Strain Name:
C57BL/6J-MtgxR6664Btlr/Mmmh
Stock Number:
044784-MU
Citation ID:
RRID:MMRRC_044784-MU
Other Names:
R6664 (G1)
Major Collection:

Strain Information

Fgb
Name: fibrinogen beta chain
Synonyms: 2510049G14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 110135
HGNC: HGNC:3662
Homologene: 3772
Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Synonyms: p110beta, 1110001J02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74769
HGNC: HGNC:8976
Homologene: 21250
Gatad2a
Name: GATA zinc finger domain containing 2A
Synonyms: 1110066C11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234366
Homologene: 9766
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 9030227G01Rik, 2510002A14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Tango6
Name: transport and golgi organization 6
Synonyms: Tmco7, Tango6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 272538
Homologene: 52121
Ccdc18
Name: coiled-coil domain containing 18
Synonyms: 1700021E15Rik, 4932411G06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73254
Homologene: 35455
Dcaf13
Name: DDB1 and CUL4 associated factor 13
Synonyms: LOC223499, Wdsof1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223499
Homologene: 6430
Fbxo45
Name: F-box protein 45
Synonyms: 2610017J04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268882
Homologene: 14713
Ifitm7
Name: interferon induced transmembrane protein 7
Synonyms: Mil4, 4933438K12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74482
HGNC: HGNC:5414
Ripor2
Name: RHO family interacting cell polarization regulator 2
Synonyms: Fam65b, 6330500D04Rik, 1700108N18Rik, E430013J17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 193385
Homologene: 9284
AU040320
Name: expressed sequence AU040320
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100317
Homologene: 11764
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230676
Homologene: 49413
Nr4a3
Name: nuclear receptor subfamily 4, group A, member 3
Synonyms: Nor1, MINOR, NOR-1, TEC
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18124
HGNC: HGNC:7982
Homologene: 5074
Cyp4f18
Name: cytochrome P450, family 4, subfamily f, polypeptide 18
Synonyms: 1810054N16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72054
Homologene: 128623
Magi2
Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
Synonyms: S-SCAM, Acvrinp1, Magi-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 50791
Homologene: 8189
Fbxw16
Name: F-box and WD-40 domain protein 16
Synonyms: 7420402K12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320083
Homologene: 110776
Auh
Name: AU RNA binding protein/enoyl-coenzyme A hydratase
Synonyms: W91705
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11992
HGNC: HGNC:890
Homologene: 1284
Vmn2r111
Name: vomeronasal 2, receptor 111
Synonyms: EG210876
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210876
Homologene: 86604
Jmjd4
Name: jumonji domain containing 4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 194952
Homologene: 11306
Btn1a1
Name: butyrophilin, subfamily 1, member A1
Synonyms: Btn
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12231
HGNC: HGNC:1135
Homologene: 1312
Sik2
Name: salt inducible kinase 2
Synonyms: Snf1lk2, G630080D20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235344
Homologene: 22875
Or1j12
Name: olfactory receptor family 1 subfamily J member 12
Synonyms: Olfr340, MOR136-1, GA_x6K02T2NLDC-33147742-33148680
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258953
Homologene: 74159
Itih1
Name: inter-alpha trypsin inhibitor, heavy chain 1
Synonyms: Intin1, Itih-1, inter-alpha (globulin) inhibitor, H1 polypeptide
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16424
HGNC: HGNC:6166
Homologene: 1667
Map3k21
Name: mitogen-activated protein kinase kinase kinase 21
Synonyms: BC021891
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234878
Homologene: 32778
Bmp2k
Name: BMP2 inducible kinase
Synonyms: 4933417M22Rik, BIKE
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 140780
Homologene: 34134
Zfp945
Name: zinc finger protein 945
Synonyms: C730040L01Rik, A630033E08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240041
Homologene: 133214
Aadacl4fm5
Name: AADACL4 family member 5
Synonyms: Gm438, LOC329993
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329993
Homologene: 135765
Or52e5
Name: olfactory receptor family 52 subfamily E member 5
Synonyms: MOR32-5, GA_x6K02T2PBJ9-7698491-7699432, Olfr678
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258753
Homologene: 27254
Prl3a1
Name: prolactin family 3, subfamily a, member 1
Synonyms: 1600016E11Rik, PLP-I, Plpi, Prlpi, PLP-H
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67000
Homologene: 49844
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 2 at 36,453,098 bp
  • A to T, chromosome 3 at 83,046,759 bp
  • G to A, chromosome 4 at 48,056,006 bp
  • G to A, chromosome 4 at 118,391,745 bp
  • A to T, chromosome 4 at 126,835,650 bp
  • T to C, chromosome 4 at 144,777,399 bp
  • C to T, chromosome 5 at 20,702,397 bp
  • A to G, chromosome 5 at 73,132,481 bp
  • A to T, chromosome 5 at 97,088,130 bp
  • C to T, chromosome 5 at 108,168,100 bp
  • T to A, chromosome 7 at 105,070,188 bp
  • A to G, chromosome 8 at 69,917,489 bp
  • A to T, chromosome 8 at 71,989,915 bp
  • T to A, chromosome 8 at 106,742,114 bp
  • A to G, chromosome 8 at 125,941,871 bp
  • T to C, chromosome 9 at 50,935,457 bp
  • T to C, chromosome 9 at 99,094,538 bp
  • T to C, chromosome 9 at 109,438,258 bp
  • T to C, chromosome 11 at 59,450,419 bp
  • A to G, chromosome 13 at 23,459,320 bp
  • A to T, chromosome 13 at 24,675,820 bp
  • C to A, chromosome 13 at 27,270,211 bp
  • G to C, chromosome 13 at 52,898,667 bp
  • T to C, chromosome 14 at 30,933,436 bp
  • T to C, chromosome 15 at 39,118,888 bp
  • T to C, chromosome 16 at 13,983,749 bp
  • T to C, chromosome 16 at 32,238,416 bp
  • T to C, chromosome 17 at 22,559,051 bp
  • A to G, chromosome 17 at 22,852,365 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6664 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044784-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.