Strain Name:
C57BL/6J-MtgxR6774Btlr/Mmmh
Stock Number:
044890-MU
Citation ID:
RRID:MMRRC_044890-MU
Other Names:
R6774 (G1)
Major Collection:

Strain Information

Bmp7
Name: bone morphogenetic protein 7
Synonyms: osteogenic protein 1, OP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12162
HGNC: HGNC:1074
Homologene: 20410
Mob4
Name: MOB family member 4, phocein
Synonyms: Mobkl3, Prei3, 2610109B12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19070
Homologene: 9116
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: Edd1, Edd, 4432411E13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: slip, DNAPDcs, DNA-PKcs, DNA-PK, DOXNPH, XRCC7, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Synj2
Name: synaptojanin 2
Synonyms: SJ2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20975
Homologene: 117703
Pard3
Name: par-3 family cell polarity regulator
Synonyms: ASIP, PAR-3, D8Ertd580e, Pard3a, Par3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93742
Homologene: 10489
Atr
Name: ataxia telangiectasia and Rad3 related
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245000
HGNC: HGNC:882
Homologene: 96916
Gtf3c1
Name: general transcription factor III C 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233863
HGNC: HGNC:4664
Homologene: 31040
Usp10
Name: ubiquitin specific peptidase 10
Synonyms: 2610014N07Rik, Uchrp
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22224
Homologene: 31294
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: 2810449H11Rik, D130015N03Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Trim27
Name: tripartite motif-containing 27
Synonyms: Rfp
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19720
HGNC: HGNC:9975
Homologene: 111010
Zfp35
Name: zinc finger protein 35
Synonyms: Zfp-35
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 22694
Homologene: 133081
Cmas
Name: cytidine monophospho-N-acetylneuraminic acid synthetase
Synonyms: CMP-sialic acid synthetase, D6Bwg0250e, CMP-Neu5Ac synthase
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12764
Homologene: 7670
Myc
Name: myelocytomatosis oncogene
Synonyms: bHLHe39, Myc2, c-myc, Nird, Niard
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17869
HGNC: HGNC:7553
Homologene: 31092
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7, LOC381341, Dnahc7a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Ntng2
Name: netrin G2
Synonyms: Lmnt2, 2610016D08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 171171
Homologene: 13053
Tfap2a
Name: transcription factor AP-2, alpha
Synonyms: AP-2 alpha, Tcfap2a, Ap2tf, Ap2, AP2alpha, Ap-2 (a)
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21418
VEGA: 13
Homologene: 2421
1700017B05Rik
Name: RIKEN cDNA 1700017B05 gene
Synonyms: D9Ertd278e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74211
VEGA: 9
Homologene: 19283
Usp54
Name: ubiquitin specific peptidase 54
Synonyms: 4930429G18Rik, C030002J06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 78787
Homologene: 90902
Capn11
Name: calpain 11
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268958
HGNC: HGNC:1478
Homologene: 21392
Rapgef4
Name: Rap guanine nucleotide exchange factor (GEF) 4
Synonyms: 5730402K07Rik, 1300003D15Rik, cAMP-GEFII, 6330581N18Rik, Epac2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56508
Homologene: 4451
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Vmn2r103
Name: vomeronasal 2, receptor 103
Synonyms: EG627636
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627636
Homologene: 115024
Afap1l1
Name: actin filament associated protein 1-like 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106877
Homologene: 18728
Kif17
Name: kinesin family member 17
Synonyms: Kif17b, 5930435E01Rik, N-4 kinesin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16559
Homologene: 5883
Uspl1
Name: ubiquitin specific peptidase like 1
Synonyms: E430026A01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231915
Homologene: 4235
Ahnak2
Name: AHNAK nucleoprotein 2
Synonyms: LOC382643
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100041194
Homologene: 131081
Pwwp2b
Name: PWWP domain containing 2B
Synonyms: D930023J19Rik, D7Ertd517e, Pwwp2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101631
Homologene: 19056
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: mdig, 6430526J12Rik, Megf7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Tnxb
Name: tenascin XB
Synonyms: Tnx, TN-MHC
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 81877
Homologene: 49589
Adam34l
Name: a disintegrin and metallopeptidase domain 34 like
Synonyms: Gm5346
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384813
Homologene: 78104
Zfp712
Name: zinc finger protein 712
Synonyms: mszf89, mszf31, 4921504N20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78251
VEGA: 13
Homologene: 136296
Heg1
Name: heart development protein with EGF-like domains 1
Synonyms: 4632417D23Rik, 9530025L16Rik, 5530401I02Rik, LOC268884
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 77446
Homologene: 35276
Nprl3
Name: nitrogen permease regulator-like 3
Synonyms: HS-40, Mare, m(alpha)RE, -14 gene, Phg, HS-26, Prox1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17168
Homologene: 8091
Mmp1b
Name: matrix metallopeptidase 1b (interstitial collagenase)
Synonyms: Mcol-B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83996
HGNC: HGNC:7155
Homologene: 130791
Myo5c
Name: myosin VC
Synonyms: 9130003O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208943
VEGA: 9
HGNC: HGNC:7604
Homologene: 135711
Mamdc4
Name: MAM domain containing 4
Synonyms: LOC381352
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381352
Homologene: 17102
Crat
Name: carnitine acetyltransferase
Synonyms: CARAT
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12908
HGNC: HGNC:2342
Homologene: 598
A430033K04Rik
Name: RIKEN cDNA A430033K04 gene
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243308
Homologene: 65621
Gcc2
Name: GRIP and coiled-coil domain containing 2
Synonyms: 2600014C01Rik, 0610043A03Rik, 2210420P05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70297
Homologene: 45639
Cntn5
Name: contactin 5
Synonyms: NB-2, 6720426O10Rik, A830025P08Rik, LOC244683
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244682
HGNC: HGNC:2175
Homologene: 28447
Spata31e5
Name: spermatogenesis associated 31 subfamily E member 5
Synonyms: Gm597, LOC210962
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210962
Or5p50
Name: olfactory receptor family 5 subfamily P member 50
Synonyms: MOR204-21, Olfr469, GA_x6K02T2PBJ9-10152980-10152036
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258418
Homologene: 44979
Or4a67
Name: olfactory receptor family 4 subfamily A member 67
Synonyms: MOR225-12, Olfr1200, GA_x6K02T2Q125-50243231-50242221
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257887
Homologene: 123770
9930111J21Rik1
Name: RIKEN cDNA 9930111J21 gene 1
Synonyms: 9930111J21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 667214
Homologene: 83188
Kti12
Name: KTI12 homolog, chromatin associated
Synonyms: 1110001A12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100087
Homologene: 6347
Ppcs
Name: phosphopantothenoylcysteine synthetase
Synonyms: 6330579B17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 106564
Homologene: 6173
Trim72
Name: tripartite motif-containing 72
Synonyms: mitsugumin 53, MG53
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434246
Homologene: 66924
Or1f19
Name: olfactory receptor family 1 subfamily F member 19
Synonyms: MOR131-1, Olfr161, GA_x54KRFPKG5P-112942-113883
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258859
Homologene: 51784
Ccdc103
Name: coiled-coil domain containing 103
Synonyms: 1700039D13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 73293
Homologene: 45831
Gm29666
Name: predicted gene 29666
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 108168254
Or7e171-ps1
Name: olfactory receptor family 7 subfamily E member 171, pseudogene 1
Synonyms: GA_x6K02T2PVTD-13682249-13681321, MOR146-11_p, Olfr863-ps1, MOR146-5P
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258070
Gm3573
Name: predicted gene 3573
Type: Gene
Species: Mouse
Chromosome: 14
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 28,776,893 bp
  • A to G, chromosome 1 at 53,698,651 bp
  • A to G, chromosome 1 at 55,148,429 bp
  • C to T, chromosome 1 at 164,186,878 bp
  • T to C, chromosome 2 at 25,566,936 bp
  • T to C, chromosome 2 at 29,197,090 bp
  • G to A, chromosome 2 at 30,413,183 bp
  • A to G, chromosome 2 at 72,225,775 bp
  • C to T, chromosome 2 at 88,767,884 bp
  • G to A, chromosome 2 at 91,511,504 bp
  • A to G, chromosome 2 at 172,872,958 bp
  • G to A, chromosome 4 at 108,848,455 bp
  • T to C, chromosome 4 at 119,419,088 bp
  • A to G, chromosome 4 at 138,274,995 bp
  • A to G, chromosome 5 at 138,646,450 bp
  • T to A, chromosome 5 at 149,214,094 bp
  • A to G, chromosome 6 at 142,764,421 bp
  • T to A, chromosome 7 at 107,823,188 bp
  • G to T, chromosome 7 at 125,641,621 bp
  • T to G, chromosome 7 at 128,010,386 bp
  • T to C, chromosome 7 at 139,255,987 bp
  • T to A, chromosome 8 at 43,625,183 bp
  • T to C, chromosome 8 at 119,951,972 bp
  • T to C, chromosome 8 at 127,410,747 bp
  • T to C, chromosome 9 at 7,387,914 bp
  • T to C, chromosome 9 at 10,144,217 bp
  • A to T, chromosome 9 at 19,941,774 bp
  • A to T, chromosome 9 at 57,256,625 bp
  • TCCC to TCC, chromosome 9 at 66,501,188 bp
  • A to T, chromosome 9 at 75,289,186 bp
  • A to C, chromosome 9 at 79,706,337 bp
  • A to T, chromosome 9 at 95,927,213 bp
  • A to G, chromosome 10 at 58,281,439 bp
  • A to G, chromosome 11 at 32,237,381 bp
  • A to G, chromosome 11 at 48,947,316 bp
  • T to C, chromosome 11 at 102,882,693 bp
  • C to T, chromosome 12 at 112,773,738 bp
  • T to A, chromosome 13 at 21,192,454 bp
  • T to A, chromosome 13 at 40,728,754 bp
  • T to C, chromosome 13 at 67,041,504 bp
  • A to G, chromosome 14 at 20,577,228 bp
  • A to T, chromosome 14 at 42,187,515 bp
  • A to T, chromosome 15 at 38,015,135 bp
  • G to A, chromosome 15 at 61,988,279 bp
  • A to T, chromosome 15 at 84,914,059 bp
  • T to A, chromosome 16 at 3,592,516 bp
  • G to T, chromosome 16 at 15,725,461 bp
  • C to A, chromosome 16 at 33,738,268 bp
  • C to T, chromosome 17 at 6,038,015 bp
  • A to G, chromosome 17 at 19,773,511 bp
  • C to A, chromosome 17 at 34,709,632 bp
  • C to T, chromosome 17 at 45,657,330 bp
  • G to A, chromosome 18 at 24,002,958 bp
  • A to T, chromosome 18 at 61,755,661 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R6774 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
044890-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.