Strain Name:
C57BL/6J-MtgxR6757Btlr/Mmmh
Stock Number:
044873-MU
Citation ID:
RRID:MMRRC_044873-MU
Other Names:
R6757 (G1)
Major Collection:

Strain Information

Dntt
Name: deoxynucleotidyltransferase, terminal
Synonyms: Tdt
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21673
VEGA: 19
HGNC: HGNC:2983
Homologene: 3014
Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489
Fzd8
Name: frizzled class receptor 8
Synonyms: mFZ8, Fz8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14370
VEGA: 18
HGNC: HGNC:4046
Homologene: 40606
Myo1b
Name: myosin IB
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17912
HGNC: HGNC:7596
Homologene: 7856
Pole
Name: polymerase (DNA directed), epsilon
Synonyms: pol-epsilon
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18973
HGNC: HGNC:9177
Homologene: 4539
Slc39a14
Name: solute carrier family 39 (zinc transporter), member 14
Synonyms: G630015O18Rik, Zip14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 213053
Homologene: 15037
Dag1
Name: dystroglycan 1
Synonyms: beta-dystroglycan, alpha-dystroglycan, D9Wsu13e, DG, dystrophin associated glycoprotein 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13138
HGNC: HGNC:2666
Homologene: 3234
Kdm2a
Name: lysine (K)-specific demethylase 2A
Synonyms: Gm4560, Fbl7, Fbxl11, 5530401A10Rik, Jhdm1a, lalina, Cxxc8
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225876
Homologene: 56564
Epha5
Name: Eph receptor A5
Synonyms: bsk, Hek7, Rek7, Ehk1, Els1, Cek7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13839
HGNC: HGNC:3389
Homologene: 55824
Garre1
Name: granule associated Rac and RHOG effector 1
Synonyms: 4931406P16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233103
Homologene: 8795
Usp40
Name: ubiquitin specific peptidase 40
Synonyms: B230215L03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227334
Homologene: 32400
Nrp1
Name: neuropilin 1
Synonyms: NP-1, Npn1, NPN-1, Neuropilin-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18186
HGNC: HGNC:8004
Homologene: 2876
Gnptab
Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms: EG432486
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432486
Homologene: 32576
Bmi1
Name: Bmi1 polycomb ring finger oncogene
Synonyms: Bmi1, Pcgf4, Bmi-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12151
Homologene: 3797
Fpr-rs4
Name: formyl peptide receptor, related sequence 4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14291
HGNC: HGNC:3827
Homologene: 130629
Spata31e5
Name: spermatogenesis associated 31 subfamily E member 5
Synonyms: LOC210962, Gm597
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210962
A830018L16Rik
Name: RIKEN cDNA A830018L16 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320492
Homologene: 14194
Cpm
Name: carboxypeptidase M
Synonyms: 5730456K23Rik, 1110060I01Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70574
HGNC: HGNC:2311
Homologene: 35367
Or10g3
Name: olfactory receptor family 10 subfamily G member 3
Synonyms: MOR223-5, GA_x6K02T2RJGY-622120-623061, Olfr1512
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258424
HGNC: HGNC:8171
Homologene: 27165
Gstt1
Name: glutathione S-transferase, theta 1
Synonyms: Gstt1-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14871
HGNC: HGNC:4641
Homologene: 134739
Cyp2a22
Name: cytochrome P450, family 2, subfamily a, polypeptide 22
Synonyms: EG233005
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233005
Homologene: 69128
Myl10
Name: myosin, light chain 10, regulatory
Synonyms: PLRLC-A, PLRLC, PLRLC-C, 1700027I08Rik, Mylc2pl, PLRLC-B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59310
Homologene: 69341
Art2a
Name: ADP-ribosyltransferase 2a
Synonyms: Rt-6, Rt6-1, Rt6, Art2a-ps
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11871
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 11,596,334 bp
  • A to C, chromosome 1 at 28,780,110 bp
  • C to T, chromosome 1 at 51,813,048 bp
  • A to T, chromosome 1 at 87,980,037 bp
  • C to T, chromosome 2 at 18,684,029 bp
  • A to C, chromosome 5 at 84,105,878 bp
  • T to C, chromosome 5 at 110,303,610 bp
  • G to C, chromosome 5 at 136,697,971 bp
  • A to C, chromosome 7 at 26,939,204 bp
  • G to A, chromosome 7 at 34,239,077 bp
  • G to T, chromosome 7 at 101,555,014 bp
  • T to A, chromosome 8 at 128,425,868 bp
  • A to C, chromosome 9 at 108,218,017 bp
  • A to G, chromosome 10 at 11,181,508 bp
  • A to T, chromosome 10 at 75,798,383 bp
  • T to C, chromosome 10 at 88,437,502 bp
  • A to G, chromosome 10 at 117,671,638 bp
  • A to G, chromosome 14 at 52,372,715 bp
  • A to T, chromosome 14 at 70,310,884 bp
  • C to T, chromosome 17 at 18,022,132 bp
  • T to A, chromosome 18 at 9,213,238 bp
  • T to C, chromosome 19 at 4,319,243 bp
  • A to T, chromosome 19 at 41,037,162 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6757 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044873-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.