1
Name: bone morphogenetic protein 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12153
VEGA: 14
HGNC: HGNC:1067
Homologene: 55955
Wnt2b
Name: wingless-type MMTV integration site family, member 2B
Synonyms: Wnt13
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22414
Homologene: 22526
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, D930005K06Rik, Zubr1, p600, 1810009A16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Chsy1
Name: chondroitin sulfate synthase 1
Synonyms: skt
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269941
Homologene: 8950
Zfp60
Name: zinc finger protein 60
Synonyms: 6330516O17Rik, Mfg-3, Mfg3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22718
Homologene: 137228
Heatr6
Name: HEAT repeat containing 6
Synonyms: 2700008B19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217026
Homologene: 11116
Qser1
Name: glutamine and serine rich 1
Synonyms: 4732486I23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99003
Homologene: 11710
Sfxn3
Name: sideroflexin 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 94280
VEGA: 19
Homologene: 23394
Myo7a
Name: myosin VIIA
Synonyms: nmf371, polka, Myo7, Hdb, USH1B
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17921
HGNC: HGNC:7606
Homologene: 219
Hephl1
Name: hephaestin-like 1
Synonyms: zyklopen, thd, LOC244698, cw, Zp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244698
Homologene: 9112
Cfap53
Name: cilia and flagella associated protein 53
Synonyms: Ccdc11, 4933415I03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74453
Homologene: 27056
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Nlrp9c
Name: NLR family, pyrin domain containing 9C
Synonyms: Nalp-zeta, Nalp9c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330490
Homologene: 116072
Kif1a
Name: kinesin family member 1A
Synonyms: ATSV, N-3 kinesin, Kns1, LOC381283, C630002N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16560
HGNC: HGNC:888
Homologene: 99729
Abca15
Name: ATP-binding cassette, sub-family A member 15
Synonyms: 4930500I12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320631
Homologene: 87255
Specc1
Name: sperm antigen with calponin homology and coiled-coil domains 1
Synonyms: Cytsb, 2810012G08Rik, B230396K10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432572
Homologene: 45157
Ankrd50
Name: ankyrin repeat domain 50
Synonyms: E430012K20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99696
Homologene: 129859
Ros1
Name: Ros1 proto-oncogene
Synonyms: Ros-1, c-ros
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19886
Homologene: 2207
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 9130019P20Rik, 4933432B13Rik, A530027J04Rik, 1110004O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 108857
Homologene: 87006
Mfsd13a
Name: major facilitator superfamily domain containing 13a
Synonyms: 4930538D17Rik, Tmem180, 4930449A08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75146
Homologene: 12592
Cdh4
Name: cadherin 4
Synonyms: R-Cadh, Rcad, R-cadherin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12561
HGNC: HGNC:1763
Homologene: 48044
Klhdc7b
Name: kelch domain containing 7B
Synonyms: EG546648
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 546648
Homologene: 34707
Asb15
Name: ankyrin repeat and SOCS box-containing 15
Synonyms: 4930400E23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78910
Homologene: 43797
Abcc2
Name: ATP-binding cassette, sub-family member 2
Synonyms: multidrug resistance protein 2, Mrp2, Cmoat
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12780
HGNC: HGNC:53
Homologene: 68052
Or8g20
Name: olfactory receptor family 8 subfamily G member 20
Synonyms: IB3, Olfr44, MOR171-5, GA_x6K02T2PVTD-33181773-33180838
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18343
VEGA: 9
HGNC: HGNC:8484
Homologene: 133633
Plxnc1
Name: plexin C1
Synonyms: 2510048K12Rik, CD232, vespr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54712
HGNC: HGNC:9106
Homologene: 4211
Vmn2r112
Name: vomeronasal 2, receptor 112
Synonyms: EG628185
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 628185
Homologene: 86604
Eif2b4
Name: eukaryotic translation initiation factor 2B, subunit 4 delta
Synonyms: Eif2b
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13667
HGNC: HGNC:3260
Homologene: 5976
Tmem44
Name: transmembrane protein 44
Synonyms: 1700007N03Rik, 9330161C17Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224090
Homologene: 26702
Glb1l3
Name: galactosidase, beta 1 like 3
Synonyms: 4921509F24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70893
Homologene: 72240
Or2z2
Name: olfactory receptor family 2 subfamily Z member 2
Synonyms: Olfr30, MTPCR07, GA_x6K02T2NKPP-957001-957948, MOR281-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18329
Homologene: 131139
Kbtbd4
Name: kelch repeat and BTB (POZ) domain containing 4
Synonyms: 2510026C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67136
Homologene: 32320
Or4e5
Name: olfactory receptor family 4 subfamily E member 5
Synonyms: MOR244-1, GA_x6K02T2RJGY-491851-492792, MOR28, Olfr1507
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57269
HGNC: HGNC:8296
Homologene: 10736
B4galnt2
Name: beta-1,4-N-acetyl-galactosaminyl transferase 2
Synonyms: Dlb1, Dlb-1, Galgt2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14422
Homologene: 7329
Cutal
Name: cutA divalent cation tolerance homolog-like
Synonyms: D730039F16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77996
Homologene: 66286
Cts7
Name: cathepsin 7
Synonyms: CTS1, Epcs71, Epcs24
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56092
VEGA: 13
Homologene: 75110
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Fcamr
Name: Fc receptor, IgA, IgM, high affinity
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 64435
Homologene: 12929
Nkx2-4
Name: NK2 homeobox 4
Synonyms: 1700001P03Rik, Nkx-2.4, tinman
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228731
HGNC: HGNC:7837
Homologene: 41526
Tagap
Name: T cell activation Rho GTPase activating protein
Synonyms: Tcd-1, tcs1, TRD, Tcd1, Tcd1a, tcs-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72536
Homologene: 44943
Pcdha7
Name: protocadherin alpha 7
Synonyms: Crnr4, Cnr4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12939
HGNC: HGNC:8673
Homologene: 117962
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 30,805,023 bp
  • C to A, chromosome 1 at 46,649,340 bp
  • A to G, chromosome 1 at 46,649,351 bp
  • A to T, chromosome 1 at 93,077,698 bp
  • A to G, chromosome 1 at 130,813,202 bp
  • C to T, chromosome 2 at 34,885,921 bp
  • T to A, chromosome 2 at 90,909,769 bp
  • A to G, chromosome 2 at 104,780,260 bp
  • G to T, chromosome 2 at 147,083,940 bp
  • C to T, chromosome 2 at 179,780,428 bp
  • T to C, chromosome 3 at 37,642,722 bp
  • T to A, chromosome 3 at 38,457,361 bp
  • C to A, chromosome 3 at 103,052,868 bp
  • C to A, chromosome 3 at 104,953,186 bp
  • T to C, chromosome 4 at 48,205,130 bp
  • C to A, chromosome 4 at 139,473,624 bp
  • C to T, chromosome 5 at 31,192,207 bp
  • A to G, chromosome 6 at 24,562,633 bp
  • A to G, chromosome 6 at 38,434,462 bp
  • T to A, chromosome 7 at 26,371,322 bp
  • T to C, chromosome 7 at 27,748,726 bp
  • A to G, chromosome 7 at 66,110,193 bp
  • T to A, chromosome 7 at 98,054,503 bp
  • T to G, chromosome 7 at 120,346,006 bp
  • T to C, chromosome 7 at 131,984,101 bp
  • C to T, chromosome 9 at 15,081,964 bp
  • T to C, chromosome 9 at 26,859,588 bp
  • A to G, chromosome 9 at 39,484,752 bp
  • C to A, chromosome 9 at 82,900,741 bp
  • G to T, chromosome 10 at 52,142,203 bp
  • C to A, chromosome 10 at 94,943,876 bp
  • A to T, chromosome 11 at 58,455,568 bp
  • T to G, chromosome 11 at 62,146,418 bp
  • G to T, chromosome 11 at 70,023,953 bp
  • A to T, chromosome 11 at 83,759,365 bp
  • T to A, chromosome 11 at 95,891,921 bp
  • A to G, chromosome 12 at 100,551,536 bp
  • A to T, chromosome 13 at 61,355,003 bp
  • C to T, chromosome 13 at 100,152,136 bp
  • T to G, chromosome 13 at 100,161,844 bp
  • C to T, chromosome 14 at 52,490,793 bp
  • A to T, chromosome 14 at 70,490,618 bp
  • A to G, chromosome 15 at 89,387,089 bp
  • T to C, chromosome 15 at 99,470,815 bp
  • T to C, chromosome 16 at 30,537,551 bp
  • T to A, chromosome 16 at 77,059,288 bp
  • T to C, chromosome 17 at 7,933,714 bp
  • T to A, chromosome 17 at 22,601,179 bp
  • A to T, chromosome 18 at 36,600,783 bp
  • A to G, chromosome 18 at 36,974,486 bp
  • A to G, chromosome 18 at 74,300,209 bp
  • T to A, chromosome 19 at 29,288,710 bp
  • T to A, chromosome 19 at 43,812,502 bp
  • G to A, chromosome 19 at 45,049,915 bp
  • T to C, chromosome 19 at 46,367,866 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6653 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044774-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.