Strain Name:
C57BL/6J-MtgxR6693Btlr/Mmmh
Stock Number:
044811-MU
Citation ID:
RRID:MMRRC_044811-MU
Other Names:
R6693 (G1)
Major Collection:

Strain Information

Pdpk1
Name: 3-phosphoinositide dependent protein kinase 1
Synonyms: Pkb kinase, Pdk1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18607
Homologene: 37643
Lmf1
Name: lipase maturation factor 1
Synonyms: 2400010G15Rik, Tmem112
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 76483
Homologene: 23384
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Shroom3
Name: shroom family member 3
Synonyms: D5Ertd287e, Shrm, Shrm3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27428
Homologene: 9263
Rps6ka5
Name: ribosomal protein S6 kinase, polypeptide 5
Synonyms: 6330404E13Rik, MSK1, 3110005L17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73086
VEGA: 12
Homologene: 48302
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: tbl, 2810449H11Rik, D130015N03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Nedd1
Name: neural precursor cell expressed, developmentally down-regulated gene 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17997
VEGA: 10
HGNC: HGNC:7723
Homologene: 7439
Sucla2
Name: succinate-Coenzyme A ligase, ADP-forming, beta subunit
Synonyms: 4930547K18Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20916
Homologene: 2856
Tgif1
Name: TGFB-induced factor homeobox 1
Synonyms: Tgif
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21815
Homologene: 7574
Arhgap23
Name: Rho GTPase activating protein 23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 58996
Homologene: 104145
Adamtsl1
Name: ADAMTS-like 1
Synonyms: 5930437A14Rik, punctin-1, 6720426B09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77739
Homologene: 64642
Aak1
Name: AP2 associated kinase 1
Synonyms: D6Ertd245e, 5530400K14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269774
Homologene: 128746
Slc12a7
Name: solute carrier family 12, member 7
Synonyms: Kcc4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20499
VEGA: 13
Homologene: 21312
Slc16a4
Name: solute carrier family 16 (monocarboxylic acid transporters), member 4
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229699
Homologene: 74529
Myo6
Name: myosin VI
Synonyms: rsv, Myo6rsv, Tlc
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17920
HGNC: HGNC:7605
Homologene: 56417
Pax9
Name: paired box 9
Synonyms: Pax-9
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18511
HGNC: HGNC:8623
Homologene: 31360
Kif17
Name: kinesin family member 17
Synonyms: Kif17b, 5930435E01Rik, N-4 kinesin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16559
Homologene: 5883
1110002E22Rik
Name: RIKEN cDNA 1110002E22 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 102634333
Homologene: 131709
Slc25a45
Name: solute carrier family 25, member 45
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107375
Homologene: 76679
Adam25
Name: ADAM metallopeptidase domain 25
Synonyms: testase 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23793
HGNC: HGNC:199
Homologene: 128364
Cfap65
Name: cilia and flagella associated protein 65
Synonyms: B230363K08Rik, Ccdc108
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241116
Homologene: 28093
Rbak
Name: RB-associated KRAB zinc finger
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57782
Homologene: 23287
Cpeb2
Name: cytoplasmic polyadenylation element binding protein 2
Synonyms: A630055H10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231207
Homologene: 17995
Mmp13
Name: matrix metallopeptidase 13
Synonyms: interstitial collagenase, MMP-13, Clg, collagenase-1, Mmp1, Collagenase-3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17386
VEGA: 9
HGNC: HGNC:7159
Homologene: 20548
Chrm3
Name: cholinergic receptor, muscarinic 3, cardiac
Synonyms: Chrm-3, muscarinic acetylcholine receptor 3, M3R
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12671
HGNC: HGNC:1952
Homologene: 20191
Klhl25
Name: kelch-like 25
Synonyms: 2810402K13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207952
Homologene: 32546
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240776
Homologene: 16121
Pcdhb15
Name: protocadherin beta 15
Synonyms: PcdhbO, Pcdhb7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93886
HGNC: HGNC:8692
Homologene: 32429
Scg2
Name: secretogranin II
Synonyms: SgII, Chgc
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20254
Homologene: 2591
Tmem8b
Name: transmembrane protein 8B
Synonyms: 4930500O05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242409
Homologene: 72894
Glb1l
Name: galactosidase, beta 1-like
Synonyms: 4833408P15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74577
Homologene: 75208
Or9m1
Name: olfactory receptor family 9 subfamily M member 1
Synonyms: GA_x6K02T2Q125-49403456-49402524, MOR173-2, Olfr1154
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258641
Homologene: 74192
Or8g17
Name: olfactory receptor family 8 subfamily G member 17
Synonyms: M15, Olfr146, MOR171-10, GA_x6K02T2PVTD-32715386-32714466
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258742
VEGA: 9
Adgrg7
Name: adhesion G protein-coupled receptor G7
Synonyms: 9130020O16Rik, Gpr128
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239853
Homologene: 13115
Zfp971
Name: zinc finger protein 971
Synonyms: Etohi1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 626848
Homologene: 134324
Fbxw27
Name: F-box and WD-40 domain protein 27
Synonyms: 1700124P09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76998
Homologene: 110776
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 74,917,286 bp
  • T to C, chromosome 1 at 75,209,101 bp
  • G to T, chromosome 1 at 79,436,020 bp
  • A to T, chromosome 1 at 140,351,227 bp
  • A to G, chromosome 2 at 87,903,308 bp
  • G to T, chromosome 2 at 178,033,431 bp
  • T to C, chromosome 3 at 107,303,064 bp
  • T to C, chromosome 3 at 138,069,154 bp
  • A to G, chromosome 4 at 43,669,837 bp
  • C to A, chromosome 4 at 86,342,886 bp
  • T to C, chromosome 4 at 123,473,808 bp
  • C to A, chromosome 4 at 138,286,480 bp
  • A to T, chromosome 5 at 43,285,912 bp
  • G to A, chromosome 5 at 92,940,758 bp
  • T to C, chromosome 5 at 143,174,111 bp
  • C to T, chromosome 6 at 86,965,515 bp
  • T to C, chromosome 7 at 75,866,813 bp
  • A to T, chromosome 8 at 40,754,531 bp
  • A to T, chromosome 9 at 7,280,245 bp
  • C to T, chromosome 9 at 39,018,801 bp
  • G to A, chromosome 9 at 66,478,976 bp
  • T to A, chromosome 9 at 80,245,731 bp
  • T to C, chromosome 9 at 109,788,044 bp
  • T to C, chromosome 10 at 92,698,337 bp
  • A to G, chromosome 11 at 97,466,517 bp
  • T to A, chromosome 12 at 56,709,731 bp
  • A to G, chromosome 12 at 100,573,829 bp
  • T to C, chromosome 13 at 9,877,422 bp
  • G to T, chromosome 13 at 73,797,537 bp
  • T to A, chromosome 14 at 73,568,667 bp
  • T to A, chromosome 16 at 56,770,224 bp
  • A to T, chromosome 17 at 24,111,126 bp
  • A to T, chromosome 17 at 25,645,278 bp
  • T to A, chromosome 17 at 70,850,890 bp
  • A to T, chromosome 18 at 37,474,341 bp
  • T to C, chromosome 19 at 5,880,134 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6693 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044811-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.