Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR6703Btlr/Mmmh
Stock Number:
044821-MU
Citation ID:
RRID:MMRRC_044821-MU
Other Names:
R6703 (G1)
Major Collection:

Strain Information

Rtn4rl1
Name: reticulon 4 receptor-like 1
Synonyms: Ngr3, Ngrh2, Ngrl2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237847
Homologene: 18611
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Csnk2a1
Name: casein kinase 2, alpha 1 polypeptide
Synonyms: Csnk2a1-rs4, CK2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12995
Homologene: 90874
S1pr3
Name: sphingosine-1-phosphate receptor 3
Synonyms: LPb3, S1P3, Edg3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13610
VEGA: 13
HGNC: HGNC:3167
Homologene: 3829
Mef2c
Name: myocyte enhancer factor 2C
Synonyms: 9930028G15Rik, 5430401D19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17260
HGNC: HGNC:6996
Homologene: 31087
Senp6
Name: SUMO/sentrin specific peptidase 6
Synonyms: E130319N12Rik, 2810017C20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215351
Homologene: 9196
Akap13
Name: A kinase anchor protein 13
Synonyms: AKAP-Lbc, PROTO-LBC, PROTO-LB, Ht31, 5730522G15Rik, 1700026G02Rik, 5830460E08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 90,779,439 bp
  • C to T, chromosome 1 at 90,792,462 bp
  • C to T, chromosome 1 at 91,427,949 bp
  • A to G, chromosome 1 at 162,318,687 bp
  • C to T, chromosome 1 at 171,530,583 bp
  • G to A, chromosome 1 at 188,996,529 bp
  • A to G, chromosome 2 at 25,249,890 bp
  • A to G, chromosome 2 at 30,903,121 bp
  • A to T, chromosome 2 at 76,671,762 bp
  • G to A, chromosome 2 at 104,777,325 bp
  • T to A, chromosome 2 at 111,490,109 bp
  • C to G, chromosome 2 at 136,059,563 bp
  • A to T, chromosome 2 at 144,559,189 bp
  • A to G, chromosome 2 at 152,258,688 bp
  • G to A, chromosome 3 at 45,381,299 bp
  • T to C, chromosome 3 at 51,664,612 bp
  • T to C, chromosome 3 at 89,408,590 bp
  • A to T, chromosome 3 at 118,897,200 bp
  • C to T, chromosome 3 at 127,544,224 bp
  • T to C, chromosome 4 at 98,946,672 bp
  • A to T, chromosome 4 at 156,224,793 bp
  • T to C, chromosome 5 at 24,446,946 bp
  • C to T, chromosome 5 at 123,499,469 bp
  • T to A, chromosome 6 at 24,449,745 bp
  • A to C, chromosome 6 at 48,905,714 bp
  • A to T, chromosome 6 at 61,638,511 bp
  • T to G, chromosome 6 at 122,078,694 bp
  • A to G, chromosome 6 at 123,235,594 bp
  • C to T, chromosome 6 at 124,663,222 bp
  • A to T, chromosome 6 at 126,890,082 bp
  • G to T, chromosome 6 at 143,833,465 bp
  • T to C, chromosome 7 at 17,090,396 bp
  • T to C, chromosome 7 at 27,971,641 bp
  • T to G, chromosome 7 at 29,002,396 bp
  • T to C, chromosome 7 at 75,602,898 bp
  • C to A, chromosome 7 at 143,069,318 bp
  • A to G, chromosome 8 at 44,953,046 bp
  • A to G, chromosome 8 at 70,756,448 bp
  • A to T, chromosome 9 at 38,657,777 bp
  • A to T, chromosome 9 at 42,071,201 bp
  • T to C, chromosome 9 at 65,593,263 bp
  • A to G, chromosome 9 at 80,121,921 bp
  • A to G, chromosome 9 at 88,422,914 bp
  • T to C, chromosome 9 at 105,144,559 bp
  • T to A, chromosome 10 at 21,621,659 bp
  • T to A, chromosome 10 at 62,973,294 bp
  • T to A, chromosome 10 at 92,868,734 bp
  • T to A, chromosome 10 at 128,397,782 bp
  • A to G, chromosome 11 at 60,492,992 bp
  • G to A, chromosome 11 at 75,265,528 bp
  • A to T, chromosome 11 at 76,694,162 bp
  • A to G, chromosome 11 at 116,684,387 bp
  • T to C, chromosome 12 at 113,305,033 bp
  • A to T, chromosome 13 at 51,419,439 bp
  • T to A, chromosome 13 at 83,625,406 bp
  • A to G, chromosome 14 at 50,127,231 bp
  • A to G, chromosome 14 at 55,864,478 bp
  • C to T, chromosome 15 at 85,092,031 bp
  • C to A, chromosome 15 at 98,257,272 bp
  • T to G, chromosome 16 at 5,089,464 bp
  • T to G, chromosome 16 at 15,670,528 bp
  • T to C, chromosome 16 at 18,151,191 bp
  • T to C, chromosome 16 at 19,407,372 bp
  • A to G, chromosome 16 at 46,463,842 bp
  • C to T, chromosome 17 at 20,268,463 bp
  • C to A, chromosome 17 at 24,447,131 bp
  • A to G, chromosome 18 at 5,214,044 bp
  • A to G, chromosome 18 at 58,609,839 bp
  • G to A, chromosome 19 at 4,749,814 bp
  • C to A, chromosome 19 at 4,749,815 bp
  • A to T, chromosome 19 at 7,435,045 bp
  • A to T, chromosome 19 at 40,962,506 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6703 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044821-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.