Strain Name:
C57BL/6J-MtgxR6704Btlr/Mmmh
Stock Number:
044822-MU
Citation ID:
RRID:MMRRC_044822-MU
Other Names:
R6704 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Septin4
Name: septin 4
Synonyms: ARTS, Bh5, Gm11492, septin H5, Sept4, cell division control-related protein 2b, Pnutl2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18952
HGNC: HGNC:9165
Homologene: 6107
Col3a1
Name: collagen, type III, alpha 1
Synonyms: Col3a-1, Tsk2, Tsk-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12825
HGNC: HGNC:2201
Homologene: 55433
Omd
Name: osteomodulin
Synonyms: OSAD, SLRR2C, osteoadherin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 27047
VEGA: 13
HGNC: HGNC:8134
Homologene: 3677
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, trabeculin alpha, Acf7
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Dnmbp
Name: dynamin binding protein
Synonyms: Tuba, 2410003L07Rik, 2410003M15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 71972
Homologene: 9061
Tpr
Name: translocated promoter region, nuclear basket protein
Synonyms: 2610029M07Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108989
Homologene: 37753
Mical3
Name: microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms: C130040D16Rik, MICAL-3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 194401
Homologene: 85288
Polr3a
Name: polymerase (RNA) III (DNA directed) polypeptide A
Synonyms: RPC1, RPC155, 9330175N20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218832
VEGA: 14
Homologene: 5124
Ruvbl1
Name: RuvB-like AAA ATPase 1
Synonyms: Pontin52, 2510009G06Rik, Tip49a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56505
Homologene: 37839
Serpini1
Name: serine (or cysteine) peptidase inhibitor, clade I, member 1
Synonyms: Spi17, Neuroserpin, Ns, PI12
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20713
HGNC: HGNC:8943
Homologene: 21045
Rad50
Name: RAD50 double strand break repair protein
Synonyms: Mrell, Rad50l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19360
HGNC: HGNC:9816
Homologene: 38092
Myt1
Name: myelin transcription factor 1
Synonyms: NZF-2a, NZF-2b, Nztf2, Nzf2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17932
HGNC: HGNC:7622
Homologene: 3332
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Tmem131
Name: transmembrane protein 131
Synonyms: CC28, YR-23, D1Bwg0491e, Rw1, Neg, 2610524E03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56030
Homologene: 32428
Pfkl
Name: phosphofructokinase, liver, B-type
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18641
HGNC: HGNC:8876
Homologene: 55668
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, 2310038E12Rik, Fath
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Pcnx3
Name: pecanex homolog 3
Synonyms: Pcnxl3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 104401
Homologene: 17000
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Asxl3
Name: ASXL transcriptional regulator 3
Synonyms: D430002O22Rik, LOC381127, D930044O18Rik, C230079D11Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 211961
Homologene: 19371
Mlxipl
Name: MLX interacting protein-like
Synonyms: WS-bHLH, bHLHd14, Wbscr14, ChREBP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 58805
Homologene: 32507
Nlrp2
Name: NLR family, pyrin domain containing 2
Synonyms: E330007A02Rik, Nalp2, Pan1, Nbs1, PYPAF2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232827
Homologene: 56789
Ptchd4
Name: patched domain containing 4
Synonyms: 3110082D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627626
VEGA: 17
Homologene: 78322
Cd109
Name: CD109 antigen
Synonyms: Gov platelet alloantigens, 9930012E15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235505
Homologene: 25183
Nlrc3
Name: NLR family, CARD domain containing 3
Synonyms: Caterpiller 16.2, D230007K08Rik, CLR16.2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268857
Homologene: 18720
Kcnma1
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms: 5730414M22Rik, Slo, MaxiK, BKCa, BK channel alpha subunit, mSlo1, Slo1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16531
HGNC: HGNC:6284
Homologene: 1693
Pappa
Name: pregnancy-associated plasma protein A
Synonyms: PAPP-A, IGFBP-4ase, 8430414N03Rik, PAG1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18491
HGNC: HGNC:8602
Homologene: 31097
Evx2
Name: even-skipped homeobox 2
Synonyms: Evx-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14029
HGNC: HGNC:3507
Homologene: 74879
Or5h19
Name: olfactory receptor family 5 subfamily H member 19
Synonyms: Olfr187, GA_x54KRFPKG5P-55265713-55264787, MOR183-8
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258319
Homologene: 133069
Mcam
Name: melanoma cell adhesion molecule
Synonyms: s-endo, 1-gicerin, CD146, Muc18, s-gicerin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 84004
HGNC: HGNC:6934
Homologene: 4742
Fndc1
Name: fibronectin type III domain containing 1
Synonyms: 1110027O12Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68655
Ugt2b36
Name: UDP glucuronosyltransferase 2 family, polypeptide B36
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231396
Homologene: 128251
Hyou1
Name: hypoxia up-regulated 1
Synonyms: Orp150, Cab140, CBP-140, Grp170, 140 kDa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12282
Homologene: 4658
Ccdc152
Name: coiled-coil domain containing 152
Synonyms: ENSMUSG00000071814
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 100039139
VEGA: 15
Homologene: 79247
Or9r7
Name: olfactory receptor family 9 subfamily R member 7
Synonyms: MOR210-3, GA_x6K02T2PULF-11797746-11796799, Olfr824
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258669
Homologene: 45026
Ermn
Name: ermin, ERM-like protein
Synonyms: A330104H05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77767
Homologene: 12683
Zc2hc1c
Name: zinc finger, C2HC-type containing 1C
Synonyms: 2810002I04Rik, Fam164c
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72350
Homologene: 23461
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 36,796,180 bp
  • T to C, chromosome 1 at 45,347,732 bp
  • A to G, chromosome 1 at 150,406,508 bp
  • T to C, chromosome 2 at 58,048,034 bp
  • C to A, chromosome 2 at 74,656,155 bp
  • A to G, chromosome 2 at 181,811,212 bp
  • T to C, chromosome 3 at 75,637,948 bp
  • G to A, chromosome 4 at 65,204,924 bp
  • C to T, chromosome 4 at 123,410,762 bp
  • C to A, chromosome 5 at 87,092,131 bp
  • A to T, chromosome 5 at 135,137,240 bp
  • T to A, chromosome 6 at 88,479,205 bp
  • T to C, chromosome 6 at 121,009,800 bp
  • A to C, chromosome 7 at 5,325,041 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • T to C, chromosome 8 at 45,024,373 bp
  • T to A, chromosome 9 at 44,136,920 bp
  • T to C, chromosome 9 at 44,381,134 bp
  • T to C, chromosome 9 at 53,458,853 bp
  • T to C, chromosome 9 at 78,680,075 bp
  • T to C, chromosome 10 at 12,745,291 bp
  • C to T, chromosome 10 at 77,996,366 bp
  • T to A, chromosome 10 at 130,126,155 bp
  • T to C, chromosome 11 at 53,698,918 bp
  • T to A, chromosome 11 at 87,589,030 bp
  • T to C, chromosome 12 at 8,010,379 bp
  • A to T, chromosome 12 at 85,290,484 bp
  • A to G, chromosome 13 at 49,589,873 bp
  • G to A, chromosome 14 at 24,002,814 bp
  • A to G, chromosome 14 at 24,461,842 bp
  • T to A, chromosome 15 at 3,280,713 bp
  • C to T, chromosome 16 at 3,965,081 bp
  • T to C, chromosome 16 at 59,035,862 bp
  • A to G, chromosome 17 at 7,771,810 bp
  • A to G, chromosome 17 at 42,317,040 bp
  • G to A, chromosome 18 at 22,517,305 bp
  • A to T, chromosome 19 at 5,686,487 bp
  • T to C, chromosome 19 at 43,901,213 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6704 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044822-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.