Strain Name:
C57BL/6J-MtgxR6763Btlr/Mmmh
Stock Number:
044879-MU
Citation ID:
RRID:MMRRC_044879-MU
Other Names:
R6763 (G1)
Major Collection:

Strain Information

Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Cwc27
Name: CWC27 spliceosome-associated protein
Synonyms: Sdccag10, 3110009E13Rik, NY-CO-10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67285
Homologene: 21192
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: D3Ertd775e, Lba
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Nln
Name: neurolysin (metallopeptidase M3 family)
Synonyms: 4930472G13Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 75805
VEGA: 13
Homologene: 69315
Cabin1
Name: calcineurin binding protein 1
Synonyms: Cain, Ppp3in, A330070M20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 104248
VEGA: 10
Homologene: 49307
Aspm
Name: abnormal spindle microtubule assembly
Synonyms: Sha1, MCPH5, D330028K02Rik, Aspm, Calmbp1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12316
Homologene: 7650
Nup133
Name: nucleoporin 133
Synonyms: 4832420O05Rik, mermaid
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234865
Homologene: 32402
Lmtk2
Name: lemur tyrosine kinase 2
Synonyms: AATYK2, KPI-2, cprk, KPI2, A330101P12Rik, BREK, 2900041G10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231876
Homologene: 8948
Gas2l3
Name: growth arrest-specific 2 like 3
Synonyms: LOC237436, 8430435B07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237436
VEGA: 10
Homologene: 18386
Niban2
Name: niban apoptosis regulator 2
Synonyms: Fam129b, 9130404D14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227737
Homologene: 11269
E130308A19Rik
Name: RIKEN cDNA E130308A19 gene
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230259
Homologene: 136157
Rtca
Name: RNA 3'-terminal phosphate cyclase
Synonyms: Rtcd1, 2310009A18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66368
Homologene: 2766
Ccbe1
Name: collagen and calcium binding EGF domains 1
Synonyms: 9430093N24Rik, 4933426F18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 320924
Homologene: 15852
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Cand2
Name: cullin associated and neddylation dissociated 2 (putative)
Synonyms: Tp120b, 2210404G23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67088
Homologene: 41657
Sdccag8
Name: serologically defined colon cancer antigen 8
Synonyms: 5730470G24Rik, CCCAP, 2700048G21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 76816
Homologene: 4839
Garnl3
Name: GTPase activating RANGAP domain-like 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99326
Homologene: 13003
Svil
Name: supervillin
Synonyms: B430302E16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225115
Homologene: 25090
Prkcb
Name: protein kinase C, beta
Synonyms: Prkcb1, Prkcb2, A130082F03Rik, Pkcb, PKC-Beta
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18751
HGNC: HGNC:9395
Homologene: 56424
Unc80
Name: unc-80, NALCN activator
Synonyms: C230061B10Rik, C030018G13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329178
Homologene: 122243
Wdfy4
Name: WD repeat and FYVE domain containing 4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 545030
Homologene: 83473
Ptpro
Name: protein tyrosine phosphatase receptor type O
Synonyms: PTP-BK, PTPROt, GLEPP1, Ptpn15, PTP-U2, PTP-phi, D28, PTP-oc
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19277
HGNC: HGNC:9678
Homologene: 21564
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: 2300002I04Rik, MUC5, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 9130019P20Rik, 4933432B13Rik, A530027J04Rik, 1110004O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 108857
Homologene: 87006
Chaf1b
Name: chromatin assembly factor 1, subunit B
Synonyms: CAF-I 60 kDa subunit, CAF1A, CAF1, CAF1P60, MPHOSPH7, CAF-1 subunit B, 2600017H24Rik, CAF-IP60
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110749
HGNC: HGNC:1911
Homologene: 48346
Celsr3
Name: cadherin, EGF LAG seven-pass G-type receptor 3
Synonyms: Fmi1, flamingo, Adgrc3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 107934
HGNC: HGNC:3230
Homologene: 1077
Zfp518a
Name: zinc finger protein 518A
Synonyms: 6330417C12Rik, 2810401C22Rik, Zfp518
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72672
VEGA: 19
Homologene: 19378
Atp8a2
Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Synonyms: wl, Ib, agil
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50769
Homologene: 4443
Ceacam14
Name: CEA cell adhesion molecule 14
Synonyms: 1600025E09Rik, 1600021E03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67084
Homologene: 135962
Actrt2
Name: actin-related protein T2
Synonyms: Arpm2, Arp-T2, 1700052K15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73353
Homologene: 23647
Clec2d
Name: C-type lectin domain family 2, member d
Synonyms: Ocil, Clrb, Clr-b
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93694
Homologene: 136309
Rab11fip5
Name: RAB11 family interacting protein 5 (class I)
Synonyms: RIP11, 9130206P09Rik, GAF1, D6Ertd32e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52055
Homologene: 9158
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Aaas
Name: achalasia, adrenocortical insufficiency, alacrimia
Synonyms: D030041N15Rik, GL003, Aladin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223921
VEGA: 15
Homologene: 9232
Adra1b
Name: adrenergic receptor, alpha 1b
Synonyms: alpha1B-adrenergic receptor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11548
HGNC: HGNC:278
Homologene: 55477
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 46,628,890 bp
  • A to G, chromosome 1 at 66,521,477 bp
  • A to T, chromosome 1 at 139,470,517 bp
  • A to G, chromosome 1 at 176,854,627 bp
  • T to C, chromosome 2 at 32,911,448 bp
  • T to C, chromosome 2 at 33,054,196 bp
  • A to G, chromosome 3 at 86,354,263 bp
  • A to G, chromosome 3 at 116,507,749 bp
  • A to T, chromosome 4 at 59,752,288 bp
  • A to G, chromosome 4 at 154,667,379 bp
  • T to A, chromosome 5 at 144,173,797 bp
  • A to G, chromosome 6 at 85,342,170 bp
  • T to A, chromosome 6 at 115,799,969 bp
  • C to A, chromosome 6 at 129,184,144 bp
  • A to G, chromosome 6 at 137,418,281 bp
  • A to G, chromosome 7 at 17,815,343 bp
  • A to G, chromosome 7 at 122,594,664 bp
  • A to G, chromosome 7 at 141,862,284 bp
  • T to C, chromosome 8 at 123,944,278 bp
  • A to G, chromosome 9 at 108,827,350 bp
  • A to G, chromosome 10 at 75,746,730 bp
  • T to C, chromosome 10 at 89,413,369 bp
  • A to G, chromosome 11 at 43,776,006 bp
  • A to T, chromosome 13 at 104,035,655 bp
  • T to C, chromosome 13 at 104,811,301 bp
  • G to T, chromosome 14 at 33,042,512 bp
  • T to A, chromosome 14 at 60,008,408 bp
  • C to T, chromosome 15 at 8,135,895 bp
  • C to A, chromosome 15 at 102,340,022 bp
  • A to G, chromosome 16 at 93,891,505 bp
  • A to G, chromosome 17 at 67,746,873 bp
  • G to T, chromosome 18 at 5,056,437 bp
  • A to G, chromosome 18 at 36,642,969 bp
  • A to T, chromosome 18 at 66,061,388 bp
  • A to G, chromosome 19 at 40,913,748 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6763 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044879-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.