Strain Name:
C57BL/6J-MtgxR6749Btlr/Mmmh
Stock Number:
044866-MU
Citation ID:
RRID:MMRRC_044866-MU
Other Names:
R6749 (G1)
Major Collection:

Strain Information

Myo10
Name: myosin X
Synonyms: myosin-X, D15Ertd600e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Hgf
Name: hepatocyte growth factor
Synonyms: scatter factor, NK1, SF/HGF, HGF/SF, NK2, C230052L06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15234
HGNC: HGNC:4893
Homologene: 503
Sema4b
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
Synonyms: SemC, Semac
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20352
Homologene: 8426
Znfx1
Name: zinc finger, NFX1-type containing 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98999
Homologene: 10877
Mmachc
Name: methylmalonic aciduria cblC type, with homocystinuria
Synonyms: 1810037K07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67096
Homologene: 12082
Erbin
Name: Erbb2 interacting protein
Synonyms: 1700028E05Rik, Erbin, Erbb2ip
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 59079
Homologene: 41282
Lrmda
Name: leucine rich melanocyte differentiation associated
Synonyms: Oca7, 1700112E06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76633
Homologene: 49975
Lipc
Name: lipase, hepatic
Synonyms: HL, Hpl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15450
VEGA: 9
HGNC: HGNC:6619
Homologene: 199
Pigr
Name: polymeric immunoglobulin receptor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18703
HGNC: HGNC:8968
Homologene: 1984
Prpf39
Name: pre-mRNA processing factor 39
Synonyms: Srcs1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328110
Homologene: 32377
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: 6030441H18Rik, Mtmr15
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Cntfr
Name: ciliary neurotrophic factor receptor
Synonyms: Cntfralpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12804
HGNC: HGNC:2170
Homologene: 9619
Cacfd1
Name: calcium channel flower domain containing 1
Synonyms: mFwe, 5930434B04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381356
HGNC: HGNC:1365
Homologene: 41182
Ptprs
Name: protein tyrosine phosphatase receptor type S
Synonyms: PTP-NU3, PTPsigma, RPTPsigma, Ptpt9
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19280
HGNC: HGNC:9681
Homologene: 20626
Siglecg
Name: sialic acid binding Ig-like lectin G
Synonyms: mSiglec-G, A630096C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243958
Homologene: 13228
Esrp1
Name: epithelial splicing regulatory protein 1
Synonyms: 2210008M09Rik, Rbm35a
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 207920
Homologene: 9785
Zfpm2
Name: zinc finger protein, multitype 2
Synonyms: FOG-2, FOG2, B330005D23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 22762
VEGA: 15
Homologene: 8008
Camk1
Name: calcium/calmodulin-dependent protein kinase I
Synonyms: D6Ertd263e, CaMKIalpha, Camk
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52163
HGNC: HGNC:1459
Homologene: 117458
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Il12rb2
Name: interleukin 12 receptor, beta 2
Synonyms: IL-12RB2, Ifnm, A930027I18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16162
HGNC: HGNC:5972
Homologene: 1197
Slc4a3
Name: solute carrier family 4 (anion exchanger), member 3
Synonyms: Ae3, A930038D23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20536
Homologene: 129474
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Sult2a3
Name: sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3
Synonyms: Gm6955
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 629203
Homologene: 37741
Arhgef15
Name: Rho guanine nucleotide exchange factor 15
Synonyms: D530030K12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 442801
Homologene: 18345
Vars2
Name: valyl-tRNA synthetase 2, mitochondrial
Synonyms: 1190004I24Rik, Vars2l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68915
Homologene: 57502
Myo5b
Name: myosin VB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Krt78
Name: keratin 78
Synonyms: 2310030B04Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 332131
VEGA: 15
Homologene: 65261
Tektl1
Name: tektin like 1
Synonyms: 4931413A09Rik, Ccdc105
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70976
VEGA: 10
Homologene: 18299
Ift140
Name: intraflagellar transport 140
Synonyms: Wdtc2, Tce5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106633
Homologene: 40979
Aatk
Name: apoptosis-associated tyrosine kinase
Synonyms: AATYK1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11302
HGNC: HGNC:21
Homologene: 74861
Slc6a20a
Name: solute carrier family 6 (neurotransmitter transporter), member 20A
Synonyms: A730081N20Rik, Xtrp3s1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102680
Homologene: 10625
Tmem63c
Name: transmembrane protein 63c
Synonyms: 9330187M14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217733
Homologene: 33129
Rsad1
Name: radical S-adenosyl methionine domain containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237926
Homologene: 41252
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433070
Or2y1f
Name: olfactory receptor family 2 subfamily Y member 1F
Synonyms: GA_x6K02T2QP88-6141322-6140387, MOR256-25, Olfr1392
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258462
Homologene: 81347
Pde4c
Name: phosphodiesterase 4C, cAMP specific
Synonyms: dunce, Dpde1, E130301F19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110385
HGNC: HGNC:8782
Homologene: 20256
Pmp2
Name: peripheral myelin protein 2
Synonyms: P2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18857
HGNC: HGNC:9117
Homologene: 20589
Padi3
Name: peptidyl arginine deiminase, type III
Synonyms: PAD type III, Pad3, Pdi3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18601
Homologene: 7882
Gata5
Name: GATA binding protein 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14464
Homologene: 32031
Ift57
Name: intraflagellar transport 57
Synonyms: MHS4R2, HIPPI, 4833420A15Rik, Esrrbl1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 73916
Homologene: 32383
Bdh2
Name: 3-hydroxybutyrate dehydrogenase, type 2
Synonyms: 1810026B04Rik, Dhrs6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69772
Homologene: 134268
Cdc14a
Name: CDC14 cell division cycle 14A
Synonyms: CDC14A2, CDC14a1, Cdc14, A830059A17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229776
HGNC: HGNC:1718
Homologene: 75343
Tedc1
Name: tubulin epsilon and delta complex 1
Synonyms: 4930427A07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104732
Homologene: 77129
Bmp5
Name: bone morphogenetic protein 5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12160
HGNC: HGNC:1072
Homologene: 22412
Trim68
Name: tripartite motif-containing 68
Synonyms: SS-56, F730114J12Rik, Rnf137
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101700
Homologene: 9991
Trav5-1
Name: T cell receptor alpha variable 5-1
Synonyms: Trav5-1 T-cell receptor alpha chain V region 5-1, Gm7124
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 633740
Pcdhgb4
Name: protocadherin gamma subfamily B, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93701
HGNC: HGNC:8711
Homologene: 74507
Spata19
Name: spermatogenesis associated 19
Synonyms: 1700001L23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75469
VEGA: 9
Homologene: 12602
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 75,554,538 bp
  • A to G, chromosome 1 at 130,846,548 bp
  • T to C, chromosome 2 at 27,018,455 bp
  • T to C, chromosome 2 at 76,865,256 bp
  • T to A, chromosome 2 at 82,978,394 bp
  • T to C, chromosome 2 at 167,056,599 bp
  • A to G, chromosome 2 at 180,334,350 bp
  • T to C, chromosome 3 at 10,182,482 bp
  • T to C, chromosome 3 at 116,297,158 bp
  • T to A, chromosome 3 at 135,300,691 bp
  • A to T, chromosome 4 at 11,357,519 bp
  • T to A, chromosome 4 at 41,663,232 bp
  • C to A, chromosome 4 at 116,704,541 bp
  • T to C, chromosome 4 at 140,795,853 bp
  • T to A, chromosome 5 at 16,613,642 bp
  • G to T, chromosome 6 at 67,361,966 bp
  • G to A, chromosome 6 at 113,334,525 bp
  • T to A, chromosome 7 at 14,082,704 bp
  • A to G, chromosome 7 at 43,408,979 bp
  • T to A, chromosome 7 at 64,372,486 bp
  • T to A, chromosome 7 at 80,220,201 bp
  • T to C, chromosome 7 at 102,678,783 bp
  • T to C, chromosome 8 at 70,746,010 bp
  • T to C, chromosome 9 at 27,397,980 bp
  • A to G, chromosome 9 at 70,823,386 bp
  • A to T, chromosome 9 at 75,776,093 bp
  • A to G, chromosome 9 at 123,637,070 bp
  • A to C, chromosome 10 at 78,752,838 bp
  • A to G, chromosome 11 at 49,294,050 bp
  • A to T, chromosome 11 at 68,954,557 bp
  • T to C, chromosome 11 at 94,543,340 bp
  • T to G, chromosome 11 at 103,502,097 bp
  • A to G, chromosome 11 at 120,010,774 bp
  • A to G, chromosome 12 at 65,056,274 bp
  • T to A, chromosome 12 at 87,075,665 bp
  • C to T, chromosome 12 at 113,158,082 bp
  • G to T, chromosome 13 at 103,834,377 bp
  • G to T, chromosome 14 at 22,027,276 bp
  • T to C, chromosome 14 at 52,622,945 bp
  • T to C, chromosome 15 at 25,714,110 bp
  • G to T, chromosome 15 at 40,954,708 bp
  • G to A, chromosome 15 at 101,950,923 bp
  • G to A, chromosome 16 at 49,760,984 bp
  • C to T, chromosome 17 at 18,598,090 bp
  • A to G, chromosome 17 at 25,098,916 bp
  • A to G, chromosome 17 at 35,666,713 bp
  • A to G, chromosome 17 at 56,437,884 bp
  • G to T, chromosome 18 at 37,721,229 bp
  • G to A, chromosome 18 at 74,701,503 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6749 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044866-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.