Strain Name:
C57BL/6J-MtgxR6705Btlr/Mmmh
Stock Number:
044823-MU
Citation ID:
RRID:MMRRC_044823-MU
Other Names:
R6705 (G1)
Major Collection:

Strain Information

Shc1
Name: src homology 2 domain-containing transforming protein C1
Synonyms: p66, p66shc, ShcA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20416
Homologene: 7934
Ccn2
Name: cellular communication network factor 2
Synonyms: Fisp12, Ccn2, Ctgf, hypertrophic chondrocyte-specific gene product 24, Hcs24
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14219
HGNC: HGNC:2500
Homologene: 1431
Ppp1r14c
Name: protein phosphatase 1, regulatory inhibitor subunit 14C
Synonyms: 6330514J04Rik, KEPI
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76142
VEGA: 10
Homologene: 12805
Ddx23
Name: DEAD box helicase 23
Synonyms: 4921506D17Rik, 3110082M05Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 74351
Homologene: 3542
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 4921505C17Rik, 6030405M08Rik, D530039E11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Hdac5
Name: histone deacetylase 5
Synonyms: mHDA1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15184
Homologene: 3995
Comp
Name: cartilage oligomeric matrix protein
Synonyms: TSP5, thrombospondin-5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12845
HGNC: HGNC:2227
Homologene: 74
Slk
Name: STE20-like kinase
Synonyms: SLK, 9A2, mSLK, Etk4, Stk2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20874
Homologene: 22515
Etaa1
Name: Ewing tumor-associated antigen 1
Synonyms: 5730466H23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68145
Homologene: 10369
Helb
Name: helicase (DNA) B
Synonyms: D10Ertd664e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 117599
Homologene: 50463
Xrn2
Name: 5'-3' exoribonuclease 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24128
Homologene: 6927
Nav2
Name: neuron navigator 2
Synonyms: Rainb1, POMFIL2, Unc53H2, 5330421F07Rik, HELAD1, RAINB2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Tbc1d5
Name: TBC1 domain family, member 5
Synonyms: 1600014N05Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72238
VEGA: 17
Homologene: 8834
Afdn
Name: afadin, adherens junction formation factor
Synonyms: AF6, S-afadin, 5033403D15Rik, Afadin, I-afadin, Mllt4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17356
HGNC: HGNC:7137
Homologene: 21202
Vps39
Name: VPS39 HOPS complex subunit
Synonyms: A230065P22Rik, Vam6P, Vam6, mVam6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269338
Homologene: 41025
Kdm3b
Name: KDM3B lysine (K)-specific demethylase 3B
Synonyms: JHDM2B, Jmjd1b, 5830462I21Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 277250
VEGA: 18
HGNC: HGNC:1337
Homologene: 41145
Ppfia1
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Synonyms: Liprin-alpha1, liprin, C030014K08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233977
HGNC: HGNC:9245
Homologene: 20802
Lrrc55
Name: leucine rich repeat containing 55
Synonyms: LOC241528, A330097E02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241528
VEGA: 2
Homologene: 19385
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Zfp236
Name: zinc finger protein 236
Synonyms: LOC240456
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 329002
Homologene: 7198
Mphosph9
Name: M-phase phosphoprotein 9
Synonyms: 9630025B04Rik, MPP9, 4930548D04Rik, B930097C17Rik, MPP-9
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269702
HGNC: HGNC:7215
Homologene: 11256
Fam168b
Name: family with sequence similarity 168, member B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214469
Homologene: 18390
Gtf3c2
Name: general transcription factor IIIC, polypeptide 2, beta
Synonyms: 2610510G03Rik, 1300004C11Rik, TFIIIC110, TFIIIC-BETA
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71752
HGNC: HGNC:4665
Homologene: 37490
Gas2l2
Name: growth arrest-specific 2 like 2
Synonyms: OTTMUSG00000000934
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237891
Homologene: 16409
Skint10
Name: selection and upkeep of intraepithelial T cells 10
Synonyms: A030001H23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230613
Homologene: 136292
Myf6
Name: myogenic factor 6
Synonyms: MRF4, bHLHc4, herculin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17878
VEGA: 10
HGNC: HGNC:7566
Homologene: 1850
Or6c1b
Name: olfactory receptor family 6 subfamily C member 1B
Synonyms: Olfr786, GA_x6K02T2PULF-11116958-11117896, MOR111-5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258542
HGNC: HGNC:8355
Homologene: 133582
Ablim1
Name: actin-binding LIM protein 1
Synonyms: abLIM-S, 9330196J19Rik, 2210411C18Rik, abLIM-L, abLIM-M, 4833406P10Rik, Limab1, 2610209L21Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226251
HGNC: HGNC:78
Homologene: 40994
Nup210
Name: nucleoporin 210
Synonyms: gp190, gp210, Pom210
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54563
Homologene: 41286
Erlin2
Name: ER lipid raft associated 2
Synonyms: Spfh2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244373
HGNC: HGNC:1356
Homologene: 5193
Nfe2l1
Name: nuclear factor, erythroid derived 2,-like 1
Synonyms: TCF-11, NRF1, TCF11, Lcrf1, LCR-F1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18023
HGNC: HGNC:7781
Homologene: 20685
Tiam2
Name: T cell lymphoma invasion and metastasis 2
Synonyms: STEF, 3000002F19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 24001
VEGA: 17
Homologene: 40796
Wdr27
Name: WD repeat domain 27
Synonyms: 0610012K18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71682
VEGA: 17
Homologene: 18417
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Or8b4
Name: olfactory receptor family 8 subfamily B member 4
Synonyms: MOR163-1, Olfr878, GA_x6K02T2PVTD-31600511-31601440
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258794
HGNC: HGNC:8473
Homologene: 17395
Ppp1r3g
Name: protein phosphatase 1, regulatory subunit 3G
Synonyms: 1600032L17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 76487
Homologene: 109865
Or8b12
Name: olfactory receptor family 8 subfamily B member 12
Synonyms: Olfr874, MOR161-2, GA_x6K02T2PVTD-31428850-31429782
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258882
Homologene: 17377
Cant1
Name: calcium activated nucleotidase 1
Synonyms: D11Bwg0554e, 5830420C20Rik, Shapy, Apy1h, SCAN-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76025
Homologene: 69460
Vmn1r174
Name: vomeronasal 1 receptor 174
Synonyms: V1rd22
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404291
Homologene: 79577
Aldh5a1
Name: aldhehyde dehydrogenase family 5, subfamily A1
Synonyms: OTTMUSG00000000613, 6330403E24Rik, D630032B01Rik, SSADH
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 214579
HGNC: HGNC:408
Homologene: 840
Or13a18
Name: olfactory receptor family 13 subfamily A member 18
Synonyms: MOR253-8, GA_x6K02T2PBJ9-42759973-42760905, IF5, ID12, IB7, Olfr46
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18345
Homologene: 110491
D1Pas1
Name: DNA segment, Chr 1, Pasteur Institute 1
Synonyms: Pl10
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110957
HGNC: HGNC:2745
Homologene: 135966
Zbp1
Name: Z-DNA binding protein 1
Synonyms: mZaDLM, 2010010H03Rik, Dai
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 58203
Homologene: 10972
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 34,828,783 bp
  • G to T, chromosome 1 at 186,968,379 bp
  • A to T, chromosome 2 at 85,196,355 bp
  • A to T, chromosome 2 at 120,320,676 bp
  • A to G, chromosome 2 at 147,036,662 bp
  • A to T, chromosome 2 at 173,213,887 bp
  • C to T, chromosome 3 at 89,422,959 bp
  • A to T, chromosome 4 at 112,773,104 bp
  • C to A, chromosome 5 at 31,166,008 bp
  • T to C, chromosome 5 at 124,290,964 bp
  • A to T, chromosome 6 at 70,608,020 bp
  • G to T, chromosome 6 at 91,087,960 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • C to A, chromosome 7 at 23,754,426 bp
  • T to C, chromosome 7 at 49,551,916 bp
  • T to A, chromosome 7 at 140,610,784 bp
  • G to A, chromosome 7 at 144,519,174 bp
  • T to A, chromosome 8 at 27,036,440 bp
  • C to A, chromosome 8 at 70,376,737 bp
  • T to A, chromosome 9 at 37,746,734 bp
  • T to A, chromosome 9 at 37,918,784 bp
  • A to T, chromosome 10 at 3,366,890 bp
  • T to A, chromosome 10 at 24,595,955 bp
  • C to T, chromosome 10 at 107,493,829 bp
  • G to A, chromosome 10 at 115,587,288 bp
  • A to G, chromosome 10 at 120,089,811 bp
  • G to A, chromosome 10 at 129,437,072 bp
  • T to C, chromosome 11 at 17,945,639 bp
  • G to A, chromosome 11 at 83,422,636 bp
  • A to C, chromosome 11 at 96,827,625 bp
  • T to C, chromosome 11 at 102,201,236 bp
  • G to T, chromosome 11 at 118,407,872 bp
  • A to T, chromosome 13 at 24,912,270 bp
  • C to A, chromosome 13 at 35,968,897 bp
  • A to G, chromosome 15 at 6,794,012 bp
  • G to A, chromosome 15 at 98,652,968 bp
  • G to A, chromosome 17 at 3,518,243 bp
  • G to A, chromosome 17 at 13,888,021 bp
  • A to T, chromosome 17 at 14,934,590 bp
  • T to C, chromosome 17 at 51,025,175 bp
  • A to G, chromosome 18 at 34,819,873 bp
  • T to A, chromosome 18 at 82,633,737 bp
  • A to G, chromosome 19 at 47,609,059 bp
  • G to A, chromosome 19 at 57,215,821 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6705 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044823-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.