Strain Name:
C57BL/6J-MtgxR6770Btlr/Mmmh
Stock Number:
044886-MU
Citation ID:
RRID:MMRRC_044886-MU
Other Names:
R6770 (G1)
Major Collection:

Strain Information

Ldb2
Name: LIM domain binding 2
Synonyms: CLIM1, CLIM-1a, CLIM-1b, Ldb3, CLP-36
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16826
HGNC: HGNC:6533
Homologene: 989
Ptpn14
Name: protein tyrosine phosphatase, non-receptor type 14
Synonyms: PTP36, OTTMUSG00000022087, C130080N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19250
HGNC: HGNC:9647
Homologene: 3941
Zfp423
Name: zinc finger protein 423
Synonyms: Ebfaz, Roaz, Zfp104, ataxia1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94187
Homologene: 9010
Adk
Name: adenosine kinase
Synonyms: AK, 2310026J05Rik, 5033405D03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11534
VEGA: 14
HGNC: HGNC:257
Homologene: 4891
Srgap2
Name: SLIT-ROBO Rho GTPase activating protein 2
Synonyms: 9930124L22Rik, FBP2, Fnbp2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14270
Homologene: 52683
Usp46
Name: ubiquitin specific peptidase 46
Synonyms: 1190009E20Rik, 2410018I08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69727
Homologene: 56957
Ctbp1
Name: C-terminal binding protein 1
Synonyms: CtBP1-S, CtBP1-L, D4S115h, CtBP3/BARS, D5H4S115E, BARS, D5H4S115
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13016
HGNC: HGNC:2494
Homologene: 1015
Sltm
Name: SAFB-like, transcription modulator
Synonyms: 5730555F13Rik, 5730455C01Rik, 9130215G10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66660
VEGA: 9
Homologene: 11696
Plekhg5
Name: pleckstrin homology domain containing, family G (with RhoGef domain) member 5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269608
Homologene: 10768
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: LOC381562, A930005E13Rik, D930005K06Rik, Zubr1, p600, 1810009A16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Bach2
Name: BTB and CNC homology, basic leucine zipper transcription factor 2
Synonyms: E030004N02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12014
Homologene: 7240
Btnl9
Name: butyrophilin-like 9
Synonyms: D330012D11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237754
Homologene: 68540
Dnajc1
Name: DnaJ heat shock protein family (Hsp40) member C1
Synonyms: Dnajl1, D230036H06Rik, MTJ1, ERdj1, 4733401K02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13418
Homologene: 7293
Siva1
Name: SIVA1, apoptosis-inducing factor
Synonyms: CD27bp
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 30954
VEGA: 12
Homologene: 4692
Suv39h2
Name: suppressor of variegation 3-9 2
Synonyms: 4930507K23Rik, D2Ertd544e, KMT1B, Suv39h histone methyltransferase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64707
Homologene: 32548
Eml2
Name: echinoderm microtubule associated protein like 2
Synonyms: 1600029N02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 72205
Homologene: 8125
Stxbp1
Name: syntaxin binding protein 1
Synonyms: nsec1, Sxtbp1, Munc-18a, Unc18h, Munc18-1, N-sec1, Rb-sec1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20910
Homologene: 2382
Cfi
Name: complement component factor i
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12630
HGNC: HGNC:5394
Homologene: 171
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Scn6a, Nax, NaG, Nav2, Nav2.3, 1110034K09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20272
Homologene: 55706
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: OTTMUSG00000005786, LOC380698
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Gm5114
Name: predicted gene 5114
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330513
Homologene: 45597
Ppic
Name: peptidylprolyl isomerase C
Synonyms: cyclophilin C, CyP-20c
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19038
VEGA: 18
HGNC: HGNC:9256
Homologene: 727
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: mdig, 6430526J12Rik, Megf7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Gbe1
Name: 1,4-alpha-glucan branching enzyme 1
Synonyms: D16Ertd536e, 2310045H19Rik, 2810426P10Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74185
HGNC: HGNC:4180
Homologene: 129
Otoa
Name: otoancorin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246190
Homologene: 71803
Ina
Name: internexin neuronal intermediate filament protein, alpha
Synonyms: NF66, NF-66
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226180
HGNC: HGNC:6057
Homologene: 10433
Nrap
Name: nebulin-related anchoring protein
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18175
HGNC: HGNC:7988
Homologene: 4499
Nrxn1
Name: neurexin I
Synonyms: alpha-latrotoxin receptor (calcium-dependent), 1700062G21Rik, neurexin I alpha, 9330127H16Rik, neurexin I alpha, neurexin I beta, neurexin I beta, neurexin I alpha, neurexin I beta, A230068P09Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18189
HGNC: HGNC:8008
Homologene: 21005
Ttc28
Name: tetratricopeptide repeat domain 28
Synonyms: 2310015L07Rik, TPRBK
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 209683
Homologene: 41023
Fbxo39
Name: F-box protein 39
Synonyms: 1700010H23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 628100
Homologene: 15156
Irs3
Name: insulin receptor substrate 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16369
HGNC: HGNC:6127
Homologene: 84788
Cdh10
Name: cadherin 10
Synonyms: C030011H18Rik, A830016G23Rik, C030003B10Rik, T2-cadherin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320873
HGNC: HGNC:1749
Homologene: 68530
Or4a75
Name: olfactory receptor family 4 subfamily A member 75
Synonyms: Olfr1248, MOR231-10, GA_x6K02T2Q125-51059648-51058725
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258787
Homologene: 133613
Or1e25
Name: olfactory receptor family 1 subfamily E member 25
Synonyms: MOR135-5, GA_x6K02T2P1NL-3773152-3774090, Olfr384, GA_x6K02T2P1NL-3739520-3740032, Olfr386
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193053
Homologene: 105206
Btnl4
Name: butyrophilin-like 4
Synonyms: NG11, Btn3a3, EG632126
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 632126
Homologene: 106849
Tas2r136
Name: taste receptor, type 2, member 136
Synonyms: Tas2r36, mt2r52
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 353165
Homologene: 136304
Pigz
Name: phosphatidylinositol glycan anchor biosynthesis, class Z
Synonyms: F630022B06Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239827
Homologene: 130742
Bin1
Name: bridging integrator 1
Synonyms: Amphl, Amphiphysin 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 30948
VEGA: 18
HGNC: HGNC:1052
Homologene: 113707
Or52n20
Name: olfactory receptor family 52 subfamily N member 20
Synonyms: Olfr659, MOR34-4, GA_x6K02T2PBJ9-7298889-7299857
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259052
Homologene: 74118
Nde1
Name: nudE neurodevelopment protein 1
Synonyms: mNudE, 2810027M15Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67203
Homologene: 32354
Slc4a1ap
Name: solute carrier family 4 (anion exchanger), member 1, adaptor protein
Synonyms: kanadaptin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 20534
Homologene: 7543
Otud1
Name: OTU domain containing 1
Synonyms: 4933428L19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71198
Homologene: 45953
Trav14-2
Name: T cell receptor alpha variable 14-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 667567
Or8c14-ps1
Name: olfactory receptor family 8 subfamily C member 14, pseudogene 1
Synonyms: MOR170-12, GA_x6K02T2PVTD-31869885-31870831, Olfr892-ps1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257911
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 131,298,510 bp
  • G to A, chromosome 1 at 189,832,773 bp
  • T to C, chromosome 2 at 3,472,551 bp
  • G to T, chromosome 2 at 18,217,271 bp
  • A to G, chromosome 2 at 19,659,182 bp
  • C to T, chromosome 2 at 32,819,889 bp
  • T to A, chromosome 2 at 66,729,184 bp
  • A to G, chromosome 2 at 89,617,862 bp
  • C to T, chromosome 2 at 91,497,303 bp
  • T to C, chromosome 3 at 129,858,730 bp
  • G to A, chromosome 4 at 32,575,240 bp
  • T to C, chromosome 4 at 139,489,182 bp
  • A to G, chromosome 4 at 152,103,079 bp
  • G to A, chromosome 5 at 31,527,882 bp
  • G to A, chromosome 5 at 33,250,860 bp
  • T to A, chromosome 5 at 44,669,396 bp
  • A to G, chromosome 5 at 74,032,354 bp
  • T to C, chromosome 5 at 111,286,140 bp
  • A to G, chromosome 5 at 137,645,213 bp
  • T to C, chromosome 6 at 132,777,382 bp
  • G to A, chromosome 7 at 19,201,163 bp
  • T to C, chromosome 7 at 39,408,543 bp
  • T to A, chromosome 7 at 104,671,518 bp
  • T to A, chromosome 7 at 121,145,614 bp
  • T to C, chromosome 8 at 87,781,817 bp
  • T to C, chromosome 9 at 38,190,183 bp
  • A to G, chromosome 9 at 70,584,777 bp
  • T to C, chromosome 11 at 49,175,565 bp
  • T to C, chromosome 11 at 59,044,036 bp
  • T to G, chromosome 11 at 72,317,796 bp
  • A to G, chromosome 11 at 73,602,978 bp
  • G to A, chromosome 12 at 112,647,924 bp
  • T to A, chromosome 13 at 11,738,462 bp
  • A to G, chromosome 14 at 21,234,914 bp
  • A to C, chromosome 14 at 53,641,172 bp
  • A to G, chromosome 15 at 18,985,222 bp
  • G to A, chromosome 16 at 14,188,378 bp
  • T to A, chromosome 16 at 31,945,750 bp
  • T to A, chromosome 16 at 70,314,265 bp
  • T to C, chromosome 16 at 70,401,838 bp
  • A to G, chromosome 17 at 34,474,037 bp
  • G to T, chromosome 17 at 90,037,179 bp
  • A to G, chromosome 18 at 32,406,149 bp
  • A to T, chromosome 18 at 53,411,585 bp
  • C to T, chromosome 19 at 47,014,927 bp
  • T to C, chromosome 19 at 56,382,537 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6770 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044886-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.