Strain Name:
C57BL/6J-MtgxR6751Btlr/Mmmh
Stock Number:
044868-MU
Citation ID:
RRID:MMRRC_044868-MU
Other Names:
R6751 (G1)
Major Collection:

Strain Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: beta fodrin, Spnb-2, spectrin G, brain spectrin, elf3, elf1, non-erythrocytic, 9930031C03Rik, Spnb2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Chrnb2
Name: cholinergic receptor nicotinic beta 2 subunit
Synonyms: [b]2-nAchR, Acrb-2, Acrb2, C030030P04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11444
HGNC: HGNC:1962
Homologene: 595
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Synonyms: 1110001J02Rik, p110beta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74769
HGNC: HGNC:8976
Homologene: 21250
Zranb3
Name: zinc finger, RAN-binding domain containing 3
Synonyms: 4933425L19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226409
Homologene: 32770
Asap1
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Synonyms: Ddef1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13196
HGNC: HGNC:2720
Homologene: 7684
Osbpl8
Name: oxysterol binding protein-like 8
Synonyms: ORP-8, D330025H14Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237542
VEGA: 10
Homologene: 68813
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Ifrd1
Name: interferon-related developmental regulator 1
Synonyms: PC4, Tis7, Ifnl
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 15982
HGNC: HGNC:5456
Homologene: 31043
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Nckap5l
Name: NCK-associated protein 5-like
Synonyms: C230021P08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 380969
Homologene: 18924
Casr
Name: calcium-sensing receptor
Synonyms: CaR, Gprc2a, cation sensing receptor
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12374
HGNC: HGNC:1514
Homologene: 332
Ntng2
Name: netrin G2
Synonyms: Lmnt2, 2610016D08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 171171
Homologene: 13053
Aco1
Name: aconitase 1
Synonyms: Irp1, Irebp, Aco-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11428
HGNC: HGNC:117
Homologene: 1657
Scn10a
Name: sodium channel, voltage-gated, type X, alpha
Synonyms: Nav1.8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20264
VEGA: 9
Homologene: 21300
Vps50
Name: VPS50 EARP/GARPII complex subunit
Synonyms: 8430415E05Rik, 1700034M03Rik, Ccdc132
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73288
Homologene: 11498
Supt6
Name: SPT6, histone chaperone and transcription elongation factor
Synonyms: SPT6, 5131400N11Rik, Supt6h
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20926
Homologene: 40661
Pabpc1
Name: poly(A) binding protein, cytoplasmic 1
Synonyms: Pabpl1, Pabp1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18458
Homologene: 37638
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: l(7)-3Rn, Ten-m4, Doc4, l7Rn3, ELM2, Odz4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Dnaaf4
Name: dynein axonemal assembly factor 4
Synonyms: EKN1, 1700010I24Rik, b2b811Clo, Dyx1c1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67685
Homologene: 12173
Serpina3c
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3C
Synonyms: Kalbp, 1A1, Klkbp, alpha-1 antiproteinase
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16625
HGNC: HGNC:16
Homologene: 111129
Tfap2a
Name: transcription factor AP-2, alpha
Synonyms: Ap-2 (a), AP-2 alpha, Ap2tf, Ap2, Tcfap2a, AP2alpha
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21418
VEGA: 13
Homologene: 2421
Il17f
Name: interleukin 17F
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 257630
Homologene: 17115
Synrg
Name: synergin, gamma
Synonyms: L71-5, Ap1gbp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217030
HGNC: HGNC:557
Homologene: 105680
Plxdc2
Name: plexin domain containing 2
Synonyms: 1200007L24Rik, Tem7r, 5430431D22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67448
Homologene: 41666
Eml5
Name: echinoderm microtubule associated protein like 5
Synonyms: C130068M19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319670
VEGA: 12
Homologene: 26807
Dync2i1
Name: dynein 2 intermediate chain 1
Synonyms: D430033N04Rik, Wdr60, Dync2l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217935
VEGA: 12
Homologene: 23067
Pde4b
Name: phosphodiesterase 4B, cAMP specific
Synonyms: dunce, Dpde4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18578
HGNC: HGNC:8781
Homologene: 1953
Arhgef28
Name: Rho guanine nucleotide exchange factor 28
Synonyms: RIP2, RhoGEF, Rho specific exchange factor, D13Bwg1089e, 9230110L08Rik, p190RhoGEF, Rgnef
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110596
VEGA: 13
Homologene: 8078
Itga11
Name: integrin alpha 11
Synonyms: 4732459H24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319480
HGNC: HGNC:6136
Homologene: 8151
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Gabra5
Name: gamma-aminobutyric acid type A receptor subunit alpha 5
Synonyms: A230018I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110886
HGNC: HGNC:4079
Homologene: 20219
1110002E22Rik
Name: RIKEN cDNA 1110002E22 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 102634333
Homologene: 131709
Zscan20
Name: zinc finger and SCAN domains 20
Synonyms: Zfp31
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269585
Homologene: 51463
Cacng5
Name: calcium channel, voltage-dependent, gamma subunit 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 140723
HGNC: HGNC:1409
Homologene: 15424
Dym
Name: dymeclin
Synonyms: 1810041M12Rik, C030019K18Rik, 4933427L07Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 69190
VEGA: 18
Homologene: 69237
Vmn2r56
Name: vomeronasal 2, receptor 56
Synonyms: EG629079
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 629079
Homologene: 104040
Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Synonyms: CMR1, TRPP8, Trp-p8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171382
Homologene: 23433
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Psapl1
Name: prosaposin-like 1
Synonyms: 2310020A21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76943
Homologene: 105928
Adcy6
Name: adenylate cyclase 6
Synonyms: AC6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11512
VEGA: 15
HGNC: HGNC:237
Homologene: 22400
Dyrk1b
Name: dual-specificity tyrosine phosphorylation regulated kinase 1b
Synonyms: Mirk
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13549
HGNC: HGNC:3092
Homologene: 31253
Gpc5
Name: glypican 5
Synonyms: A230034F01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 103978
HGNC: HGNC:4453
Homologene: 3285
Vnn3
Name: vanin 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 26464
Homologene: 48295
Or8b40
Name: olfactory receptor family 8 subfamily B member 40
Synonyms: GA_x6K02T2PVTD-31795028-31795957, MOR162-2, Olfr889
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258475
Homologene: 138311
Tfap2d
Name: transcription factor AP-2, delta
Synonyms: Tcfap2d
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226896
Homologene: 17700
Nlrp4f
Name: NLR family, pyrin domain containing 4F
Synonyms: Nalp-kappa, C330026N02Rik, Nalp4f
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 97895
VEGA: 13
Homologene: 87252
Ak8
Name: adenylate kinase 8
Synonyms: 1190002A17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68870
Homologene: 17622
Or8g55
Name: olfactory receptor family 8 subfamily G member 55
Synonyms: GA_x6K02T2PVTD-33572803-33573747, MOR171-17, Olfr972
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258603
VEGA: 9
Homologene: 121532
Vmn2r71
Name: vomeronasal 2, receptor 71
Synonyms: EG233445
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233445
Homologene: 115466
Or8g37
Name: olfactory receptor family 8 subfamily G member 37
Synonyms: GA_x6K02T2PVTD-33517322-33518257, MOR171-16, Olfr970
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258604
VEGA: 9
Homologene: 121532
Galnt17
Name: polypeptide N-acetylgalactosaminyltransferase 17
Synonyms: E330012B09Rik, Gcap8, Galnt19, Wbscr17
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212996
Homologene: 49707
Cyp4a14
Name: cytochrome P450, family 4, subfamily a, polypeptide 14
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13119
Homologene: 134697
Rtkn2
Name: rhotekin 2
Synonyms: B130039D23Rik, RTKN2, Mbf, Plekhk1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 170799
Homologene: 17065
Abhd17a
Name: abhydrolase domain containing 17A
Synonyms: 1700013O15Rik, D10Bwg1364e, Fam108a
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216169
Homologene: 50272
Vmn1r158
Name: vomeronasal 1 receptor 158
Synonyms: Gm16455
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043067
Homologene: 104166
Ccnq
Name: cyclin Q
Synonyms: 1810009O10Rik, cyclin M, Fam58b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69109
Homologene: 13362
Zscan25
Name: zinc finger and SCAN domain containing 25
Synonyms: EG666311, Zfp498
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 666311
Homologene: 64820
Phlda1
Name: pleckstrin homology like domain, family A, member 1
Synonyms: TDAG51, DT1P1B11, Tdag
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21664
HGNC: HGNC:8933
Homologene: 7203
Zfp772
Name: zinc finger protein 772
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232855
Homologene: 128539
Sox12
Name: SRY (sex determining region Y)-box 12
Synonyms: 2010205A02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20667
Homologene: 5057
Or51r1
Name: olfactory receptor family 51 subfamily R member 1
Synonyms: GA_x6K02T2PBJ9-5297243-5298193, MOR16-1, Olfr550
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259108
Homologene: 17507
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 19,103,283 bp
  • A to G, chromosome 1 at 20,779,489 bp
  • T to C, chromosome 1 at 88,384,706 bp
  • T to A, chromosome 1 at 127,959,819 bp
  • T to A, chromosome 1 at 150,734,518 bp
  • A to T, chromosome 2 at 16,548,141 bp
  • T to A, chromosome 2 at 28,709,945 bp
  • A to G, chromosome 2 at 29,228,043 bp
  • T to C, chromosome 2 at 152,396,758 bp
  • A to T, chromosome 3 at 53,653,665 bp
  • A to T, chromosome 3 at 89,761,576 bp
  • A to T, chromosome 3 at 138,066,210 bp
  • T to C, chromosome 4 at 8,833,866 bp
  • T to A, chromosome 4 at 40,188,330 bp
  • T to C, chromosome 4 at 88,827,750 bp
  • A to T, chromosome 4 at 102,602,671 bp
  • T to A, chromosome 4 at 115,491,194 bp
  • G to T, chromosome 4 at 128,585,875 bp
  • C to A, chromosome 5 at 36,204,959 bp
  • T to A, chromosome 5 at 131,081,590 bp
  • T to A, chromosome 5 at 145,290,563 bp
  • A to G, chromosome 6 at 3,600,274 bp
  • C to T, chromosome 7 at 7,203,717 bp
  • T to C, chromosome 7 at 12,694,792 bp
  • C to T, chromosome 7 at 22,789,881 bp
  • C to A, chromosome 7 at 28,186,709 bp
  • T to C, chromosome 7 at 57,418,334 bp
  • G to A, chromosome 7 at 85,619,887 bp
  • A to T, chromosome 7 at 96,845,712 bp
  • G to GACGGCGGCT, chromosome 7 at 97,579,909 bp
  • G to A, chromosome 7 at 102,578,499 bp
  • T to G, chromosome 9 at 38,115,975 bp
  • T to A, chromosome 9 at 39,819,897 bp
  • T to C, chromosome 9 at 39,873,680 bp
  • G to A, chromosome 9 at 62,768,584 bp
  • TCCC to TCC, chromosome 9 at 66,501,188 bp
  • A to G, chromosome 9 at 72,961,975 bp
  • G to T, chromosome 9 at 99,094,521 bp
  • T to C, chromosome 9 at 119,671,551 bp
  • C to T, chromosome 10 at 23,869,625 bp
  • T to A, chromosome 10 at 68,041,453 bp
  • T to C, chromosome 10 at 80,586,587 bp
  • A to G, chromosome 10 at 82,283,497 bp
  • T to C, chromosome 10 at 111,275,013 bp
  • T to C, chromosome 10 at 111,506,694 bp
  • T to C, chromosome 11 at 30,117,859 bp
  • A to G, chromosome 11 at 78,208,949 bp
  • T to C, chromosome 11 at 78,751,124 bp
  • T to C, chromosome 11 at 83,981,425 bp
  • C to A, chromosome 11 at 107,877,553 bp
  • C to T, chromosome 12 at 40,203,914 bp
  • T to C, chromosome 12 at 98,865,400 bp
  • A to G, chromosome 12 at 104,151,500 bp
  • A to T, chromosome 12 at 116,213,456 bp
  • T to A, chromosome 13 at 40,728,754 bp
  • A to T, chromosome 13 at 65,194,429 bp
  • G to A, chromosome 13 at 98,075,247 bp
  • A to G, chromosome 14 at 115,369,951 bp
  • A to T, chromosome 15 at 36,597,534 bp
  • A to G, chromosome 15 at 64,094,412 bp
  • T to C, chromosome 15 at 98,596,205 bp
  • A to G, chromosome 15 at 99,423,161 bp
  • T to C, chromosome 16 at 36,515,588 bp
  • G to A, chromosome 18 at 75,286,647 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6751 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044868-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.