Strain Name:
C57BL/6J-MtgxR6722Btlr/Mmmh
Stock Number:
044840-MU
Citation ID:
RRID:MMRRC_044840-MU
Other Names:
R6722 (G1)
Major Collection:

Strain Information

Pdx1
Name: pancreatic and duodenal homeobox 1
Synonyms: IDX-1, pdx-1, IPF-1, STF-1, Ipf1, Mody4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18609
HGNC: HGNC:6107
Homologene: 175
Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20370
Homologene: 10948
Pzp
Name: PZP, alpha-2-macroglobulin like
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11287
Homologene: 104112
Rbpms
Name: RNA binding protein gene with multiple splicing
Synonyms: 2010300K22Rik, hermes, 2700019M19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19663
Homologene: 38238
Mbd2
Name: methyl-CpG binding domain protein 2
Synonyms: MBD2a
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17191
HGNC: HGNC:6917
Homologene: 2918
Triobp
Name: TRIO and F-actin binding protein
Synonyms: EST478828, Mus EST 478828, Tara
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110253
Homologene: 5104
Parvb
Name: parvin, beta
Synonyms: affixin, D15Gsk1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170736
Homologene: 8342
Zfp985
Name: zinc finger protein 985
Synonyms: Gm13154
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433804
Homologene: 133076
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ankyrin-G, Ank-3, Ankyrin-3, 2900054D09Rik, AnkG
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Ncapd3
Name: non-SMC condensin II complex, subunit D3
Synonyms: 2810487N22Rik, B130055D15Rik, 4632407J06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 78658
VEGA: 9
Homologene: 41021
Stxbp3
Name: syntaxin binding protein 3
Synonyms: Munc-18c, Stxbp3, Stxbp3a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20912
Homologene: 5260
Ttll4
Name: tubulin tyrosine ligase-like family, member 4
Synonyms: 4632407P03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67534
Homologene: 8764
Pus10
Name: pseudouridylate synthase 10
Synonyms: 4933435A13Rik, Ccdc139, 2810013G11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74467
Homologene: 12566
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235627
Homologene: 86422
Tln1
Name: talin 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21894
Homologene: 21267
Slc12a4
Name: solute carrier family 12, member 4
Synonyms: K-Cl Co-transporter-1, KCC1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20498
Homologene: 21056
Pnisr
Name: PNN interacting serine/arginine-rich
Synonyms: Sfrs18, 5730406M06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66625
Homologene: 32802
Wdr75
Name: WD repeat domain 75
Synonyms: 2410118I19Rik, 1300003A18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73674
Homologene: 32771
Smg5
Name: SMG5 nonsense mediated mRNA decay factor
Synonyms: Smg-5 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229512
Homologene: 9095
Pde4a
Name: phosphodiesterase 4A, cAMP specific
Synonyms: Dpde2, dunce, D9Ertd60e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18577
HGNC: HGNC:8780
Homologene: 4520
Pde4d
Name: phosphodiesterase 4D, cAMP specific
Synonyms: Dpde3, 9630011N22Rik, dunce
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238871
HGNC: HGNC:8783
Dennd1c
Name: DENN domain containing 1C
Synonyms: 4432409M07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70785
VEGA: 17
Homologene: 11773
Rundc3a
Name: RUN domain containing 3A
Synonyms: Rpip8, Rap2ip
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 51799
Homologene: 4871
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: Scy, Crsh, Adgrc1, crash
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
Or4f62
Name: olfactory receptor family 4 subfamily F member 62
Synonyms: GA_x6K02T2Q125-73202172-73203134, Olfr1318, MOR245-16
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258022
Homologene: 134079
Lrp2bp
Name: Lrp2 binding protein
Synonyms: MegBP, 1700113N17Rik, 4930479L12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67620
Homologene: 10183
Lipm
Name: lipase, family member M
Synonyms: 4632427C23Rik, Lipl3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78753
VEGA: 19
Homologene: 28267
Atp1a4
Name: ATPase, Na+/K+ transporting, alpha 4 polypeptide
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 27222
Homologene: 113769
Bmal2
Name: basic helix-loop-helix ARNT like 2
Synonyms: bHLHe6, MOP9, 4632430A05Rik, Arntl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 272322
Homologene: 10609
Pde4dip
Name: phosphodiesterase 4D interacting protein (myomegalin)
Synonyms: D130016K21Rik, 9430063L05Rik, Usmg4, 4732458A06Rik, D3Bwg1078e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 83679
Homologene: 66961
Scml4
Name: Scm polycomb group protein like 4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268297
Homologene: 18262
Col6a2
Name: collagen, type VI, alpha 2
Synonyms: Col6a-2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12834
HGNC: HGNC:2212
Homologene: 1392
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, Wdr65, LOC384050, 1110020C03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Tkt
Name: transketolase
Synonyms: p68
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21881
Homologene: 68154
Cntnap5b
Name: contactin associated protein-like 5B
Synonyms: Caspr5-2, C230078M14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241175
Homologene: 104295
Vmn1r61
Name: vomeronasal 1 receptor 61
Synonyms: Gm7186
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 636731
Homologene: 41799
Sgsm2
Name: small G protein signaling modulator 2
Synonyms: D630003G22Rik, Rutbc1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 97761
Homologene: 14780
Thoc2l
Name: THO complex subunit 2-like
Synonyms: BC005561, Gm3179
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100042165
Zswim3
Name: zinc finger SWIM-type containing 3
Synonyms: 4921517A06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67538
Homologene: 15436
Cyp2a4
Name: cytochrome P450, family 2, subfamily a, polypeptide 4
Synonyms: testosterone 15alpha-hydroxylase, D7Ucla4, Cyp15a1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13086
Homologene: 85917
Krt31
Name: keratin 31
Synonyms: Krt1-1, Kha1, Ha1, MKHA-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16660
HGNC: HGNC:6448
Homologene: 74433
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: 5033413D22Rik, Gm6976, Gm29096
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Prss51
Name: serine protease 51
Synonyms: 1700007N14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100504162
Homologene: 131540
Cd84
Name: CD84 antigen
Synonyms: SLAMF5, CDw84, A130013D22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12523
HGNC: HGNC:1704
Homologene: 48249
Mrps33
Name: mitochondrial ribosomal protein S33
Synonyms: MRP-S33, Gdap3, PTD003, CGI-139
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14548
Homologene: 7729
Adam4
Name: a disintegrin and metallopeptidase domain 4
Synonyms: tMDCV
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 11498
Homologene: 86950
Coq4
Name: coenzyme Q4
Synonyms: D2Ertd97e, EST-MNCb4625
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227683
Homologene: 68641
Icam2
Name: intercellular adhesion molecule 2
Synonyms: CD102, Icam-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15896
HGNC: HGNC:5345
Homologene: 675
Castor2
Name: cytosolic arginine sensor for mTORC1 subunit 2
Synonyms: Gats, Gatsl2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80909
Homologene: 84866
Nt5c1b
Name: 5'-nucleotidase, cytosolic IB
Synonyms: CN-IB, 4921514H13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70881
Homologene: 12370
Dnaja4
Name: DnaJ heat shock protein family (Hsp40) member A4
Synonyms: Dj4, 1110021L12Rik, Hsj4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 58233
Homologene: 23110
Uba52rt
Name: ubiquitin A-52 residue ribosomal protein fusion product 1, retrotransposed
Synonyms: Gm11808
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666586
Hes2
Name: hes family bHLH transcription factor 2
Synonyms: HES-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15206
Homologene: 22455
Nthl1
Name: nth (endonuclease III)-like 1 (E.coli)
Synonyms: Nth1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18207
VEGA: 17
HGNC: HGNC:8028
Homologene: 1897
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 45,805,352 bp
  • T to C, chromosome 1 at 74,681,789 bp
  • G to A, chromosome 1 at 100,478,486 bp
  • G to A, chromosome 1 at 171,872,777 bp
  • T to C, chromosome 1 at 172,258,050 bp
  • A to T, chromosome 2 at 29,788,285 bp
  • T to A, chromosome 2 at 112,156,882 bp
  • T to A, chromosome 2 at 164,820,624 bp
  • C to T, chromosome 3 at 88,353,025 bp
  • G to A, chromosome 3 at 97,718,239 bp
  • A to G, chromosome 3 at 108,816,446 bp
  • A to G, chromosome 4 at 3,973,386 bp
  • T to A, chromosome 4 at 21,859,165 bp
  • A to G, chromosome 4 at 43,547,618 bp
  • A to C, chromosome 4 at 118,584,717 bp
  • T to C, chromosome 4 at 147,583,071 bp
  • T to G, chromosome 4 at 152,160,377 bp
  • T to A, chromosome 5 at 104,520,279 bp
  • T to C, chromosome 5 at 134,135,619 bp
  • C to T, chromosome 5 at 147,270,500 bp
  • T to C, chromosome 6 at 39,805,665 bp
  • T to A, chromosome 6 at 128,487,954 bp
  • T to A, chromosome 6 at 146,818,900 bp
  • T to A, chromosome 7 at 5,610,688 bp
  • A to G, chromosome 7 at 26,313,558 bp
  • G to T, chromosome 8 at 33,834,393 bp
  • G to A, chromosome 8 at 46,020,563 bp
  • T to C, chromosome 8 at 105,944,250 bp
  • G to A, chromosome 9 at 21,211,225 bp
  • T to C, chromosome 9 at 27,087,556 bp
  • A to G, chromosome 9 at 54,699,754 bp
  • T to C, chromosome 9 at 110,632,992 bp
  • T to C, chromosome 10 at 41,644,641 bp
  • C to T, chromosome 10 at 42,860,732 bp
  • T to C, chromosome 10 at 69,990,244 bp
  • C to T, chromosome 10 at 76,614,558 bp
  • G to A, chromosome 11 at 23,702,975 bp
  • A to C, chromosome 11 at 74,865,424 bp
  • T to C, chromosome 11 at 77,953,702 bp
  • A to G, chromosome 11 at 100,048,428 bp
  • A to G, chromosome 11 at 102,399,949 bp
  • A to G, chromosome 11 at 106,382,481 bp
  • T to A, chromosome 12 at 10,372,874 bp
  • T to G, chromosome 12 at 81,421,454 bp
  • C to A, chromosome 13 at 109,632,898 bp
  • T to C, chromosome 14 at 30,569,084 bp
  • G to T, chromosome 14 at 64,095,059 bp
  • G to A, chromosome 15 at 79,001,565 bp
  • C to T, chromosome 15 at 84,297,979 bp
  • C to A, chromosome 15 at 85,905,914 bp
  • A to G, chromosome 17 at 24,634,034 bp
  • T to C, chromosome 17 at 57,066,802 bp
  • T to A, chromosome 18 at 70,580,748 bp
  • A to T, chromosome 19 at 34,121,265 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6722 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044840-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.