Strain Name:
C57BL/6J-MtgxR6689Btlr/Mmmh
Stock Number:
044807-MU
Citation ID:
RRID:MMRRC_044807-MU
Other Names:
R6689 (G1)
Major Collection:

Strain Information

Ccn1
Name: cellular communication network factor 1
Synonyms: CCN1, Cyr61
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16007
HGNC: HGNC:2654
Homologene: 1194
Aurka
Name: aurora kinase A
Synonyms: Ark1, AIRK1, Ayk1, Stk6, IAK, aurora A, Aurora-A, IAK1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20878
Homologene: 2670
Lsm3
Name: LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Synonyms: SMX4, USS2, 1010001J12Rik, 2610005D18Rik, 6030401D18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67678
Homologene: 6548
Stim2
Name: stromal interaction molecule 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 116873
Homologene: 32490
Commd6
Name: COMM domain containing 6
Synonyms: 1700063H17Rik, 1110059J08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66200
Homologene: 52572
Mroh4
Name: maestro heat-like repeat family member 4
Synonyms: 1700016M24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69439
Homologene: 72545
Or8h10
Name: olfactory receptor family 8 subfamily H member 10
Synonyms: MOR206-4, GA_x6K02T2Q125-48465387-48464422, Olfr1100
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258587
Homologene: 34954
Kcna2
Name: potassium voltage-gated channel, shaker-related subfamily, member 2
Synonyms: Kca1-2, Kv1.2, Akr6a4, Mk-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16490
HGNC: HGNC:6220
Homologene: 21034
Lmln
Name: leishmanolysin-like (metallopeptidase M8 family)
Synonyms: 5330415H22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239833
Homologene: 13198
Ankk1
Name: ankyrin repeat and kinase domain containing 1
Synonyms: 9930020N01Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244859
VEGA: 9
Homologene: 18258
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
B4galnt4
Name: beta-1,4-N-acetyl-galactosaminyl transferase 4
Synonyms: LOC381951
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330671
Homologene: 27982
Spmip4
Name: sperm microtubule inner protein 4
Synonyms: 4921507P07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70821
Homologene: 69433
Or10c1
Name: olfactory receptor family 10 subfamily C member 1
Synonyms: Olfr95, GA_x6K02T2PSCP-1651760-1650822, MOR263-6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258506
HGNC: HGNC:8165
Homologene: 71990
Grem1
Name: gremlin 1, DAN family BMP antagonist
Synonyms: Grem, Cktsf1b1, gremlin, Drm
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 23892
HGNC: HGNC:2001
Homologene: 8022
Hp
Name: haptoglobin
Synonyms: HP-1, preHP2, zonulin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 15439
Homologene: 121756
Elobl
Name: elongin B-like
Synonyms: Gm15698, Tceb2l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217066
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 2 at 86,978,154 bp
  • T to C, chromosome 2 at 113,749,931 bp
  • A to G, chromosome 2 at 172,370,393 bp
  • C to A, chromosome 3 at 107,105,027 bp
  • T to A, chromosome 3 at 145,647,788 bp
  • G to A, chromosome 5 at 54,115,976 bp
  • A to G, chromosome 6 at 50,589,109 bp
  • GATATATA to GATATATATA, chromosome 6 at 91,519,635 bp
  • C to T, chromosome 7 at 141,067,984 bp
  • C to T, chromosome 8 at 109,575,720 bp
  • T to A, chromosome 9 at 49,420,476 bp
  • T to A, chromosome 10 at 115,466,608 bp
  • T to C, chromosome 11 at 88,965,093 bp
  • C to A, chromosome 14 at 101,640,459 bp
  • A to G, chromosome 15 at 74,612,003 bp
  • A to G, chromosome 16 at 33,104,782 bp
  • C to G, chromosome 17 at 37,211,157 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6689 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044807-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.