Strain Name:
C57BL/6J-MtgxR6692Btlr/Mmmh
Stock Number:
044810-MU
Citation ID:
RRID:MMRRC_044810-MU
Other Names:
R6692 (G1)
Major Collection:

Strain Information

Mov10
Name: Mov10 RISC complex RNA helicase
Synonyms: Mov-10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17454
HGNC: HGNC:7200
Homologene: 10365
Cep290
Name: centrosomal protein 290
Synonyms: b2b1752Clo, Nphp6, Kiaa, b2b1454Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216274
VEGA: 10
Homologene: 77213
Swap70
Name: SWA-70 protein
Synonyms: 70kDa
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20947
Homologene: 7557
Exoc2
Name: exocyst complex component 2
Synonyms: Gm29675, Sec5, Sec5l1, 2410030I24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66482
Homologene: 10122
G3bp1
Name: G3BP stress granule assembly factor 1
Synonyms: GAP SH3 binding protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 27041
Homologene: 38096
Nedd1
Name: neural precursor cell expressed, developmentally down-regulated gene 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17997
VEGA: 10
HGNC: HGNC:7723
Homologene: 7439
Zkscan5
Name: zinc finger with KRAB and SCAN domains 5
Synonyms: hKraba1, Zfp95
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22757
Homologene: 8734
Cenph
Name: centromere protein H
Synonyms: CENP-H, 2410018A12Rik, 1700021I11Rik, ENP, 2610042E16Rik, 2810046K12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26886
Homologene: 32519
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225115
Homologene: 25090
Ahcyl1
Name: S-adenosylhomocysteine hydrolase-like 1
Synonyms: DCAL, 1110034F20Rik, Ahcy-rs3, IRBIT
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229709
HGNC: HGNC:344
Homologene: 77353
Mphosph9
Name: M-phase phosphoprotein 9
Synonyms: MPP9, 4930548D04Rik, 9630025B04Rik, MPP-9, B930097C17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269702
HGNC: HGNC:7215
Homologene: 11256
Fam168b
Name: family with sequence similarity 168, member B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214469
Homologene: 18390
Ttn
Name: titin
Synonyms: 2310036G12Rik, 2310057K23Rik, D330041I19Rik, mdm, connectin, D830007G01Rik, 1100001C23Rik, shru, 2310074I15Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pld1
Name: phospholipase D1
Synonyms: Pld1a, Pld1b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18805
HGNC: HGNC:9067
Homologene: 116234
Lonp1
Name: lon peptidase 1, mitochondrial
Synonyms: Prss15, 1200017E13Rik, LON
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74142
VEGA: 17
HGNC: HGNC:9479
Homologene: 3521
Cyp4f40
Name: cytochrome P450, family 4, subfamily f, polypeptide 40
Synonyms: EG631304
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 631304
VEGA: 17
Homologene: 117991
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: Spacrcan, PG10.2, IPM200
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224224
Homologene: 9439
Stpg2
Name: sperm tail PG rich repeat containing 2
Synonyms: B930007M17Rik, LOC381476
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381476
Homologene: 52167
Vmn1r231
Name: vomeronasal 1 receptor 231
Synonyms: V1re7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171230
Rhbdf1
Name: rhomboid 5 homolog 1
Synonyms: Dist, Egfr-rs, Dist1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13650
Homologene: 32085
Map3k13
Name: mitogen-activated protein kinase kinase kinase 13
Synonyms: C130026N12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71751
VEGA: 16
HGNC: HGNC:6852
Homologene: 37958
Stk19
Name: serine/threonine kinase 19
Synonyms: G11, RP1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54402
Homologene: 10449
Kdm4d
Name: lysine (K)-specific demethylase 4D
Synonyms: Jmjd2d
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244694
Homologene: 69244
Sult2a5
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 5
Synonyms: EG434264, Gm15438
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434264
Homologene: 37741
Try10
Name: trypsin 10
Synonyms: trypsinogen 10
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 436522
Homologene: 134623
Slc22a16
Name: solute carrier family 22 (organic cation transporter), member 16
Synonyms: CT2, OKB1, OCT6, 4921504E14Rik, FLIPT2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70840
Homologene: 41957
Cdc14b
Name: CDC14 cell division cycle 14B
Synonyms: 2810432N10Rik, A530086E13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218294
VEGA: 13
Homologene: 104197
Pde3a
Name: phosphodiesterase 3A, cGMP inhibited
Synonyms: A930022O17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54611
HGNC: HGNC:8778
Homologene: 708
Cyp4f17
Name: cytochrome P450, family 4, subfamily f, polypeptide 17
Synonyms: EG208285
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 208285
VEGA: 17
Homologene: 129713
Sccpdh
Name: saccharopine dehydrogenase (putative)
Synonyms: C330023F11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109232
Homologene: 9334
Mdfic2
Name: MyoD family inhibitor domain containing 2
Synonyms: Gm765, LOC330390
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330390
Homologene: 66631
Siae
Name: sialic acid acetylesterase
Synonyms: clone 165, Ysg2, LSE
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22619
Homologene: 8001
Aldh1b1
Name: aldehyde dehydrogenase 1 family, member B1
Synonyms: 2700007F14Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72535
HGNC: HGNC:407
Homologene: 115470
Lypla2
Name: lysophospholipase 2
Synonyms: lysophospholipase II, LysoII
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26394
HGNC: HGNC:6738
Homologene: 100964
Vpreb1a
Name: V-set pre-B cell surrogate light chain 1A
Synonyms: Vpreb1, CD179a, Vpreb-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22362
Homologene: 84741
Or10ag55-ps1
Name: olfactory receptor family 10 subfamily AG member 55, pseudogene 1
Synonyms: GA_x6K02T2Q125-48769330-48770299, MOR264-27_p, MOR264-10P, Olfr1117-ps1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258110
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 34,836,741 bp
  • T to A, chromosome 1 at 179,684,227 bp
  • T to C, chromosome 2 at 76,896,369 bp
  • T to A, chromosome 2 at 76,919,092 bp
  • A to G, chromosome 2 at 87,308,992 bp
  • T to A, chromosome 3 at 28,041,199 bp
  • A to G, chromosome 3 at 104,818,044 bp
  • C to T, chromosome 3 at 107,675,085 bp
  • G to A, chromosome 3 at 139,522,977 bp
  • T to C, chromosome 4 at 45,803,427 bp
  • C to A, chromosome 4 at 135,970,862 bp
  • T to G, chromosome 5 at 63,937,867 bp
  • G to T, chromosome 5 at 124,260,116 bp
  • A to G, chromosome 5 at 145,221,084 bp
  • G to A, chromosome 6 at 41,357,821 bp
  • T to G, chromosome 6 at 98,248,208 bp
  • T to A, chromosome 6 at 141,479,346 bp
  • T to A, chromosome 7 at 13,624,132 bp
  • T to A, chromosome 7 at 110,269,919 bp
  • A to G, chromosome 8 at 104,837,287 bp
  • A to T, chromosome 9 at 14,463,065 bp
  • T to G, chromosome 9 at 37,642,799 bp
  • G to A, chromosome 10 at 40,603,905 bp
  • T to C, chromosome 10 at 92,698,337 bp
  • T to A, chromosome 10 at 100,569,144 bp
  • T to C, chromosome 11 at 32,215,652 bp
  • T to A, chromosome 11 at 55,493,509 bp
  • A to G, chromosome 13 at 30,935,507 bp
  • T to C, chromosome 13 at 64,215,563 bp
  • T to C, chromosome 13 at 100,772,735 bp
  • A to G, chromosome 16 at 16,868,802 bp
  • T to C, chromosome 16 at 21,905,237 bp
  • T to A, chromosome 16 at 56,252,333 bp
  • T to C, chromosome 17 at 20,890,483 bp
  • T to C, chromosome 17 at 32,506,976 bp
  • C to G, chromosome 17 at 32,675,742 bp
  • C to T, chromosome 17 at 34,824,794 bp
  • C to T, chromosome 17 at 56,619,230 bp
  • A to G, chromosome 18 at 5,082,853 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6692 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044810-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.