Strain Name:
C57BL/6J-MtgxR6694Btlr/Mmmh
Stock Number:
044812-MU
Citation ID:
RRID:MMRRC_044812-MU
Other Names:
R6694 (G1)
Major Collection:

Strain Information

Kit
Name: KIT proto-oncogene receptor tyrosine kinase
Synonyms: SCO1, Steel Factor Receptor, belly-spot, SCO5, Tr-kit, Dominant white spotting, Gsfsco1, SOW3, c-KIT, CD117, Gsfsco5, Gsfsow3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16590
HGNC: HGNC:6342
Homologene: 187
Mtrr
Name: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210009
VEGA: 13
HGNC: HGNC:7473
Homologene: 11419
Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72895
Homologene: 12485
Arhgap10
Name: Rho GTPase activating protein 10
Synonyms: A930033B01Rik, PSGAP-m, PSGAP-s
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 78514
Homologene: 12695
Sae1
Name: SUMO1 activating enzyme subunit 1
Synonyms: Uble1a, 2610044L12Rik, SUMO-1 activating enzyme subunit 1, HSPC140, D7Ertd177e, AOS1, 2400010M20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56459
Homologene: 4019
Zfp523
Name: zinc finger protein 523
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224656
Homologene: 2569
Kif20a
Name: kinesin family member 20A
Synonyms: Rabkinesin-6, Rab6kifl
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19348
VEGA: 18
HGNC: HGNC:9787
Homologene: 38093
Timeless
Name: timeless circadian clock 1
Synonyms: tim
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21853
Homologene: 31206
Rc3h2
Name: ring finger and CCCH-type zinc finger domains 2
Synonyms: 2900024N03Rik, D930043C02Rik, 9430019J22Rik, Mnab, Rnf164
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319817
Homologene: 28276
Plk4
Name: polo like kinase 4
Synonyms: Stk18, Sak
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20873
Homologene: 7962
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Ctnnd1
Name: catenin delta 1
Synonyms: catenin (cadherin associated protein), delta 1, P120, Catns, p120-catenin, Ctnnd
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12388
HGNC: HGNC:2515
Homologene: 1017
Lhx4
Name: LIM homeobox protein 4
Synonyms: Gsh-4, Gsh4, A330062J17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16872
Homologene: 56497
Zfp74
Name: zinc finger protein 74
Synonyms: Zfp66, KRAB8, 2810054M15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72723
Homologene: 51861
Zap70
Name: zeta-chain (TCR) associated protein kinase
Synonyms: TZK, Srk, ZAP-70
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22637
Homologene: 839
Med18
Name: mediator complex subunit 18
Synonyms: 2810046C01Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67219
Homologene: 9756
Exoc1
Name: exocyst complex component 1
Synonyms: Sec3p, SEC3, Sec3l1, 2810407P21Rik, A730011E05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69940
Homologene: 41241
Rapgef3
Name: Rap guanine nucleotide exchange factor (GEF) 3
Synonyms: 2310016P22Rik, 9330170P05Rik, Epac1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223864
Homologene: 21231
Arap3
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Synonyms: DRAG1, E030006K04Rik, Centd3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106952
VEGA: 18
Homologene: 11199
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1289Clo, b2b1203Clo, Dnahc11, b2b1279Clo, avc4, b2b1727Clo, b2b598Clo, lrd
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Ccdc116
Name: coiled-coil domain containing 116
Synonyms: 4930432J16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 76872
Homologene: 51873
Polq
Name: polymerase (DNA directed), theta
Synonyms: A430110D14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77782
HGNC: HGNC:9186
Homologene: 32727
Usp29
Name: ubiquitin specific peptidase 29
Synonyms: Ocat
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57775
Homologene: 49641
Mrps30
Name: mitochondrial ribosomal protein S30
Synonyms: 2610020A16Rik, Pdcd9
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 59054
HGNC: HGNC:8769
Homologene: 9607
Exoc3l
Name: exocyst complex component 3-like
Synonyms: C730015A04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 277978
Homologene: 18629
Rab11fip2
Name: RAB11 family interacting protein 2 (class I)
Synonyms: nRip11, A830046J09Rik, Rab11-FIP2, 4930470G04Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74998
Homologene: 8937
Cd53
Name: CD53 antigen
Synonyms: Ox-44, Tspan25
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12508
HGNC: HGNC:1686
Homologene: 20152
Ddx60
Name: DExD/H box helicase 60
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234311
Homologene: 23031
Aoc1l2
Name: amine oxidase copper containing 1-like 2
Synonyms: 1600015I10Rik, Doxl1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69761
HGNC: HGNC:80
Homologene: 79726
Ubxn8
Name: UBX domain protein 8
Synonyms: Rep-8, D0H8S2298E, Ubxd6, Rep8h
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108159
Homologene: 4149
Zfp93
Name: zinc finger protein 93
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22755
Homologene: 117959
Grid2
Name: glutamate receptor, ionotropic, delta 2
Synonyms: tpr, B230104L07Rik, GluRdelta2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14804
HGNC: HGNC:4576
Homologene: 74399
Sit1
Name: suppression inducing transmembrane adaptor 1
Synonyms: Sit
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54390
Homologene: 8694
Slc5a11
Name: solute carrier family 5 (sodium/glucose cotransporter), member 11
Synonyms: 2010013B02Rik, Kst1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233836
Homologene: 14184
Siae
Name: sialic acid acetylesterase
Synonyms: clone 165, Ysg2, LSE
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22619
Homologene: 8001
Semp2l2b
Name: SUMO/sentrin specific peptidase 2-like 2B
Synonyms: 4930444G20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 114671
Homologene: 130042
Nuak2
Name: NUAK family, SNF1-like kinase, 2
Synonyms: Snark, 1200013B22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74137
Homologene: 12539
Or2y1g
Name: olfactory receptor family 2 subfamily Y member 1G
Synonyms: MOR256-67_i, Olfr1393, GA_x6K02T2QP88-6154577-6153642, MOR256-24
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258463
Homologene: 81347
Tcfl5
Name: transcription factor-like 5 (basic helix-loop-helix)
Synonyms: Figlb, FIG beta
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277353
Homologene: 4814
Timd2
Name: T cell immunoglobulin and mucin domain containing 2
Synonyms: Tim2, TIM-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 171284
Homologene: 82236
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,782,517 bp
  • T to G, chromosome 1 at 132,332,310 bp
  • T to C, chromosome 1 at 155,704,710 bp
  • A to G, chromosome 2 at 37,400,543 bp
  • T to C, chromosome 2 at 84,624,505 bp
  • A to G, chromosome 2 at 180,622,654 bp
  • T to C, chromosome 3 at 40,801,828 bp
  • T to A, chromosome 3 at 106,767,386 bp
  • C to T, chromosome 4 at 43,483,311 bp
  • C to T, chromosome 4 at 132,459,982 bp
  • T to C, chromosome 5 at 75,640,757 bp
  • T to A, chromosome 5 at 76,549,552 bp
  • G to A, chromosome 6 at 48,930,546 bp
  • C to G, chromosome 6 at 63,931,047 bp
  • T to A, chromosome 6 at 113,143,708 bp
  • A to G, chromosome 7 at 6,962,277 bp
  • G to T, chromosome 7 at 16,368,536 bp
  • A to T, chromosome 7 at 24,275,913 bp
  • G to A, chromosome 7 at 29,935,134 bp
  • A to T, chromosome 7 at 42,614,186 bp
  • ATGGCG to ATGGCGACGGTGGCG, chromosome 7 at 97,579,904 bp
  • GCGGCGGC to GCGGCGGCGACGGCGGC, chromosome 7 at 97,579,928 bp
  • A to G, chromosome 7 at 123,267,789 bp
  • G to T, chromosome 8 at 33,621,544 bp
  • A to G, chromosome 8 at 62,037,070 bp
  • A to G, chromosome 8 at 77,411,063 bp
  • G to C, chromosome 8 at 105,290,490 bp
  • T to A, chromosome 9 at 37,616,823 bp
  • T to C, chromosome 10 at 22,067,721 bp
  • T to G, chromosome 10 at 128,239,999 bp
  • A to T, chromosome 11 at 46,670,952 bp
  • A to T, chromosome 11 at 49,280,552 bp
  • T to C, chromosome 12 at 118,186,882 bp
  • C to T, chromosome 13 at 68,564,333 bp
  • C to T, chromosome 13 at 118,386,961 bp
  • A to G, chromosome 15 at 97,759,984 bp
  • T to C, chromosome 16 at 17,142,791 bp
  • T to A, chromosome 16 at 37,015,173 bp
  • T to G, chromosome 17 at 28,200,472 bp
  • A to G, chromosome 18 at 34,625,526 bp
  • A to C, chromosome 18 at 37,991,537 bp
  • T to C, chromosome 19 at 59,937,275 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6694 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044812-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.