Strain Name:
C57BL/6J-MtgxR6718Btlr/Mmmh
Stock Number:
044836-MU
Citation ID:
RRID:MMRRC_044836-MU
Other Names:
R6718 (G1)
Major Collection:

Strain Information

Otx1
Name: orthodenticle homeobox 1
Synonyms: jv, A730044F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18423
HGNC: HGNC:8521
Homologene: 7875
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, D230004K18Rik, Megalin, Gp330
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Col6a1
Name: collagen, type VI, alpha 1
Synonyms: Col6a-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12833
HGNC: HGNC:2211
Homologene: 1391
Parvb
Name: parvin, beta
Synonyms: affixin, D15Gsk1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170736
Homologene: 8342
Afg3l2
Name: AFG3-like AAA ATPase 2
Synonyms: Emv66, 2310036I02Rik, par
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69597
VEGA: 18
HGNC: HGNC:315
Homologene: 4947
Pms2
Name: PMS1 homolog2, mismatch repair system component
Synonyms: DNA mismatch repair, mismatch repair
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18861
Homologene: 133560
Ranbp10
Name: RAN binding protein 10
Synonyms: 4432417N03Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74334
Homologene: 49639
Spindoc
Name: spindlin interactor and repressor of chromatin binding
Synonyms: AI846148
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68229
VEGA: 19
Homologene: 19195
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Asb8
Name: ankyrin repeat and SOCS box-containing 8
Synonyms: C430011H06Rik, 4930539L19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78541
Homologene: 32572
Kmt2d
Name: lysine (K)-specific methyltransferase 2D
Synonyms: Mll4, C430014K11Rik, Mll2, bapa
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 381022
HGNC: HGNC:7133
Homologene: 86893
Tmprss9
Name: transmembrane protease, serine 9
Synonyms: Serase-1B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432478
VEGA: 10
Homologene: 115302
Or7g33
Name: olfactory receptor family 7 subfamily G member 33
Synonyms: GA_x6K02T2PVTD-13277703-13276786, Olfr853, MOR154-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258908
HGNC: HGNC:8466
Homologene: 133623
Maf
Name: MAF bZIP transcription factor
Synonyms: 2810401A20Rik, A230108G15Rik, c-maf
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17132
HGNC: HGNC:6776
Homologene: 74552
Cdh18
Name: cadherin 18
Synonyms: B230220E17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320865
HGNC: HGNC:1757
Homologene: 55858
Hoxc5
Name: homeobox C5
Synonyms: Hox-6.2, Hox-3.4
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 15424
HGNC: HGNC:5127
Homologene: 41296
Slc30a9
Name: solute carrier family 30 (zinc transporter), member 9
Synonyms: 2310024J23Rik, GAC63
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 109108
HGNC: HGNC:1329
Homologene: 4627
Mrgpra3
Name: MAS-related GPR, member A3
Synonyms: MrgA3, G protein-coupled receptor
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233222
Homologene: 131159
Pigu
Name: phosphatidylinositol glycan anchor biosynthesis, class U
Synonyms: Cdc91l1, 5430426F17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228812
Homologene: 6553
Pura
Name: purine rich element binding protein A
Synonyms: CAGER-1, ssCRE-BP, Pur-alpha, Pur alpha
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19290
HGNC: HGNC:9701
Homologene: 4279
Pex11a
Name: peroxisomal biogenesis factor 11 alpha
Synonyms: PEX11alpha
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18631
HGNC: HGNC:8852
Homologene: 20829
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 2 at 69,483,780 bp
  • A to G, chromosome 2 at 155,301,286 bp
  • T to C, chromosome 5 at 67,333,100 bp
  • T to C, chromosome 5 at 143,923,489 bp
  • C to T, chromosome 7 at 47,589,696 bp
  • A to G, chromosome 7 at 79,737,482 bp
  • A to G, chromosome 8 at 105,774,628 bp
  • C to A, chromosome 8 at 115,706,800 bp
  • G to T, chromosome 9 at 19,537,199 bp
  • T to A, chromosome 9 at 79,699,605 bp
  • A to G, chromosome 10 at 76,725,050 bp
  • A to G, chromosome 10 at 80,890,364 bp
  • T to C, chromosome 11 at 21,996,412 bp
  • A to G, chromosome 15 at 23,226,749 bp
  • C to T, chromosome 15 at 84,297,979 bp
  • A to G, chromosome 15 at 98,136,134 bp
  • TATGCTGCTG to TATGCTGCTGATGCTGCTG, chromosome 15 at 98,849,586 bp
  • C to T, chromosome 15 at 98,850,539 bp
  • A to G, chromosome 15 at 103,014,266 bp
  • A to G, chromosome 18 at 36,287,643 bp
  • G to A, chromosome 18 at 67,421,276 bp
  • C to T, chromosome 19 at 7,358,416 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6718 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044836-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.