Strain Name:
C57BL/6J-MtgxR6681Btlr/Mmmh
Stock Number:
044800-MU
Citation ID:
RRID:MMRRC_044800-MU
Other Names:
R6681 (G1)
Major Collection:

Strain Information

Rest
Name: RE1-silencing transcription factor
Synonyms: 2610008J04Rik, NRSF
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19712
HGNC: HGNC:9966
Homologene: 4099
Otx1
Name: orthodenticle homeobox 1
Synonyms: jv, A730044F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Kdm5b
Name: lysine demethylase 5B
Synonyms: Rb-Bp2, 2210016I17Rik, Jarid1b, 2010009J12Rik, D1Ertd202e, Plu1, PLU-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75605
Homologene: 48448
Fam53a
Name: family with sequence similarity 53, member A
Synonyms: 5430419M09Rik, DNTNP, 2410018C17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74504
Homologene: 18660
Ttc39b
Name: tetratricopeptide repeat domain 39B
Synonyms: 1810054D07Rik, 9130422G05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69863
Homologene: 25228
Dennd2c
Name: DENN domain containing 2C
Synonyms: A930010I20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329727
Homologene: 19542
Slc30a6
Name: solute carrier family 30 (zinc transporter), member 6
Synonyms: ZnT6, ZnT-6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210148
VEGA: 17
Homologene: 32380
Rttn
Name: rotatin
Synonyms: 4921538A15Rik, C530033I08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 246102
VEGA: 18
Homologene: 65275
Fh1
Name: fumarate hydratase 1
Synonyms: fumarase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14194
HGNC: HGNC:3700
Homologene: 115
Scp2
Name: sterol carrier protein 2, liver
Synonyms: SCPx, SCP-2, ns-LTP, NSL-TP, nonspecific lipid transfer protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20280
Homologene: 37717
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Cuzd1
Name: CUB and zona pellucida-like domains 1
Synonyms: UO-44, Itmap1, UTCZP, ERG-1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16433
Homologene: 7389
Trpv5
Name: transient receptor potential cation channel, subfamily V, member 5
Synonyms: CaT2, ECaC1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194352
HGNC: HGNC:3145
Homologene: 10520
Hmgcll1
Name: 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208982
Homologene: 27863
Abca4
Name: ATP-binding cassette, sub-family A member 4
Synonyms: Rim protein, RmP, D430003I15Rik, Abc10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11304
HGNC: HGNC:34
Homologene: 298
Mrps30
Name: mitochondrial ribosomal protein S30
Synonyms: 2610020A16Rik, Pdcd9
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 59054
HGNC: HGNC:8769
Homologene: 9607
Scn9a
Name: sodium channel, voltage-gated, type IX, alpha
Synonyms: PN1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20274
Homologene: 2237
Myh2
Name: myosin, heavy polypeptide 2, skeletal muscle, adult
Synonyms: Myhs-f, MyHC-IIa, MHC2A, Myhsf1, Myhs-f1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17882
HGNC: HGNC:7572
Homologene: 23019
Or5j1
Name: olfactory receptor family 5 subfamily J member 1
Synonyms: GA_x6K02T2Q125-48541463-48540525, MOR172-8_p, Olfr1106, MOR172-6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258747
Homologene: 27251
Tmc5
Name: transmembrane channel-like gene family 5
Synonyms: 4932443L08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74424
Homologene: 11713
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Or5b98
Name: olfactory receptor family 5 subfamily B member 98
Synonyms: Olfr1450, GA_x6K02T2RE5P-3283121-3284098, MOR202-33
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258368
Vmn1r45
Name: vomeronasal 1 receptor 45
Synonyms: V1ra2, V1r2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22297
Homologene: 130651
Mamdc4
Name: MAM domain containing 4
Synonyms: LOC381352
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381352
Homologene: 17102
Tmprss11c
Name: transmembrane protease, serine 11c
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 435845
Homologene: 78847
Sgsm2
Name: small G protein signaling modulator 2
Synonyms: D630003G22Rik, Rutbc1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 97761
Homologene: 14780
Or10j3b
Name: olfactory receptor family 10 subfamily J member 3B
Synonyms: MOR267-2, GA_x6K02T2R7CC-630397-629456, Olfr1404
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258881
Homologene: 133587
Kbtbd3
Name: kelch repeat and BTB (POZ) domain containing 3
Synonyms: 2200003A07Rik, Bklhd3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69149
Homologene: 12300
Sorcs2
Name: sortilin-related VPS10 domain containing receptor 2
Synonyms: VPS10 domain receptor protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81840
Homologene: 56899
Serpinb8
Name: serine (or cysteine) peptidase inhibitor, clade B, member 8
Synonyms: CAP-2, NK10, ovalbumin, Spi8, CAP2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20725
HGNC: HGNC:8952
Homologene: 74445
Ttll6
Name: tubulin tyrosine ligase-like family, member 6
Synonyms: D11Moh44e, 4932418K24Rik, D11Moh43e, t8130b59
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237930
Homologene: 18229
Pira13
Name: paired-Ig-like receptor A13
Synonyms: ENSMUSG00000074419, Gm15448
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100041146
Homologene: 134028
Ccdc62
Name: coiled-coil domain containing 62
Synonyms: G1-485-3, repro29, LOC208908
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208908
Homologene: 82466
Sec61a2
Name: SEC61 translocon subunit alpha 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57743
Homologene: 38481
Dpp4
Name: dipeptidylpeptidase 4
Synonyms: Dpp-4, THAM, Cd26
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13482
HGNC: HGNC:3009
Homologene: 3279
Slfn5
Name: schlafen 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327978
Homologene: 18839
Vezt
Name: vezatin, adherens junctions transmembrane protein
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215008
Homologene: 9739
Catsperb
Name: cation channel sperm associated auxiliary subunit beta
Synonyms: 4932415G16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 271036
VEGA: 12
Homologene: 81904
Dcun1d1
Name: defective in cullin neddylation 1 domain containing 1
Synonyms: Rp42, pTes3, DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae), SCCRO, Tes3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 114893
Homologene: 10773
Zfp865
Name: zinc finger protein 865
Synonyms: 6430526N21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319748
Homologene: 19652
Pus7l
Name: pseudouridylate synthase 7-like
Synonyms: 3000003F02Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78895
Homologene: 12842
Slc26a10
Name: solute carrier family 26, member 10
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216441
VEGA: 10
Homologene: 66953
Or8g54
Name: olfactory receptor family 8 subfamily G member 54
Synonyms: MOR171-7, Olfr969, GA_x6K02T2PVTD-33492981-33493916
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258823
VEGA: 9
Homologene: 121532
Ech1
Name: enoyl coenzyme A hydratase 1, peroxisomal
Synonyms: dienoyl-CoA isomerase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 51798
HGNC: HGNC:3149
Homologene: 1069
Gpatch11
Name: G patch domain containing 11
Synonyms: 2310002B06Rik, Ccdc75
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 53951
VEGA: 17
Homologene: 44687
Dnase1l1
Name: deoxyribonuclease 1-like 1
Synonyms: Dnl1ll, G4.8, Dnase1ll, 2310005K03Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 69537
HGNC: HGNC:2957
Homologene: 4896
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 53,521,226 bp
  • T to A, chromosome 1 at 107,597,591 bp
  • T to C, chromosome 1 at 134,613,269 bp
  • C to A, chromosome 1 at 173,216,406 bp
  • T to C, chromosome 1 at 175,619,124 bp
  • G to A, chromosome 2 at 5,876,408 bp
  • C to A, chromosome 2 at 25,567,744 bp
  • A to T, chromosome 2 at 62,348,549 bp
  • T to C, chromosome 2 at 66,563,342 bp
  • T to C, chromosome 2 at 87,048,598 bp
  • C to T, chromosome 3 at 35,895,670 bp
  • A to G, chromosome 3 at 103,131,661 bp
  • A to T, chromosome 3 at 122,121,798 bp
  • A to T, chromosome 4 at 83,240,048 bp
  • G to T, chromosome 4 at 108,091,316 bp
  • A to G, chromosome 5 at 33,607,840 bp
  • C to A, chromosome 5 at 36,397,810 bp
  • A to G, chromosome 5 at 77,280,997 bp
  • T to A, chromosome 5 at 86,289,260 bp
  • A to G, chromosome 5 at 123,934,093 bp
  • C to G, chromosome 6 at 41,653,354 bp
  • T to A, chromosome 6 at 89,934,003 bp
  • C to T, chromosome 6 at 121,838,724 bp
  • T to A, chromosome 7 at 3,822,252 bp
  • T to C, chromosome 7 at 5,029,451 bp
  • C to T, chromosome 7 at 28,830,338 bp
  • G to A, chromosome 7 at 118,669,304 bp
  • A to G, chromosome 7 at 131,311,683 bp
  • A to T, chromosome 9 at 4,330,687 bp
  • T to A, chromosome 9 at 39,795,414 bp
  • A to T, chromosome 9 at 76,081,449 bp
  • A to T, chromosome 10 at 81,720,888 bp
  • A to G, chromosome 10 at 93,996,997 bp
  • G to T, chromosome 10 at 127,173,661 bp
  • C to A, chromosome 11 at 21,997,037 bp
  • G to A, chromosome 11 at 67,178,348 bp
  • A to T, chromosome 11 at 74,865,378 bp
  • G to A, chromosome 11 at 82,956,378 bp
  • T to A, chromosome 11 at 96,138,863 bp
  • C to T, chromosome 12 at 101,624,735 bp
  • A to T, chromosome 13 at 118,380,598 bp
  • G to A, chromosome 15 at 94,527,865 bp
  • T to C, chromosome 17 at 74,404,032 bp
  • T to C, chromosome 17 at 78,840,099 bp
  • C to A, chromosome 18 at 89,014,611 bp
  • A to G, chromosome 19 at 12,954,459 bp
  • C to T, chromosome X at 74,277,038 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6681 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044800-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.