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Strain Name:
C57BL/6J-MtgxR6742Btlr/Mmmh
Stock Number:
044859-MU
Citation ID:
RRID:MMRRC_044859-MU
Other Names:
R6742 (G1)
Major Collection:

Strain Information

Sox10
Name: SRY (sex determining region Y)-box 10
Synonyms: Sox21, gt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20665
VEGA: 15
Homologene: 5055
Lmtk2
Name: lemur tyrosine kinase 2
Synonyms: 2900041G10Rik, KPI-2, cprk, KPI2, A330101P12Rik, BREK, AATYK2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231876
Homologene: 8948
Fasn
Name: fatty acid synthase
Synonyms: FAS, A630082H08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, Ankyrin-3, AnkG, 2900054D09Rik, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Cntrob
Name: centrobin, centrosomal BRCA2 interacting protein
Synonyms: Lip8, 9830165K03Rik, Nip2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216846
Homologene: 14205
Rrp1b
Name: ribosomal RNA processing 1B
Synonyms: 2600005C20Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72462
Homologene: 57086
Ntng2
Name: netrin G2
Synonyms: Lmnt2, 2610016D08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 171171
Homologene: 13053
Rbl1
Name: RB transcriptional corepressor like 1
Synonyms: p107, retinoblastoma-like 1 (p107)
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19650
HGNC: HGNC:9893
Homologene: 2172
Tars1
Name: threonyl-tRNA synthetase 1
Synonyms: ThrRS, D15Wsu59e, Tars
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110960
VEGA: 15
Homologene: 11852
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Ubac1
Name: ubiquitin associated domain containing 1
Synonyms: 1110033G07Rik, Ubadc1, Kpc2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98766
Homologene: 9409
Raph1
Name: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
Synonyms: C730009O10Rik, 9430025M21Rik, lamellipodin, Lpd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77300
Homologene: 71030
Skic2
Name: SKI2 subunit of superkiller complex
Synonyms: Ski2w, 4930534J06Rik, Skiv2l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 108077
Homologene: 123971
Zfpm2
Name: zinc finger protein, multitype 2
Synonyms: FOG-2, FOG2, B330005D23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22762
VEGA: 15
Homologene: 8008
Itga2
Name: integrin alpha 2
Synonyms: VLA-2 receptor, alpha 2 subunit, CD49B, DX5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16398
VEGA: 13
HGNC: HGNC:6137
Homologene: 1662
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Ccdc127
Name: coiled-coil domain containing 127
Synonyms: 5430420E17Rik, 0610011N22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67433
Homologene: 11482
Tnfrsf1a
Name: tumor necrosis factor receptor superfamily, member 1a
Synonyms: TNF receptor alpha chain, CD120a, TNF-R1, p55, TNF-R55, TNFRp55, Tnfr1, TNF-R-I, TNFR60, TNFAR, p55-R, TNFRI, TNF-alpha-R1, TNF-alphaR1, TNFalpha-R1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21937
Homologene: 828
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b598Clo, b2b1289Clo, b2b1727Clo, b2b1203Clo, b2b1279Clo, Dnahc11, avc4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Vmn2r19
Name: vomeronasal 2, receptor 19
Synonyms: EG232358
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232358
Homologene: 84037
Ppfia4
Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Synonyms: 1110008G13Rik, LOC100042382, Liprin-alpha4, Gm3812
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68507
HGNC: HGNC:9248
Homologene: 66200
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
AI182371
Name: expressed sequence AI182371
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98870
Homologene: 87268
Rwdd4a
Name: RWD domain containing 4A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 192174
Homologene: 16059
Adgb
Name: androglobin
Synonyms: 9130014G24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215772
Homologene: 100289
Evpl
Name: envoplakin
Synonyms: 210kDa protein
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14027
HGNC: HGNC:3503
Homologene: 1506
Tshz2
Name: teashirt zinc finger family member 2
Synonyms: Mtsh2, Sdccag33l, 2900073F20Rik, Zfp218, teashirt2, Tsh2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228911
Homologene: 35258
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Speer4a1
Name: spermatogenesis associated glutamate (E)-rich protein 4A1
Synonyms: SPEER-4A, 1700027N01Rik, Speer4a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75657
Homologene: 69402
Usp4
Name: ubiquitin specific peptidase 4 (proto-oncogene)
Synonyms: Unp, F730026I20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22258
Homologene: 20716
Ccdc149
Name: coiled-coil domain containing 149
Synonyms: LOC242997, Gm447
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100503884
Homologene: 65264
Vmn2r87
Name: vomeronasal 2, receptor 87
Synonyms: EG625131
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625131
Homologene: 129606
Nlrp4f
Name: NLR family, pyrin domain containing 4F
Synonyms: Nalp-kappa, C330026N02Rik, Nalp4f
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 97895
VEGA: 13
Homologene: 87252
Pik3c2b
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Synonyms: PI3K-C2beta, C330011J12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240752
HGNC: HGNC:8972
Homologene: 20582
Zfp78
Name: zinc finger protein 78
Synonyms: KRAB12, Zfp77
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330463
Homologene: 128524
Rnase4
Name: ribonuclease, RNase A family 4
Synonyms: C730049F20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 58809
VEGA: 14
Homologene: 10576
Scarf2
Name: scavenger receptor class F, member 2
Synonyms: Srec2, SREC-II
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224024
VEGA: 16
Homologene: 17817
Lrrc32
Name: leucine rich repeat containing 32
Synonyms: D7H11S833E, D11S833Eh, Garp, EG434215
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434215
HGNC: HGNC:4161
Homologene: 4027
Rnf146
Name: ring finger protein 146
Synonyms: 2610509H23Rik, Iduna
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68031
Homologene: 12227
Timp3
Name: tissue inhibitor of metalloproteinase 3
Synonyms: Timp-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21859
Homologene: 36322
Yod1
Name: YOD1 deubiquitinase
Synonyms: 9930028C20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226418
Homologene: 13176
Wfdc2
Name: WAP four-disulfide core domain 2
Synonyms: WAP5, HE4, 1600023A02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67701
Homologene: 4450
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 60,525,720 bp
  • G to A, chromosome 1 at 130,717,538 bp
  • A to G, chromosome 1 at 133,075,821 bp
  • A to C, chromosome 1 at 134,329,171 bp
  • T to C, chromosome 2 at 26,005,406 bp
  • T to G, chromosome 2 at 29,200,928 bp
  • G to T, chromosome 2 at 35,084,705 bp
  • T to C, chromosome 2 at 41,471,120 bp
  • G to A, chromosome 2 at 157,169,998 bp
  • A to T, chromosome 2 at 164,562,786 bp
  • A to G, chromosome 2 at 169,883,757 bp
  • A to T, chromosome 5 at 26,036,056 bp
  • G to A, chromosome 5 at 52,405,133 bp
  • T to A, chromosome 5 at 144,148,357 bp
  • C to T, chromosome 6 at 12,408,816 bp
  • A to G, chromosome 6 at 121,678,036 bp
  • A to T, chromosome 6 at 123,329,958 bp
  • A to T, chromosome 6 at 125,356,948 bp
  • A to G, chromosome 7 at 6,378,278 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • T to C, chromosome 7 at 98,498,832 bp
  • T to A, chromosome 8 at 47,547,963 bp
  • G to A, chromosome 9 at 88,588,346 bp
  • G to A, chromosome 9 at 108,374,239 bp
  • G to A, chromosome 10 at 10,411,849 bp
  • A to C, chromosome 10 at 29,347,532 bp
  • T to C, chromosome 10 at 69,991,582 bp
  • C to A, chromosome 10 at 82,058,422 bp
  • G to A, chromosome 10 at 86,300,878 bp
  • A to T, chromosome 10 at 130,472,527 bp
  • T to A, chromosome 11 at 9,328,168 bp
  • G to A, chromosome 11 at 69,322,923 bp
  • T to C, chromosome 11 at 116,222,814 bp
  • T to C, chromosome 11 at 120,810,453 bp
  • T to C, chromosome 12 at 118,113,894 bp
  • T to A, chromosome 13 at 62,454,479 bp
  • C to T, chromosome 13 at 65,187,440 bp
  • G to T, chromosome 13 at 74,352,923 bp
  • T to A, chromosome 13 at 114,836,525 bp
  • G to T, chromosome 14 at 51,105,029 bp
  • A to T, chromosome 15 at 11,394,341 bp
  • G to A, chromosome 15 at 41,101,718 bp
  • T to C, chromosome 15 at 79,156,476 bp
  • G to A, chromosome 16 at 17,806,487 bp
  • A to G, chromosome 17 at 32,056,934 bp
  • G to A, chromosome 17 at 34,845,190 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6742 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044859-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.