Strain Name:
C57BL/6J-MtgxR6765Btlr/Mmmh
Stock Number:
044881-MU
Citation ID:
RRID:MMRRC_044881-MU
Other Names:
R6765 (G1)
Major Collection:

Strain Information

Mc1r
Name: melanocortin 1 receptor
Synonyms: Mshra, Mcr1, extension recessive yellow, e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17199
HGNC: HGNC:6929
Homologene: 1789
Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: N-CoR, Rxrip13, A230020K14Rik, 5730405M06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Gpr37l1
Name: G protein-coupled receptor 37-like 1
Synonyms: D0Kist8, CAG-18
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171469
Homologene: 3500
Khdc4
Name: KH domain containing 4, pre-mRNA splicing factor
Synonyms: 2810403A07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74200
Homologene: 41761
Arid4b
Name: AT-rich interaction domain 4B
Synonyms: BRCAA1, RBBP1L1, SAP180, 6720480E17Rik, 6330417L24Rik, Rbp1l1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94246
Homologene: 12847
Map1b
Name: microtubule-associated protein 1B
Synonyms: Mtap-5, Mtap5, LC1, Mtap1b, MAP5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Trp53bp1
Name: transformation related protein 53 binding protein 1
Synonyms: p53BP1, 53BP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27223
Homologene: 4137
Adipor2
Name: adiponectin receptor 2
Synonyms: 1110001I14Rik, D6Ucla1e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68465
Homologene: 56119
Ap3b1
Name: adaptor-related protein complex 3, beta 1 subunit
Synonyms: rim2, AP-3, Hps2, recombination induced mutation 2, beta3A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11774
VEGA: 13
HGNC: HGNC:566
Homologene: 68125
Zfp106
Name: zinc finger protein 106
Synonyms: sirm, H3a, Sh3bp3, Cd-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20402
Homologene: 40787
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, A330049M09Rik, enaptin165, nesprin-1, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Wwc2
Name: WW, C2 and coiled-coil domain containing 2
Synonyms: D8Ertd594e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52357
Homologene: 32618
Pwp1
Name: PWP1 homolog, endonuclein
Synonyms: 2610205J09Rik, 2310058A11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103136
Homologene: 5129
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218236
VEGA: 13
Homologene: 8752
Zfp981
Name: zinc finger protein 981
Synonyms: Gm13247
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100041433
Homologene: 133076
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12294
Homologene: 74929
Vwc2
Name: von Willebrand factor C domain containing 2
Synonyms: cradin, Brorin, A930041G11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 319922
Homologene: 18542
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Ap1b1
Name: adaptor protein complex AP-1, beta 1 subunit
Synonyms: beta-prime adaptin, b2b1660Clo, Adtb1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11764
HGNC: HGNC:554
Homologene: 21972
Cdk12
Name: cyclin dependent kinase 12
Synonyms: Crkrs, D11Ertd752e, 1810022J16Rik, Crk7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69131
Homologene: 128632
Vps26b
Name: VPS26 retromer complex component B
Synonyms: 2310075A12Rik, 1810012I05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69091
VEGA: 9
Homologene: 3601
Nrbp1
Name: nuclear receptor binding protein 1
Synonyms: B230344L17Rik, Nrbp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 192292
HGNC: HGNC:7993
Homologene: 8373
Lnpep
Name: leucyl/cystinyl aminopeptidase
Synonyms: 4732490P18Rik, vp165, gp160, IRAP, 2010309L07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240028
VEGA: 17
HGNC: HGNC:6656
Homologene: 21148
Psmd5
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
Synonyms: S5b, 1500032A03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66998
HGNC: HGNC:9563
Homologene: 37999
Adamtsl3
Name: ADAMTS-like 3
Synonyms: punctin-2, 9230119C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269959
Homologene: 18912
Kcnu1
Name: potassium channel, subfamily U, member 1
Synonyms: Kcnma3, Slo3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16532
Homologene: 7392
Pkhd1
Name: polycystic kidney and hepatic disease 1
Synonyms: tigmin, FPC
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241035
HGNC: HGNC:9016
Homologene: 16336
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Fhip2a
Name: FHF complex subunit HOOK interacting protein 2A
Synonyms: Fam160b1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226252
VEGA: 19
Homologene: 28133
Clcn2
Name: chloride channel, voltage-sensitive 2
Synonyms: nmf240, ClC-2, Clc2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12724
HGNC: HGNC:2020
Homologene: 3213
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Dlgap2
Name: DLG associated protein 2
Synonyms: DAP2, Sapap2, 6430596N04Rik, SAP90/PSD-95-associated protein 2, PSD-95/SAP90-binding protein 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244310
HGNC: HGNC:2906
Homologene: 3484
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Atp2c2
Name: ATPase, Ca++ transporting, type 2C, member 2
Synonyms: 1810010G06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69047
Homologene: 73463
Farp1
Name: FERM, ARH/RhoGEF and pleckstrin domain protein 1
Synonyms: Cdep
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 223254
HGNC: HGNC:3591
Homologene: 38098
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 434341
Homologene: 88935
Sclt1
Name: sodium channel and clathrin linker 1
Synonyms: 4931421F20Rik, 2610207F23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67161
Homologene: 27031
Nhsl1
Name: NHS like 1
Synonyms: D10Bwg0940e, A630035H13Rik, 5730409E15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215819
Homologene: 27834
Pcdhb13
Name: protocadherin beta 13
Synonyms: PcdhbM, Pcdbh6
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93884
HGNC: HGNC:8691
Homologene: 10338
Aoc1
Name: amine oxidase, copper-containing 1
Synonyms: Abp1, 1600012D06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76507
HGNC: HGNC:80
Homologene: 68159
Akt3
Name: thymoma viral proto-oncogene 3
Synonyms: Nmf350, PKB gamma, D930002M15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23797
HGNC: HGNC:393
Homologene: 55904
Or4c116
Name: olfactory receptor family 4 subfamily C member 116
Synonyms: GA_x6K02T2Q125-50591144-50590209, MOR233-3, Olfr1221
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258904
Homologene: 73987
Rmc1
Name: regulator of MON1-CCZ1
Synonyms: 3110002H16Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 76482
Homologene: 8341
Tmem163
Name: transmembrane protein 163
Synonyms: 2610024A01Rik, SV31
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72160
Homologene: 12798
Or8k27
Name: olfactory receptor family 8 subfamily K member 27
Synonyms: Olfr1065, GA_x6K02T2Q125-47915274-47914333, MOR190-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258403
Homologene: 74195
Itih3
Name: inter-alpha trypsin inhibitor, heavy chain 3
Synonyms: Itih-3, Intin3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16426
HGNC: HGNC:6168
Homologene: 1669
Mpped1
Name: metallophosphoesterase domain containing 1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223726
HGNC: HGNC:1306
Homologene: 15012
Gm12185
Name: predicted gene 12185
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 620913
Homologene: 83188
Upb1
Name: ureidopropionase, beta
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103149
Homologene: 9471
Ccdc136
Name: coiled-coil domain containing 136
Synonyms: 4921511K06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232664
Homologene: 23378
Dhrs13
Name: dehydrogenase/reductase 13
Synonyms: dehydrogenase/reductase (SDR family) member 13, 2610209N15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70451
Homologene: 64807
Csrnp2
Name: cysteine-serine-rich nuclear protein 2
Synonyms: CSRNP-2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 207785
VEGA: 15
Homologene: 32743
Gsto2
Name: glutathione S-transferase omega 2
Synonyms: 1700020F09Rik, 4930425C18Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68214
Homologene: 57057
Or10g9
Name: olfactory receptor family 10 subfamily G member 9
Synonyms: MOR223-1, GA_x6K02T2PVTD-33699706-33698771, Olfr979
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 259112
VEGA: 9
Homologene: 81556
Qsox1
Name: quiescin Q6 sulfhydryl oxidase 1
Synonyms: Qscn6, b2b2673Clo, QSOX, 1300003H02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 104009
HGNC: HGNC:9756
Homologene: 37690
Prrt2
Name: proline-rich transmembrane protein 2
Synonyms: 1500031I19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69017
Homologene: 114328
Zfp551
Name: zinc finger protein 551
Synonyms: 9630004E07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 619331
Homologene: 64631
Trav13n-4
Name: T cell receptor alpha variable 13N-4
Synonyms: ENSMUSG00000072517, Gm10907
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100126460
Bhlhe23
Name: basic helix-loop-helix family, member e23
Synonyms: beta-cell E-box transactivating factor 4, Bhlhb4, A930001L02Rik, BETA4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 140489
Homologene: 50956
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 20,058,339 bp
  • G to T, chromosome 1 at 127,551,341 bp
  • T to C, chromosome 1 at 135,167,122 bp
  • A to G, chromosome 1 at 155,791,105 bp
  • A to T, chromosome 1 at 177,050,190 bp
  • A to C, chromosome 2 at 34,856,533 bp
  • A to G, chromosome 2 at 82,986,432 bp
  • T to C, chromosome 2 at 86,445,236 bp
  • G to T, chromosome 2 at 89,112,296 bp
  • T to C, chromosome 2 at 120,539,454 bp
  • T to C, chromosome 2 at 121,209,309 bp
  • C to A, chromosome 2 at 180,776,343 bp
  • T to C, chromosome 3 at 41,730,902 bp
  • G to T, chromosome 3 at 88,686,429 bp
  • T to A, chromosome 4 at 146,537,906 bp
  • G to A, chromosome 5 at 31,245,846 bp
  • A to G, chromosome 5 at 137,393,147 bp
  • G to A, chromosome 6 at 29,405,941 bp
  • A to G, chromosome 6 at 48,905,937 bp
  • A to C, chromosome 6 at 119,357,242 bp
  • G to A, chromosome 7 at 12,416,840 bp
  • C to A, chromosome 7 at 82,567,024 bp
  • T to A, chromosome 7 at 127,019,597 bp
  • G to A, chromosome 8 at 14,743,284 bp
  • A to T, chromosome 8 at 25,913,645 bp
  • A to G, chromosome 8 at 47,900,791 bp
  • C to T, chromosome 8 at 94,490,368 bp
  • A to T, chromosome 8 at 119,753,017 bp
  • A to G, chromosome 8 at 123,407,696 bp
  • T to C, chromosome 9 at 27,012,808 bp
  • A to C, chromosome 9 at 40,001,197 bp
  • A to T, chromosome 10 at 5,143,285 bp
  • A to T, chromosome 10 at 18,531,314 bp
  • A to T, chromosome 10 at 75,438,144 bp
  • G to A, chromosome 10 at 85,884,533 bp
  • T to A, chromosome 11 at 5,019,427 bp
  • C to T, chromosome 11 at 11,154,215 bp
  • A to G, chromosome 11 at 48,915,704 bp
  • T to C, chromosome 11 at 62,373,446 bp
  • T to A, chromosome 11 at 78,037,139 bp
  • T to A, chromosome 11 at 98,224,529 bp
  • T to A, chromosome 13 at 14,187,315 bp
  • A to G, chromosome 13 at 48,891,964 bp
  • T to A, chromosome 13 at 94,462,509 bp
  • A to C, chromosome 13 at 99,425,941 bp
  • T to C, chromosome 14 at 29,055,977 bp
  • C to T, chromosome 14 at 30,909,473 bp
  • A to T, chromosome 14 at 53,364,100 bp
  • G to A, chromosome 14 at 121,222,654 bp
  • G to A, chromosome 15 at 83,836,383 bp
  • C to T, chromosome 15 at 100,482,693 bp
  • A to C, chromosome 16 at 20,707,668 bp
  • G to A, chromosome 17 at 17,530,496 bp
  • G to A, chromosome 17 at 30,748,568 bp
  • A to G, chromosome 18 at 12,176,146 bp
  • T to C, chromosome 18 at 37,443,610 bp
  • T to A, chromosome 19 at 18,877,765 bp
  • A to T, chromosome 19 at 47,871,788 bp
  • A to G, chromosome 19 at 57,378,745 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6765 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044881-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.