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Strain Name:
C57BL/6J-MtgxR6767Btlr/Mmmh
Stock Number:
044883-MU
Citation ID:
RRID:MMRRC_044883-MU
Other Names:
R6767 (G1)
Major Collection:

Strain Information

Cadps
Name: Ca2+-dependent secretion activator
Synonyms: CAPS1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27062
VEGA: 14
HGNC: HGNC:1426
Homologene: 2755
Kera
Name: keratocan
Synonyms: SLRR2B, CNA2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16545
VEGA: 10
HGNC: HGNC:6309
Homologene: 5106
Nrg1
Name: neuregulin 1
Synonyms: HGL, HRG, Hgl, SMDF, GGF, ARIA, heregulin, D230005F13Rik, HRGalpha, 6030402G23Rik, GGFII, NDF
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211323
HGNC: HGNC:7997
Homologene: 138451
Luc7l3
Name: LUC7-like 3 (S. cerevisiae)
Synonyms: 3300001P08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67684
Homologene: 75056
Mtss1
Name: MTSS I-BAR domain containing 1
Synonyms: MIM, D130001D01Rik, 2310003N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 211401
VEGA: 15
Homologene: 8841
Cib4
Name: calcium and integrin binding family member 4
Synonyms: 1700041E20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73259
Homologene: 18990
Cnst
Name: consortin, connexin sorting protein
Synonyms: 9630058J23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226744
Homologene: 17139
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 52,076,583 bp
  • T to C, chromosome 1 at 131,129,590 bp
  • C to A, chromosome 1 at 133,912,710 bp
  • A to T, chromosome 1 at 177,050,190 bp
  • C to T, chromosome 1 at 179,609,954 bp
  • A to T, chromosome 3 at 63,755,344 bp
  • A to T, chromosome 3 at 79,430,023 bp
  • A to G, chromosome 3 at 94,450,221 bp
  • C to T, chromosome 4 at 63,356,294 bp
  • T to C, chromosome 4 at 96,762,696 bp
  • C to T, chromosome 4 at 117,178,188 bp
  • C to T, chromosome 4 at 149,906,844 bp
  • T to A, chromosome 5 at 30,534,245 bp
  • T to C, chromosome 5 at 65,817,187 bp
  • T to C, chromosome 5 at 105,018,612 bp
  • T to C, chromosome 5 at 121,439,865 bp
  • T to A, chromosome 6 at 43,346,793 bp
  • T to A, chromosome 6 at 57,390,221 bp
  • A to G, chromosome 6 at 63,931,015 bp
  • T to G, chromosome 6 at 72,631,292 bp
  • C to A, chromosome 6 at 73,133,608 bp
  • T to C, chromosome 6 at 88,222,652 bp
  • T to G, chromosome 6 at 124,304,779 bp
  • A to T, chromosome 7 at 8,920,140 bp
  • A to C, chromosome 7 at 12,970,600 bp
  • A to T, chromosome 7 at 32,334,495 bp
  • A to G, chromosome 7 at 45,887,491 bp
  • G to A, chromosome 7 at 83,998,624 bp
  • A to G, chromosome 7 at 102,023,412 bp
  • A to G, chromosome 7 at 127,596,585 bp
  • A to G, chromosome 8 at 13,465,784 bp
  • T to C, chromosome 8 at 25,240,800 bp
  • T to C, chromosome 8 at 31,917,895 bp
  • G to A, chromosome 8 at 43,626,914 bp
  • A to G, chromosome 8 at 47,900,791 bp
  • T to C, chromosome 8 at 64,964,236 bp
  • G to T, chromosome 8 at 111,476,101 bp
  • C to G, chromosome 9 at 58,033,244 bp
  • A to G, chromosome 10 at 78,193,511 bp
  • A to G, chromosome 10 at 97,609,172 bp
  • T to C, chromosome 11 at 53,979,502 bp
  • G to T, chromosome 11 at 60,750,753 bp
  • G to T, chromosome 11 at 94,292,953 bp
  • A to T, chromosome 11 at 98,637,884 bp
  • A to G, chromosome 11 at 116,536,156 bp
  • T to C, chromosome 11 at 120,817,487 bp
  • T to A, chromosome 12 at 11,271,820 bp
  • T to A, chromosome 12 at 34,287,529 bp
  • T to G, chromosome 12 at 104,409,062 bp
  • A to G, chromosome 12 at 105,766,607 bp
  • A to C, chromosome 12 at 112,764,115 bp
  • C to T, chromosome 13 at 21,116,057 bp
  • T to A, chromosome 13 at 23,757,022 bp
  • T to C, chromosome 13 at 42,154,727 bp
  • A to G, chromosome 13 at 92,508,199 bp
  • T to A, chromosome 14 at 12,550,888 bp
  • A to G, chromosome 14 at 60,046,722 bp
  • A to G, chromosome 14 at 118,267,236 bp
  • T to C, chromosome 15 at 58,953,581 bp
  • T to A, chromosome 15 at 91,841,398 bp
  • A to G, chromosome 16 at 17,376,982 bp
  • C to T, chromosome 16 at 20,738,626 bp
  • T to A, chromosome 17 at 18,107,545 bp
  • T to A, chromosome 17 at 35,053,053 bp
  • T to A, chromosome 17 at 36,043,131 bp
  • T to C, chromosome 18 at 15,062,175 bp
  • A to G, chromosome 19 at 8,117,045 bp
  • G to T, chromosome 19 at 48,713,571 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6767 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044883-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.