Strain Name:
C57BL/6J-MtgxR6662Btlr/Mmmh
Stock Number:
044782-MU
Citation ID:
RRID:MMRRC_044782-MU
Other Names:
R6662 (G1)
Major Collection:

Strain Information

Ubl3
Name: ubiquitin-like 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 24109
Homologene: 5153
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Dph5
Name: diphthamide biosynthesis 5
Synonyms: 2410012M04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69740
Homologene: 6471
Ccdc14
Name: coiled-coil domain containing 14
Synonyms: G630039H03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239839
VEGA: 16
Homologene: 32549
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Garem1
Name: GRB2 associated regulator of MAPK1 subtype 1
Synonyms: LOC381126, Fam59a, Garem
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 381126
VEGA: 18
Homologene: 11237
Trio
Name: triple functional domain (PTPRF interacting)
Synonyms: 6720464I07Rik, Solo
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223435
VEGA: 15
Homologene: 20847
Kcnh5
Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238271
VEGA: 12
HGNC: HGNC:6254
Homologene: 15858
Itih5
Name: inter-alpha-trypsin inhibitor, heavy chain 5
Synonyms: 5430408M01Rik, 4631408O11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209378
Homologene: 57115
Neto2
Name: neuropilin (NRP) and tolloid (TLL)-like 2
Synonyms: 5530601C23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74513
Homologene: 32387
Moxd1
Name: monooxygenase, DBH-like 1
Synonyms: 3230402N08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 59012
Homologene: 22904
Grm2
Name: glutamate receptor, metabotropic 2
Synonyms: 4930441L02Rik, Gprc1b, mGluR2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 108068
HGNC: HGNC:4594
Homologene: 20229
Pde4b
Name: phosphodiesterase 4B, cAMP specific
Synonyms: dunce, Dpde4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18578
HGNC: HGNC:8781
Homologene: 1953
Omp
Name: olfactory marker protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18378
HGNC: HGNC:8136
Homologene: 36195
Casp6
Name: caspase 6
Synonyms: Mch2, mCASP-6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12368
HGNC: HGNC:1507
Homologene: 37455
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Uckl1
Name: uridine-cytidine kinase 1-like 1
Synonyms: Urkl1, 1110007H10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68556
Homologene: 101414
Slco1a6
Name: solute carrier organic anion transporter family, member 1a6
Synonyms: organic anion-transporting polypeptide, Oatp-5, Slc21a13, 4930422F19Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28254
Homologene: 23416
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Catsperg2
Name: cation channel sperm associated auxiliary subunit gamma 2
Synonyms: 1700067C01Rik, CATSPERG
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76718
Homologene: 10915
BC034090
Name: cDNA sequence BC034090
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 207792
Homologene: 19490
Aox3
Name: aldehyde oxidase 3
Synonyms: 1200011D03Rik, AOH1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71724
Homologene: 90899
Ablim1
Name: actin-binding LIM protein 1
Synonyms: abLIM-S, 9330196J19Rik, 2210411C18Rik, abLIM-L, abLIM-M, 4833406P10Rik, Limab1, 2610209L21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226251
HGNC: HGNC:78
Homologene: 40994
Mybpc2
Name: myosin binding protein C, fast-type
Synonyms: Fast-type C-protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233199
HGNC: HGNC:7550
Homologene: 3331
Cfap45
Name: cilia and flagella associated protein 45
Synonyms: Ccdc19, 1700028D05Rik, Nesg1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71870
Homologene: 71837
Zfp983
Name: zinc finger protein 983
Synonyms: 3110052M02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73229
VEGA: 17
Tchp
Name: trichoplein, keratin filament binding
Synonyms: A930031F18Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77832
Homologene: 12686
Rassf9
Name: Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
Synonyms: Pamci
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237504
Homologene: 3976
Ces1b
Name: carboxylesterase 1B
Synonyms: Gm5158
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382044
HGNC: HGNC:1863
Homologene: 117484
Slc26a3
Name: solute carrier family 26, member 3
Synonyms: 9130013M11Rik, Dra, 9030623B18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13487
HGNC: HGNC:3018
Homologene: 55435
Aldh3a1
Name: aldehyde dehydrogenase family 3, subfamily A1
Synonyms: Aldh, Ahd4, Aldh3, Ahd-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11670
HGNC: HGNC:405
Homologene: 20175
Trdn
Name: triadin
Synonyms: triadin-1, EG432451, triadin 3, triadin 1, 2310045H21Rik, triadin-2, triadin-3, triadin 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76757
VEGA: 10
Homologene: 38137
Prss33
Name: serine protease 33
Synonyms: tryptase-6, mT6, Eos
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 353130
Homologene: 77185
Mgat5
Name: mannoside acetylglucosaminyltransferase 5
Synonyms: GlcNAc-TV, beta1,6N-acetylglucosaminyltransferase V, 4930471A21Rik, 5330407H02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107895
HGNC: HGNC:7049
Homologene: 1808
Acox1
Name: acyl-Coenzyme A oxidase 1, palmitoyl
Synonyms: AOX, D130055E20Rik, Acyl-CoA oxidase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11430
HGNC: HGNC:119
Homologene: 38299
Akr1b1
Name: aldo-keto reductase family 1 member B
Synonyms: Aldr1, Aldor1, Akr1b3, ALR2, Ahr-1, AR, Ahr1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11677
HGNC: HGNC:381
Homologene: 133743
Oxsm
Name: 3-oxoacyl-ACP synthase, mitochondrial
Synonyms: 4933425A18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71147
Homologene: 5820
Zfp786
Name: zinc finger protein 786
Synonyms: A730012O14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330301
Homologene: 51849
D730048I06Rik
Name: RIKEN cDNA D730048I06 gene
Synonyms:
Type: Gene
Species: Mouse
Chromosome: 9
Ncs1
Name: neuronal calcium sensor 1
Synonyms: 9430075O15Rik, Freq, NCS-1, A730032G13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14299
HGNC: HGNC:3953
Homologene: 5719
Il1rn
Name: interleukin 1 receptor antagonist
Synonyms: IL-1ra, F630041P17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16181
HGNC: HGNC:6000
Homologene: 11163
Ifit3b
Name: interferon-induced protein with tetratricopeptide repeats 3B
Synonyms: I830012O16Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667370
HGNC: HGNC:5411
Homologene: 1189
Tas2r107
Name: taste receptor, type 2, member 107
Synonyms: STC 5-1, mt2r43, T2R4, T2R07, Tas2r7, mGR06
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387342
Homologene: 137369
Bad
Name: BCL2-associated agonist of cell death
Synonyms: Bbc2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12015
HGNC: HGNC:936
Homologene: 3189
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 58,118,615 bp
  • C to A, chromosome 1 at 127,469,237 bp
  • G to T, chromosome 1 at 155,226,339 bp
  • T to C, chromosome 1 at 172,529,850 bp
  • A to T, chromosome 2 at 10,249,181 bp
  • A to T, chromosome 2 at 24,336,875 bp
  • A to T, chromosome 2 at 29,158,114 bp
  • T to A, chromosome 2 at 31,287,360 bp
  • C to T, chromosome 2 at 76,755,898 bp
  • G to A, chromosome 2 at 150,266,252 bp
  • A to G, chromosome 2 at 181,573,260 bp
  • G to T, chromosome 3 at 38,956,821 bp
  • G to A, chromosome 3 at 115,928,556 bp
  • A to G, chromosome 3 at 129,912,226 bp
  • A to G, chromosome 4 at 102,601,898 bp
  • A to T, chromosome 4 at 144,273,105 bp
  • A to G, chromosome 5 at 114,720,015 bp
  • A to T, chromosome 5 at 148,509,306 bp
  • C to T, chromosome 6 at 34,310,004 bp
  • T to C, chromosome 6 at 47,826,986 bp
  • A to T, chromosome 6 at 131,659,489 bp
  • G to A, chromosome 6 at 142,133,215 bp
  • G to A, chromosome 7 at 29,719,513 bp
  • A to G, chromosome 7 at 44,506,166 bp
  • A to G, chromosome 7 at 98,145,339 bp
  • A to T, chromosome 8 at 85,663,215 bp
  • A to G, chromosome 8 at 93,064,069 bp
  • C to A, chromosome 9 at 35,790,000 bp
  • C to T, chromosome 9 at 106,648,053 bp
  • A to G, chromosome 10 at 5,128,416 bp
  • A to C, chromosome 10 at 24,284,760 bp
  • A to T, chromosome 10 at 33,474,487 bp
  • T to A, chromosome 10 at 102,546,038 bp
  • G to A, chromosome 11 at 61,214,655 bp
  • A to G, chromosome 11 at 116,175,323 bp
  • A to T, chromosome 12 at 31,457,346 bp
  • C to A, chromosome 12 at 75,007,611 bp
  • A to G, chromosome 14 at 16,242,287 bp
  • G to T, chromosome 15 at 27,854,996 bp
  • T to C, chromosome 16 at 34,690,794 bp
  • T to C, chromosome 17 at 21,662,085 bp
  • T to C, chromosome 17 at 23,833,960 bp
  • T to C, chromosome 18 at 21,148,247 bp
  • T to A, chromosome 19 at 6,951,070 bp
  • A to G, chromosome 19 at 34,611,937 bp
  • A to G, chromosome 19 at 57,073,853 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6662 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044782-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.