Strain Name:
C57BL/6J-MtgxR6767Btlr/Mmmh
Stock Number:
044883-MU
Citation ID:
RRID:MMRRC_044883-MU
Other Names:
R6767 (G1)
Major Collection:

Strain Information

Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Kera
Name: keratocan
Synonyms: SLRR2B, CNA2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16545
VEGA: 10
HGNC: HGNC:6309
Homologene: 5106
Nrg1
Name: neuregulin 1
Synonyms: ARIA, HRGalpha, NDF, D230005F13Rik, HGL, Hgl, HRG, GGFII, SMDF, 6030402G23Rik, heregulin, GGF
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211323
HGNC: HGNC:7997
Homologene: 138451
Luc7l3
Name: LUC7-like 3 (S. cerevisiae)
Synonyms: 3300001P08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67684
Homologene: 75056
Mtss1
Name: MTSS I-BAR domain containing 1
Synonyms: 2310003N14Rik, MIM, D130001D01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 211401
VEGA: 15
Homologene: 8841
Cib4
Name: calcium and integrin binding family member 4
Synonyms: 1700041E20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73259
Homologene: 18990
Cnst
Name: consortin, connexin sorting protein
Synonyms: 9630058J23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226744
Homologene: 17139
Dyrk3
Name: dual-specificity tyrosine phosphorylation regulated kinase 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226419
HGNC: HGNC:3094
Homologene: 55762
Wdr59
Name: WD repeat domain 59
Synonyms: 5430401O09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319481
Homologene: 38685
Tcf7l1
Name: transcription factor 7 like 1 (T cell specific, HMG box)
Synonyms: Tcf3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21415
Homologene: 7563
Rnf40
Name: ring finger protein 40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233900
Homologene: 8856
Pi4ka
Name: phosphatidylinositol 4-kinase alpha
Synonyms: Pik4ca
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224020
HGNC: HGNC:8983
Homologene: 11171
Naa25
Name: N(alpha)-acetyltransferase 25, NatB auxiliary subunit
Synonyms: C330023M02Rik, 4833422K13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231713
Homologene: 6891
Rnf121
Name: ring finger protein 121
Synonyms: 4930544L10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75212
Homologene: 10132
Fasn
Name: fatty acid synthase
Synonyms: FAS, A630082H08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
N4bp2
Name: NEDD4 binding protein 2
Synonyms: B3bp, LOC386488, LOC333789
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 333789
Homologene: 32396
Wwc2
Name: WW, C2 and coiled-coil domain containing 2
Synonyms: D8Ertd594e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 52357
Homologene: 32618
Tacc1
Name: transforming, acidic coiled-coil containing protein 1
Synonyms: 4833447E04Rik, Tacc1, B230378H13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320165
Homologene: 4575
Kif2c
Name: kinesin family member 2C
Synonyms: 4930402F02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73804
HGNC: HGNC:6393
Homologene: 21355
Trappc10
Name: trafficking protein particle complex 10
Synonyms: b2b2613Clo, Tmem1, LOC380642, b2b2416Clo, B230307C21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216131
VEGA: 10
Homologene: 37751
Sphk1
Name: sphingosine kinase 1
Synonyms: 1110006G24Rik, SK1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20698
Homologene: 39748
Smc6
Name: structural maintenance of chromosomes 6
Synonyms: 2810489L22Rik, 3830418C19Rik, Smc6l1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67241
VEGA: 12
Homologene: 41575
Gsdma3
Name: gasdermin A3
Synonyms: Rim3, Dfl, Fgn, Gsdm1l, Bsk, Rco2, Gsdm3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 450219
Ak7
Name: adenylate kinase 7
Synonyms: 4930502N02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 78801
VEGA: 12
Homologene: 14268
Cemip
Name: cell migration inducing protein, hyaluronan binding
Synonyms: Hybid, 12H19.01.T7, 9930013L23Rik, 6330404C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80982
Homologene: 10268
Top3a
Name: topoisomerase (DNA) III alpha
Synonyms: Top IIIa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21975
Homologene: 3394
Spmip2
Name: sperm microtubule inner protein 2
Synonyms: Gm17359
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100233207
Homologene: 105634
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Orm3
Name: orosomucoid 3
Synonyms: Orm-3, Agp-3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18407
Homologene: 130632
Stat4
Name: signal transducer and activator of transcription 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20849
Homologene: 20679
Chrd
Name: chordin
Synonyms: Chd
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12667
HGNC: HGNC:1949
Homologene: 2774
Gm12695
Name: predicted gene 12695
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 620779
Homologene: 51847
Gas6
Name: growth arrest specific 6
Synonyms: Gas-6, growth arrest-specific, GAS 6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14456
HGNC: HGNC:4168
Homologene: 638
Slc22a21
Name: solute carrier family 22 (organic cation transporter), member 21
Synonyms: Slc22a9, Octn3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56517
Homologene: 137336
Pld4
Name: phospholipase D family member 4
Synonyms: thss
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104759
VEGA: 12
Homologene: 16350
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384813
Homologene: 78104
Hivep1
Name: human immunodeficiency virus type I enhancer binding protein 1
Synonyms: alphaA-CRYBP1, Cryabp1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110521
VEGA: 13
HGNC: HGNC:4920
Homologene: 1596
Tpk1
Name: thiamine pyrophosphokinase
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 29807
Homologene: 6960
Smgc
Name: submandibular gland protein C
Synonyms: Sfc21, 2310010P21Rik, DXImx49e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223809
Serpina3n
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3N
Synonyms: Spi2/eb.4, alpha-1 antiproteinase, Spi2-2, Spi2.2, antitrypsin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20716
HGNC: HGNC:16
Homologene: 111129
Akt3
Name: thymoma viral proto-oncogene 3
Synonyms: Nmf350, PKB gamma, D930002M15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23797
HGNC: HGNC:393
Homologene: 55904
Kctd1
Name: potassium channel tetramerisation domain containing 1
Synonyms: 4933402K10Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106931
VEGA: 18
Homologene: 65999
Grid2
Name: glutamate receptor, ionotropic, delta 2
Synonyms: tpr, B230104L07Rik, GluRdelta2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14804
HGNC: HGNC:4576
Homologene: 74399
Vmn2r91
Name: vomeronasal 2, receptor 91
Synonyms: EG665210
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665210
Homologene: 115024
Spsb1
Name: splA/ryanodine receptor domain and SOCS box containing 1
Synonyms: SSB1, 1110014L01Rik, 4930422J18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74646
Homologene: 11832
Ccdc33
Name: coiled-coil domain containing 33
Synonyms: 4930535E21Rik, LOC382077
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382077
Homologene: 19641
Hdac9
Name: histone deacetylase 9
Synonyms: Hdac7b, Mitr, D030072B18Rik, HDRP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 79221
Homologene: 128578
Zfyve16
Name: zinc finger, FYVE domain containing 16
Synonyms: B130024H06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218441
Homologene: 8826
Atp8a2
Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Synonyms: wl, Ib, agil
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50769
Homologene: 4443
Plch1
Name: phospholipase C, eta 1
Synonyms: PLCeta1, Plcl3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Sorcs3
Name: sortilin-related VPS10 domain containing receptor 3
Synonyms: 6330404A12Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66673
VEGA: 19
Homologene: 8986
Mrpl9
Name: mitochondrial ribosomal protein L9
Synonyms: 8030480E20Rik, C330013D18Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78523
Homologene: 12696
Cd163
Name: CD163 antigen
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93671
HGNC: HGNC:1631
Homologene: 128811
Dnajb8
Name: DnaJ heat shock protein family (Hsp40) member B8
Synonyms: 1700016F14Rik, mDj6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56691
Homologene: 23184
Tmem192
Name: transmembrane protein 192
Synonyms: 3110005G23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73067
Homologene: 16751
Gbp8
Name: guanylate-binding protein 8
Synonyms: 5830443L24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76074
Or2w1b
Name: olfactory receptor family 2 subfamily W member 1B
Synonyms: GA_x6K02T2QHY8-12126170-12125935, MOR256-31, Olfr1369
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 404504
HGNC: HGNC:8281
Slc22a28
Name: solute carrier family 22, member 28
Synonyms: Gm5631
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 434674
VEGA: 19
Homologene: 77136
Zfp324
Name: zinc finger protein 324
Synonyms: D430030K24Rik, ZF5128
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243834
Homologene: 8648
Prelp
Name: proline arginine-rich end leucine-rich repeat
Synonyms: SLRR2A, 7330409J17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 116847
HGNC: HGNC:9357
Homologene: 2041
Gm9376
Name: predicted gene 9376
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 668814
Gm6034
Name: predicted gene 6034
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 547347
Syngr4
Name: synaptogyrin 4
Synonyms: 1700016O14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 58867
Homologene: 8258
Vmn1r18
Name: vomeronasal 1 receptor 18
Synonyms: V1rc26
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171199
Homologene: 138094
Clic1
Name: chloride intracellular channel 1
Synonyms: Clcp, G6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 114584
HGNC: HGNC:2062
Homologene: 20343
Vmn2r40
Name: vomeronasal 2, receptor 40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100042781
Homologene: 113703
H4c2
Name: H4 clustered histone 2
Synonyms: Hist1h4b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 326620
Homologene: 134466
Scgb1b12
Name: secretoglobin, family 1B, member 12
Synonyms: Gm9140, Abpa12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668381
Homologene: 114479
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 52,076,583 bp
  • T to C, chromosome 1 at 131,129,590 bp
  • C to A, chromosome 1 at 133,912,710 bp
  • A to T, chromosome 1 at 177,050,190 bp
  • C to T, chromosome 1 at 179,609,954 bp
  • A to T, chromosome 3 at 63,755,344 bp
  • A to T, chromosome 3 at 79,430,023 bp
  • A to G, chromosome 3 at 94,450,221 bp
  • C to T, chromosome 4 at 63,356,294 bp
  • T to C, chromosome 4 at 96,762,696 bp
  • C to T, chromosome 4 at 117,178,188 bp
  • C to T, chromosome 4 at 149,906,844 bp
  • T to A, chromosome 5 at 30,534,245 bp
  • T to C, chromosome 5 at 65,817,187 bp
  • T to C, chromosome 5 at 105,018,612 bp
  • T to C, chromosome 5 at 121,439,865 bp
  • T to A, chromosome 6 at 43,346,793 bp
  • T to A, chromosome 6 at 57,390,221 bp
  • A to G, chromosome 6 at 63,931,015 bp
  • T to G, chromosome 6 at 72,631,292 bp
  • C to A, chromosome 6 at 73,133,608 bp
  • T to C, chromosome 6 at 88,222,652 bp
  • T to G, chromosome 6 at 124,304,779 bp
  • A to T, chromosome 7 at 8,920,140 bp
  • A to C, chromosome 7 at 12,970,600 bp
  • A to T, chromosome 7 at 32,334,495 bp
  • A to G, chromosome 7 at 45,887,491 bp
  • G to A, chromosome 7 at 83,998,624 bp
  • A to G, chromosome 7 at 102,023,412 bp
  • A to G, chromosome 7 at 127,596,585 bp
  • A to G, chromosome 8 at 13,465,784 bp
  • T to C, chromosome 8 at 25,240,800 bp
  • T to C, chromosome 8 at 31,917,895 bp
  • G to A, chromosome 8 at 43,626,914 bp
  • A to G, chromosome 8 at 47,900,791 bp
  • T to C, chromosome 8 at 64,964,236 bp
  • G to T, chromosome 8 at 111,476,101 bp
  • C to G, chromosome 9 at 58,033,244 bp
  • A to G, chromosome 10 at 78,193,511 bp
  • A to G, chromosome 10 at 97,609,172 bp
  • T to C, chromosome 11 at 53,979,502 bp
  • G to T, chromosome 11 at 60,750,753 bp
  • G to T, chromosome 11 at 94,292,953 bp
  • A to T, chromosome 11 at 98,637,884 bp
  • A to G, chromosome 11 at 116,536,156 bp
  • T to C, chromosome 11 at 120,817,487 bp
  • T to A, chromosome 12 at 11,271,820 bp
  • T to A, chromosome 12 at 34,287,529 bp
  • T to G, chromosome 12 at 104,409,062 bp
  • A to G, chromosome 12 at 105,766,607 bp
  • A to C, chromosome 12 at 112,764,115 bp
  • C to T, chromosome 13 at 21,116,057 bp
  • T to A, chromosome 13 at 23,757,022 bp
  • T to C, chromosome 13 at 42,154,727 bp
  • A to G, chromosome 13 at 92,508,199 bp
  • T to A, chromosome 14 at 12,550,888 bp
  • A to G, chromosome 14 at 60,046,722 bp
  • A to G, chromosome 14 at 118,267,236 bp
  • T to C, chromosome 15 at 58,953,581 bp
  • T to A, chromosome 15 at 91,841,398 bp
  • A to G, chromosome 16 at 17,376,982 bp
  • C to T, chromosome 16 at 20,738,626 bp
  • T to A, chromosome 17 at 18,107,545 bp
  • T to A, chromosome 17 at 35,053,053 bp
  • T to A, chromosome 17 at 36,043,131 bp
  • T to C, chromosome 18 at 15,062,175 bp
  • A to G, chromosome 19 at 8,117,045 bp
  • G to T, chromosome 19 at 48,713,571 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6767 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044883-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.