Strain Name:
C57BL/6J-MtgxR6687Btlr/Mmmh
Stock Number:
044805-MU
Citation ID:
RRID:MMRRC_044805-MU
Other Names:
R6687 (G1)
Major Collection:

Strain Information

Wnt3
Name: wingless-type MMTV integration site family, member 3
Synonyms: Int-4, Wnt-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22415
Homologene: 22527
Fam3c
Name: FAM3 metabolism regulating signaling molecule C
Synonyms: Fam3c, Ilei, D6Wsu176e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 27999
Homologene: 8926
Rpl38
Name: ribosomal protein L38
Synonyms: Tss, Ts, Rbt, 0610025G13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67671
Homologene: 87098
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: med, nmf335, mnd-2, nmf58, ataxia 3, nmf2, motor end-plate disease, NaCh6, mnd2, C630029C19Rik, seal, NMF335, Nav1.6, nur14
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20273
Homologene: 7927
Gpbp1
Name: GC-rich promoter binding protein 1
Synonyms: 1700034P14Rik, D230035M11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73274
Homologene: 11292
Larp1
Name: La ribonucleoprotein 1, translational regulator
Synonyms: Larp, 1810024J12Rik, 3110040D16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73158
Homologene: 9089
Phkb
Name: phosphorylase kinase beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102093
HGNC: HGNC:8927
Homologene: 247
Adgrl4
Name: adhesion G protein-coupled receptor L4
Synonyms: Eltd1, 1110033N21Rik, Etl, EGF-TM7 receptor
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 170757
Homologene: 11170
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Slco1a6
Name: solute carrier organic anion transporter family, member 1a6
Synonyms: 4930422F19Rik, Oatp-5, Slc21a13, organic anion-transporting polypeptide
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28254
Homologene: 23416
Col5a2
Name: collagen, type V, alpha 2
Synonyms: 1110014L14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12832
HGNC: HGNC:2210
Homologene: 20119
Sycp2
Name: synaptonemal complex protein 2
Synonyms: 3830402K23Rik, 4930518F03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320558
Homologene: 8604
Insr
Name: insulin receptor
Synonyms: IR-B, 4932439J01Rik, D630014A15Rik, IR, CD220, IR-A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16337
HGNC: HGNC:6091
Homologene: 20090
Wdr83
Name: WD repeat domain containing 83
Synonyms: Morg1, 1500041N16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67836
Homologene: 12194
Myo1c
Name: myosin IC
Synonyms: myosin-Ibeta, mm1beta, myr2, C80397
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17913
HGNC: HGNC:7597
Homologene: 32046
Rpap2
Name: RNA polymerase II associated protein 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231571
Homologene: 11733
AI661453
Name: expressed sequence AI661453
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224833
Homologene: 138294
Spag17
Name: sperm associated antigen 17
Synonyms: PF6, 4931427F14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74362
Homologene: 52601
Slc51a
Name: solute carrier family 51, alpha subunit
Synonyms: Osta, D630035O19Rik, OSTalpha
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106407
Homologene: 44941
Kcna2
Name: potassium voltage-gated channel, shaker-related subfamily, member 2
Synonyms: Mk-2, Akr6a4, Kca1-2, Kv1.2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16490
HGNC: HGNC:6220
Homologene: 21034
Dennd3
Name: DENN domain containing 3
Synonyms: E030003N15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105841
Homologene: 28254
Dlg5
Name: discs large MAGUK scaffold protein 5
Synonyms: 4933429D20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71228
HGNC: HGNC:2904
Homologene: 3486
Mettl18
Name: methyltransferase like 18
Synonyms: 2810422O20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69962
Homologene: 32680
Loxl3
Name: lysyl oxidase-like 3
Synonyms: Lor2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16950
Homologene: 56591
Lrrc8e
Name: leucine rich repeat containing 8 family, member E
Synonyms: 1810049O03Rik, C87354
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72267
Homologene: 11817
Cfd
Name: complement factor D
Synonyms: factor D, DF, D component (adipsin) of complement, Adn
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11537
VEGA: 10
HGNC: HGNC:2771
Homologene: 20453
Lrrc14b
Name: leucine rich repeat containing 14B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 432779
Homologene: 47758
Atp6ap1l
Name: ATPase, H+ transporting, lysosomal accessory protein 1-like
Synonyms: EG435376
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 435376
Homologene: 28130
Ttc12
Name: tetratricopeptide repeat domain 12
Synonyms: E330017O07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235330
Homologene: 32375
Or3a4
Name: olfactory receptor family 3 subfamily A member 4
Synonyms: GA_x6K02T2P1NL-4211516-4210581, MOR255-1, Olfr399
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259006
Homologene: 27325
Psmb5
Name: proteasome (prosome, macropain) subunit, beta type 5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19173
VEGA: 14
HGNC: HGNC:9542
Homologene: 55690
Mup12
Name: major urinary protein 12
Synonyms: Gm2024
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100039054
Homologene: 74304
Ighv9-3
Name: immunoglobulin heavy variable V9-3
Synonyms: ENSMUSG00000072803
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 780825
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 45,383,604 bp
  • A to G, chromosome 1 at 150,745,033 bp
  • A to G, chromosome 1 at 163,996,800 bp
  • C to T, chromosome 2 at 178,354,960 bp
  • C to A, chromosome 3 at 100,092,950 bp
  • C to A, chromosome 3 at 107,105,027 bp
  • T to C, chromosome 3 at 151,542,755 bp
  • T to C, chromosome 4 at 60,741,309 bp
  • T to C, chromosome 5 at 107,603,630 bp
  • G to C, chromosome 6 at 22,328,670 bp
  • A to T, chromosome 6 at 83,050,664 bp
  • T to C, chromosome 6 at 142,099,350 bp
  • C to T, chromosome 8 at 3,198,111 bp
  • A to G, chromosome 8 at 4,234,798 bp
  • C to T, chromosome 8 at 85,080,149 bp
  • T to C, chromosome 8 at 86,029,546 bp
  • A to G, chromosome 9 at 49,438,418 bp
  • G to A, chromosome 10 at 79,891,719 bp
  • A to G, chromosome 11 at 58,057,330 bp
  • C to A, chromosome 11 at 74,054,384 bp
  • T to C, chromosome 11 at 75,672,201 bp
  • G to T, chromosome 11 at 103,812,585 bp
  • T to C, chromosome 11 at 114,668,768 bp
  • G to A, chromosome 12 at 114,140,924 bp
  • T to C, chromosome 13 at 74,360,762 bp
  • A to G, chromosome 13 at 90,886,723 bp
  • T to C, chromosome 13 at 111,438,085 bp
  • C to T, chromosome 14 at 24,190,373 bp
  • C to A, chromosome 14 at 54,616,673 bp
  • G to A, chromosome 15 at 73,556,366 bp
  • T to C, chromosome 15 at 100,974,627 bp
  • A to T, chromosome 16 at 32,479,725 bp
  • A to G, chromosome 17 at 47,467,002 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6687 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044805-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.