Strain Name:
C57BL/6J-MtgxR6752Btlr/Mmmh
Stock Number:
044869-MU
Citation ID:
RRID:MMRRC_044869-MU
Other Names:
R6752 (G1)
Major Collection:

Strain Information

Mtmr14
Name: myotubularin related protein 14
Synonyms: 1110061O04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 97287
Homologene: 11203
Sptlc1
Name: serine palmitoyltransferase, long chain base subunit 1
Synonyms: Lcb1, Spt1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 268656
VEGA: 13
Homologene: 4681
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: C130002K18Rik, 5430435M13Rik, 2610207I05Rik, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Dock4
Name: dedicator of cytokinesis 4
Synonyms: EST N28122, 6330411N01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238130
VEGA: 12
Homologene: 56680
Zfp292
Name: zinc finger protein 292
Synonyms: Zn-16, Zn-15, Krox-10, Zfp-15, 9430062L07Rik, 5730450D02Rik, Zfp15
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 30046
Homologene: 8493
Inppl1
Name: inositol polyphosphate phosphatase-like 1
Synonyms: SHIP2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16332
HGNC: HGNC:6080
Homologene: 1204
Myt1
Name: myelin transcription factor 1
Synonyms: NZF-2b, NZF-2a, Nztf2, Nzf2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17932
HGNC: HGNC:7622
Homologene: 3332
Igfbp5
Name: insulin-like growth factor binding protein 5
Synonyms: IGFBP-5, IGFBP-5P
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16011
HGNC: HGNC:5474
Homologene: 56489
Acaca
Name: acetyl-Coenzyme A carboxylase alpha
Synonyms: acetyl-CoA carboxylase, Acc1, LOC327983, Acac, A530025K05Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107476
HGNC: HGNC:84
Homologene: 31015
Arhgap23
Name: Rho GTPase activating protein 23
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 58996
Homologene: 104145
Chst2
Name: carbohydrate sulfotransferase 2
Synonyms: Gn6st, N-acetylglucosamine-6-O-sulfotransferase, GST-2, C130041E03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54371
HGNC: HGNC:1970
Homologene: 3150
Ccbe1
Name: collagen and calcium binding EGF domains 1
Synonyms: 9430093N24Rik, 4933426F18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 320924
Homologene: 15852
Ifne
Name: interferon epsilon
Synonyms: Ifnt1, Ifne1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230405
Homologene: 18534
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: Mpr300, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Zfp599
Name: zinc finger protein 599
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235048
Homologene: 138456
Myh15
Name: myosin, heavy chain 15
Synonyms: EG667772
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 667772
VEGA: 16
Homologene: 18929
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, A230079K17Rik, Gm980, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Vipr1
Name: vasoactive intestinal peptide receptor 1
Synonyms: VIP-R1, VPAC1, VIP receptor subtype 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22354
Homologene: 3399
Aox1
Name: aldehyde oxidase 1
Synonyms: retinal oxidase, Aox-1, Aox-2, Aox2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11761
HGNC: HGNC:553
Homologene: 68165
Rnh1
Name: ribonuclease/angiogenin inhibitor 1
Synonyms: RNH
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 107702
Homologene: 2204
Myo3b
Name: myosin IIIB
Synonyms: A430065P19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 329421
Homologene: 51393
Rab11fip2
Name: RAB11 family interacting protein 2 (class I)
Synonyms: Rab11-FIP2, nRip11, 4930470G04Rik, A830046J09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74998
Homologene: 8937
Stat2
Name: signal transducer and activator of transcription 2
Synonyms: 1600010G07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20847
VEGA: 10
Homologene: 3952
Syt16
Name: synaptotagmin XVI
Synonyms: Strep14, syt14r, Syt14l
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238266
VEGA: 12
Homologene: 12902
Akt3
Name: thymoma viral proto-oncogene 3
Synonyms: PKB gamma, D930002M15Rik, Nmf350
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23797
HGNC: HGNC:393
Homologene: 55904
Zfp944
Name: zinc finger protein 944
Synonyms: 6330416L07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 319615
VEGA: 17
Homologene: 133237
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: TJ6s, ATP6a2, Atp6n2, Tj6, 8430408C20Rik, V-ATPase a2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21871
Homologene: 56523
Tspyl1
Name: testis-specific protein, Y-encoded-like 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22110
Homologene: 22522
Ntn4
Name: netrin 4
Synonyms: beta-netrin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 57764
Homologene: 10934
Dmrt2
Name: doublesex and mab-3 related transcription factor 2
Synonyms: Terra
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226049
VEGA: 19
HGNC: HGNC:2935
Homologene: 17111
Agbl2
Name: ATP/GTP binding protein-like 2
Synonyms: A430081C19Rik, Ccp2, Ccp2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 271813
Homologene: 11715
Ube4a
Name: ubiquitination factor E4A
Synonyms: UFD2b, 9930123J21Rik, 4732444G18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 140630
Homologene: 3517
Skint7
Name: selection and upkeep of intraepithelial T cells 7
Synonyms: C130057D23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 328505
Homologene: 106613
Itih3
Name: inter-alpha trypsin inhibitor, heavy chain 3
Synonyms: Intin3, Itih-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16426
HGNC: HGNC:6168
Homologene: 1669
Or10ag52
Name: olfactory receptor family 10 subfamily AG member 52
Synonyms: GA_x6K02T2Q125-48697747-48698727, MOR264-25, Olfr1113
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404327
Homologene: 27114
Zfp184
Name: zinc finger protein 184 (Kruppel-like)
Synonyms: 4930500C15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 193452
Homologene: 113602
Galnt7
Name: polypeptide N-acetylgalactosaminyltransferase 7
Synonyms: ppGaNTase-T7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 108150
HGNC: HGNC:4129
Homologene: 9685
Pom121l2
Name: POM121 transmembrane nucleoporin like 2
Synonyms: LOC195236
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 195236
Homologene: 123536
Birc3
Name: baculoviral IAP repeat-containing 3
Synonyms: MIAP2, IAP2, Api2, cIAP2, cIAP-2, HIAP2, MIHC, RNF49
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11796
HGNC: HGNC:591
Homologene: 899
Skint4
Name: selection and upkeep of intraepithelial T cells 4
Synonyms: 9530098N22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320640
Irgm1
Name: immunity-related GTPase family M member 1
Synonyms: LRG-47, Iigp3, Ifi1, Irgm
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15944
Homologene: 134089
H2-Q6
Name: histocompatibility 2, Q region locus 6
Synonyms: Qa6, Qa-6, H-2Q6, 0610037M15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 110557
Homologene: 128352
Sostdc1
Name: sclerostin domain containing 1
Synonyms: Sostl, ectodin, Wise, USAG-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66042
VEGA: 12
Homologene: 9154
Mrps10
Name: mitochondrial ribosomal protein S10
Synonyms: Rpms10, 1110038B19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64657
Homologene: 10028
Mfsd1
Name: major facilitator superfamily domain containing 1
Synonyms: 1200003O06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66868
Homologene: 11228
Sh3tc2
Name: SH3 domain and tetratricopeptide repeats 2
Synonyms: D430044G18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225608
VEGA: 18
Homologene: 11596
Klra4
Name: killer cell lectin-like receptor, subfamily A, member 4
Synonyms: Chok, Ly49d, ly49r129
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16635
Homologene: 110821
Zkscan14
Name: zinc finger with KRAB and SCAN domains 14
Synonyms: 2810437E14Rik, 2310046C23Rik, Zfp99
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67235
Homologene: 11342
Asmt
Name: acetylserotonin O-methyltransferase
Synonyms: Hiomt
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 107626
VEGA: X
HGNC: HGNC:750
Gm16506
Name: predicted gene 16506
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 102634304
Homologene: 128452
Or5h27
Name: olfactory receptor family 5 subfamily H member 27, pseudogene 1
Synonyms: GA_x54KRFPKG5P-55400292-55399363, MOR183-3, Olfr197
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258477
Homologene: 36984
Pcdhgb4
Name: protocadherin gamma subfamily B, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93701
HGNC: HGNC:8711
Homologene: 74507
Psmb5
Name: proteasome (prosome, macropain) subunit, beta type 5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19173
VEGA: 14
HGNC: HGNC:9542
Homologene: 55690
Or5b114-ps1
Name: olfactory receptor family 5 subfamily B member 114, pseudogene 1
Synonyms: GA_x6K02T2RE5P-3706029-3706953, MOR202-21, Olfr1468-ps1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258192
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 58,047,239 bp
  • T to C, chromosome 1 at 72,863,909 bp
  • A to T, chromosome 1 at 177,050,190 bp
  • A to G, chromosome 1 at 181,593,452 bp
  • A to G, chromosome 2 at 70,289,512 bp
  • A to G, chromosome 2 at 87,213,044 bp
  • G to A, chromosome 2 at 90,803,074 bp
  • G to T, chromosome 2 at 181,801,082 bp
  • T to A, chromosome 3 at 55,968,309 bp
  • A to T, chromosome 3 at 56,037,219 bp
  • T to A, chromosome 3 at 67,596,603 bp
  • A to C, chromosome 4 at 34,808,593 bp
  • A to G, chromosome 4 at 88,880,082 bp
  • T to A, chromosome 4 at 111,980,266 bp
  • T to C, chromosome 4 at 112,119,863 bp
  • A to G, chromosome 5 at 124,641,514 bp
  • T to A, chromosome 5 at 145,195,506 bp
  • T to C, chromosome 6 at 113,240,397 bp
  • G to T, chromosome 6 at 130,062,028 bp
  • G to A, chromosome 7 at 101,832,542 bp
  • A to G, chromosome 7 at 118,163,316 bp
  • A to G, chromosome 7 at 141,163,441 bp
  • G to A, chromosome 8 at 57,652,951 bp
  • G to A, chromosome 9 at 7,857,344 bp
  • G to A, chromosome 9 at 22,249,544 bp
  • A to T, chromosome 9 at 44,925,948 bp
  • A to T, chromosome 9 at 79,633,424 bp
  • C to A, chromosome 9 at 95,404,749 bp
  • A to G, chromosome 9 at 121,653,893 bp
  • T to C, chromosome 10 at 34,282,587 bp
  • A to G, chromosome 10 at 93,734,175 bp
  • T to C, chromosome 10 at 128,283,753 bp
  • T to C, chromosome 11 at 48,866,463 bp
  • T to C, chromosome 11 at 84,195,483 bp
  • T to C, chromosome 11 at 97,452,248 bp
  • T to C, chromosome 12 at 36,314,412 bp
  • T to A, chromosome 12 at 40,820,617 bp
  • A to T, chromosome 12 at 74,229,213 bp
  • C to A, chromosome 13 at 21,959,408 bp
  • T to G, chromosome 13 at 21,981,769 bp
  • C to A, chromosome 13 at 53,335,358 bp
  • C to T, chromosome 14 at 30,923,489 bp
  • A to G, chromosome 14 at 43,727,419 bp
  • T to C, chromosome 14 at 54,616,755 bp
  • A to G, chromosome 16 at 17,376,982 bp
  • A to G, chromosome 16 at 49,182,927 bp
  • T to A, chromosome 16 at 59,186,331 bp
  • G to A, chromosome 17 at 12,714,944 bp
  • G to A, chromosome 17 at 22,339,519 bp
  • A to G, chromosome 17 at 35,428,127 bp
  • A to G, chromosome 17 at 47,377,815 bp
  • T to A, chromosome 18 at 37,720,651 bp
  • C to A, chromosome 18 at 61,961,037 bp
  • C to T, chromosome 18 at 66,076,307 bp
  • T to A, chromosome 19 at 13,375,526 bp
  • A to G, chromosome 19 at 25,678,342 bp
  • T to C, chromosome 19 at 59,907,043 bp
  • A to G, chromosome X at 170,676,361 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6752 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044869-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.